LOCUS       NM_000844               4149 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 7 (GRM7), transcript
            variant 1, mRNA.
ACCESSION   NM_000844
VERSION     NM_000844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4149)
  AUTHORS   Januel,L., Chatron,N., Rivier-Ringenbach,C., Cabet,S., Labalme,A.,
            Sahin,Y., Darvish,H., Kruer,M., Bakhtiari,S., Sanlaville,D., de
            Sainte Agathe,J.M. and Lesca,G.
  TITLE     GRM7-related disorder: five additional patients from three
            independent families and review of the literature
  JOURNAL   Eur J Med Genet 67, 104893 (2024)
   PUBMED   38070825
  REMARK    GeneRIF: GRM7-related disorder: five additional patients from three
            independent families and review of the literature.
            Review article
REFERENCE   2  (bases 1 to 4149)
  AUTHORS   Ghafouri-Fard,S., Ahmadi Teshnizi,S., Azizi,S., Eslami,S.,
            Taheri,M. and Rashnoo,F.
  TITLE     Associations between GRM7 polymorphisms and obesity in patients
            selected for sleeve gastrectomy
  JOURNAL   Metab Brain Dis 38 (8), 2765-2771 (2023)
   PUBMED   37882887
  REMARK    GeneRIF: Associations between GRM7 polymorphisms and obesity in
            patients selected for sleeve gastrectomy.
REFERENCE   3  (bases 1 to 4149)
  AUTHORS   Freitas,G.A. and Niswender,C.M.
  TITLE     GRM7 gene mutations and consequences for neurodevelopment
  JOURNAL   Pharmacol Biochem Behav 225, 173546 (2023)
   PUBMED   37003303
  REMARK    GeneRIF: GRM7 gene mutations and consequences for neurodevelopment.
            Review article
REFERENCE   4  (bases 1 to 4149)
  AUTHORS   Wang,L., Tang,X., Liang,P., Zhou,C., Sun,Y. and Liang,Y.
  TITLE     Correlation between variants of the CREB1 and GRM7 genes and risk
            of depression
  JOURNAL   BMC Psychiatry 23 (1), 3 (2023)
   PUBMED   36597080
  REMARK    GeneRIF: Correlation between variants of the CREB1 and GRM7 genes
            and risk of depression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4149)
  AUTHORS   Schulz,H.L., Stohr,H. and Weber,B.H.
  TITLE     Characterization of three novel isoforms of the metabotrobic
            glutamate receptor 7 (GRM7)
  JOURNAL   Neurosci Lett 326 (1), 37-40 (2002)
   PUBMED   12052533
  REMARK    GeneRIF: Identified additional splicing variants involving the 3'
            end of the GRM7 coding sequence and resulting in three putative
            novel isoforms.
REFERENCE   6  (bases 1 to 4149)
  AUTHORS   Nakajima,Y., Yamamoto,T., Nakayama,T. and Nakanishi,S.
  TITLE     A relationship between protein kinase C phosphorylation and
            calmodulin binding to the metabotropic glutamate receptor subtype 7
  JOURNAL   J Biol Chem 274 (39), 27573-27577 (1999)
   PUBMED   10488094
REFERENCE   7  (bases 1 to 4149)
  AUTHORS   Phillips,T., Makoff,A., Murrison,E., Mimmack,M., Waldvogel,H.,
            Faull,R., Rees,S. and Emson,P.
  TITLE     Immunohistochemical localisation of mGluR7 protein in the rodent
            and human cerebellar cortex using subtype specific antibodies
  JOURNAL   Brain Res Mol Brain Res 57 (1), 132-141 (1998)
   PUBMED   9630572
REFERENCE   8  (bases 1 to 4149)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   9  (bases 1 to 4149)
  AUTHORS   Flor,P.J., Van Der Putten,H., Ruegg,D., Lukic,S., Leonhardt,T.,
            Bence,M., Sansig,G., Knopfel,T. and Kuhn,R.
  TITLE     A novel splice variant of a metabotropic glutamate receptor, human
            mGluR7b
  JOURNAL   Neuropharmacology 36 (2), 153-159 (1997)
   PUBMED   9144652
REFERENCE   10 (bases 1 to 4149)
  AUTHORS   Makoff,A., Pilling,C., Harrington,K. and Emson,P.
  TITLE     Human metabotropic glutamate receptor type 7: molecular cloning and
            mRNA distribution in the CNS
  JOURNAL   Brain Res Mol Brain Res 40 (1), 165-170 (1996)
   PUBMED   8840028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312488.1, X94552.1,
            AB209214.1, AK123326.1 and AC077690.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000844.3.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system, and it activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors
            that have been divided into three groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5, and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2009].
            
            Transcript Variant: This variant (1, also known as hmGluR7a)
            encodes the predominant isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312488.1, SRR1660805.22489.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357716.9/ ENSP00000350348.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AK312488.1         1-495
            496-2469            X94552.1           460-2433
            2470-2725           AB209214.1         1461-1716
            2726-3057           X94552.1           2690-3021
            3058-4147           AK123326.1         1869-2958
            4148-4149           AC077690.2         2164-2165           c
FEATURES             Location/Qualifiers
     source          1..4149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.1"
     gene            1..4149
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /note="glutamate metabotropic receptor 7"
                     /db_xref="GeneID:2917"
                     /db_xref="HGNC:HGNC:4599"
                     /db_xref="MIM:604101"
     exon            1..793
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..3022
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; metabotropic glutamate receptor 7; protein
                     phosphatase 1, regulatory subunit 87; glutamate receptor,
                     metabotropic 7"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 7 isoform a
                     precursor"
                     /protein_id="NP_000835.1"
                     /db_xref="CCDS:CCDS43042.1"
                     /db_xref="GeneID:2917"
                     /db_xref="HGNC:HGNC:4599"
                     /db_xref="MIM:604101"
                     /translation="MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIR
                     IEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLG
                     ARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS
                     VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGW
                     NYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLD
                     TPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAI
                     TIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTG
                     QERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK
                     YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIED
                     MQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYD
                     QRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRAS
                     GRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYR
                     IFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNP
                     EQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC
                     IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNV
                     QKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLV
                     I"
     exon            794..1010
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1152
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1307
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1448
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1649
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1789
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2725
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2972
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..4149
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4123..4128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /note="hexamer: AATAAA"
     polyA_site      4149
                     /gene="GRM7"
                     /gene_synonym="GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA;
                     PPP1R87"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgggc tgttggagag agcgagcagc aagccggtga gcgcgagcgc ggcgcgccgg
       61 ccggctaacc cgagagcgcg aggcgcccca ggctggcagg cgccgcggga cccctcaccc
      121 tctctggtcg cccctccccg gattccccca ccctccgtgc ctgcaggagc ccctgggctt
      181 tcccggagga gctcgccctg aagggcccgg acctcggcga gcccaccacc gttccctcca
      241 gcgccgccgc cgccaccgca gcagccggag cagcatggtc cagctgagga agctgctccg
      301 cgtcctgact ttgatgaagt tcccctgctg cgtgctggag gtgctcctgt gcgcgctggc
      361 ggcggcggcg cgcggccagg agatgtacgc cccgcactca atccggatcg agggggacgt
      421 caccctcggg gggctgttcc ccgtgcacgc caagggtccc agcggagtgc cctgcggcga
      481 catcaagagg gaaaacggga tccacaggct ggaagcgatg ctctacgccc tggaccagat
      541 caacagtgat cccaacctac tgcccaacgt gacgctgggc gcgcggatcc tggacacttg
      601 ttccagggac acttacgcgc tcgaacagtc gcttactttc gtccaggcgc tcatccagaa
      661 ggacacctcc gacgtgcgct gcaccaacgg cgaaccgccg gttttcgtca agccggagaa
      721 agtagttgga gtgattgggg cttcggggag ttcggtctcc atcatggtag ccaacatcct
      781 gaggctcttc cagatccccc agattagtta tgcatcaacg gcacccgagc taagtgatga
      841 ccggcgctat gacttcttct ctcgcgtggt gccacccgat tccttccaag cccaggccat
      901 ggtagacatt gtaaaggccc taggctggaa ttatgtgtct accctcgcat cggaaggaag
      961 ttatggagag aaaggtgtgg agtccttcac gcagatttcc aaagaggcag gtggactctg
     1021 cattgcccag tccgtgagaa tcccccagga acgcaaagac aggaccattg actttgatag
     1081 aattatcaaa cagctcctgg acacccccaa ctccagggcc gtcgtgattt ttgccaacga
     1141 tgaggatata aagcagatcc ttgcagcagc caaaagagct gaccaagttg gccattttct
     1201 ttgggtggga tcagacagct ggggatccaa aataaaccca ctgcaccagc atgaagatat
     1261 cgcagaaggg gccatcacca ttcagcccaa gcgagccacg gtggaagggt ttgatgccta
     1321 ctttacgtcc cgtacacttg aaaacaacag aagaaatgta tggtttgccg aatactggga
     1381 ggaaaacttc aactgcaagt tgacgattag tgggtcaaaa aaagaagaca cagatcgcaa
     1441 atgcacagga caggagagaa ttggaaaaga ttccaactat gagcaggagg gtaaagtcca
     1501 gttcgtgatt gacgcagtct atgctatggc tcacgccctt caccacatga acaaggatct
     1561 ctgtgctgac taccggggtg tctgcccaga gatggagcaa gctggaggca agaagttgct
     1621 gaagtatata cgcaatgtta atttcaatgg tagtgctggc actccagtga tgtttaacaa
     1681 gaacggggat gcacctgggc gttatgacat ctttcagtac cagaccacaa acaccagcaa
     1741 cccgggttac cgtctgatcg ggcagtggac agacgaactt cagctcaata tagaagacat
     1801 gcagtggggt aaaggagtcc gagagatacc cgcctcagtg tgcacactac catgtaagcc
     1861 aggacagaga aagaagacac agaaaggaac tccttgctgt tggacctgtg agccttgcga
     1921 tggttaccag taccagtttg atgagatgac atgccagcat tgcccctatg accagaggcc
     1981 caatgaaaat cgaaccggat gccaggatat tcccatcatc aaactggagt ggcactcccc
     2041 ctgggctgtg attcctgtct tcctggcaat gttggggatc attgccacca tctttgtcat
     2101 ggccactttc atccgctaca atgacacgcc cattgtccgg gcatctgggc gggaactcag
     2161 ctatgttctt ttgacgggca tctttctttg ctacatcatc actttcctga tgattgccaa
     2221 accagatgtg gcagtgtgtt ctttccggcg agttttcttg ggcttgggta tgtgcatcag
     2281 ttatgcagcc ctcttgacga aaacaaatcg gatttatcgc atatttgagc agggcaagaa
     2341 atcagtaaca gctcccagac tcataagccc aacatcacaa ctggcaatca cttccagttt
     2401 aatatcagtt cagcttctag gggtgttcat ttggtttggt gttgatccac ccaacatcat
     2461 catagactat gatgaacaca agacaatgaa ccctgagcaa gccagagggg ttctcaagtg
     2521 tgacattaca gatctccaaa tcatttgctc cttgggatat agcattcttc tcatggtcac
     2581 atgtactgtg tatgccatca agactcgggg tgtacccgag aattttaacg aagccaagcc
     2641 cattggattc actatgtaca cgacatgtat agtatggctt gccttcattc caattttttt
     2701 tggcaccgct caatcagcgg aaaagctcta catacaaact accacgctta caatctccat
     2761 gaacctaagt gcatcagtgg cgctggggat gctatacatg ccgaaagtgt acatcatcat
     2821 tttccaccct gaactcaatg tccagaaacg gaagcgaagc ttcaaggcgg tagtcacagc
     2881 agccaccatg tcatcgaggc tgtcacacaa acccagtgac agacccaacg gtgaggcaaa
     2941 gaccgagctc tgtgaaaacg tagacccaaa cagccctgct gcaaaaaaga agtatgtcag
     3001 ttataataac ctggttatct aacctgttcc attccatgga accatggagg aggaagaccc
     3061 tcagttattt tgtcacccaa cctggcatag gactctttgg tcctacccgc ttcccatcac
     3121 cggaggagct tccccggccg ggagaccagt gttagaggat ccaagcgacc taaacagctg
     3181 ctttatgaaa tatccttact ttatctgggc ttaataagtc actgacatca gcactgccaa
     3241 ctcggctgca attgtggacc ttccctacca aagggagtgt tgaaactcaa gtcccgccct
     3301 ggctctttag aatggaccac tgagagccac aggaccgttt tggggctgac ctgtcttatt
     3361 acgtatgtac ttctaggttg caaggttttg aaattttctg tacagtttgt gaggaccttt
     3421 gcactttgcc atctgatgtc gtacctcggt tcactgtttg ttttcgaatg ccttgttttc
     3481 atagagccct attctctcag acggtggaat atttggaaaa attttaaaac aattaaaatt
     3541 ttaaagcaat cttggcagac taaaacaagt acatctgtac atgactgtat aattacgatt
     3601 atagtaccac tgcacatcat gttttttttt ttaagacaaa aaagatgttt aaagaccaaa
     3661 aactgtgctg agaaagtatg ccccacctat ctttggtata tgataggtta cataaaagga
     3721 aggtattggc tgaactgaat agaggtcttg atctttggaa tgcatgccag taatgtattt
     3781 tacagtacat gtttattatg ttcaatattt gtatttgtgt tctcttttgt tatttttaat
     3841 tagggtatat gaatattttg caataatttt aataattatt aagctgtttg aaggaaagaa
     3901 tatggatttt tcatgtcttg aggttttgtt catgccccct ttgactgatc agtgtgataa
     3961 ggactttagg aaaaaaagca tgtatgtttt ttactgtttg taataagtac tttcgttaat
     4021 cttgctgctt atgtgccaat ttagtggaaa aaaacaaccc ttgctgaaaa attccctctt
     4081 tccattctct ttcaattctg tgatattgtc caagaatgta tcaataaaat actttggtta
     4141 actttttta
//
