LOCUS       NM_005308               6798 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens G protein-coupled receptor kinase 5 (GRK5), mRNA.
ACCESSION   NM_005308
VERSION     NM_005308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6798)
  AUTHORS   Liccardo,D., Valletta,A., Spagnuolo,G., Vinciguerra,C.,
            Lauria,M.R., Perrotta,A., Del Giudice,C., De Luca,F., Rengo,G.,
            Rengo,S., Rengo,C. and Cannavo,A.
  TITLE     Porphyromonas gingivalis virulence factors induce toxic effects in
            SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective
            strategy
  JOURNAL   J Biotechnol 393, 7-16 (2024)
   PUBMED   39033880
  REMARK    GeneRIF: Porphyromonas gingivalis virulence factors induce toxic
            effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a
            protective strategy.
REFERENCE   2  (bases 1 to 6798)
  AUTHORS   Ijaz,K., Zakiullah,-., Shah,H., Ali,S., Raziq,M. and Bahadar,H.
  TITLE     Association of GRK5 variant rs10886471 with the therapeutic effect
            of repaglinide in patients of type 2 diabetes mellitus in Peshawar,
            Pakistan
  JOURNAL   Pak J Pharm Sci 37 (2(Special)), 417-421 (2024)
   PUBMED   38822544
  REMARK    GeneRIF: Association of GRK5 variant rs10886471 with the
            therapeutic effect of repaglinide in patients of type 2 diabetes
            mellitus in Peshawar, Pakistan.
REFERENCE   3  (bases 1 to 6798)
  AUTHORS   Xiang,H., Huang,J., Song,A., Liu,F., Xiong,J. and Zhang,C.
  TITLE     GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway
  JOURNAL   FASEB J 38 (2), e23422 (2024)
   PUBMED   38206179
  REMARK    GeneRIF: GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling
            pathway.
REFERENCE   4  (bases 1 to 6798)
  AUTHORS   Xu,M., Shao,Y., Lin,K., Liu,Y., Lin,Y., Lin,Y., Yang,R., Liu,L.,
            Yin,M., Liao,S., Jiang,S. and He,J.
  TITLE     Genetic Arg-304-His substitution in GRK5 protects against sepsis
            progression by alleviating NF-kappaB-mediated inflammation
  JOURNAL   Int Immunopharmacol 115, 109629 (2023)
   PUBMED   36584571
  REMARK    GeneRIF: Genetic Arg-304-His substitution in GRK5 protects against
            sepsis progression by alleviating NF-kappaB-mediated inflammation.
REFERENCE   5  (bases 1 to 6798)
  AUTHORS   Xiu,Y., Cao,S., Jiang,R. and Zhou,Y.
  TITLE     lncRNA LINC01315 promotes malignancy of triple-negative breast
            cancer and predicts poor outcomes by modulating
            microRNA-876-5p/GRK5
  JOURNAL   Bioengineered 13 (4), 10001-10009 (2022)
   PUBMED   35412954
  REMARK    GeneRIF: lncRNA LINC01315 promotes malignancy of triple-negative
            breast cancer and predicts poor outcomes by modulating
            microRNA-876-5p/GRK5.
REFERENCE   6  (bases 1 to 6798)
  AUTHORS   Nagayama,Y., Tanaka,K., Hara,T., Namba,H., Yamashita,S.,
            Taniyama,K. and Niwa,M.
  TITLE     Involvement of G protein-coupled receptor kinase 5 in homologous
            desensitization of the thyrotropin receptor
  JOURNAL   J Biol Chem 271 (17), 10143-10148 (1996)
   PUBMED   8626574
REFERENCE   7  (bases 1 to 6798)
  AUTHORS   Bullrich,F., Druck,T., Kunapuli,P., Gomez,J., Gripp,K.W.,
            Schlegelberger,B., Lasota,J., Aronson,M., Cannizzaro,L.A.,
            Huebner,K. et al.
  TITLE     Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G
            protein-coupled receptor kinases GRK5 and GRK6
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 250-254 (1995)
   PUBMED   7789183
REFERENCE   8  (bases 1 to 6798)
  AUTHORS   Kunapuli,P., Gurevich,V.V. and Benovic,J.L.
  TITLE     Phospholipid-stimulated autophosphorylation activates the G
            protein-coupled receptor kinase GRK5
  JOURNAL   J Biol Chem 269 (14), 10209-10212 (1994)
   PUBMED   8144599
REFERENCE   9  (bases 1 to 6798)
  AUTHORS   Kunapuli,P., Onorato,J.J., Hosey,M.M. and Benovic,J.L.
  TITLE     Expression, purification, and characterization of the G
            protein-coupled receptor kinase GRK5
  JOURNAL   J Biol Chem 269 (2), 1099-1105 (1994)
   PUBMED   8288567
REFERENCE   10 (bases 1 to 6798)
  AUTHORS   Kunapuli,P. and Benovic,J.L.
  TITLE     Cloning and expression of GRK5: a member of the G protein-coupled
            receptor kinase family
  JOURNAL   Proc Natl Acad Sci U S A 90 (12), 5588-5592 (1993)
   PUBMED   7685906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355861.19, BC018116.1,
            L15388.1, BC064506.1, CN290123.1, BQ184611.1 and AL355273.30.
            
            On May 17, 2019 this sequence version replaced NM_005308.2.
            
            Summary: This gene encodes a member of the guanine
            nucleotide-binding protein (G protein)-coupled receptor kinase
            subfamily of the Ser/Thr protein kinase family. The protein
            phosphorylates the activated forms of G protein-coupled receptors
            thus initiating their deactivation. It has also been shown to play
            a role in regulating the motility of polymorphonuclear leukocytes
            (PMNs). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.197397.1,
                                           SRR1803614.188637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392870.3/ ENSP00000376609.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL355861.19        48500-48613
            115-158             BC018116.1         97-140
            159-206             L15388.1           32-79
            207-293             BC064506.1         87-173
            294-495             BC018116.1         270-471
            496-2464            BC064506.1         376-2344
            2465-2487           L15388.1           2335-2357
            2488-2508           L15388.1           2360-2380
            2509-2574           CN290123.1         557-622
            2575-2581           CN290123.1         624-630
            2582-2605           L15388.1           2453-2476
            2606-2670           L15388.1           2478-2542
            2671-2672           BQ184611.1         18-19               c
            2673-6798           AL355273.30        76322-80447
FEATURES             Location/Qualifiers
     source          1..6798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..6798
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /note="G protein-coupled receptor kinase 5"
                     /db_xref="GeneID:2869"
                     /db_xref="HGNC:HGNC:4544"
                     /db_xref="MIM:600870"
     exon            1..399
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2120
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /EC_number="2.7.11.16"
                     /note="g protein-coupled receptor kinase GRK5"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 5"
                     /protein_id="NP_005299.1"
                     /db_xref="CCDS:CCDS7612.1"
                     /db_xref="GeneID:2869"
                     /db_xref="HGNC:HGNC:4544"
                     /db_xref="MIM:600870"
                     /translation="MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCED
                     LRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKG
                     KEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHE
                     YLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE
                     KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY
                     NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV
                     KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV
                     KREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN
                     MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVS
                     IPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSS
                     PSSKTSFNHHINSNHVSSNSTGSS"
     exon            400..495
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..608
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..686
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            687..787
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            788..880
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            881..944
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1085
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1276
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1314
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1404
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1613
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1751
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1889
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2021
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..6798
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /note="hexamer: ATTAAA"
     polyA_site      2672
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /note="major polyA site"
     polyA_site      2705
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
     regulatory      2770..2775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /note="hexamer: ATTAAA"
     polyA_site      2808
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
     regulatory      6777..6782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
                     /note="hexamer: AATAAA"
     polyA_site      6798
                     /gene="GRK5"
                     /gene_synonym="FP2025; GPRK5"
ORIGIN      
        1 agaagcatcc gaggcattaa agcatccgag ggagccggag gggaggagaa tggagtgaca
       61 gagacacgcg gagggtgggg ggtggggggg agcgtgttga gggagggggg aggggggaca
      121 cagagggagg aagaagcggc ggcggcggcg gcggcggcgg cggctcctct ttgcagaggg
      181 ggaaactctt gggctgagag caggaataat gcggtaggca aggcgggctg ctggctcccc
      241 cggctccggc agcagcggcg gcagcccgag cagcggcagc agcagcggca gcaccccagg
      301 cgctgacagc cccgccggcc ggctccgttg ctgaccgccg actgtcaatg gagctggaaa
      361 acatcgtggc caacacggtc ttgctgaaag ccagggaagg gggcggagga aagcgcaaag
      421 ggaaaagcaa gaagtggaaa gaaatcctga agttccctca cattagccag tgtgaagacc
      481 tccgaaggac catagacaga gattactgca gtttatgtga caagcagcca atcgggaggc
      541 tgcttttccg gcagttttgt gaaaccaggc ctgggctgga gtgttacatt cagttcctgg
      601 actccgtggc agaatatgaa gttactccag atgaaaaact gggagagaaa gggaaggaaa
      661 ttatgaccaa gtacctcacc ccaaagtccc ctgttttcat agcccaagtt ggccaagacc
      721 tggtctccca gacggaggag aagctcctac agaagccgtg caaagaactc ttttctgcct
      781 gtgcacagtc tgtccacgag tacctgaggg gagaaccatt ccacgaatat ctggacagca
      841 tgttttttga ccgctttctc cagtggaagt ggttggaaag gcaaccggtg accaaaaaca
      901 ctttcaggca gtatcgagtg ctaggaaaag ggggcttcgg ggaggtctgt gcctgccagg
      961 ttcgggccac gggtaaaatg tatgcctgca agcgcttgga gaagaagagg atcaaaaaga
     1021 ggaaagggga gtccatggcc ctcaatgaga agcagatcct cgagaaggtc aacagtcagt
     1081 ttgtggtcaa cctggcctat gcctacgaga ccaaggatgc actgtgcttg gtcctgacca
     1141 tcatgaatgg gggtgacctg aagttccaca tctacaacat gggcaaccct ggcttcgagg
     1201 aggagcgggc cttgttttat gcggcagaga tcctctgcgg cttagaagac ctccaccgtg
     1261 agaacaccgt ctaccgagat ctgaaacctg aaaacatcct gttagatgat tatggccaca
     1321 ttaggatctc agacctgggc ttggctgtga agatccccga gggagacctg atccgcggcc
     1381 gggtgggcac tgttggctac atggctccag aggtcctgaa caaccagagg tacggcctga
     1441 gccccgacta ctggggcctt ggctgcctca tctatgagat gatcgagggc cagtcgccgt
     1501 tccgcggccg caaggagaag gtgaagcggg aggaggtgga ccgccgggtc ctggagacgg
     1561 aggaggtgta ctcccacaag ttctccgagg aggccaagtc catctgcaag atgctgctca
     1621 cgaaagatgc gaagcagagg ctgggctgcc aggaggaggg ggctgcagag gtcaagagac
     1681 accccttctt caggaacatg aacttcaagc gcttagaagc cgggatgttg gaccctccct
     1741 tcgttccaga cccccgcgct gtgtactgta aggacgtgct ggacatcgag cagttctcca
     1801 ctgtgaaggg cgtcaatctg gaccacacag acgacgactt ctactccaag ttctccacgg
     1861 gctctgtgtc catcccatgg caaaacgaga tgatagaaac agaatgcttt aaggagctga
     1921 acgtgtttgg acctaatggt accctcccgc cagatctgaa cagaaaccac cctccggaac
     1981 cgcccaagaa agggctgctc cagagactct tcaagcggca gcatcagaac aattccaaga
     2041 gttcgcccag ctccaagacc agttttaacc accacataaa ctcaaaccat gtcagctcga
     2101 actccaccgg aagcagctag tttcggctct ggcctccaag tccacagtgg aaccagccca
     2161 gacccttctc cttagaagtg gaagtagtgg agcccctgct ctggtggggc tgccagggga
     2221 gaccccggga gccggggaag gaggccgtcc atcccgtcga cgtagaacct cgaggtttct
     2281 caaagaaatt tccactcagg tctgttttcc gaggcggccc cggccggggt ggattggatt
     2341 tgtctttggt gaacattgca atagaaatcc aattggatac gacaacttgc acgtatttta
     2401 atagcgtcat aactagaact gaattttgtc tttatgattt ttaaagaaaa gttttgtaaa
     2461 tttctctact gtctcagttt acattttgta tatttgtatt taaatgaaag tgagactttg
     2521 agggtgtata ttttctgtgc agccactgtt aagccatgtg ttccaaggca ttttagcggg
     2581 gagggggtta tcaaaaaaaa aaaaatgtga ctcaagactt ccagagcctc aaatgagaaa
     2641 atgtctttat taaatgtaga aagtgatcca tacttcacct ttgaaggatt ggttgtattt
     2701 acccacatct atctctggag ccatttcctc acattggtgt cacccttctg tcggcttgga
     2761 acaatctgaa ttaaatgttc cagacacacg tgggacttcc ccctcccagc cagaatgtcc
     2821 tctcctgggg ccctcggagt cgcctaggct gagcccttct cctcgagggg cacgccgagc
     2881 cactgtcgca cccacctctg tctgctcttc cttcaggaag gcggctggca cgcggatcta
     2941 ggtgtttgca gcctggtggg cgatgggcct ctttccttct aagcaggtcc tgactgctaa
     3001 agccagtcat ttgcaagagg tttgcattgg gggatttttg ctctattttt aacagaagca
     3061 taggaccgta aagatgtgtc atgaaacccc aagtgtccca aagcctcggg gcccacagga
     3121 gcatcgggaa gtgaggcagt gcgctcatcc tgacggagca gcgtcgtgtc tgtagcgggg
     3181 agggaggctg gcccaggggc ccggcatgtt cctgaagcgt tcacagggtt ttgagacctt
     3241 cacagcccca tcaatgtgct ggcccatgtg gcatggatgg ggtagtctct ctgggcaaat
     3301 gagaggccca aggagagacc aagccaccaa agggctcaag acaaagtcac tgttccttcc
     3361 ccaggaaggt ggggcagagg caagatctat cggacatttc aaagtttcag gcaggagctc
     3421 ctagaggact tggtggcttt gccagcccag gggcctctga aggcagcccc cagacccttg
     3481 tagcagggct gtccatcccc agggagcagc tggccacctc ctcctgcctc gaagaagtga
     3541 ccaggggcca atctgctccc acctcccgtc caggacaggg tgaacatttg acctcactgt
     3601 cccctgcccg gctgagtccc tgatgtctga ctgtgccacc cagcagctgc cagggtctct
     3661 caccatgtgg accctgccct agctgcagct gcacctcctg tcaaaagtgc agactcgcag
     3721 gttccacccc aaaccacaga atgggaatgc ctgggagccc acccctgctg tgggctctca
     3781 gcggggcttt gggggtgatc atcccaaaca catttctctg gatgacgcag gcagcattgg
     3841 agcatgagcc gtggggagga cagtcgtgag cacaccagct gtgaggcccg gtttccatgc
     3901 ctaacccccg gactctaccc ctgggtcctg gggcgtaccg ctaaaagggt cctggccttt
     3961 gggactgatc attttgaggc ccttttacaa agaaatgggg gagaagaaat agctgggctt
     4021 ccctcaaatc tttttaatgt gcagtatttt tttgttcaag accagctctt gttttatgag
     4081 gctccttcca ttacctttct tgggctgaat gcaaaacaaa tacagccaca ttcaagtctt
     4141 ccaaggaagt agaaaactct ttgaatggta tcttaagatc cttaagctct tgctgaactt
     4201 cctttttcaa tgaaaagaag gaccatcatc ctaggatggt caccagccca agccaccacc
     4261 ccagccaccc atccaggagg ttggttcctt ttgcccagtt catagcagct cagtccttac
     4321 cagatggatt cttggtgttg ggaagcagcc tctttttatt cctgaaaggc aatgccctgt
     4381 ccgtttgcag tagagaatcc ccagggagca agaaagatga cagaagtgtg gctgccgtgt
     4441 ttctaggtca tgagagctct ggcgatacta ccacaaggcc tgcacgtgga ctctatgata
     4501 acttgagtct tccatcatgt ttgccaccag ccctccctga gtgcccagag gagatggggg
     4561 cagagtcact tggcctacta aagcctcctg ttccttctgg ctcatgcatt gctttgtggt
     4621 aagagaaagg aagtctttag aacagcgcct gggaatcagc ccttctccct actgagtccc
     4681 cagtcctgtc ccttccctga ctcgctcctc ctccaacctt ggtttctata gctgcatttt
     4741 tttttttttt tttttttgag acaagatctc attgtgttcc ccaggctgaa gtgcagtggc
     4801 atgattctgg ctcactgcag cctcaaactc ctgagtccaa gctatcctcc tgcctcagcc
     4861 tccgaggtag ctgggaccat aggcgtgcac caccatactc agctaatttt taaaattttt
     4921 tgtagagatg gggggggggt ctccccatgt tgcccaggct ggcctcgaat tcctgagccc
     4981 aagctatcct cctgcctcag cctcccaaag tgctgaggtt ataggtgtga gccactgtcc
     5041 ctggcctata cggtcatttt ttaaaagata ttttaaaatt aaaagcaaac aacactgtcc
     5101 acccatctac ctgtccagga taaggcatat ttggacggtg aacggattta ctctcgttca
     5161 tgcatttgag cgcttcacag aagagtcttt cttgctccag gcatgacatt ttttttcacc
     5221 agacgttcac tgacttcgtg actttgaggt gagacatggg atctctcaga agcgtctctg
     5281 catctgcatt tcaggagatg agctgctgtc cctggtggac agaggcggtc tctgccatgg
     5341 tcaccatgat gccctacaag tgtttattga gtcccctggg gggcacccag aataccaccc
     5401 aaaatagcaa gaagacccgg tccccgcctt gcggacgatg cactcacatg ccacagcaac
     5461 ccattctcgc ctcttccttg gccgggaacc cggggctcta gggctgctcg ctgctgctgt
     5521 ggcctgcgca gccacgggag gcttcctgaa aggcattgct cggaggggcg ggggcgggga
     5581 ggcctagcct gccccacaga cacagctgtg aggcctgggt catacacata ccagcaagca
     5641 gctgccgaga caaatggtgg tgggaagtcc tgggaacaca cacagccttt gcattgacag
     5701 cacaagtagg atcagagccc aggtgagccc ctgaggatac cgaggccttc cctccctgag
     5761 gcccgcaagt ctccatgcgt ctcccgggag cctggccccg ctgcagaaat cccttctctt
     5821 cctccacacc ctgtcctttc cccaaaggct cgtgttatca gttccagcta cccatcgact
     5881 ttcccaccga gccgctgccc tcaaaacgga gggggcaccg cagcctcctt gagcctggca
     5941 tcccaggcct tgccaaaggg gacggtggct tcctggataa ttggaaatct ctgagaagaa
     6001 gaggaaacac ctgagtgaca ctcagctgtc ctctggggtc ccctggtgtg catgcacgtc
     6061 ctcctgaata cctgtacttc caagaggtgg tctcctgttt tcataaccca acactctgag
     6121 ataggatctt ccaacttttt agccccggct gtggaaagat agtgagtatg aagtctttgt
     6181 gcatttggaa gtgacatcgc tgtgtggatt atgaatacag agagctgcca tcttcctgat
     6241 cacaatagac cacgattgca aagcctcctc tcccagagac cccttctgcg cctgccctcc
     6301 ccacccacca cccagctgtt gaagctcagc gtgtgcaagt cagaccctgc acaggccggg
     6361 ggtgtctcac ctggcctaaa cgtaaaggct tgtgccggag acagtgattg aaaacatttg
     6421 aaaagccagc tctccctggc agagaaagac acttcccccc caaagtggaa tttagatgtc
     6481 tttccctagt ccatcaagaa gtcatttttg taacagtccc taagcgagtg ttctcaatta
     6541 gaagagttta gtggcttttg gtgttgttaa aataataaga atccttctag catccaaagc
     6601 tttctaattt ttttcaggga gatttggaca ttaatgaatg gaaacttcca cagtggcggt
     6661 cactcctgaa ggcagcggct tctgttctcc cgctgctgta actctgtgtg ttccgtctat
     6721 cgcgtcacag tgccgctgga tctagatgga gccactgttg ttgtttttaa aagagaaata
     6781 aattccttaa tggaagta
//
