LOCUS       NM_000840               4268 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript
            variant 1, mRNA.
ACCESSION   NM_000840 XM_005250286
VERSION     NM_000840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4268)
  AUTHORS   Maier,J.P., Ravi,V.M., Kueckelhaus,J., Behringer,S.P., Garrelfs,N.,
            Will,P., Sun,N., von Ehr,J., Goeldner,J.M., Pfeifer,D., Follo,M.,
            Hannibal,L., Walch,A.K., Hofmann,U.G., Beck,J., Heiland,D.H.,
            Schnell,O. and Joseph,K.
  TITLE     Inhibition of metabotropic glutamate receptor III facilitates
            sensitization to alkylating chemotherapeutics in glioblastoma
  JOURNAL   Cell Death Dis 12 (8), 723 (2021)
   PUBMED   34290229
  REMARK    GeneRIF: Inhibition of metabotropic glutamate receptor III
            facilitates sensitization to alkylating chemotherapeutics in
            glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4268)
  AUTHORS   Lu,J. and Li,Y.
  TITLE     Circ_0079593 facilitates proliferation, metastasis, glucose
            metabolism and inhibits apoptosis in melanoma by regulating the
            miR-516b/GRM3 axis
  JOURNAL   Mol Cell Biochem 475 (1-2), 227-237 (2020)
   PUBMED   32839935
  REMARK    GeneRIF: Circ_0079593 facilitates proliferation, metastasis,
            glucose metabolism and inhibits apoptosis in melanoma by regulating
            the miR-516b/GRM3 axis.
REFERENCE   3  (bases 1 to 4268)
  AUTHORS   La,T.M., Yamada,H., Seiriki,S., Li,S.A., Fujise,K., Katsumi,N.,
            Abe,T., Watanabe,M. and Takei,K.
  TITLE     Internalization of AMPA-type Glutamate Receptor in the MIN6
            Pancreatic beta-cell Line
  JOURNAL   Cell Struct Funct 45 (2), 121-130 (2020)
   PUBMED   32581155
  REMARK    GeneRIF: Internalization of AMPA-type Glutamate Receptor in the
            MIN6 Pancreatic beta-cell Line.
REFERENCE   4  (bases 1 to 4268)
  AUTHORS   Gregory,J.M., McDade,K., Livesey,M.R., Croy,I., Marion de Proce,S.,
            Aitman,T., Chandran,S. and Smith,C.
  TITLE     Spatial transcriptomics identifies spatially dysregulated
            expression of GRM3 and USP47 in amyotrophic lateral sclerosis
  JOURNAL   Neuropathol Appl Neurobiol 46 (5), 441-457 (2020)
   PUBMED   31925813
  REMARK    GeneRIF: Spatial transcriptomics identifies spatially dysregulated
            expression of GRM3 and USP47 in amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 4268)
  AUTHORS   Huang,C.Y., Hsueh,Y.M., Chen,L.C., Cheng,W.C., Yu,C.C., Chen,W.J.,
            Lu,T.L., Lan,K.J., Lee,C.H., Huang,S.P. and Bao,B.Y.
  TITLE     Clinical significance of glutamate metabotropic receptors in renal
            cell carcinoma risk and survival
  JOURNAL   Cancer Med 7 (12), 6104-6111 (2018)
   PUBMED   30488581
  REMARK    GeneRIF: We identified multiple novel associations of genetic
            variants in GRM3, GRM4, and GRM5 with the risk and the survival of
            renal cell carcinoma (RCC). These relationships were supported by
            gene expression profiles obtained using bioinformatics analysis.
            Specifically, the expression of GRM4 and GRM5 showed an increasing
            trend in RCC tissues, compared to that in normal tissue, whereas
            GRM3 was downregulated in RCC.
REFERENCE   6  (bases 1 to 4268)
  AUTHORS   Corti,C., Xuereb,J.H., Corsi,M. and Ferraguti,F.
  TITLE     Identification and characterization of the promoter region of the
            GRM3 gene
  JOURNAL   Biochem Biophys Res Commun 286 (2), 381-387 (2001)
   PUBMED   11500049
REFERENCE   7  (bases 1 to 4268)
  AUTHORS   Corti,C., Sala,C.F., Yang,F., Corsi,M., Xuereb,J.H. and
            Ferraguti,F.
  TITLE     Genomic organization of the human metabotropic glutamate receptor
            subtype 3
  JOURNAL   J Neurogenet 14 (4), 207-225 (2000)
   PUBMED   11342382
REFERENCE   8  (bases 1 to 4268)
  AUTHORS   Makoff,A., Volpe,F., Lelchuk,R., Harrington,K. and Emson,P.
  TITLE     Molecular characterization and localization of human metabotropic
            glutamate receptor type 3
  JOURNAL   Brain Res Mol Brain Res 40 (1), 55-63 (1996)
   PUBMED   8840013
REFERENCE   9  (bases 1 to 4268)
  AUTHORS   Emile,L., Mercken,L., Apiou,F., Pradier,L., Bock,M.D., Menager,J.,
            Clot,J., Doble,A. and Blanchard,J.C.
  TITLE     Molecular cloning, functional expression, pharmacological
            characterization and chromosomal localization of the human
            metabotropic glutamate receptor type 3
  JOURNAL   Neuropharmacology 35 (5), 523-530 (1996)
   PUBMED   8887960
REFERENCE   10 (bases 1 to 4268)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004829.2, BC041407.1,
            X77748.1 and AC002081.1.
            
            On Aug 13, 2020 this sequence version replaced NM_000840.2.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041407.1, X77748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361669.7/ ENSP00000355316.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC004829.2         27461-27465
            6-1391              BC041407.1         8-1393
            1392-4262           X77748.1           540-3410
            4263-4265           BC041407.1         4265-4267
            4266-4268           AC002081.1         47757-47759
FEATURES             Location/Qualifiers
     source          1..4268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11-q21.12"
     gene            1..4268
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /note="glutamate metabotropic receptor 3"
                     /db_xref="GeneID:2913"
                     /db_xref="HGNC:HGNC:4595"
                     /db_xref="MIM:601115"
     exon            1..964
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1572
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1105..3744
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; metabotropic glutamate receptor 3; glutamate
                     receptor, metabotropic 3"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 3 isoform 1
                     precursor"
                     /protein_id="NP_000831.2"
                     /db_xref="CCDS:CCDS5600.1"
                     /db_xref="GeneID:2913"
                     /db_xref="HGNC:HGNC:4595"
                     /db_xref="MIM:601115"
                     /translation="MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGL
                     FPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRD
                     TYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANL
                     LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVAS
                     EGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFM
                     RSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFD
                     RYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMF
                     VVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDA
                     DSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQ
                     CSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLP
                     EDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGL
                     SYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKF
                     ISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLIS
                     LTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRV
                     QTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQS
                     SASTYVPTVCNGREVLDSTTSSL"
     exon            1573..2428
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3495
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3670
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..4268
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4243..4248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /note="hexamer: AATAAA"
     polyA_site      4268
                     /gene="GRM3"
                     /gene_synonym="GLUR3; GPRC1C; mGlu3; MGLUR3"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgtgca gttgagtcgc gagtacggct gagctgcgta ccggcctccc tggctctcac
       61 actccctctc tgctcccgct ctcctaatct cctctggcat gcggtcagcc ccctgcccag
      121 ggaccacagg agagttcttg taaggactgt tagtccctgc ttacctgaaa gccaagcgct
      181 ctagcagagc tttaaagttg gagccgccac cctccctacc gccccatgcc ccttcacccc
      241 actccgaaat tcaccgacct ttgcatgcac tgcctaagga tttcagagtg aggcaaagca
      301 gtcggcaaat ctaccctggc ttttcgtata aaaatcctct cgtctaggta ccctggctca
      361 ctgaagactc tgcagatata cccttataag agggagggtg ggggagggaa aagaacgaga
      421 gagggaggaa agaatgaaaa ggagaggatg ccaggaggtc cgtgcttctg ccaagagtcc
      481 caattagatg cgacggcttc agcctggtca aggtgaagga aagttgcttc cgcgcctagg
      541 aagtgggttt gcctgataag agaaggagga ggggactcgg ctgggaagag ctcccctccc
      601 ctccgcggaa gaccactggg tcccctcttt ccccaacctc ctccctctct tctactccac
      661 ccctccgttt tcccactccc cactgactcg gatgcctgga tgttctgcca ccgggcagtg
      721 gtccagcgtg cagccgggag ggggcagggg cagggggcac tgtgacagga agctgcgcgc
      781 acaagttggc catttcgagg gcaaaataag ttctcccttg gatttggaaa ggacaaagcc
      841 agtaagctac ctcttttgtg tcggatgagg aggaccaacc atgagccaga gcccgggtgc
      901 aggctcaccg ccgccgctgc caccgcggtc agctccagtt cctgccagga gttgtcggtg
      961 cgaggaattt tgtgacaggc tctgttagtc tgttcctccc ttatttgaag gacaggccaa
     1021 agatccagtt tggaaatgag agaggactag catgacacat tggctccacc attgatatct
     1081 cccagaggta cagaaacagg attcatgaag atgttgacaa gactgcaagt tcttacctta
     1141 gctttgtttt caaagggatt tttactctct ttaggggacc ataactttct aaggagagag
     1201 attaaaatag aaggtgacct tgttttaggg ggcctgtttc ctattaacga aaaaggcact
     1261 ggaactgaag aatgtgggcg aatcaatgaa gaccgaggga ttcaacgcct ggaagccatg
     1321 ttgtttgcta ttgatgaaat caacaaagat gattacttgc taccaggagt gaagttgggt
     1381 gttcacattt tggatacatg ttcaagggat acctatgcat tggagcaatc actggagttt
     1441 gtcagggcat ctttgacaaa agtggatgaa gctgagtata tgtgtcctga tggatcctat
     1501 gccattcaag aaaacatccc acttctcatt gcaggggtca ttggtggctc ttatagcagt
     1561 gtttccatac aggtggcaaa cctgctgcgg ctcttccaga tccctcagat cagctacgca
     1621 tccaccagcg ccaaactcag tgataagtcg cgctatgatt actttgccag gaccgtgccc
     1681 cccgacttct accaggccaa agccatggct gagatcttgc gcttcttcaa ctggacctac
     1741 gtgtccacag tagcctccga gggtgattac ggggagacag ggatcgaggc cttcgagcag
     1801 gaagcccgcc tgcgcaacat ctgcatcgct acggcggaga aggtgggccg ctccaacatc
     1861 cgcaagtcct acgacagcgt gatccgagaa ctgttgcaga agcccaacgc gcgcgtcgtg
     1921 gtcctcttca tgcgcagcga cgactcgcgg gagctcattg cagccgccag ccgcgccaat
     1981 gcctccttca cctgggtggc cagcgacggc tggggcgcgc aggagagcat catcaagggc
     2041 agcgagcatg tggcctacgg cgccatcacc ctggagctgg cctcccagcc tgtccgccag
     2101 ttcgaccgct acttccagag cctcaacccc tacaacaacc accgcaaccc ctggttccgg
     2161 gacttctggg agcaaaagtt tcagtgcagc ctccagaaca aacgcaacca caggcgcgtc
     2221 tgcgacaagc acctggccat cgacagcagc aactacgagc aagagtccaa gatcatgttt
     2281 gtggtgaacg cggtgtatgc catggcccac gctttgcaca aaatgcagcg caccctctgt
     2341 cccaacacta ccaagctttg tgatgctatg aagatcctgg atgggaagaa gttgtacaag
     2401 gattacttgc tgaaaatcaa cttcacggct ccattcaacc caaataaaga tgcagatagc
     2461 atagtcaagt ttgacacttt tggagatgga atggggcgat acaacgtgtt caatttccaa
     2521 aatgtaggtg gaaagtattc ctacttgaaa gttggtcact gggcagaaac cttatcgcta
     2581 gatgtcaact ctatccactg gtcccggaac tcagtcccca cttcccagtg cagcgacccc
     2641 tgtgccccca atgaaatgaa gaatatgcaa ccaggggatg tctgctgctg gatttgcatc
     2701 ccctgtgaac cctacgaata cctggctgat gagtttacct gtatggattg tgggtctgga
     2761 cagtggccca ctgcagacct aactggatgc tatgaccttc ctgaggacta catcaggtgg
     2821 gaagacgcct gggccattgg cccagtcacc attgcctgtc tgggttttat gtgtacatgc
     2881 atggttgtaa ctgtttttat caagcacaac aacacaccct tggtcaaagc atcgggccga
     2941 gaactctgct acatcttatt gtttggggtt ggcctgtcat actgcatgac attcttcttc
     3001 attgccaagc catcaccagt catctgtgca ttgcgccgac tcgggctggg gagttccttc
     3061 gctatctgtt actcagccct gctgaccaag acaaactgca ttgcccgcat cttcgatggg
     3121 gtcaagaatg gcgctcagag gccaaaattc atcagcccca gttctcaggt tttcatctgc
     3181 ctgggtctga tcctggtgca aattgtgatg gtgtctgtgt ggctcatcct ggaggcccca
     3241 ggcaccagga ggtataccct tgcagagaag cgggaaacag tcatcctaaa atgcaatgtc
     3301 aaagattcca gcatgttgat ctctcttacc tacgatgtga tcctggtgat cttatgcact
     3361 gtgtacgcct tcaaaacgcg gaagtgccca gaaaatttca acgaagctaa gttcataggt
     3421 tttaccatgt acaccacgtg catcatctgg ttggccttcc tccctatatt ttatgtgaca
     3481 tcaagtgact acagagtgca gacgacaacc atgtgcatct ctgtcagcct gagtggcttt
     3541 gtggtcttgg gctgtttgtt tgcacccaag gttcacatca tcctgtttca accccagaag
     3601 aatgttgtca cacacagact gcacctcaac aggttcagtg tcagtggaac tgggaccaca
     3661 tactctcagt cctctgcaag cacgtatgtg ccaacggtgt gcaatgggcg ggaagtcctc
     3721 gactccacca cctcatctct gtgattgtga attgcagttc agttcttgtg tttttagact
     3781 gttagacaaa agtgctcacg tgcagctcca gaatatggaa acagagcaaa agaacaaccc
     3841 tagtaccttt ttttagaaac agtacgataa attatttttg aggactgtat atagtgatgt
     3901 gctagaactt tctaggctga gtctagtgcc cctattatta acaattcccc cagaacatgg
     3961 aaataaccat tgtttacaga gctgagcatt ggtgacaggg tctgacatgg tcagtctact
     4021 aaaaaacaaa aaaaaaaaac aaaaaaaaaa aaacaaaaga aaaaaataaa aatacggtgg
     4081 caatattatg taaccttttt tcctatgaag ttttttgtag gtccttgttg taactaattt
     4141 aggatgagtt tctatgttgt atattaaagt tacattatgt gtaacagatt gattttctca
     4201 gcacaaaata aaaagcatct gtattaatgt aaagatactg agaataaaac cttcaaggtt
     4261 ttccagca
//
