LOCUS       NM_020137               3031 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GRIP1 associated protein 1 (GRIPAP1), mRNA.
ACCESSION   NM_020137
VERSION     NM_020137.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Wilkinson,B., Evgrafov,O.V., Zheng,D., Hartel,N., Knowles,J.A.,
            Graham,N.A., Ichida,J.K. and Coba,M.P.
  TITLE     Endogenous Cell Type-Specific Disrupted in Schizophrenia 1
            Interactomes Reveal Protein Networks Associated With
            Neurodevelopmental Disorders
  JOURNAL   Biol Psychiatry 85 (4), 305-316 (2019)
   PUBMED   29961565
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Chiu,S.L., Diering,G.H., Ye,B., Takamiya,K., Chen,C.M., Jiang,Y.,
            Niranjan,T., Schwartz,C.E., Wang,T. and Huganir,R.L.
  TITLE     GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal
            Recycling of AMPA Receptors
  JOURNAL   Neuron 93 (6), 1405-1419 (2017)
   PUBMED   28285821
  REMARK    GeneRIF: results demonstrate a requirement for normal recycling
            endosome function in AMPAR-dependent synaptic function and neuronal
            connectivity in vivo, and suggest a potential role for GRASP1 in
            the pathophysiology of human cognitive disorders.
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Hoogenraad,C.C., Popa,I., Futai,K., Martinez-Sanchez,E., Wulf,P.S.,
            van Vlijmen,T., Dortland,B.R., Oorschot,V., Govers,R., Monti,M.,
            Heck,A.J., Sheng,M., Klumperman,J., Rehmann,H., Jaarsma,D.,
            Kapitein,L.C. and van der Sluijs,P.
  TITLE     Neuron specific Rab4 effector GRASP-1 coordinates membrane
            specialization and maturation of recycling endosomes
  JOURNAL   PLoS Biol 8 (1), e1000283 (2010)
   PUBMED   20098723
  REMARK    Erratum:[PLoS Biol. 2010;8(9)
            doi:10.1371/annotation/b17dfb99-8809-4c5a-86c2-c2a0f7ca7f5e..
            Sanchez-Martinez, Emma [corrected to Martinez-Sanchez, Emma]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3031)
  AUTHORS   Ye,B., Yu,W.P., Thomas,G.M. and Huganir,R.L.
  TITLE     GRASP-1 is a neuronal scaffold protein for the JNK signaling
            pathway
  JOURNAL   FEBS Lett 581 (23), 4403-4410 (2007)
   PUBMED   17761173
  REMARK    GeneRIF: Results suggest that GRASP-1 serves as a scaffold protein
            to facilitate MEKK-1 activation of JNK signaling in neurons.
REFERENCE   8  (bases 1 to 3031)
  AUTHORS   Stinton,L.M., Selak,S. and Fritzler,M.J.
  TITLE     Identification of GRASP-1 as a novel 97 kDa autoantigen localized
            to endosomes
  JOURNAL   Clin Immunol 116 (2), 108-117 (2005)
   PUBMED   15897011
  REMARK    GeneRIF: GRASP-1 was identified as an soluble autoantigen that has
            numerous coiled-coil domains throughout the protein.
REFERENCE   9  (bases 1 to 3031)
  AUTHORS   Ye,B., Sugo,N., Hurn,P.D. and Huganir,R.L.
  TITLE     Physiological and pathological caspase cleavage of the neuronal
            RasGEF GRASP-1 as detected using a cleavage site-specific antibody
  JOURNAL   Neuroscience 114 (1), 217-227 (2002)
   PUBMED   12207967
REFERENCE   10 (bases 1 to 3031)
  AUTHORS   Ye,B., Liao,D., Zhang,X., Zhang,P., Dong,H. and Huganir,R.L.
  TITLE     GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP
            complex
  JOURNAL   Neuron 26 (3), 603-617 (2000)
   PUBMED   10896157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233294.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020137.4.
            
            Summary: This gene encodes a guanine nucleotide exchange factor for
            the Ras family of small G proteins (RasGEF). The encoded protein
            interacts in a complex with glutamate receptor interacting protein
            1 (GRIP1) and plays a role in the regulation of AMPA receptor
            function. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.171255.1,
                                           SRR1660803.126606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376423.8/ ENSP00000365606.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC233294.3         120582-120658       c
            78-144              AC233294.3         117832-117898       c
            145-206             AC233294.3         117632-117693       c
            207-233             AC233294.3         116548-116574       c
            234-341             AC233294.3         115644-115751       c
            342-492             AC233294.3         111822-111972       c
            493-677             AC233294.3         109320-109504       c
            678-725             AC233294.3         109079-109126       c
            726-757             AC233294.3         108366-108397       c
            758-805             AC233294.3         108229-108276       c
            806-905             AC233294.3         108005-108104       c
            906-983             AC233294.3         106515-106592       c
            984-1076            AC233294.3         106179-106271       c
            1077-1211           AC233294.3         103662-103796       c
            1212-1307           AC233294.3         102169-102264       c
            1308-1520           AC233294.3         101622-101834       c
            1521-1634           AC233294.3         101373-101486       c
            1635-1712           AC233294.3         100189-100266       c
            1713-1808           AC233294.3         99990-100085        c
            1809-1865           AC233294.3         99810-99866         c
            1866-1965           AC233294.3         99609-99708         c
            1966-2096           AC233294.3         96699-96829         c
            2097-2219           AC233294.3         94635-94757         c
            2220-2313           AC233294.3         94412-94505         c
            2314-2468           AC233294.3         93549-93703         c
            2469-3031           AC233294.3         92117-92679         c
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..3031
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /note="GRIP1 associated protein 1"
                     /db_xref="GeneID:56850"
                     /db_xref="HGNC:HGNC:18706"
                     /db_xref="MIM:300408"
     exon            1..77
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2561
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /codon_start=1
                     /product="GRIP1-associated protein 1"
                     /protein_id="NP_064522.4"
                     /db_xref="CCDS:CCDS35248.1"
                     /db_xref="GeneID:56850"
                     /db_xref="HGNC:HGNC:18706"
                     /db_xref="MIM:300408"
                     /translation="MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQK
                     VAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSK
                     LCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGK
                     EAGKFSAVSEGQGDPPGGLAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQ
                     AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA
                     RTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAE
                     NNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ
                     ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE
                     LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTV
                     EELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQ
                     DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKR
                     ADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS
                     AVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMA
                     EDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNM
                     LEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGETS"
     exon            78..144
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..206
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..233
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..341
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..492
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..677
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..725
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..757
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..805
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..905
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..983
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1076
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1211
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1307
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1520
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1634
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1712
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1808
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1865
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1965
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2096
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2219
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2313
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2468
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..3031
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3031
                     /gene="GRIPAP1"
                     /gene_synonym="GRASP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagaaag ctggcggggg ggtgggggga ggaacatggc gcaagctctg tctgaggagg
       61 agtttcagcg gatgcaggct cagctcctgg aactccggac aaacaactac cagctttcag
      121 atgaactacg caagaatggt gttgaactca ccagtcttcg acagaaggtc gcctacttgg
      181 ataaggagtt cagcaaagct cagaaggcac tgagcaagag caagaaagct caggaagtcg
      241 aggtattgct gagtgaaaat gagatgctgc aggcaaagct gcacagccag gaggaggact
      301 tccgtttgca gaacagcaca ctaatggccg agttcagcaa gctctgcagc cagatggaac
      361 agctggagca agagaaccag caactgaagg agggggctgc aggagcaggg gttgcccaag
      421 ctgggcccct cgtggatggg gagctgctga ggctacaggc tgaaaacaca gccttgcaga
      481 agaacgtggc agccctgcag gaacgctatg ggaaagaagc cgggaagttc tcagctgtca
      541 gtgagggcca gggggatccc ccagggggcc tggcccccac cgtcctggcc cccatgccgt
      601 tggcagaggt ggagctgaaa tgggaaatgg agaaagagga gaagagattg ctctgggaac
      661 agctgcaagg cttagagagc tcaaagcagg ccgaaacatc caggctgcag gaggaacttg
      721 ctaagctctc cgagaaactg aaaaagaaac aagaaagttt ttgccgtctg cagacagaaa
      781 aggagactct gtttaatgac agcaggaaca agattgagga attacaacaa cggaaggaag
      841 ctgatcacaa agcccagttg gctcgaaccc agaagctgca gcaggaactt gaggctgcca
      901 atcagagctt ggcagagctg agagatcagc ggcaggggga gcgcctggaa catgcagcag
      961 ctttgcgggc cctacaagat caggtatcca tccagagtgc agatgcacag gaacaagtgg
     1021 aagggctttt ggctgagaac aatgccttga ggactagcct ggctgccctg gagcagatcc
     1081 aaacagcaaa gacccaagaa ctgaatatgc tccgggaaca gaccactggg ctggcagctg
     1141 agttgcagca gcagcaggct gagtacgagg accttatggg acagaaagat gacctcaact
     1201 cccagctcca ggagtcatta cgggccaata gtcgactgct ggaacaactt caagaaatag
     1261 ggcaggagaa ggagcagttg acccaggaat tacaggaggc tcggaagagt gcggagaagc
     1321 ggaaggccat gctggatgag ctagcaatgg aaacgctgca agagaagtcc cagcacaagg
     1381 aagagctggg agcagttcgt ctacggcatg agaaggaggt gctgggggtg cgtgcccgct
     1441 atgagcgtga gctccgagag ctgcatgaag acaagaagcg tcaggaggag gagctccgtg
     1501 ggcagatccg ggaggagaag gcccggacac gggagctgga gactctccag cagacagtgg
     1561 aagaacttca agctcaggta cattccatgg atggagccaa gggctggttt gaacggcgct
     1621 tgaaggaagc cgaggaatcc ctgcagcagc agcagcagga acaagaggaa gccctcaagc
     1681 agtgtcggga gcagcacgct gccgagctga agggcaagga ggaggagcta caggatgtac
     1741 gggatcagct cgagcaggcc caggaggagc gggactgcca cctgaagacc attagcagcc
     1801 tgaagcagga ggtgaaggac acagtggatg ggcagaggat cctggagaag aagggcagtg
     1861 ctgcgctcaa ggacctcaag cggcagctgc atttggagcg gaaacgggca gataagctgc
     1921 aggagcgact gcaggacatc ctcactaaca gcaagagccg ctcaggcctt gaggagctgg
     1981 ttctctcaga gatgaactca ccaagccgga cccagacagg ggacagcagt agcatctcct
     2041 ccttcagcta ccgggagatc ttgcgggaaa aggagagctc ggctgttcca gccaggtcct
     2101 tatccagcag ccctcaagcc cagccccctc ggccagcaga gctgtcagat gaggaagtgg
     2161 ctgagctctt tcagcggctg gcagagacac agcaggagaa atggatgctg gaggagaagg
     2221 tgaagcacct ggaagtgagc agtgcttcca tggcagagga cctctgccgg aagagcgcca
     2281 tcattgagac ctacgtcatg gacagccgga tcgatgtgtc tgtggcagca ggccacacag
     2341 accgcagcgg gctgggcagc gtcctgagag acctagtgaa gccaggtgac gagaaccttc
     2401 gggagatgaa caagaagctg cagaacatgc tggaggagca gctcaccaag aatatgcact
     2461 tgcacaagga tatggaagtt ctgtcccagg aaattgtgcg gctcagcaag gagtgcgtgg
     2521 ggcctcctga cccagaccta gagccaggag aaaccagcta aagacctgca ggctgcaccc
     2581 acctcctccc cttcctaccc cctaggatgc tattcccttg ggctgtggtg gaaaaatgag
     2641 ggctggagcc aaaatcaaat agcttgggag actggacatt aaaggggcta gaggcctgat
     2701 ggttagtgtt aatgatcctg tcttagggca gaggccacca gggagtgggg atcctgaggg
     2761 aaggggcagg gatttctcct tcttcttggt cctggctccc aagggcttct gtcttcatct
     2821 ctgcatgagc tctccttccc agagaccaac tctttttatt ttattttatt ttatttttta
     2881 atttatgtct ggagcctggc tactctgcat ttgggattgg ggatgctggg tgggtgtgtg
     2941 gtccatgttc agcgttctag caacacgtgt gtgtgtgtgt gtgtaaaggc tatgcagcca
     3001 aaataccatc tggccagacg ggcccaccca c
//
