LOCUS       NM_001080423            7724 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens glutamate receptor interacting protein 2 (GRIP2),
            mRNA.
ACCESSION   NM_001080423 XM_005265501 XM_042936
VERSION     NM_001080423.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7724)
  AUTHORS   Lu,W. and Ziff,E.B.
  TITLE     PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
  JOURNAL   Neuron 47 (3), 407-421 (2005)
   PUBMED   16055064
REFERENCE   2  (bases 1 to 7724)
  AUTHORS   Lin,S.H., Arai,A.C., Wang,Z., Nothacker,H.P. and Civelli,O.
  TITLE     The carboxyl terminus of the prolactin-releasing peptide receptor
            interacts with PDZ domain proteins involved in
            alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor
            clustering
  JOURNAL   Mol Pharmacol 60 (5), 916-923 (2001)
   PUBMED   11641419
REFERENCE   3  (bases 1 to 7724)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095762.1, AB051506.2, AC090952.3 and AK024507.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080423.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051506.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621039.5/ ENSP00000478352.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK095762.1         2-14
            14-636              AB051506.2         1-623
            637-637             AC090952.3         152217-152217
            638-1515            AB051506.2         625-1502
            1516-1516           AC090952.3         159664-159664
            1517-1629           AB051506.2         1504-1616
            1630-1630           AC090952.3         160259-160259
            1631-1995           AB051506.2         1618-1982
            1996-2583           AK024507.1         337-924
            2584-6313           AB051506.2         2571-6300
            6314-6722           AC090952.3         183450-183858
            6723-7720           AB051506.2         6709-7706
            7721-7724           AC090952.3         184857-184860
FEATURES             Location/Qualifiers
     source          1..7724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..7724
                     /gene="GRIP2"
                     /note="glutamate receptor interacting protein 2"
                     /db_xref="GeneID:80852"
                     /db_xref="HGNC:HGNC:23841"
     exon            1..74
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3166
                     /gene="GRIP2"
                     /codon_start=1
                     /product="glutamate receptor-interacting protein 2"
                     /protein_id="NP_001073892.3"
                     /db_xref="CCDS:CCDS46766.2"
                     /db_xref="GeneID:80852"
                     /db_xref="HGNC:HGNC:23841"
                     /translation="MLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFR
                     GITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGI
                     HLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGF
                     VLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALAT
                     LRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITI
                     DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQS
                     QRPLRPSEAVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPF
                     SSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIV
                     HTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRV
                     LSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSV
                     ELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQ
                     ILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVI
                     SGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDR
                     PLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGG
                     PGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPP
                     TSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRP
                     WQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVR
                     PDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSR
                     APRSPGPSSPRML"
     exon            75..155
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..291
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..437
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..524
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..600
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..746
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..894
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1064
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1190
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1340
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1527
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1673
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1754
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1821
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1967
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2112
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2252
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2432
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2607
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2713
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2857
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3004
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..7724
                     /gene="GRIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5643..5648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIP2"
                     /note="hexamer: AATAAA"
     polyA_site      5662
                     /gene="GRIP2"
                     /note="major polyA site"
     regulatory      7525..7530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIP2"
                     /note="hexamer: ATTACA"
     polyA_site      7551
                     /gene="GRIP2"
     regulatory      7616..7621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIP2"
                     /note="hexamer: AATACA"
     polyA_site      7617
                     /gene="GRIP2"
     polyA_site      7639
                     /gene="GRIP2"
     regulatory      7700..7705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIP2"
                     /note="hexamer: AATACA"
     polyA_site      7724
                     /gene="GRIP2"
ORIGIN      
        1 gagttggtgg gcagcagggg agacaatagc gaacatgctg tgtgggctca gccgggagac
       61 ccctggagag gcggacgatg ggccctactc caaaggaggc aaggacgcag gaggggccga
      121 cgtttccctg gcgtgccgca gacagagcat tccagaggag ttccgaggga tcactgtggt
      181 ggagctgatc aagaaagaag gcagcacgct gggcctgact atctcaggtg gcaccgacaa
      241 ggatggaaag cccagggtct ccaacctgag acctggggga cttgcagcca ggagtgatct
      301 gctgaacatt ggtgactata ttcggtctgt gaacgggatc cacctgacca ggctccgcca
      361 cgatgagatc atcaccctgc tcaagaatgt gggcgagcgc gtggtgctgg aggtggagta
      421 tgagctgccc ccgcccgctc ctgagaataa ccccaggatc atttcaaaga cagtggacgt
      481 ctccctctac aaggagggca atagctttgg ctttgtcctt agaggaggtg cccatgaaga
      541 tgggcacaag tcccgcccgc ttgtcctgac ctacgtgcgg cccggtggcc ctgccgacag
      601 ggagggctcc ctgaaggtgg gcgacaggct gctcagtgtc gatggaatcc cgctgcacgg
      661 ggccagccat gccaccgccc tggccaccct gcggcagtgc agccacgagg cactctttca
      721 ggtggagtat gatgtggcca cccctgacac ggtggctaat gcttcgggac ccttgatggt
      781 ggaaatagtc aagacgccag ggtctgccct ggggatctcg ctcaccacca cctccctccg
      841 gaacaagtca gtcattacca tcgaccgcat caagccagcc agcgtggtgg acaggagcgg
      901 agccctgcac cctggagacc acatcctgtc catcgatggc accagcatgg aacactgctc
      961 gctgcttgag gccaccaagc tcctggccag catttcagag aaggtgcggc tggagatcct
     1021 gcctgtgccc cagagtcagc ggccactgag gccctcagag gcagtgaaag tgcagaggag
     1081 tgagcagctg caccgctggg acccctgcgt gccctcctgc cacagccccc ggcccggcca
     1141 ctgcaggatg cccacctggg ccacacctgc tggccaggac caaagccgat ccttgtcttc
     1201 aactcccttt tcctcgccga ccttgaacca cgccttttcc tgcaacaacc ccagcaccct
     1261 tccccgtgga tcccagccca tgagtcctcg aactacaatg gggcggagga ggcagcgaag
     1321 aagggaacac aagagctcgt tgtcgctagc ctccagcacg gtggggccgg gcgggcagat
     1381 tgtgcacacg gagaccacgg aggtcgtgct ctgtggagac cccctcagcg gctttggcct
     1441 ccagctccag ggcggcatct tcgccaccga gaccctgtcc tccccacccc tcgtgtgctt
     1501 catcgagcct gacagtccgg ctgagaggtg tgggctgctg caggtggggg accgtgtcct
     1561 gtccatcaat ggcattgcca ccgaggacgg gactatggag gaagccaacc agctcctgcg
     1621 ggacgccgca ctggcccaca aggtcgtgct ggaggtggag ttcgatgtgg cggagtccgt
     1681 catcccaagc agtggcacct tccacgtgaa gctgcccaag aagcgcagcg tggagctggg
     1741 catcaccatc agctcggcca gcaggaaacg aggggagccc ttgatcatct ccgacatcaa
     1801 gaaaggcagc gtggcacaca ggacgggcac cctggagcca ggcgacaagc tactggccat
     1861 tgacaatatc cgcctggaca actgccccat ggaggacgcc gtgcaaatcc tgcggcagtg
     1921 cgaggacctg gtgaagctga agatccggaa ggacgaggac aactctgatg agctggagac
     1981 cacaggtgcc gtcagttaca cagtggagct gaagcgctac gggggtcccc tgggcatcac
     2041 catttcgggc acggaggaac cttttgaccc cattgtcatc tcaggcctca ccaagcgtgg
     2101 cctggctgag aggactggtg ccatccacgt gggggaccgc attctggcca tcaacaacgt
     2161 tagcctcaag ggccggccgc tgagcgaggc catccacctc ctgcaggtgg ctggagagac
     2221 cgtcacactg aagatcaaga agcaactaga ccgtcccctc ctaccccgca agtcgggcag
     2281 cctcagtgag accagtgatg ctgatgagga cccagcagat gccctgaaag gaggcctgcc
     2341 agcagcccgc ttctcgccgg ctgtgcccag tgtggacagt gctgtggagt cttgggacag
     2401 ctcggccacc gagggtggct ttgggggccc agggtcctat acaccacagg cagcagcccg
     2461 gggcacgacc ccccaggagc ggaggcctgg ctggctgagg ggcagccccc cacccaccga
     2521 gccccggagg acgagctata ccccaacccc agctgacgag agctttccag aggaggagga
     2581 ggaggatgat tgggagccgc caacgagccc agcccctggc cctgcccgag aggagggctt
     2641 ctggcgcatg tttggagaag ctctcgaaga cctggagtca tgtggtcagt cagagctgct
     2701 gagggaactg gaggcatcca tcatgacggg caccgtgcag agggtggccc tcgagggcag
     2761 gcctggccac cggccttggc agaggggccg ggaggtacga gcctctcctg cagaaatgga
     2821 ggagctgttg ctgcctacac ccttggagat gcacaaggtg accctgcaca aggaccccat
     2881 gcggcatgac tttggtttca gcgtctcaga tggcctcctg gaaaaaggtg tctatgtcca
     2941 cactgtgcgc cctgatgggc cagcccaccg tggaggcctc cagcccttcg acagggtcct
     3001 gcaggtcaac cacgtccgta cacgggactt cgactgctgc ctggcggtgc cactcctggc
     3061 cgaggcgggt gatgtcttgg agctgatcat cagccgcaag ccgcacacgg cacacagcag
     3121 ccgggccccc cgatcgccag gccccagcag tccccggatg ctctgaagtc agcatgtggg
     3181 ccgaactcct aaggggccac ccaggcagat cctggctccc agacacgtag ctgggctgga
     3241 gaagcggcca cccactcatt catctgttgg tctggcagac tctgagcctg ggatgatgct
     3301 tggtctctgt tccccaggtc tgtggtgact ggggtgccag gcagggaggt cctgccctag
     3361 ttggagtgac agctggggtc tctcgccaag ttgggtctcc aagatgccca gaggagcctc
     3421 ccttaagaag ggttggcaca ggctgctcag ccgagaggag agaggcctgg gggctgtccc
     3481 aggtctctgt ggggcctcct tggagaggtc gaagatgtag ggagcacttc ctcccagcaa
     3541 agccatggag ctggaatgag ctgcaaggag gagtgagttc tcggtcacag gaggtgagca
     3601 ggcaggagct ggatacccca gcgcagtcat gcattggggt atgaggcatt cccatgatgc
     3661 gtgcacacgc gcttgggggt tggcttcctg atggggagcc acttcatcta gagactcggc
     3721 caccaggaag gatgctgctt cggatgggag cccagctcct tcgcttctcc agaatagggg
     3781 tttggggctt gctagtcctg agattctgag attcccagaa tctggtcccc acttatgaga
     3841 ctcttaagtt ggggcgtctg ggatcccagg aagtgctggc cctttgattc tgaaagtggg
     3901 tgattctttg atttcagcat ctcagtctga agcttctggg acttgagact gtggttctgg
     3961 gcccattggg caggctctat gggccttggg ctctcagccc tcctgcttct tctgtaggcc
     4021 gtgtggccac tgacccatct gcacgtccgc tcagcccaag cccctccatg tgggaggggt
     4081 cattttgggg caaaagaccc tggagcttcc attcacctgc catccagtga aaattgaaaa
     4141 gcgatggacg caggacctgt gaggcggtag cgctcctctt tacagccaga tcagtggagg
     4201 aagaggagaa agagggaggg agatgggaga gaaatgggcc agagaaaaag atgggacact
     4261 cttgcccagt ggagggtgtc caaagtgctt attcaaagaa gtctattccc acttgaaatc
     4321 tggaagcacc agcatccctt aaaatcattg tcctcagtgt ccacaaatca gagaccctct
     4381 tcattttgag aagggtgtgg gcctcccctg gtggtctagt gagtggtgcc tgggatggag
     4441 tgggcgggca ggtgtagcca gggctgggga tgtgctttgc ctggcccagt tctcacaggg
     4501 gtctcaggaa aacggggcac ccactcccac ctccatctgt ctccaacctg gggtccctgg
     4561 aggccagaaa agtgctcttc catttgaggg aacagatgag gagtcaagag gtctgttctt
     4621 ttcaccctgg gtctgttacc tgtttgctgt gtgaccctgt ctgggttgga cccccagccc
     4681 ctctggacga tcacgggtgg acagtctgag cagacacagg cctcctggtc agggccggaa
     4741 ccatctctgc cgacccacca aggccccctt ggggacctgc ccacgctgtc tcctggaggc
     4801 ctgcctccct tacccctccc ctccacttcg ctgggctctg ccccttggtg ccctccctga
     4861 gggccctgca tgcttgtgcc tggggtgctc agcgcctctg ctatcttgga ttcccgtgta
     4921 ctcagcccag agtgaaaggg cactgtctac ctgtcacagg gcaccaagtg aaagccaaga
     4981 gccctcactt ttgagggtga gggacagcac agcagaggtg tggcttctgg atgcaagcag
     5041 ccatagctgt gtgaccttgg acaggtggct cagcctctct ggacctctgc taagcaacag
     5101 ggctggacag gacacactct cagggcctct cggcttggga aaactgcatt gactccagga
     5161 ctccaggcga gggaagatgc acccgactct aactaatacc cccctccctc ctcgggctga
     5221 ggcctctgcc attctcccaa aagtatgcaa tcaggcccgc ggtgggcctc ccagccatgc
     5281 cggcctcctc atatgcaata tttcttctgg cttctcatgg ggatggttca tccccgactt
     5341 gaaatttcct gacacctttc cccagtgagc gccctgcctg cctatgcatt ttgggaacag
     5401 cccctgtgac atgtcccctt ccacctgccc tctcccccaa agctgtattt ttctctggct
     5461 gagattagaa cacattcctt gtaaagtatt tttctacatc gggttttctt agggctctcg
     5521 ggaagcacaa ggggctgtat tgcaaaggcc gcttatggtc tgtttggggc cctcgtctaa
     5581 gtctttgtcc caccaggggt tgcagtggct tgggggtagg tgccatgggg atgatttttt
     5641 aaaataaaat tatttaaatc cacctagagt agaagtttgc tttttaaaaa aatcatggat
     5701 tggcaagagt cagcttctgt atgggtctgg tgacatctca cctgcttttg atgattcatt
     5761 aattcaaaaa gtttgccatt tgcttccatc atccagcccc tgggcaacat gaatcagaca
     5821 gatttaggtc atgtctgcac attctggtgg caggcagaca atcaacaagt aagcaaataa
     5881 ataattattt caaaaggcat caagtgcaac aaagaaaaca agggagtaac gggatagagg
     5941 gaccagggtg aggggcttta gctcacaata ttaggagggg tttctctcaa gaggcgacat
     6001 ttgcaatgag acctgaagac aggagccagc ctccatggag acctggagga agagtgtctc
     6061 aggcagcggg cacagctagt gcaaaggccc tgagatagga acgagtttga cggtctcaag
     6121 gaagagaaag aaggcctggg aggggaatgg ggctggagac taggttggag gtagcaggaa
     6181 tcagtcgtga aggcttgggt agggggagca aatttgattc tctgcgcagc agaaagccag
     6241 aggcaggcag tggtgcctgc atatggagtc tctttagccc aggttgggaa ggtagtggca
     6301 ggagggcagc ctcaggtctg gctgctgccc tggagtgtcc agagagtgtc tagggcaggt
     6361 gagctacagg gtctgggacc cagaggccag ggccaggccc cactggggag gccacagttc
     6421 tgtgagcaga ggaagagctt ctttccagga agcgagtact ctgtcttggg agtggtgtag
     6481 gcagggggaa ggccaaggga ggcagcaggc cttgctctaa gcgctttgca agagcttgct
     6541 ggatcctccc aatagccttt ggaggtgggc tctattcctg tcccatcatt acagatgagg
     6601 aaacaggcac agagaggtta cgtaatttgc ccaagtccac acaggtagta agggatggaa
     6661 ccagggcttg aacacaagcc acatggccca gtacacatag agagaggcag gcaggtaggc
     6721 ataggctgtc agaaagagcc agaaaatggg ggtagggtgg tcttctattc taacattgtc
     6781 tataaatgag ttactgagaa ttttgtctgg ttagttgggc aaagggctca actgactccc
     6841 gagtttgtcc atcccaaagg gtggggggcg ctgttggcag gaaggctgcc ccaaacatgg
     6901 acctgttgtg accccagaga gcccctaact gggtattaat gagcgcctgc acctgacggt
     6961 gggggagtgg gagaagggca atcaggtttg ctccccctct accctttccc ccactccgcc
     7021 acccgctttc tgcccttctg gcaggtcagc ccaaggctaa agaggaggga ctgaaagccg
     7081 cagcaggtga gcacctaagg ccaagagcat cacctccaat catcctggtg gccttgatgg
     7141 ggacaatggt ttattccaga tggggaaact gaggctcagg tgactgctgc cagatctccc
     7201 agctgtacag ggctgggcat gtagcaggta gaatcagtag agccagtaga gccaagagct
     7261 catgggcccg ggtgcgaatc caggttcttt catggacttg ctgtgtaccc ctgagtgagc
     7321 aagctgcttc ctctgtgagc ctccatgtgg gaacctctaa cctgggaaaa tacctacctt
     7381 tgaggagcgt cctgggattg gacgggaagc cctttataaa atgtaaagcg tttggcaaac
     7441 gttgaggggg aaatacctca ccagaacaca acccacacat gttggatgtt aaaaaggaaa
     7501 tgtttatttt catgttataa ggtgattaca aactcctcta aaaaaagcaa agatgaattt
     7561 aaaatattga tatacatatt tatctaaaaa gcaaaagaga aaaaaacccc tgcaaaatac
     7621 agggaatcat atcataaaac atttatacac aaaagcttgt atactgcaag actgaactac
     7681 acaccaagga tcttgttcaa atacaaatgt tcctcctcag aaaa
//
