LOCUS       NM_001009184            1858 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit
            associated protein 1 (GRINA), transcript variant 2, mRNA.
ACCESSION   NM_001009184 XM_291268
VERSION     NM_001009184.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Yan,Z., Li,P., Xue,Y., Tian,H., Zhou,T. and Zhang,G.
  TITLE     Glutamate receptor, ionotropic, N-methyl D-aspartate-associated
            protein 1 promotes colorectal cancer cell proliferation and
            metastasis, and is negatively regulated by miR-296-3p
  JOURNAL   Mol Med Rep 24 (4) (2021)
   PUBMED   34368871
  REMARK    GeneRIF: Glutamate receptor, ionotropic, Nmethyl
            Daspartateassociated protein 1 promotes colorectal cancer cell
            proliferation and metastasis, and is negatively regulated by
            miR2963p.
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Ma,H., Zhang,X., Li,N., Lu,X., Wei,Y., Yuan,N., Tian,G. and Li,S.
  TITLE     Glutamate receptor, ionotropic, N-methyl D-aspartate-associated
            protein 1, a potential target of miR-296, facilitates proliferation
            and migration of rectal cancer cells
  JOURNAL   Biosci Biotechnol Biochem 84 (10), 2077-2084 (2020)
   PUBMED   32657216
  REMARK    GeneRIF: Glutamate receptor, ionotropic, N-methyl
            D-aspartate-associated protein 1, a potential target of miR-296,
            facilitates proliferation and migration of rectal cancer cells.
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Jimenez-Gonzalez,V., Ogalla-Garcia,E., Garcia-Quintanilla,M. and
            Garcia-Quintanilla,A.
  TITLE     Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis
            and Vesicle Transport
  JOURNAL   Int J Mol Sci 20 (16), 4005 (2019)
   PUBMED   31426446
  REMARK    GeneRIF: The cytoplasmic N-terminal half of GRINA (which spans a
            Proline-rich domain) contains a potential DNA-binding sequence, in
            addition to cleavage target sites and probable PY-nuclear
            localization sequences, that may enable it to be released from the
            rest of the protein and enter the nucleus under suitable
            conditions, where it could participate in the transcription,
            alternative splicing, and mRNA export. [review]
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Rice,S.J., Tselepi,M., Sorial,A.K., Aubourg,G., Shepherd,C.,
            Almarza,D., Skelton,A.J., Pangou,I., Deehan,D., Reynard,L.N. and
            Loughlin,J.
  TITLE     Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes
            Through the Identification and Characterization of Novel
            Methylation Quantitative Trait Loci
  JOURNAL   Arthritis Rheumatol 71 (8), 1285-1296 (2019)
   PUBMED   30730609
  REMARK    GeneRIF: PLEC encodes plectin, a cytoskeletal protein that
            maintains tissue integrity. GRINA encodes TMBIM3, which regulates
            cell survival. We hypothesized that in a joint predisposed to
            Osteoarthritis (OA), expression of these genes alters to combat
            aberrant biomechanics and is epigenetically regulated. However,
            carriage of the OA risk-conferring allele at this locus hinders
            this response and contributes to disease development.
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Lewis,T.B., Wood,S., Michaelis,E.K., DuPont,B.R. and Leach,R.J.
  TITLE     Localization of a gene for a glutamate binding subunit of a NMDA
            receptor (GRINA) to 8q24
  JOURNAL   Genomics 32 (1), 131-133 (1996)
   PUBMED   8786101
REFERENCE   9  (bases 1 to 1858)
  AUTHORS   Collins,C., Duff,C., Duncan,A.M., Planells-Cases,R., Sun,W.,
            Norremolle,A., Michaelis,E., Montal,M., Worton,R. and Hayden,M.R.
  TITLE     Mapping of the human NMDA receptor subunit (NMDAR1) and the
            proposed NMDA receptor glutamate-binding subunit (NMDARA1) to
            chromosomes 9q34.3 and chromosome 8, respectively
  JOURNAL   Genomics 17 (1), 237-239 (1993)
   PUBMED   8406459
REFERENCE   10 (bases 1 to 1858)
  AUTHORS   Kumar,K.N., Tilakaratne,N., Johnson,P.S., Allen,A.E. and
            Michaelis,E.K.
  TITLE     Cloning of cDNA for the glutamate-binding subunit of an NMDA
            receptor complex
  JOURNAL   Nature 354 (6348), 70-73 (1991)
   PUBMED   1719427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109322.16.
            
            On Nov 23, 2018 this sequence version replaced NM_001009184.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.337802.1,
                                           SRR3476690.757968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395068.9/ ENSP00000378507.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC109322.16        81696-81839         c
            145-547             AC109322.16        80293-80695         c
            548-660             AC109322.16        80091-80203         c
            661-861             AC109322.16        79817-80017         c
            862-990             AC109322.16        79522-79650         c
            991-1134            AC109322.16        79287-79430         c
            1135-1858           AC109322.16        78480-79203         c
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1858
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /note="glutamate ionotropic receptor NMDA type subunit
                     associated protein 1"
                     /db_xref="GeneID:2907"
                     /db_xref="HGNC:HGNC:4589"
                     /db_xref="MIM:138251"
     exon            1..144
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..547
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1284
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /note="transmembrane BAX inhibitor motif containing 3;
                     glutamate [NMDA] receptor-associated protein 1; glutamate
                     receptor, NMDA subtype, glutamate-binding subunit;
                     putative MAPK-activating protein PM02; NMDA receptor
                     glutamate-binding subunit; transmembrane BAX inhibitor
                     motif-containing protein 3; glutamate receptor,
                     ionotropic, N-methyl D-aspartate-associated protein 1
                     (glutamate binding); lifeguard 1"
                     /codon_start=1
                     /product="protein lifeguard 1"
                     /protein_id="NP_001009184.1"
                     /db_xref="CCDS:CCDS34961.1"
                     /db_xref="GeneID:2907"
                     /db_xref="HGNC:HGNC:4589"
                     /db_xref="MIM:138251"
                     /translation="MSHEKSFLVSGDNYPPPNPGYPGGPQPPMPPYAQPPYPGAPYPQ
                     PPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQG
                     PYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQA
                     FIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCG
                     DFRRKHPWNLVALSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTR
                     YDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLLGN
                     KQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAKE"
     exon            548..660
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..861
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..990
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1134
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1858
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /note="hexamer: AATAAA"
     polyA_site      1858
                     /gene="GRINA"
                     /gene_synonym="HNRGW; LFG1; NMDARA1; TMBIM3"
                     /note="major polyA site"
ORIGIN      
        1 acaaggcccc gctgcgtctt ccgagccgca ggcgcaggcc cagctgagcg gccgccgagc
       61 gggtgcgggt gcgggcgcat cggccatcac cgcgcggccg cgcagcggac accgtgcgta
      121 ccggcctgcg gcgcccggcc accggggcgg accgcggaac ccgaggccat gtcccatgaa
      181 aagagttttt tggtgtctgg ggacaactat cctcccccca accctggata tccggggggg
      241 ccccagccac ccatgccccc ctatgctcag cctccctacc ctggggcccc ttacccacag
      301 ccccctttcc agccctcccc ctacggtcag ccagggtacc cccatggccc cagcccctac
      361 ccccaagggg gctacccaca gggtccctac ccccaagggg gctacccaca gggcccctac
      421 ccacaagagg gctacccaca gggcccctac ccccaagggg gctaccccca ggggccatat
      481 ccccagagcc ccttcccccc caacccctat ggacagccac aggtcttccc aggacaagac
      541 cctgactcac cccagcatgg aaactaccag gaggagggtc ccccatccta ctatgacaac
      601 caggacttcc ctgccaccaa ctgggatgac aagagcatcc gacaggcctt catccgcaag
      661 gtgttcctag tgctgacctt gcagctgtcg gtgaccctgt ccacggtgtc tgtgttcact
      721 tttgttgcgg aggtgaaggg ctttgtccgg gagaatgtct ggacctacta tgtctcctat
      781 gctgtcttct tcatctctct catcgtcctc agctgttgtg gggacttccg gcgaaagcac
      841 ccctggaacc ttgttgcact gtcggtcctg accgccagcc tgtcgtacat ggtggggatg
      901 atcgccagct tctacaacac cgaggcagtc atcatggccg tgggcatcac cacagccgtc
      961 tgcttcaccg tcgtcatctt ctccatgcag acccgctacg acttcacctc atgcatgggc
     1021 gtgctcctgg tgagcatggt ggtgctcttc atcttcgcca ttctctgcat cttcatccgg
     1081 aaccgcatcc tggagatcgt gtacgcctca ctgggcgctc tgctcttcac ctgcttcctc
     1141 gcagtggaca cccagctgct actggggaac aagcagctgt ccctgagccc agaagagtat
     1201 gtgtttgctg cgctgaacct gtacacagac atcatcaaca tcttcctgta catcctcacc
     1261 atcattggcc gcgccaagga gtagccgagc tccagctcgc tgtgcccgct caggtggcac
     1321 ggctggcctg gaccctgccc ctggcacggc agtgccagct gtacttcccc tctctcttgt
     1381 ccccaggcac agcctaggga aaaggatgcc tctctccaac cctcctgtat gtacactgca
     1441 gatacttcca tttggacccg ctgtggccac agcatggccc ctttagtcct cccgcccccg
     1501 ccaaggggca ccaaggccac gtttccgtgc cacctcctgt ctactcattg ttgcatgagc
     1561 cctgtctgcc agcccacccc agggactggg ggcagcacca ggtcccgggg agagggattg
     1621 agccaagagg tgagggtgca cgtcttccct cctgtcccag ctccccagcc tggcgtagag
     1681 cacccctccc ctccccccca cccccctgga gtgctgccct ctggggacat gcggagtggg
     1741 ggtcttatcc ctgtgctgag ccctgagggc agagaggatg gcatgtttca ggggaggggg
     1801 aagccttcct ctcaatttgt tgtcagtgaa attccaataa atgggatttg ctctctgc
//
