LOCUS       XM_006714858            2701 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens G protein-coupled receptor kinase 6 (GRK6),
            transcript variant X1, mRNA.
ACCESSION   XM_006714858
VERSION     XM_006714858.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006714858.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..2701
                     /gene="GRK6"
                     /gene_synonym="GPRK6"
                     /note="G protein-coupled receptor kinase 6; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 46 ESTs, 209 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 117 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2870"
                     /db_xref="HGNC:HGNC:4545"
                     /db_xref="MIM:600869"
     CDS             227..1906
                     /gene="GRK6"
                     /gene_synonym="GPRK6"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 6 isoform X1"
                     /protein_id="XP_006714921.1"
                     /db_xref="GeneID:2870"
                     /db_xref="HGNC:HGNC:4545"
                     /db_xref="MIM:600869"
                     /translation="MPHPCALGLWTQQLPSLPTERDYHSLCERQPIGRLLFREFCATR
                     PELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQR
                     LEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYR
                     VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS
                     LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER
                     IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF
                     SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ
                     LLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
                     EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLD
                     WKGQPPAPPKKGLLQRLFSRQRIAVETAATARKSSPPASSPQPEAPTSSWR"
     polyA_site      2701
                     /gene="GRK6"
                     /gene_synonym="GPRK6"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtgtaaatca ggagacaatg cagggaggtg gatggaggcc tgggctctgg agccagactc
       61 ccggctgtgt gacactgagc tagtcagtta gcctctctgg gcctcacagc cccaaaacag
      121 ctgtgcccac ctgagggttg tggtgagggt tctgaagaag attgtggcta ccacactgca
      181 gagctggaag ctgttgtggg ggcccagggc ctggtggtgt gggcacatgc cccacccatg
      241 tgctctcggg ctgtggaccc agcagcttcc atcactgcca acagagcgtg actatcacag
      301 cctgtgcgag cggcagccca ttgggcgcct gctgttccga gagttctgtg ccacgaggcc
      361 ggagctgagc cgctgcgtcg ccttcctgga tggggtggcc gagtatgaag tgaccccgga
      421 tgacaagcgg aaggcatgtg ggcggcagct aacgcagaat tttctgagcc acacgggtcc
      481 tgacctcatc cctgaggtcc cccggcagct ggtgacgaac tgcacccagc ggctggagca
      541 gggtccctgc aaagaccttt tccaggaact cacccggctg acccacgagt acctgagcgt
      601 ggcccctttt gccgactacc tcgacagcat ctacttcaac cgtttcctgc agtggaagtg
      661 gctggaaagg cagccagtga ccaaaaacac cttcaggcaa taccgagtcc tgggcaaagg
      721 tggctttggg gaggtgtgcg cctgccaggt gcgggccaca ggtaagatgt atgcctgcaa
      781 gaagctagag aaaaagcgga tcaagaagcg gaaaggggag gccatggcgc tgaacgagaa
      841 gcagatcctg gagaaagtga acagtaggtt tgtagtgagc ttggcctacg cctatgagac
      901 caaggacgcg ctgtgcctgg tgctgacact gatgaacggg ggcgacctca agttccacat
      961 ctaccacatg ggccaggctg gcttccccga agcgcgggcc gtcttctacg ccgccgagat
     1021 ctgctgtggc ctggaggacc tgcaccggga gcgcatcgtg tacagggacc tgaagcccga
     1081 gaacatcttg ctggatgacc acggccacat ccgcatctct gacctgggac tagctgtgca
     1141 tgtgcccgag ggccagacca tcaaagggcg tgtgggcacc gtgggttaca tggctccgga
     1201 ggtggtgaag aatgaacggt acacgttcag ccctgactgg tgggcgctcg gctgcctcct
     1261 gtacgagatg atcgcaggcc agtcgccctt ccagcagagg aagaagaaga tcaagcggga
     1321 ggaggtggag cggctggtga aggaggtccc cgaggagtat tccgagcgct tttccccgca
     1381 ggcccgctca ctttgctcac agctcctctg caaggaccct gccgaacgcc tggggtgtcg
     1441 tgggggcagt gcccgcgagg tgaaggagca ccccctcttt aagaagctga acttcaagcg
     1501 gctgggagct ggcatgctgg agccgccgtt caagcctgac ccccaggcca tttactgcaa
     1561 ggatgttctg gacattgaac agttctctac ggtcaagggc gtggagctgg agcctaccga
     1621 ccaggacttc taccagaagt ttgccacagg cagtgtgccc atcccctggc agaacgagat
     1681 ggtggagacc gagtgcttcc aagagctgaa tgtctttggg ctggatggct cagttccccc
     1741 agacctggac tggaagggcc agccacctgc acctcctaaa aagggactgc tgcagagact
     1801 cttcagtcgc caaaggattg ctgtggaaac tgcagcgaca gcgaggaaga gctccccacc
     1861 cgcctctagc ccccagcccg aggcccccac cagcagttgg cggtagcagc tactccgagc
     1921 gccgtttaca gttttgcaca gtgatcttcc ccattgtcca ctcaagtcgt ggcctgggga
     1981 acacagacgg agctgtcccc agtgtcctcc gtccctcagc ccctggcctg gctgagtttg
     2041 gcagggcctg ggccatccct gggacaaagg tgcgtccctt cagctcttct ccgtggagct
     2101 cggggctttc tgtatttatg tatttgtacg aatgtatata gcgaccagag cattcttaat
     2161 tcccgccgca gacctggcgc ccccgccttg gctcctgggg gcagccagcc ctggctggga
     2221 gagcgggagc tggcagagga gccactgcca aactcaaggc tcctctggcc cagcttggat
     2281 ggctgagggt ggtcacaccc ctgagccttc agcactgtgc tggccacccc ggcctctgag
     2341 taagactcgt gcctccccct gctgccctgg gctcaggctg ctaccctctg gggcccaaag
     2401 ctgtcccttc tcagtgcttg tcagcgctgg gtctggggcc tctgtatgcc ctaggcctgt
     2461 gccaaagtgg ccagagattg ggctgcctgt gatacccatc agcccactgc cccggccggc
     2521 ccagataggt ctgcctctgc cttccagctc ccacagcctg gtccctgata ctgggctctg
     2581 tcctgcagac acctctttca gaaacgccca agcccagccc ctaggagggg gtggggcatc
     2641 cctggtcaac cctcaaacat tccggactcc cctcataaca atagacacat gtgcccagca
     2701 a
//
