LOCUS       NM_001143831            7996 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 5 (GRM5), transcript
            variant a, mRNA.
ACCESSION   NM_001143831 XM_006718828
VERSION     NM_001143831.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7996)
  AUTHORS   Weiss,E.R., Davis,M.T., Asch,R.H., D'Souza,D.C., Cool,R. and
            Esterlis,I.
  TITLE     Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the
            Intersection of Trauma and Cannabis Use
  JOURNAL   Int J Neuropsychopharmacol 27 (10) (2024)
   PUBMED   39320043
  REMARK    GeneRIF: Metabotropic Glutamate Receptor 5 as a Potential Biomarker
            of the Intersection of Trauma and Cannabis Use.
REFERENCE   2  (bases 1 to 7996)
  AUTHORS   Asch,R.H., Worhunsky,P.D., Davis,M.T., Holmes,S.E., Cool,R.,
            Boster,S., Carson,R.E., Blumberg,H.P. and Esterlis,I.
  TITLE     Deficits in prefrontal metabotropic glutamate receptor 5 are
            associated with functional alterations during emotional processing
            in bipolar disorder
  JOURNAL   J Affect Disord 361, 415-424 (2024)
   PUBMED   38876317
  REMARK    GeneRIF: Deficits in prefrontal metabotropic glutamate receptor 5
            are associated with functional alterations during emotional
            processing in bipolar disorder.
REFERENCE   3  (bases 1 to 7996)
  AUTHORS   Boutonnet,M., Carpena,C., Bouquier,N., Chastagnier,Y.,
            Font-Ingles,J., Moutin,E., Tricoire,L., Chemin,J. and Perroy,J.
  TITLE     Voltage tunes mGlu5 receptor function, impacting synaptic
            transmission
  JOURNAL   Br J Pharmacol 181 (12), 1793-1811 (2024)
   PUBMED   38369690
  REMARK    GeneRIF: Voltage tunes mGlu5 receptor function, impacting synaptic
            transmission.
REFERENCE   4  (bases 1 to 7996)
  AUTHORS   Krishna Kumar,K., Wang,H., Habrian,C., Latorraca,N.R., Xu,J.,
            O'Brien,E.S., Zhang,C., Montabana,E., Koehl,A., Marqusee,S.,
            Isacoff,E.Y. and Kobilka,B.K.
  TITLE     Stepwise activation of a metabotropic glutamate receptor
  JOURNAL   Nature 629 (8013), 951-956 (2024)
   PUBMED   38632403
  REMARK    GeneRIF: Stepwise activation of a metabotropic glutamate receptor.
            Erratum:[Nature. 2024 May;629(8013):E13. doi:
            10.1038/s41586-024-07470-5. PMID: 38702522]
REFERENCE   5  (bases 1 to 7996)
  AUTHORS   Wang,J., He,Y., Chen,X., Huang,L., Li,J., You,Z., Huang,Q., Ren,S.,
            He,K., Schibli,R., Mu,L., Guan,Y., Guo,Q., Zhao,J. and Xie,F.
  TITLE     Metabotropic glutamate receptor 5 (mGluR5) is associated with
            neurodegeneration and amyloid deposition in Alzheimer's disease: A
            [18F]PSS232 PET/MRI study
  JOURNAL   Alzheimers Res Ther 16 (1), 9 (2024)
   PUBMED   38217040
  REMARK    GeneRIF: Metabotropic glutamate receptor 5 (mGluR5) is associated
            with neurodegeneration and amyloid deposition in Alzheimer's
            disease: A [[18]F]PSS232 PET/MRI study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7996)
  AUTHORS   Nash,M.S., Schell,M.J., Atkinson,P.J., Johnston,N.R., Nahorski,S.R.
            and Challiss,R.A.
  TITLE     Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and
            inositol 1,4,5-trisphosphate oscillation frequency. Receptor
            density versus agonist concentration
  JOURNAL   J Biol Chem 277 (39), 35947-35960 (2002)
   PUBMED   12119301
  REMARK    GeneRIF: mGLUR5 and 1,4,5-InsP3 signaling control calcium release
REFERENCE   7  (bases 1 to 7996)
  AUTHORS   Devon,R.S., Anderson,S., Teague,P.W., Muir,W.J., Murray,V.,
            Pelosi,A.J., Blackwood,D.H. and Porteous,D.J.
  TITLE     The genomic organisation of the metabotropic glutamate receptor
            subtype 5 gene, and its association with schizophrenia
  JOURNAL   Mol Psychiatry 6 (3), 311-314 (2001)
   PUBMED   11326300
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7996)
  AUTHORS   Daggett,L.P., Sacaan,A.I., Akong,M., Rao,S.P., Hess,S.D., Liaw,C.,
            Urrutia,A., Jachec,C., Ellis,S.B., Dreessen,J. et al.
  TITLE     Molecular and functional characterization of recombinant human
            metabotropic glutamate receptor subtype 5
  JOURNAL   Neuropharmacology 34 (8), 871-886 (1995)
   PUBMED   8532169
REFERENCE   9  (bases 1 to 7996)
  AUTHORS   Minakami,R., Katsuki,F., Yamamoto,T., Nakamura,K. and Sugiyama,H.
  TITLE     Molecular cloning and the functional expression of two isoforms of
            human metabotropic glutamate receptor subtype 5
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1136-1143 (1994)
   PUBMED   7908515
REFERENCE   10 (bases 1 to 7996)
  AUTHORS   Minakami,R., Katsuki,F. and Sugiyama,H.
  TITLE     A variant of metabotropic glutamate receptor subtype 5: an
            evolutionally conserved insertion with no termination codon
  JOURNAL   Biochem Biophys Res Commun 194 (2), 622-627 (1993)
   PUBMED   7688218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001482.4, AP000626.5,
            AP001828.5, AP006215.1 and AP003120.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 15, 2020 this sequence version replaced
            XM_006718828.4, NM_001143831.2.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 3 protein family. The encoded protein is a metabatropic
            glutamate receptor, whose signaling activates a
            phosphatidylinositol-calcium second messenger system. This protein
            may be involved in the regulation of neural network activity and
            synaptic plasticity. Glutamatergic neurotransmission is involved in
            most aspects of normal brain function and can be perturbed in many
            neuropathologic conditions. A pseudogene of this gene has been
            defined on chromosome 11. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2014].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305447.5/ ENSP00000306138.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AP001482.4         7080-7286           c
            208-1068            AP000626.5         82875-83735         c
            1069-1318           AP001828.5         20274-20523         c
            1319-1554           AP006215.1         60542-60777         c
            1555-1801           AP006215.1         12092-12338         c
            1802-1970           AP006215.1         4558-4726           c
            1971-2097           AP003120.4         187468-187594       c
            2098-3037           AP003120.4         163920-164859       c
            3038-3133           AP003120.4         122176-122271       c
            3134-7996           AP003120.4         101509-106371       c
FEATURES             Location/Qualifiers
     source          1..7996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2-q14.3"
     gene            1..7996
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /note="glutamate metabotropic receptor 5"
                     /db_xref="GeneID:2915"
                     /db_xref="HGNC:HGNC:4597"
                     /db_xref="MIM:604102"
     exon            1..207
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1068
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1318
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1554
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1801
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1970
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2097
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..3037
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3133
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..7996
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7966..7971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /note="hexamer: AATATA"
     polyA_site      7996
                     /gene="GRM5"
                     /gene_synonym="GPRC1E; mGlu5; MGLUR5; PPP1R86"
                     /note="major polyA site"
ORIGIN      
        1 gcgtctgccc gagcgcggca cgtgctcccg gcgctggcgc gagagagcga gcgccaccgc
       61 cgcgggcccc gcagccgttc tgcctgctgt caccgctgcc tccatcgccg acactagcgc
      121 tccagctgca gccaaggccg ctacgagagc gcaggaagcc ctcgaggagc ggctgcctgg
      181 gggcgcaagg ctcagggcgc gcacctggtt tagaagatca tgaccacatg gatcatctaa
      241 ctaaatggta catggggaca aaatggtcct ttagaaaata catctgaatt gctggctaat
      301 ttcttgattt gcgactcaac gtaggacatc gcttgttcgt agctatcaga accctcctga
      361 attttcccca ccatgctatc tttattggct tgaactcctt tcctaaaatg gtccttctgt
      421 tgatcctgtc agtcttactt ttgaaagaag atgtccgtgg gagtgcacag tccagtgaga
      481 ggagggtggt ggctcacatg ccgggtgaca tcattattgg agctctcttt tctgttcatc
      541 accagcctac tgtggacaaa gttcatgaga ggaagtgtgg ggcggtccgt gaacagtatg
      601 gcattcagag agtggaggcc atgctgcata ccctggaaag gatcaattca gaccccacac
      661 tcttgcccaa catcacactg ggctgtgaga taagggactc ctgctggcat tcggctgtgg
      721 ccctagagca gagcattgag ttcataagag attccctcat ttcttcagaa gaggaagaag
      781 gcttggtacg ctgtgtggat ggctcctcct cttccttccg ctccaagaag cccatagtag
      841 gggtcattgg gcctggctcc agttctgtag ccattcaggt ccagaatttg ctccagcttt
      901 tcaacatacc tcagattgct tactcagcaa ccagcatgga tctgagtgac aagactctgt
      961 tcaaatattt catgagggtt gtgccttcag atgctcagca ggcaagggcc atggtggaca
     1021 tagtgaagag gtacaactgg acctatgtat cagccgtgca cacagaaggc aactatggag
     1081 aaagtgggat ggaagccttc aaagatatgt cagcgaagga agggatttgc atcgcccact
     1141 cttacaaaat ctacagtaat gcaggggagc agagctttga taagctgctg aagaagctca
     1201 caagtcactt gcccaaggcc cgggtggtgg cctgcttctg tgagggcatg acggtgagag
     1261 gtctgctgat ggccatgagg cgcctgggtc tagcgggaga atttctgctt ctgggcagtg
     1321 atggctgggc tgacaggtat gatgtgacag atggatatca gcgagaagct gttggtggca
     1381 tcacaatcaa gctccaatct cccgatgtca agtggtttga tgattattat ctgaagctcc
     1441 ggccagaaac aaaccaccga aacccttggt ttcaagaatt ttggcagcat cgttttcagt
     1501 gccgactgga agggtttcca caggagaaca gcaaatacaa caagacttgc aatagttctc
     1561 tgactctgaa aacacatcat gttcaggatt ccaaaatggg atttgtgatc aacgccatct
     1621 attcgatggc ctatgggctc cacaacatgc agatgtccct ctgcccaggc tatgcaggac
     1681 tctgtgatgc catgaagcca attgatggac ggaaactttt ggagtccctg atgaaaacca
     1741 attttactgg ggtttctgga gatacgatcc tattcgatga gaatggagac tctccaggaa
     1801 ggtatgaaat aatgaatttc aaggaaatgg gaaaagatta ctttgattat atcaacgttg
     1861 gaagttggga caatggagaa ttaaaaatgg atgatgatga agtatggtcc aagaaaagca
     1921 acatcatcag atctgtgtgc agtgaaccat gtgagaaagg ccagatcaag gtgatccgaa
     1981 agggagaagt cagctgttgt tggacctgta caccttgtaa ggagaatgag tatgtctttg
     2041 atgagtacac atgcaaggca tgccaactgg ggtcttggcc cactgatgat ctcacaggtt
     2101 gtgacttgat cccagtacag tatcttcgat ggggtgaccc tgaacccatt gcagctgtgg
     2161 tgtttgcctg ccttggcctc ctggccaccc tgtttgttac tgtagtcttc atcatttacc
     2221 gtgatacacc agtagtcaag tcctcaagca gggaactctg ctacattatc cttgctggca
     2281 tctgcctggg ctacttatgt accttctgcc tcattgcgaa gcccaaacag atttactgct
     2341 accttcagag aattggcatt ggtctctccc cagccatgag ctactcagcc cttgtaacaa
     2401 agaccaaccg tattgcaagg atcctggctg gcagcaagaa gaagatctgt accaaaaagc
     2461 ccagattcat gagtgcctgt gcccagctag tgattgcttt cattctcata tgcatccagt
     2521 tgggcatcat cgttgccctc tttataatgg agcctcctga cataatgcat gactacccaa
     2581 gcattcgaga agtctacctg atctgtaaca ccaccaacct aggagttgtc actccacttg
     2641 gatacaatgg attgttgatt ttgagctgca ccttctatgc gttcaagacc agaaatgttc
     2701 cagctaactt caacgaggcc aagtatatcg ccttcacaat gtacacgacc tgcattatat
     2761 ggctagcttt tgtgccaatc tactttggca gcaactacaa aatcatcacc atgtgtttct
     2821 cggtcagcct cagtgccaca gtggccctag gctgcatgtt tgtgccgaag gtgtacatca
     2881 tcctggccaa accagagaga aacgtgcgca gcgccttcac cacatctacc gtggtgcgca
     2941 tgcatgtagg ggatggcaag tcatcctccg cagccagcag atccagcagc ctagtcaacc
     3001 tgtggaagag aaggggctcc tctggggaaa ccttaaggta caaagacagg agactggccc
     3061 agcacaagtc ggaaatagag tgtttcaccc ccaaagggag tatggggaat ggtgggagag
     3121 caacaatgag cagttccaat ggaaaatccg tcacgtgggc ccagaatgag aagagcagcc
     3181 gggggcagca cctgtggcag cgcctgtcca tccacatcaa caagaaagaa aaccccaacc
     3241 aaacggccgt catcaagccc ttccccaaga gcacggagag ccgtggcctg ggcgctggcg
     3301 ctggcgcagg cgggagcgct gggggcgtgg gggccacggg cggtgcgggc tgcgcaggcg
     3361 ccggcccagg cgggcccgag tccccagacg ccggccccaa ggcgctgtat gatgtggccg
     3421 aggctgagga gcacttcccg gcgcccgcgc ggccgcgctc accgtcgccc atcagcacgc
     3481 tgagccaccg cgcgggctcg gccagccgca cggacgacga tgtgccgtcg ctgcactcgg
     3541 agcctgtggc gcgcagcagc tcctcgcagg gctccctcat ggagcagatc agcagtgtgg
     3601 tcacccgctt cacggccaac atcagcgagc tcaactccat gatgctgtcc accgcggccc
     3661 ccagccccgg cgtcggcgcc ccgctctgct cgtcctacct gatccccaaa gagatccagt
     3721 tgcccacgac catgacgacc tttgccgaaa tccagcctct gccggccatc gaagtcacgg
     3781 gaggcgcgca gcccgcggca ggggcgcagg cggctgggga cgcggcccgg gagagccccg
     3841 cggccggtcc cgaggctgcg gccgccaagc cagacctgga ggagctggtg gctctcaccc
     3901 cgccgtcccc cttcagagac tcggtggact cggggagcac aacccccaac tcgccagtgt
     3961 ccgagtcggc cctctgtatc ccgtcgtctc ccaaatatga cactcttatc ataagagatt
     4021 acactcagag ctcctcgtcg ttgtgaatgt ccctggaaag cacgccggcc tgcgcgtgcg
     4081 gagcggagcc ccccgtgttc acacacacac aatggcaagc atagtcgcct ggttacggcc
     4141 cagggggaag atgccaaggg caccccttaa tggaaacacg agatcagtag tgctatctca
     4201 tgacaaccga cgaagaaacc gacgacaaat cttttggcag attttcttct agtggcctta
     4261 gaaaacatgg gcttttaaga aacacggctg atatctttga gggctgacaa ggcgtctctt
     4321 caaacagttc cataccaagt gctttgctct agggaagcag tgcgtgtgaa acagcgtaac
     4381 ggagggtgaa gagcatagtt aataagcaac tgtaaaaagt tttatttgtt tactttaatt
     4441 cttttcccag aagagtcttt gattcaccaa acatgaatgt acattttcta acaaactcaa
     4501 aatctgggac caaaacatca acttttttct ttcttttttc tttctttttg ttttttcttt
     4561 cctgtaaaga ccttgaaaag cagtaacttg ggtccagtat ttacggaggc gttgtgaatg
     4621 tgtcccatgc ataacacact actggatagt gagtgctgcg ctaatgtact acgtagggct
     4681 tctaccagag attttcctct ccaattgggt tgtgaaatac tcttccaaaa gcctgcatcg
     4741 gggattccac ctacttattt cagattcacc tccattaacc aagaaaacca gtggaagatt
     4801 tcttgactat ttcaccatgt tgccaatcaa tactggagta gcaaaaaaaa tattttctgg
     4861 aatactgttt tgtaattccc tcactggggt gcattgtagc tggaaattct ctttataaaa
     4921 atcattcttg agctccagcc tggctatctc tttcaagaaa catggccact ctttaggaat
     4981 gctgttgcgt ttgcattgcc aactaaaata ttaaaatatg cattggggct tcttcattcc
     5041 tttattttga gaacctgatg cacaaagagc tcctttgttc ttttcgagtc ccaccactgg
     5101 aagagtggtc catagacccc atgaagacat tgtcatgatt tgagagactg ttgttgaaag
     5161 gattaacaca atcttaatac actgaaaatt ttaactgtgt caagtcagct tagtggagat
     5221 ttagctatgc cagtgagcag tgattttaac tattcttggc tgcttaaaca gggcagctat
     5281 gaactatgac aaatgtagat ttttcaaagc aatacaaaat actaaaaaag aggaacctta
     5341 atgaatatta accacacagt ctttcttagc cattccaaaa agaggcaaag caattcttat
     5401 tttctttttt aaaataatga ttaatatgat tttgtgcact tcatactgtc actttttaaa
     5461 actacagaaa agagatttag agtataacag aaacaagtgt gctttgatag tctcaaatag
     5521 gtagaattca tagttcaaga cctgaatcca ctgtcatctc tttcttcctc ccattgcagc
     5581 tatcctcagg taccaaatgt tttgattttt aaataaggat agtaataaat ggaggaggtg
     5641 tcctataaat ttaaagttca gttgacccag ccttatactt aagatagcct tatgaaaaat
     5701 atgtgctgtg aggcagaagt atattttggc agagagaata ataaataaaa ctttttcttt
     5761 tagctcaata tccttacttt ggtaagtatt tttttttatt tcacatctac ttaacagaaa
     5821 ataaactgag aaatagaagt cagtccattg gcataattta tcattcttca ctttaaaaaa
     5881 ttctaataaa tattctgctt gagttttctt ttctgctatt tgttcttact tgcaacttta
     5941 agtcaaacct cccaatacaa aacattaaaa gctaacatta atgtactaaa gtattaattt
     6001 aaaagaaatc gaacctccca tgctagattt gaaaataaca tcatcacagc accctgatcc
     6061 caaatattac accgaggctt ttaaaatgta agtgaaatct agctaagttt catggtttca
     6121 ttaaaagcaa atgtctgcct ctatctgaaa aacaaatgga aatcttttga ggtgttaata
     6181 ccctttggat cctcatcaaa aggatggcat tcacctgagg attcctatct tgacttctta
     6241 ggtattaaaa acctttcttg atatgctcta cattttaaaa tttgttttat aaaatcctta
     6301 tgttgatttt cattttattc tcaagtacaa tacgtttcac tctagaccag ttgaagaaca
     6361 tgtttaaact ttgttcatgg tcaaattcat tttctatttt tttagtaaca tatctcttaa
     6421 aaagcacact accttataaa aaacttcatc agaaattaaa tttaatgcaa gtaaattgcc
     6481 atctgatact tccacatgct atcataatca actgtaataa taaaaatgat ttatccaatt
     6541 agaaaaggac aagatatatt tttctctgta tttctataac ttttgccact ccattgaata
     6601 cattgtatgt tggacataag attattagta atgcattctt gagatctttt attttggaat
     6661 gatgctaact ctgtctcttt gccaattcta ataccaggtt ccaagtaata actctacagt
     6721 acaaagagaa ctgaatattc attctagggc tataggatat gaacttcaca attcatttgg
     6781 gtacattctc attgaatttc cttcaaaaca atctgttcct ggtgcccagt gataattcag
     6841 tcgggaccag catgactaaa aggaagggga tatgctaagg ctcagcaaag tgaccctaaa
     6901 tgagagatat gtcccaggat ggaaagaaga agacgtggtt taaccaagtt atactgacta
     6961 atctaagcag tccactcatc cttccatttt gggaaaggag tgggggcagc ctaagaagaa
     7021 catatctgga ttgggaagaa ccgtctttct gggctaggga tggggaacag aaagggagta
     7081 tggaaagaaa aattataaga gatttgactg aagcaaggaa aaaaagcaaa tccccaaacg
     7141 tgctaatcct tgaaagtaac tatctttccc aaactactgc tgttaccagc aagtgatcag
     7201 gaagactagg agctatttct gactgtaaat gaattgtata atagctctgc tgcagttctg
     7261 tgacttccaa gccaggaatt aaatgctctt tttaagaata acaaaaaaca aaagcatttc
     7321 ctatgctagt ctcccagtaa aatgtacatg ttttggagac ttcaaaggta ttatgtgagt
     7381 tcacatttag caacagctta ttaataaccc tcaagctgtc agaatctcta tagttaccat
     7441 ttacaatttt atactgtgaa aaaatacaga tcagtgaaag cataaagaca agtcagaatt
     7501 cactttgaag agggtctgag gcctgggaga gtctctactg tctattgaag aatgaggcat
     7561 gtataaaata gttggttgaa tttcactgat cttcccaatg tgaacaaata tactatgtat
     7621 attgtgtgta tttctagaaa tcaatggcag ctgctgatgg tgttgtaatt agaaatctat
     7681 atagattata gatgttttag aaagatggtg ccaatcctaa aagatttgtg tgggctaaaa
     7741 gtgcttgtac ttactttttt ctgcacttat aactgatttg gttttaaaat tgtgtgcgtg
     7801 tatctgttct ttctctgttg tggcagcttg tactattaaa ataatagaga atgttaaatt
     7861 attttgatgt gaactgcaaa tgattttttt tcataaagtt taacattttt atcagcattg
     7921 ttttgctttg tacttgtata aatatgtttt attttagcac ttcaaaatat acttgcctgt
     7981 ttctcagttg tctaaa
//
