LOCUS       NM_000841               7368 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 4 (GRM4), transcript
            variant 1, mRNA.
ACCESSION   NM_000841
VERSION     NM_000841.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7368)
  AUTHORS   Hofmann,C.S., Carrington,S., Keller,A.N., Gregory,K.J. and
            Niswender,C.M.
  TITLE     Regulation and functional consequences of mGlu4 RNA editing
  JOURNAL   RNA 27 (10), 1220-1240 (2021)
   PUBMED   34244459
  REMARK    GeneRIF: Regulation and functional consequences of mGlu4 RNA
            editing.
REFERENCE   2  (bases 1 to 7368)
  AUTHORS   Lin,S., Han,S., Cai,X., Tan,Q., Zhou,K., Wang,D., Wang,X., Du,J.,
            Yi,C., Chu,X., Dai,A., Zhou,Y., Chen,Y., Zhou,Y., Liu,H., Liu,J.,
            Yang,D., Wang,M.W., Zhao,Q. and Wu,B.
  TITLE     Structures of Gi-bound metabotropic glutamate receptors mGlu2 and
            mGlu4
  JOURNAL   Nature 594 (7864), 583-588 (2021)
   PUBMED   34135510
  REMARK    GeneRIF: Structures of Gi-bound metabotropic glutamate receptors
            mGlu2 and mGlu4.
REFERENCE   3  (bases 1 to 7368)
  AUTHORS   Zhang,Q., Chen,X., Li,S., Yao,T. and Wu,J.
  TITLE     Association between the group III metabotropic glutamate receptor
            gene polymorphisms and attention-deficit/hyperactivity disorder and
            functional exploration of risk loci
  JOURNAL   J Psychiatr Res 132, 65-71 (2021)
   PUBMED   33068816
  REMARK    GeneRIF: Association between the group III metabotropic glutamate
            receptor gene polymorphisms and attention-deficit/hyperactivity
            disorder and functional exploration of risk loci.
REFERENCE   4  (bases 1 to 7368)
  AUTHORS   Zhang,Z., Li,N., Wei,X., Chen,B., Zhang,Y., Zhao,Y., Hu,X. and
            Hou,S.
  TITLE     GRM4 inhibits the proliferation, migration, and invasion of human
            osteosarcoma cells through interaction with CBX4
  JOURNAL   Biosci Biotechnol Biochem 84 (2), 279-289 (2020)
   PUBMED   31581881
  REMARK    GeneRIF: This is the evidence supporting the interaction between
            GRM4 and CBX4, which could inhibit the malignant behavior of
            osteosarcoma cells through the GRM4/CBX4/HIF-1alpha signaling
            pathway
REFERENCE   5  (bases 1 to 7368)
  AUTHORS   Kansara,M., Thomson,K., Pang,P., Dutour,A., Mirabello,L., Acher,F.,
            Pin,J.P., Demicco,E.G., Yan,J., Teng,M.W.L., Smyth,M.J. and
            Thomas,D.M.
  TITLE     Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4
            Regulation of IL23
  JOURNAL   Cancer Discov 9 (11), 1511-1519 (2019)
   PUBMED   31527131
  REMARK    GeneRIF: Infiltrating Myeloid Cells Drive Osteosarcoma Progression
            via GRM4 Regulation of IL23.
REFERENCE   6  (bases 1 to 7368)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   7  (bases 1 to 7368)
  AUTHORS   Gomeza,J., Mary,S., Brabet,I., Parmentier,M.L., Restituito,S.,
            Bockaert,J. and Pin,J.P.
  TITLE     Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15,
            G alpha 16, and chimeric G alpha q/i proteins: characterization of
            new antagonists
  JOURNAL   Mol Pharmacol 50 (4), 923-930 (1996)
   PUBMED   8863838
REFERENCE   8  (bases 1 to 7368)
  AUTHORS   Makoff,A., Lelchuk,R., Oxer,M., Harrington,K. and Emson,P.
  TITLE     Molecular characterization and localization of human metabotropic
            glutamate receptor type 4
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 239-248 (1996)
   PUBMED   8738157
REFERENCE   9  (bases 1 to 7368)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
REFERENCE   10 (bases 1 to 7368)
  AUTHORS   Flor,P.J., Lukic,S., Ruegg,D., Leonhardt,T., Knopfel,T. and Kuhn,R.
  TITLE     Molecular cloning, functional expression and pharmacological
            characterization of the human metabotropic glutamate receptor type
            4
  JOURNAL   Neuropharmacology 34 (2), 149-155 (1995)
   PUBMED   7617140
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA094245.1, X80818.1,
            AL590403.13 and BM683737.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000841.3.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.12994.1,
                                           SRR1660807.159777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465402, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538487.7/ ENSP00000440556.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               DA094245.1         51-331
            282-4160            X80818.1           1-3879
            4161-7040           AL590403.13        3081-5960           c
            7041-7368           BM683737.1         17-344              c
FEATURES             Location/Qualifiers
     source          1..7368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..7368
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /note="glutamate metabotropic receptor 4"
                     /db_xref="GeneID:2914"
                     /db_xref="HGNC:HGNC:4596"
                     /db_xref="MIM:604100"
     exon            1..88
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            89..970
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..3190
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutamate receptor, metabotropic 4"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 4 isoform 1
                     precursor"
                     /protein_id="NP_000832.1"
                     /db_xref="CCDS:CCDS4787.1"
                     /db_xref="GeneID:2914"
                     /db_xref="HGNC:HGNC:4596"
                     /db_xref="MIM:604100"
                     /translation="MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIR
                     IDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLG
                     ARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSS
                     VSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKW
                     NYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETS
                     NARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTI
                     LPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRE
                     RIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI
                     RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHW
                     PGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRP
                     TENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRE
                     LSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFE
                     QGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFA
                     RGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVW
                     LAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKR
                     KRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI"
     exon            971..1187
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1323
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1478
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1619
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1820
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1957
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2893
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3140
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..7368
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4135..4140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /note="hexamer: AATAAA"
     polyA_site      4160
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /note="major polyA site"
     regulatory      7349..7354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
                     /note="hexamer: ATTAAA"
     polyA_site      7368
                     /gene="GRM4"
                     /gene_synonym="GPRC1D; mGlu4; MGLUR4"
ORIGIN      
        1 gctgtacttt tctgggtgtg tgttagggag gctatgttcc tgaccctccc cctctggggt
       61 gagaaggggt ccccgccatg tcctcggggt tggtaggagg agaggattgg agctgttttc
      121 tccttgatgc caagatacgc caagctagga gcattctgcc ctttccacag tcatccaccg
      181 agaacaggcc tgcaggacgg gacaaggatc agagccttcc tgcaaccccg gccactgcct
      241 gctgtctgtg ggcctggact gtgcgggcaa ctgtgcttgg cccgagtgac aaggaggtgg
      301 gagagggtag cagcatgggc tacgcggttg gctgccctca gtccccctgc tgctgaagct
      361 gccctgccca tgcccaccca ggccgtgggg ccaggggcct gccagggcta ggagtgggcc
      421 tgccgttcat gggtctctag ggatttccga gatgcctggg aagagaggct tgggctggtg
      481 gtgggcccgg ctgccccttt gcctgctcct cagcctttac ggcccctgga tgccttcctc
      541 cctgggaaag cccaaaggcc accctcacat gaattccatc cgcatagatg gggacatcac
      601 actgggaggc ctgttcccgg tgcatggccg gggctcagag ggcaagccct gtggagaact
      661 taagaaggaa aagggcatcc accggctgga ggccatgctg ttcgccctgg atcgcatcaa
      721 caacgacccg gacctgctgc ctaacatcac gctgggcgcc cgcattctgg acacctgctc
      781 cagggacacc catgccctcg agcagtcgct gacctttgtg caggcgctca tcgagaagga
      841 tggcacagag gtccgctgtg gcagtggcgg cccacccatc atcaccaagc ctgaacgtgt
      901 ggtgggtgtc atcggtgctt cagggagctc ggtctccatc atggtggcca acatccttcg
      961 cctcttcaag ataccccaga tcagctacgc ctccacagcg ccagacctga gtgacaacag
     1021 ccgctacgac ttcttctccc gcgtggtgcc ctcggacacg taccaggccc aggccatggt
     1081 ggacatcgtc cgtgccctca agtggaacta tgtgtccaca gtggcctcgg agggcagcta
     1141 tggtgagagc ggtgtggagg ccttcatcca gaagtcccgt gaggacgggg gcgtgtgcat
     1201 cgcccagtcg gtgaagatac cacgggagcc caaggcaggc gagttcgaca agatcatccg
     1261 ccgcctcctg gagacttcga acgccagggc agtcatcatc tttgccaacg aggatgacat
     1321 caggcgtgtg ctggaggcag cacgaagggc caaccagaca ggccatttct tctggatggg
     1381 ctctgacagc tggggctcca agattgcacc tgtgctgcac ctggaggagg tggctgaggg
     1441 tgctgtcacg atcctcccca agaggatgtc cgtacgaggc ttcgaccgct acttctccag
     1501 ccgcacgctg gacaacaacc ggcgcaacat ctggtttgcc gagttctggg aggacaactt
     1561 ccactgcaag ctgagccgcc acgccctcaa gaagggcagc cacgtcaaga agtgcaccaa
     1621 ccgtgagcga attgggcagg attcagctta tgagcaggag gggaaggtgc agtttgtgat
     1681 cgatgccgtg tacgccatgg gccacgcgct gcacgccatg caccgtgacc tgtgtcccgg
     1741 ccgcgtgggg ctctgcccgc gcatggaccc tgtagatggc acccagctgc ttaagtacat
     1801 ccgaaacgtc aacttctcag gcatcgcagg gaaccctgtg accttcaatg agaatggaga
     1861 tgcgcctggg cgctatgaca tctaccaata ccagctgcgc aacgattctg ccgagtacaa
     1921 ggtcattggc tcctggactg accacctgca ccttagaata gagcggatgc actggccggg
     1981 gagcgggcag cagctgcccc gctccatctg cagcctgccc tgccaaccgg gtgagcggaa
     2041 gaagacagtg aagggcatgc cttgctgctg gcactgcgag ccttgcacag ggtaccagta
     2101 ccaggtggac cgctacacct gtaagacgtg tccctatgac atgcggccca cagagaaccg
     2161 cacgggctgc cggcccatcc ccatcatcaa gcttgagtgg ggctcgccct gggccgtgct
     2221 gcccctcttc ctggccgtgg tgggcatcgc tgccacgttg ttcgtggtga tcacctttgt
     2281 gcgctacaac gacacgccca tcgtcaaggc ctcgggccgt gaactgagct acgtgctgct
     2341 ggcaggcatc ttcctgtgct atgccaccac cttcctcatg atcgctgagc ccgaccttgg
     2401 cacctgctcg ctgcgccgaa tcttcctggg actagggatg agcatcagct atgcagccct
     2461 gctcaccaag accaaccgca tctaccgcat cttcgagcag ggcaagcgct cggtcagtgc
     2521 cccacgcttc atcagccccg cctcacagct ggccatcacc ttcagcctca tctcgctgca
     2581 gctgctgggc atctgtgtgt ggtttgtggt ggacccctcc cactcggtgg tggacttcca
     2641 ggaccagcgg acactcgacc cccgcttcgc caggggtgtg ctcaagtgtg acatctcgga
     2701 cctgtcgctc atctgcctgc tgggctacag catgctgctc atggtcacgt gcaccgtgta
     2761 tgccatcaag acacgcggcg tgcccgagac cttcaatgag gccaagccca ttggcttcac
     2821 catgtacacc acttgcatcg tctggctggc cttcatcccc atcttctttg gcacctcgca
     2881 gtcggccgac aagctgtaca tccagacgac gacgctgacg gtctcggtga gtctgagcgc
     2941 ctcggtgtcc ctgggaatgc tctacatgcc caaagtctac atcatcctct tccacccgga
     3001 gcagaacgtg cccaagcgca agcgcagcct caaagccgtc gttacggcgg ccaccatgtc
     3061 caacaagttc acgcagaagg gcaacttccg gcccaacgga gaggccaagt ctgagctctg
     3121 cgagaacctt gaggccccag cgctggccac caaacagact tacgtcactt acaccaacca
     3181 tgcaatctag cgagtccatg gagctgagca gcaggaggag gagccgtgac cctgtggaag
     3241 gtgcgtcggg ccagggccac acccaagggc ccagctgtct tgcctgcccg tgggcaccca
     3301 cggacgtggc ttggtgctga ggatagcaga gcccccagcc atcactgctg gcagcctggg
     3361 caaaccgggt gagcaacagg aggacgaggg gccggggcgg tgccaggcta ccacaagaac
     3421 ctgcgtcttg gaccattgcc cctcccggcc ccaaaccaca ggggctcagg tcgtgtgggc
     3481 cccagtgcta gatctctccc tcccttcgtc tctgtctgtg ctgttggcga cccctctgtc
     3541 tgtctccagc cctgtctttc tgttctctta tctctttgtt tcaccttttc cctctctggc
     3601 gtccccggct gcttgtactc ttggcctttt ctgtgtctcc tttctggctc ttgcctccgc
     3661 ctctctctct catcctcttt gtcctcagct cctcctgctt tcttgggtcc caccagtgtc
     3721 acttttctgc cgttttcttt cctgttctcc tctgcttcat tctcgtccag ccattgctcc
     3781 cctctccctg ccacccttcc ccagttcacc aaaccttaca tgttgcaaaa gagaaaaaag
     3841 gaaaaaaaat caaaacacaa aaaagccaaa acgaaaacaa atctcgagtg tgttgccaag
     3901 tgctgcgtcc tcctggtggc ctctgtgtgt gtccctgtgg cccgcagcct gcccgcctgc
     3961 cccgcccatc tgccgtgtgt cttgcccgcc tgccccgccc gtctgccgtc tgtcttgccc
     4021 gcctgcccgc ctgcccctcc tgccgaccac acggagttca gtgcctgggt gtttggtgat
     4081 ggttattgac gacaatgtgt agcgcatgat tgtttttata ccaagaacat ttctaataaa
     4141 aataaacaca tggttttgca cccgggctcc acatccactg agggtcctgc catgggacca
     4201 caggctcagc ctgcagctgg agggcttaga cctagaggga agcgggaact gggctctgga
     4261 gacccagggc ttgggggctg tggagactgc tccctaggct gggatctagt gtggtgtggt
     4321 gaggccttgg gcatggaggg gccagattcc caggtaaggg gcagggacat tgcaggaaat
     4381 tccaggaatc agcacctagt agtcccctaa ttagggggta tgctctgtcc cctgccctgc
     4441 agccctggga gggtaacatt tctgccttgc ctgtcctctg tctcacaccc ctcacacctg
     4501 ggactgccct tccacccctg cccccataac ctgtgcctct ctccttccag ccaggaagtc
     4561 ctcttcttga gaagttagct tcccgggctg ccagcactca tagccgtccc ctcctgcttg
     4621 tgttggctcc aggctcgggt gctaagaaga tgtgtgtctg tcctggagat cagtgtgttg
     4681 ttatgtgtcc acgtgggccc acaagtgcac ggcacaggca tggccgtgtg gctgtgttgg
     4741 ctgtgttggc tgtgtgtctg tgtgcacgtc cagcgcctcc atgcgcatgc gtgcctgtct
     4801 tgtttgcgtg tctgatcatc tgtttgggcc ccggtggctc atgcagatgc ctgtctcagg
     4861 cccatggcga gtgttcacct cagctggctt ccctggcagg ttgggaggtg ggaaacagga
     4921 gcgcttaggg gctgggctct ggctggggta aattatagag ccagaaacac aatgaggcca
     4981 taggcagcag ctggagcctg ggctgcctgt gccgtcccct cctgccctgc ccctgggtcc
     5041 tgcaccccct cccacctcca ggctagctga cagcgctatg gagcacagtg gaagggactg
     5101 gaggaaccct aggcaggggg ccacgcaggg acagagtatg agagtgtgtg tataactgag
     5161 gctgggacat tgaatcatgc caggtatgtc ttctccatca gcccactctt actcctggcc
     5221 tgggcatctc acacatctgt gcataggaaa tctcttcttc cctggggtct gtgtgcagca
     5281 cctagtagat gctcaataaa tgtttgtgtg agggaaggag acaggaaagg aagtgtctcg
     5341 ctgatcatct tgcggaatgg ttcctaagac ctctgcccag gaaagattcc acccagtgct
     5401 ccagcccggt caggcagaac taggttgcca gatcaagggt atctcccaaa agcttccagg
     5461 gcagttgggg gtgggggggt ggggggtagg gatggggaat gcagaagcgg gtgcagccag
     5521 ctctccccca gggtgactct ggcagcaccc ccatcctggg caccctgcct gctctgtggc
     5581 tcacgcccct cctgaagtga ctgatgctct gaggcccaag gctaggtcca gggcagggcc
     5641 tgcaggggtt tcatgctcag tccaggactt gcctaggtcc ccctacatct gtggggcccc
     5701 catctaggtt ctaacaggag aatcacctct ccaaggggga tgctgcccct cggctcccct
     5761 tggctctcag gaggggccct cagggactac cagtcccctg ccagtgggaa gaaatagccc
     5821 tgccctcagg gagcttccag tgtgatgggg gagatacagc agactgtgtc ccaaagtaaa
     5881 atgactgtta gaatgaggtg ggtggaggag ggaagccttg ggtgggtgtg actttgggca
     5941 tctgagcctg gggtgcagag gtgggctctg tgggcctgag gtggacagga gggaaccagg
     6001 ccctagcaag acttttgcca gctagacctg ctgcagcagt tgggagggtg ggtgctgctg
     6061 gagtcctggg tccatcacct agaaggctca ggccagtgca gccagggctg gggcccacag
     6121 ctggcctggg tgggacctgc cctgatgccc atggcaggag ggacgcctgg cccttcacaa
     6181 ttggcttggc tgctcacctt tgctctcatc ctcaattatt aatgactgga gaaagctgct
     6241 aagtatcttc agaatgttag atttcaacaa gatggggggt tcagggtccc tggcaccctg
     6301 gatagggagc cagcggcccc tagagacctt tgctgtgtgc agggggtatg tgctcacccc
     6361 cgtggcctca gcctcctcaa tgtctgaatg aaggattggg ctagcagaca tcccacccca
     6421 cagcacactt tctaaccagc aggggaactt ctagacaata gagacgctgg gctccctcca
     6481 gaacactgga cctgaacttc tggggggagg gctgggcacg ggcatatttt aaaagctccc
     6541 cagcagatgg gccgtgcagt caagtgggcc aagagtggca ccagactttg gggcttgtga
     6601 agtcaggagg gagcaacagt gcccactcga gcttgcctgg ggctcaagcc caaggctggg
     6661 ctgctgccag cctgagcaga cacccaggag cttccaggcc agctggatgc acagggcacc
     6721 tttgtggaac tcctaggacc ctggggagac ccacctcagg agcagagtct caggtccctt
     6781 ccggctctga ggggctgttc tgagctctaa tgtcttatgg tctgcccctc ccatccttac
     6841 ttctcaggcc ctggaggcag aggcatagag ccaggcagga cagaggtctc agtgggccac
     6901 atgccagctg cccccacact gcctcagcct ccaggcctcc aaggggtcct ggggagcccc
     6961 tgagaagatg ctgagcctgc ataaggctgg gcgcccctct ttctgacacc ctcactggct
     7021 ccacggctcc cccttcccat cccaggtttc catctgccca ctgaacaggg aggggaaact
     7081 gaggcactcc cctggcactg agggctcctt ctgtcatcct gcctgccctg gatggtcctg
     7141 gctgcccctc agggcttggc cctggcactg tgagcctcac agggctcaga cccccacccc
     7201 caacccagca ctaaatggca ctcggcacca gaatctcact tcagttggca aaagcagcaa
     7261 ttagcatgta atgaggcttc ttgctttatt tttaggtaac ctccaaggcc ctgcctgtgt
     7321 aattcagccc gccattgctc ggtggataat taaagcatgt caccataa
//
