LOCUS       XM_011513449            2393 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens G protein-coupled receptor kinase 4 (GRK4),
            transcript variant X5, mRNA.
ACCESSION   XM_011513449
VERSION     XM_011513449.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011513449.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..2393
                     /gene="GRK4"
                     /gene_synonym="GPRK2L; GPRK4; GRK4a; IT11"
                     /note="G protein-coupled receptor kinase 4; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 20 ESTs, 10 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2868"
                     /db_xref="HGNC:HGNC:4543"
                     /db_xref="MIM:137026"
     CDS             501..2258
                     /gene="GRK4"
                     /gene_synonym="GPRK2L; GPRK4; GRK4a; IT11"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 4 isoform X5"
                     /protein_id="XP_011511751.1"
                     /db_xref="GeneID:2868"
                     /db_xref="HGNC:HGNC:4543"
                     /db_xref="MIM:137026"
                     /translation="MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPT
                     LKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLK
                     EENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRV
                     LGKGGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGK
                     MYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNG
                     GDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIR
                     ISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSP
                     FKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGV
                     KQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYA
                     RFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFR
                     RGGCLTMVPSEKEVEPKQC"
     polyA_site      2393
                     /gene="GRK4"
                     /gene_synonym="GPRK2L; GPRK4; GRK4a; IT11"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtagtgcccc ggccgcggcg gcgaggggcg ctccctcttc agctaagccg ttagcgccga
       61 gcccgcccgg gagcgggtcg ccggccgcgg cgggcgcccc tgccagtgag cccctgtccg
      121 aagtgagcca cggcattgac tcggggctgc ccgggggcag ggcactgagg agggagttgc
      181 gcgcgcgagg cgagggcgat ggggccaaga agaaccgggg cgatagcgcg gcagcggtga
      241 cagctgggac ccgccgcggt cgggctgccc cctcccctcg ccccgaccgc tcccctgctg
      301 gtgagggcct gcggaggcgg cggcggcggc gcccttggtg gcagtggtgg cggcggagca
      361 gcctcccggg atcgtgtccg gagctcgagg agagggtggt gcccggcgag ctatgcacgg
      421 gggcggcggc gtctcctcct gttccgcctc ctcagtctcc tcggtctcgc agaatccgcc
      481 ggcggcggcg gcgccaggac atggagctcg agaacatcgt ggccaactcg ctgctgctga
      541 aagcgcgtca agaaaaggat tatagcagtc tttgtgacaa gcaaccgata ggaagacgtc
      601 tcttcaggca gttctgtgat accaaaccca ctctaaagag gcacattgaa ttcttggatg
      661 cagtggcaga atatgaagtt gccgatgatg aggaccgaag tgattgtgga ctgtcaatct
      721 tagatagatt cttcaatgat aagttggcag cccctttacc agaaatacct ccagatgttg
      781 tgacagaatg tagattggga ctgaaggagg agaacccttc caaaaaagcc tttgaggaat
      841 gtactagagt tgcccataac tacctaagag gggaaccatt tgaagaatac caagaaagct
      901 catatttttc tcagttttta caatggaaat ggctggaaag gcaacccgta acaaagaaca
      961 catttagaca ttacagagtt ctaggaaaag gcggatttgg agagcagtcc cctgtggggt
     1021 gtgcagtgga tgggagttgg aagaaacagc agcctaatgt tgatgacaca gaggcacggg
     1081 gaccagaacc tgaggctcat gatactattt tttccacttt tgtttgcgcc tgtcaagtgc
     1141 gagccacagg aaaaatgtat gcctgcaaaa agctacaaaa aaaaagaata aagaagagga
     1201 aaggtgaagc tatggctcta aatgagaaaa gaattctgga gaaagtgcaa agtagattcg
     1261 tagttagttt agcctacgct tatgaaacca aagatgcctt gtgcttggtg ctcaccatta
     1321 tgaatggagg ggatttgaag tttcacattt acaacctggg caatcccggc tttgatgagc
     1381 agagagccgt tttctatgct gcagagctgt gttgcggctt ggaagattta cagagggaaa
     1441 gaattgtata cagagacttg aagcctgaga atattctcct tgatgatcgt ggacacatcc
     1501 ggatttcaga cctcggtttg gccacagaga tcccagaagg acagagggtt cgaggaagag
     1561 ttggaacagt cggctacatg gcacctgaag ttgtcaataa tgaaaagtat acgtttagtc
     1621 ccgattggtg gggacttggc tgtctgatct atgaaatgat tcagggacat tctccattca
     1681 aaaaatacaa agagaaagtc aaatgggagg aggtcgatca aagaatcaag aatgataccg
     1741 aggagtattc tgagaagttt tcagaggatg ccaaatctat ctgcaggatg ttactcacca
     1801 agaatccaag caagcggctg ggctgcaggg gcgagggagc ggctggggtg aagcagcacc
     1861 ccgtgttcaa ggacatcaac ttcaggaggc tggaggcaaa catgctggag ccccctttct
     1921 gtcctgatcc tcatgccgtt tactgtaagg acgtcctgga tatcgagcag ttctcggtgg
     1981 tgaaagggat ctacctggac accgcagatg aagacttcta tgctcggttt gctaccgggt
     2041 gtgtctccat cccctggcag aatgagatga tcgaatctgg gtgtttcaaa gacatcaaca
     2101 aaagtgaaag tgaggaagct ttgccattag atctagacaa gaacatacat accccggttt
     2161 ccagaccaaa cagaggcttc ttctatagac tcttcagaag agggggctgc ctgaccatgg
     2221 tccccagtga gaaggaagtg gaacccaagc aatgctgagc accccggtgc ggaccacaga
     2281 gcagaccctg gcgccaggaa ggagcatgtg ttagcgtctc gtcccacctg gaattgtaat
     2341 aaatacatct aaataaaaca tgccttggga gtgtacagac ctttctgcac taa
//
