LOCUS       NM_000839               3356 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 2 (GRM2), transcript
            variant 1, mRNA.
ACCESSION   NM_000839
VERSION     NM_000839.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3356)
  AUTHORS   Zhu,X., Luo,M., An,K., Shi,D., Hou,T., Warshel,A. and Bai,C.
  TITLE     Exploring the activation mechanism of metabotropic glutamate
            receptor 2
  JOURNAL   Proc Natl Acad Sci U S A 121 (21), e2401079121 (2024)
   PUBMED   38739800
  REMARK    GeneRIF: Exploring the activation mechanism of metabotropic
            glutamate receptor 2.
REFERENCE   2  (bases 1 to 3356)
  AUTHORS   Ball,L., Bauer,J. and Krautwurst,D.
  TITLE     Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human
            Blood Leukocytes
  JOURNAL   Int J Mol Sci 24 (16), 12942 (2023)
   PUBMED   37629122
  REMARK    GeneRIF: Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in
            Human Blood Leukocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3356)
  AUTHORS   Saha,S. and Gonzalez-Maeso,J.
  TITLE     The crosstalk between 5-HT2AR and mGluR2 in schizophrenia
  JOURNAL   Neuropharmacology 230, 109489 (2023)
   PUBMED   36889432
  REMARK    GeneRIF: The crosstalk between 5-HT2AR and mGluR2 in schizophrenia.
            Review article
REFERENCE   4  (bases 1 to 3356)
  AUTHORS   Wang,J., Yang,G., Wang,X., Wen,Z., Shuai,L., Luo,J., Wang,C.,
            Sun,Z., Liu,R., Ge,J., He,X., Hua,R., Wang,X., Yang,X., Chen,W.,
            Zhong,G. and Bu,Z.
  TITLE     SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an
            internalization factor to infect cells
  JOURNAL   Cell Discov 7 (1), 119 (2021)
   PUBMED   34903715
  REMARK    Erratum:[Cell Discov. 2021 Dec 27;7(1):124. doi:
            10.1038/s41421-021-00365-z. PMID: 34961770]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3356)
  AUTHORS   Cao,A.M., Quast,R.B., Fatemi,F., Rondard,P., Pin,J.P. and
            Margeat,E.
  TITLE     Allosteric modulators enhance agonist efficacy by increasing the
            residence time of a GPCR in the active state
  JOURNAL   Nat Commun 12 (1), 5426 (2021)
   PUBMED   34521824
  REMARK    GeneRIF: Allosteric modulators enhance agonist efficacy by
            increasing the residence time of a GPCR in the active state.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3356)
  AUTHORS   Joo,A., Shibata,H., Ninomiya,H., Kawasaki,H., Tashiro,N. and
            Fukumaki,Y.
  TITLE     Structure and polymorphisms of the human metabotropic glutamate
            receptor type 2 gene (GRM2): analysis of association with
            schizophrenia
  JOURNAL   Mol Psychiatry 6 (2), 186-192 (2001)
   PUBMED   11317221
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3356)
  AUTHORS   Snow,B.E., Hall,R.A., Krumins,A.M., Brothers,G.M., Bouchard,D.,
            Brothers,C.A., Chung,S., Mangion,J., Gilman,A.G., Lefkowitz,R.J.
            and Siderovski,D.P.
  TITLE     GTPase activating specificity of RGS12 and binding specificity of
            an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
  JOURNAL   J Biol Chem 273 (28), 17749-17755 (1998)
   PUBMED   9651375
REFERENCE   8  (bases 1 to 3356)
  AUTHORS   Gomeza,J., Mary,S., Brabet,I., Parmentier,M.L., Restituito,S.,
            Bockaert,J. and Pin,J.P.
  TITLE     Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15,
            G alpha 16, and chimeric G alpha q/i proteins: characterization of
            new antagonists
  JOURNAL   Mol Pharmacol 50 (4), 923-930 (1996)
   PUBMED   8863838
REFERENCE   9  (bases 1 to 3356)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
REFERENCE   10 (bases 1 to 3356)
  AUTHORS   Flor,P.J., Lindauer,K., Puttner,I., Ruegg,D., Lukic,S., Knopfel,T.
            and Kuhn,R.
  TITLE     Molecular cloning, functional expression and pharmacological
            characterization of the human metabotropic glutamate receptor type
            2
  JOURNAL   Eur J Neurosci 7 (4), 622-629 (1995)
   PUBMED   7620613
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA528713.1, AK315816.1,
            AC099050.2 and BC041447.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000839.4.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.228073.1,
                                           SRR1803617.255923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395052.8/ ENSP00000378492.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA528713.1         36-37
            3-633               AK315816.1         1-631
            634-634             AC099050.2         85965-85965
            635-3153            AK315816.1         633-3151
            3154-3356           BC041447.1         1708-1910
FEATURES             Location/Qualifiers
     source          1..3356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..3356
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /note="glutamate metabotropic receptor 2"
                     /db_xref="GeneID:2912"
                     /db_xref="HGNC:HGNC:4594"
                     /db_xref="MIM:604099"
     exon            1..100
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..686
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2855
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; metabotropic glutamate receptor 2; glutamate
                     receptor homolog; glutamate receptor, metabotropic 2"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 2 isoform a
                     precursor"
                     /protein_id="NP_000830.2"
                     /db_xref="CCDS:CCDS2834.1"
                     /db_xref="GeneID:2912"
                     /db_xref="HGNC:HGNC:4594"
                     /db_xref="MIM:604099"
                     /translation="MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKG
                     GPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQA
                     LDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQI
                     PQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGE
                     TGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDAR
                     ELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSL
                     DPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHAL
                     HNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGI
                     GRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNE
                     VKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDA
                     WAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFI
                     AKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAI
                     CLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIA
                     LCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV
                     SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVP
                     TVCNGREVVDSTTSSL"
     exon            687..1524
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2600
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2781
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..3356
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /note="hexamer: AATAAA"
     polyA_site      3356
                     /gene="GRM2"
                     /gene_synonym="GLUR2; GPRC1B; mGlu2; MGLUR2"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcagag ccagcgagcc agcgagcgag cgagcgggag ccggagcctc gcgccccccg
       61 ctccactccg attctctccg cgccagagcc agcgcgccag gagctgggtc ccttcgcatc
      121 tctcttcttg tctgtccttt cctggtccct gtttcctcct ctctttgcct tcgctgcttc
      181 taatctcatc ccctggagac ccaggtctgc gggacccatc catccccttt ggggccatgg
      241 gatcgctgct tgcgctcctg gcactgctgc tgctgtgggg tgctgtggct gagggcccag
      301 ccaagaaggt gctgaccctg gagggagact tggtgctggg tgggctgttc ccagtgcacc
      361 agaagggcgg cccagcagag gactgtggtc ctgtcaatga gcaccgtggc atccagcgcc
      421 tggaggccat gctttttgca ctggaccgca tcaaccgtga cccgcacctg ctgcctggcg
      481 tgcgcctggg tgcacacatc ctcgacagtt gctccaagga cacacatgcg ctggagcagg
      541 cactggactt tgtgcgtgcc tcactcagcc gtggtgctga tggctcacgc cacatctgcc
      601 ccgacggctc ttatgcgacc catggtgatg ctcccactgc catcactggt gttattggcg
      661 gttcctacag tgatgtctcc atccaggtgg ccaacctctt gaggctattt cagatcccac
      721 agattagcta cgcctctacc agtgccaagc tgagtgacaa gtcccgctat gactactttg
      781 cccgcacagt gcctcctgac ttcttccaag ccaaggccat ggctgagatt ctccgcttct
      841 tcaactggac ctatgtgtcc actgtggcgt ctgagggcga ctatggcgag acaggcattg
      901 aggcctttga gctagaggct cgtgcccgca acatctgtgt ggccacctcg gagaaagtgg
      961 gccgtgccat gagccgcgcg gcctttgagg gtgtggtgcg agccctgctg cagaagccca
     1021 gtgcccgcgt ggctgtcctg ttcacccgtt ctgaggatgc ccgggagctg cttgctgcca
     1081 gccagcgcct caatgccagc ttcacctggg tggccagtga tggttggggg gccctggaga
     1141 gtgtggtggc aggcagtgag ggggctgctg agggtgctat caccatcgag ctggcctcct
     1201 accccatcag tgactttgcc tcctacttcc agagcctgga cccttggaac aacagccgga
     1261 acccctggtt ccgtgaattc tgggagcaga ggttccgctg cagcttccgg cagcgagact
     1321 gcgcagccca ctctctccgg gctgtgccct ttgagcagga gtccaagatc atgtttgtgg
     1381 tcaatgcagt gtacgccatg gcccatgcgc tccacaacat gcaccgtgcc ctctgcccca
     1441 acaccacccg gctctgtgac gcgatgcggc cagttaacgg gcgccgcctc tacaaggact
     1501 ttgtgctcaa cgtcaagttt gatgccccct ttcgcccagc tgacacccac aatgaggtcc
     1561 gctttgaccg ctttggtgat ggtattggcc gctacaacat cttcacctat ctgcgtgcag
     1621 gcagtgggcg ctatcgctac cagaaggtgg gctactgggc agaaggcttg actctggaca
     1681 ccagcctcat cccatgggcc tcaccctcag ccggccccct gcccgcctct cgctgcagtg
     1741 agccctgcct ccagaatgag gtgaagagtg tgcagccggg cgaagtctgc tgctggctct
     1801 gcattccgtg ccagccctat gagtaccgat tggacgaatt cacttgcgct gattgtggcc
     1861 tgggctactg gcccaatgcc agcctgactg gctgcttcga actgccccag gagtacatcc
     1921 gctggggcga tgcctgggct gtgggacctg tcaccatcgc ctgcctcggt gccctggcca
     1981 ccctctttgt gctgggtgtc tttgtgcggc acaatgccac accagtggtc aaggcctcag
     2041 gtcgggagct ctgctacatc ctgctgggtg gtgtcttcct ctgctactgc atgaccttca
     2101 tcttcattgc caagccatcc acggcagtgt gtaccttacg gcgtcttggt ttgggcactg
     2161 ccttctctgt ctgctactca gccctgctca ccaagaccaa ccgcattgca cgcatcttcg
     2221 gtggggcccg ggagggtgcc cagcggccac gcttcatcag tcctgcctca caggtggcca
     2281 tctgcctggc acttatctcg ggccagctgc tcatcgtggt cgcctggctg gtggtggagg
     2341 caccgggcac aggcaaggag acagcccccg aacggcggga ggtggtgaca ctgcgctgca
     2401 accaccgcga tgcaagtatg ttgggctcgc tggcctacaa tgtgctcctc atcgcgctct
     2461 gcacgcttta tgccttcaag actcgcaagt gccccgaaaa cttcaacgag gccaagttca
     2521 ttggcttcac catgtacacc acctgcatca tctggctggc attcctgccc atcttctatg
     2581 tcacctccag tgactaccgg gtacagacca ccaccatgtg cgtgtcagtc agcctcagcg
     2641 gctccgtggt gcttggctgc ctctttgcgc ccaagctgca catcatcctc ttccagccgc
     2701 agaagaacgt ggttagccac cgggcaccca ccagccgctt tggcagtgct gctgccaggg
     2761 ccagctccag ccttggccaa gggtctggct cccagtttgt ccccactgtt tgcaatggcc
     2821 gtgaggtggt ggactcgaca acgtcatcgc tttgaagacc ccatactccc gccctgacac
     2881 agctgctcct gggaacctag tgcagaccca cgtccagggc caggaggaag ttggctggag
     2941 cactgcaata atttattacc caccctatgt ctgcccccaa agtcacttac ccacctcctt
     3001 accccagctc ttcagactca gaagtcagga gccttggcca ggagcctctg cagtggccac
     3061 taactgccct tgtagctgtg tttcctcctg gccaggccca gggctcagag aggagcaagc
     3121 cagggttcac tctgccctgg acccgggtgg ctgaggacgg caggccccag tcctaaccag
     3181 caaaggtgct tccagcccag cccctccccc caactagggc cttttttatt ttttatataa
     3241 gttactctgg gatggggagg gtggttattg tgggggctgc ccctccccct gcacagtagt
     3301 ttgtcctgtg gtttattttg tattacctgt aaataaagtg gctttatttt aaaaaa
//
