LOCUS       NM_000843               6025 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 6 (GRM6), mRNA.
ACCESSION   NM_000843
VERSION     NM_000843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6025)
  AUTHORS   Liu,H.Y., Huang,J., Xiao,H., Zhang,M.J., Shi,F.F., Jiang,Y.H.,
            Du,H., He,Q. and Wang,Z.Y.
  TITLE     Pseudodominant inheritance of autosomal recessive congenital
            stationary night blindness in one family with three co-segregating
            deleterious GRM6 variants identified by next-generation sequencing
  JOURNAL   Mol Genet Genomic Med 7 (12), e952 (2019)
   PUBMED   31677249
  REMARK    GeneRIF: Study reported a rare case of pseudodominantly inherited
            autosomal recessive congenital stationary night blindness in a
            family with three co-segregating deleterious variants (p.Arg621Ter,
            p.Gly51Val, and p.Gly464Arg) of GRM6.
REFERENCE   2  (bases 1 to 6025)
  AUTHORS   Tourville,A., Michiels,C., Condroyer,C., Meunier,A., Cordonnier,M.,
            Sahel,J.A., Audo,I., Abramowicz,M. and Zeitz,C.
  TITLE     Identification of a novel GRM6 mutation in a previously described
            consanguineous family with complete congenital stationary night
            blindness
  JOURNAL   Ophthalmic Genet 40 (2), 182-184 (2019)
   PUBMED   31063016
  REMARK    GeneRIF: We identified a novel homozygous missense mutation in exon
            8 of GRM6 (NM_000843.3).
REFERENCE   3  (bases 1 to 6025)
  AUTHORS   Eleftheriou,C.G., Cehajic-Kapetanovic,J., Martial,F.P.,
            Milosavljevic,N., Bedford,R.A. and Lucas,R.J.
  TITLE     Meclofenamic acid improves the signal to noise ratio for visual
            responses produced by ectopic expression of human rod opsin
  JOURNAL   Mol Vis 23, 334-345 (2017)
   PUBMED   28659709
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6025)
  AUTHORS   Dan,H., Song,X., Li,J., Xing,Y. and Li,T.
  TITLE     Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese
            patients with Schubert-Bornschein congenital stationary night
            blindness
  JOURNAL   Ophthalmic Genet 38 (3), 206-210 (2017)
   PUBMED   27428514
REFERENCE   5  (bases 1 to 6025)
  AUTHORS   Wang,H., Su,S., Yang,M., Hu,N., Yao,Y., Zhu,R., Zhou,J., Liang,C.
            and Guan,H.
  TITLE     Association of ZNF644, GRM6, and CTNND2 genes with high myopia in
            the Han Chinese population: Jiangsu Eye Study
  JOURNAL   Eye (Lond) 30 (7), 1017-1022 (2016)
   PUBMED   27034204
  REMARK    GeneRIF: Our data suggested that genetic variants in GRM6 are
            associated with high myopia. The mechanism of GRM6 in the
            development of high myopia need to be further investigated.
REFERENCE   6  (bases 1 to 6025)
  AUTHORS   Zeitz,C., van Genderen,M., Neidhardt,J., Luhmann,U.F., Hoeben,F.,
            Forster,U., Wycisk,K., Matyas,G., Hoyng,C.B., Riemslag,F.,
            Meire,F., Cremers,F.P. and Berger,W.
  TITLE     Mutations in GRM6 cause autosomal recessive congenital stationary
            night blindness with a distinctive scotopic 15-Hz flicker
            electroretinogram
  JOURNAL   Invest Ophthalmol Vis Sci 46 (11), 4328-4335 (2005)
   PUBMED   16249515
  REMARK    GeneRIF: Affected individuals in three of five families carried
            either compound heterozygous or homozygous mutations in GRM6.
REFERENCE   7  (bases 1 to 6025)
  AUTHORS   Dryja,T.P., McGee,T.L., Berson,E.L., Fishman,G.A., Sandberg,M.A.,
            Alexander,K.R., Derlacki,D.J. and Rajagopalan,A.S.
  TITLE     Night blindness and abnormal cone electroretinogram ON responses in
            patients with mutations in the GRM6 gene encoding mGluR6
  JOURNAL   Proc Natl Acad Sci U S A 102 (13), 4884-4889 (2005)
   PUBMED   15781871
REFERENCE   8  (bases 1 to 6025)
  AUTHORS   Valerio,A., Ferraboli,S., Paterlini,M., Spano,P. and Barlati,S.
  TITLE     Identification of novel alternatively-spliced mRNA isoforms of
            metabotropic glutamate receptor 6 gene in rat and human retina
  JOURNAL   Gene 262 (1-2), 99-106 (2001)
   PUBMED   11179672
REFERENCE   9  (bases 1 to 6025)
  AUTHORS   Dhingra,A., Lyubarsky,A., Jiang,M., Pugh,E.N. Jr., Birnbaumer,L.,
            Sterling,P. and Vardi,N.
  TITLE     The light response of ON bipolar neurons requires G[alpha]o
  JOURNAL   J Neurosci 20 (24), 9053-9058 (2000)
   PUBMED   11124982
REFERENCE   10 (bases 1 to 6025)
  AUTHORS   Hashimoto,T., Inazawa,J., Okamoto,N., Tagawa,Y., Bessho,Y.,
            Honda,Y. and Nakanishi,S.
  TITLE     The whole nucleotide sequence and chromosomal localization of the
            gene for human metabotropic glutamate receptor subtype 6
  JOURNAL   Eur J Neurosci 9 (6), 1226-1235 (1997)
   PUBMED   9215706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104117.2, BY797310.2,
            BM726590.1, BY796285.2, BM681239.1, BX647168.1 and BM665594.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 5, 2018 this sequence version replaced NM_000843.3.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Mutations in this gene result in congenital
            stationary night blindness type 1B. [provided by RefSeq, May 2018].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000517717.3/ ENSP00000430767.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC104117.2         111308-111329       c
            23-413              BY797310.2         1-391
            414-565             AC104117.2         110450-110601       c
            566-782             AC104117.2         107876-108092       c
            783-918             AC104117.2         107433-107568       c
            919-1073            AC104117.2         106601-106755       c
            1074-1192           AC104117.2         105296-105414       c
            1193-1274           BM726590.1         75-156
            1275-1377           AC104117.2         104982-105084       c
            1378-1561           BY796285.2         1-184
            1562-2097           AC104117.2         102227-102762       c
            2098-2488           BM681239.1         129-519             c
            2489-2571           BX647168.1         1151-1233
            2572-5554           AC104117.2         94807-97789         c
            5555-6025           BM665594.1         15-485              c
FEATURES             Location/Qualifiers
     source          1..6025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..6025
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /note="glutamate metabotropic receptor 6"
                     /db_xref="GeneID:2916"
                     /db_xref="HGNC:HGNC:4598"
                     /db_xref="MIM:604096"
     exon            1..45
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            46..565
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2695
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /note="glutamate receptor, metabotropic 6"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 6 precursor"
                     /protein_id="NP_000834.2"
                     /db_xref="CCDS:CCDS4442.1"
                     /db_xref="GeneID:2916"
                     /db_xref="HGNC:HGNC:4598"
                     /db_xref="MIM:604096"
                     /translation="MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGL
                     FPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRD
                     TYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMV
                     ANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVST
                     LASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGI
                     IIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRA
                     SIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRD
                     STYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRF
                     NGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSG
                     DPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTP
                     NHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELS
                     YVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQG
                     KRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARG
                     VLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLA
                     FVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKR
                     SLKATSTVAAPPKGEDAEAHK"
     exon            566..782
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            783..918
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1073
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1214
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1415
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1561
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2185
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2497
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..6025
                     /gene="GRM6"
                     /gene_synonym="CSNB1B; GPRC1F; mGlu6; MGLUR6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcatctgtc acagacttgt cctgaaccga cagcggctgg cgcagcccgc tagacgagcc
       61 gatggcgcgg ccccggagag cccgggagcc gctgctcgtg gcgctgctgc cgctggcgtg
      121 gctggcgcag gcgggcctgg cgcgcgcggc gggctctgtg cgcctggcgg gcggcctgac
      181 gctgggcggc ctgttcccgg tgcacgcgcg gggcgcggcg ggccgggcgt gcgggcagct
      241 gaagaaggag cagggcgtgc accggctgga ggccatgctg tacgcgctgg accgcgtcaa
      301 cgccgacccc gagctgctgc ccggcgtgcg cctgggcgcg cggctgctgg acacctgctc
      361 gcgggacacc tacgcgctgg agcaggcgct gagcttcgtg caggcgctga tccgcggccg
      421 cggcgacggc gacgaggtgg gcgtgcgctg cccgggaggc gtccctccgc tgcgccccgc
      481 gccccccgag cgcgtcgtgg ccgtcgtggg cgcctcggcc agctccgtct ccatcatggt
      541 cgccaacgtg ctgcgcctgt ttgcgatacc ccagatcagc tatgcctcca cagccccgga
      601 gctcagcgac tccacacgct atgacttctt ctcccgggtg gtgccacccg actcctacca
      661 ggcgcaggcc atggtggaca tcgtgagggc actgggatgg aactatgtgt ccacgctggc
      721 ctccgagggc aactatggcg aaagtggggt tgaggccttc gttcagatct cccgagaggc
      781 tgggggggtc tgtattgccc agtctatcaa gattcccagg gaaccaaagc caggagagtt
      841 cagcaaggtg atcaggagac tcatggagac gcccaacgcc cggggcatca tcatctttgc
      901 caatgaggat gacatcaggc gggtcctgga ggcagctcgc caggccaacc tgaccggcca
      961 cttcctgtgg gtcggctcag acagctgggg agccaagacc tcacccatct tgagcctgga
     1021 ggacgtggcc gttggggcca tcaccatcct gcccaaaagg gcctccatcg acggatttga
     1081 ccagtacttc atgactcgat ccctggagaa caaccgcagg aacatctggt tcgccgagtt
     1141 ctgggaagag aattttaact gcaaactgac cagctcaggt acccagtcag acgattccac
     1201 ccgcaaatgc acaggcgagg aacgcatcgg ccgggactcc acctacgagc aggagggcaa
     1261 ggtgcagttt gtgattgatg cggtgtacgc cattgcccac gccctccaca gcatgcacca
     1321 ggcgctctgc cctgggcaca caggcctgtg cccggcgatg gaacccactg atgggcggat
     1381 gcttctgcag tacattcgag ctgtccgctt caatggcagc gcaggaaccc ctgtgatgtt
     1441 caacgagaac ggagatgcgc ccgggcggta cgacatcttc cagtaccagg cgaccaatgg
     1501 cagtgccagc agtggcgggt accaggcagt gggccagtgg gcagagaccc tcagactgga
     1561 tgtggaggcc ctgcagtggt ctggcgaccc ccacgaggtg ccctcgtctc tgtgcagcct
     1621 gccctgcggg ccgggggagc ggaagaagat ggtgaagggc gtcccctgct gttggcactg
     1681 cgaggcctgt gacgggtacc gcttccaggt ggacgagttc acatgcgagg cctgtcctgg
     1741 ggacatgagg cccacgccca accacacggg ctgccgcccc acacctgtgg tgcgcctgag
     1801 ctggtcctcc ccctgggcag ccccgccgct cctcctggcc gtgctgggca tcgtggccac
     1861 taccacggtg gtggccacct tcgtgcggta caacaacacg cccatcgtcc gggcctcggg
     1921 ccgagagctc agctacgtcc tcctcaccgg catcttcctc atctacgcca tcaccttcct
     1981 catggtggct gagcctgggg ccgcggtctg tgccgcccgc aggctcttcc tgggcctggg
     2041 cacgaccctc agctactctg ccctgctcac caagaccaac cgtatctacc gcatctttga
     2101 gcagggcaag cgctcggtca caccccctcc cttcatcagc cccacctcac agctggtcat
     2161 caccttcagc ctcacctccc tgcaggtggt ggggatgata gcatggctgg gggcccggcc
     2221 cccacacagc gtgattgact atgaggaaca gcggacggtg gaccccgagc aggccagagg
     2281 ggtgctcaag tgcgacatgt cggatctgtc tctcatcggc tgcctgggct acagcctcct
     2341 gctcatggtc acgtgcacag tgtacgccat caaggcccgt ggcgtgcccg agaccttcaa
     2401 cgaggccaag cccatcggct tcaccatgta caccacctgc atcatctggc tggcattcgt
     2461 gcccatcttc tttggcactg cccagtcagc tgaaaagatc tacatccaga caaccacgct
     2521 aaccgtgtcc ttgagcctga gtgcctcggt gtccctcggc atgctctacg tacccaaaac
     2581 ctacgtcatc ctcttccatc cagagcagaa tgtgcagaag cgaaagcgga gcctcaaggc
     2641 cacctccacg gtggcagccc cacccaaggg cgaggatgca gaggcccaca agtagcaggg
     2701 caggtgggaa cgggactgct tgctgcctct cctttcttcc tcttgcctcg aggtggaagc
     2761 tgtatagagc ccgggtccac ggtgaacagt cagtggcagg gagtttgcca agaccatgct
     2821 ccgcgtcggt ggggctggcc ttgagaagga actggaccca gctctacccc gattccagca
     2881 tgtgagcttc atgcttcctc accacagacc agactcgctt cccatggtgg gaaacagcca
     2941 ccgagaaggt tctagctcta gaaagggact aaacttattc tctcatccga agtccaaaga
     3001 ggatgatgaa gccctgggct ttgcctggtt tgcgggagat ttcctcccct cagtcaaccc
     3061 ccataacctg gggattgggc agtgtggaag aacgtgtaga ccccagaatg aaacatgggg
     3121 ttggagtgga ggaggagctg tctcagcaag aggagacctg gggctgtgca tctggatgga
     3181 ggcactcagg cctgggtagg attcctctgg cacggaggga gagaccctgg gtgagacccc
     3241 tgtgagcatg ggaagggcct gcagtgggcg cgggagtgag ctgaggaact ggggtgcgcc
     3301 cccatgagat tcccaatgcc atgggctttc ccccatcccc ccgggattgg gcaaggtcag
     3361 acttagagta cagctgtttt cctcccctct gtgtactccc ttaaatcacc ccaaccttgg
     3421 ccaggcatgg tggctcacac ctgtaatccc agcactttgg gaggccgagg caggtggatc
     3481 acctgaggtc cggagttcga gaccagcctg gccaatgtgg tgaaaccctg tctctactaa
     3541 aaatacaaaa attagccagg tgtgatggtg ggtgcctgta atcccagtta cttgggaggc
     3601 tgaggcagga gaatcgcttg aacctgggag gtggaggttg cagtgagctg tgattgtgcc
     3661 actgtactcc agcctgggtg acagagcgag actctgtctc aaaaaaacaa aacaaaaaaa
     3721 caccaaaaaa acccccaaac ctgaagaaat tcagatacac gtgtgtaatg ttagtgatgt
     3781 gagaacaagg agcaggggtg catttgtgtt gtgttcgggt tggggatggg tttaggagct
     3841 ccaggttggg agcagtgaca gagagtcatg gccgtggtga gggtgaatcc caagtggatg
     3901 gctcaggacg ggtatggaaa cccttcattc ctcataggta ctgggaagtc catttgcaag
     3961 ctgagcgcca ggcctgggga ggaagaggct tgggctgcag atgcacgcac atttgttttt
     4021 cactgatagt ttttacaaaa agcttggttt aagttatgga gttttatgtc cctgggagta
     4081 gaatttacat ttgttaaatt gaccactgtt taagatcagt atacattctc tagtctgtga
     4141 tgtctggagc tagttttgag ggtgaaccac actttatcca acatacaaac tttcccatgc
     4201 agcttctctg gtgcgcagtt ggttttgacc gtgggactag gtgcttctgc aggttttaag
     4261 taattaactt aaaagcttct cctctgagaa acatttctgt tgcgctactg actctccttc
     4321 tccacatttg ttgtgttcct agggcttctc tatagtgcac attaggacgt ttcatttgtt
     4381 gctgaatgct ttccagaatt atttattcca tagggtttct ctcctgtgca gctctctcat
     4441 gggtaatggg gcgtgttttc ttgccaaagg cggttccacc ctcgtgattg tatagggctc
     4501 ttctcctgta tgaactctga gatcagtgag ctctgatctc caagggaaag ttttcctgca
     4561 tttgctgttt tctcatgtct ctcccagtgt gaattctttg gtgtgcagtg cgctctggct
     4621 tctagctgaa aacttttcca cagttttaca ttcatgtggt tttctccact gtgaactctg
     4681 tgattcagaa tcagaagcag ttcttagtag aggcatttct acactgattg cactgaggat
     4741 ttctccccag tgtgaagttt ctggcataga gtcctggctt cccgcagacg actttcacac
     4801 tctgccatgt tcatgcctgt gggcctctct ggcaggaact ctgatgcacc gcgaggccca
     4861 tgtactcctg tggctttctc acattcggtc tacttgcagg gtatctccac agcatgcacc
     4921 attctgggta cagggggaca tcctctgtta ctgaagatgt tgtcatattt agtaccttca
     4981 caaggtttct ctccttccag aattttctga tgtacacaaa taactgactt ccacaagagg
     5041 gcttttccac actcggtgtg tgcatacagt ttctgcctgt gatcatttct ttatgttatt
     5101 attttatttt ttcgagatag ggtcttgctc aatttcttag gctggagtgc agtggcacga
     5161 tcatagctca ctgaagtttc gacctgggct caagcaatcc tcccgcttca gcctcctgag
     5221 tagctggtgc gcacgaccat acccagctaa tgttttattt tttgtagaga cgaggtctca
     5281 ctatgttgcc caggctggtc tcgaacttct gagctcgagc gatcctcctg cctccacctc
     5341 ccaaagtgtt cggattacaa acgtgagcca tcgcacctag cctctttgat catttctgtg
     5401 gtgttcagtg gaggttgaca gctccctaaa gattttcctg tttttttgca tgcatgggtt
     5461 tgaattcttt gaggtccaat ttatttggac ccctgaataa agttttgtgg gttttcttct
     5521 atgtgtggaa tttataaggc attcttccag tgtggtttct cttatgtcga gtgagagctg
     5581 acctgcaccg aaggttttgt cccatttgtt gcccttgaat tatttgtatg aattatatgt
     5641 tccagtgaaa atggagttct gggttggagg cttattccat gtttacacaa ttaaaattgc
     5701 agtgttcctc tctgggatga gagctctaaa gcagagtaag attacgttct gatgtaagct
     5761 ttaaccacct atttataagg tctcacctgt ggtccactgt gttgagactt ctacagaaga
     5821 gcttctgtat agtaaccatt ttcttaggct gtctcacttg tgtgaatctt ctgacacatt
     5881 tattatagct ttgtcccatt tcttatcctt tttgctcttt agaaatttcc ctttaattta
     5941 ttacattcat tgcttactgt aaagagtcca ggtaactgac tttattcagt tacttcctgt
     6001 tcaataaatt taacttttcc caaaa
//
