LOCUS       NM_133445               7838 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit 3A
            (GRIN3A), mRNA.
ACCESSION   NM_133445
VERSION     NM_133445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7838)
  AUTHORS   Michalski,K. and Furukawa,H.
  TITLE     Structure and function of GluN1-3A NMDA receptor excitatory glycine
            receptor channel
  JOURNAL   Sci Adv 10 (15), eadl5952 (2024)
   PUBMED   38598639
REFERENCE   2  (bases 1 to 7838)
  AUTHORS   Bossi,S., Pizzamiglio,L. and Paoletti,P.
  TITLE     Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain
            signaling
  JOURNAL   Trends Neurosci 46 (8), 667-681 (2023)
   PUBMED   37248111
  REMARK    GeneRIF: Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in
            brain signaling.
            Review article
REFERENCE   3  (bases 1 to 7838)
  AUTHORS   Ping,A., Yang,M., Xu,S., Li,Q., Feng,Y., Gao,K., Wang,S. and
            Duan,K.
  TITLE     Correlations between GRIN2B and GRIN3A gene polymorphisms and
            postpartum depressive symptoms in Chinese parturients undergoing
            cesarean section: A prospective cohort study
  JOURNAL   J Psychosom Res 168, 111210 (2023)
   PUBMED   36898314
  REMARK    GeneRIF: Correlations between GRIN2B and GRIN3A gene polymorphisms
            and postpartum depressive symptoms in Chinese parturients
            undergoing cesarean section: A prospective cohort study.
REFERENCE   4  (bases 1 to 7838)
  AUTHORS   Zhong,W., Wu,A., Berglund,K., Gu,X., Jiang,M.Q., Talati,J.,
            Zhao,J., Wei,L. and Yu,S.P.
  TITLE     Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA
            receptor subunit GluN3A
  JOURNAL   Alzheimers Dement 18 (2), 222-239 (2022)
   PUBMED   34151525
  REMARK    GeneRIF: Pathogenesis of sporadic Alzheimer's disease by deficiency
            of NMDA receptor subunit GluN3A.
REFERENCE   5  (bases 1 to 7838)
  AUTHORS   Skrenkova,K., Hemelikova,K., Kolcheva,M., Kortus,S., Kaniakova,M.,
            Krausova,B. and Horak,M.
  TITLE     Structural features in the glycine-binding sites of the GluN1 and
            GluN3A subunits regulate the surface delivery of NMDA receptors
  JOURNAL   Sci Rep 9 (1), 12303 (2019)
   PUBMED   31444392
  REMARK    GeneRIF: Structural features in the glycine-binding sites of the
            GluN1 and GluN3A subunits regulate the surface delivery of NMDA
            receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7838)
  AUTHORS   Wang,P., Barks,J.D. and Silverstein,F.S.
  TITLE     Tat, a human immunodeficiency virus-1-derived protein, augments
            excitotoxic hippocampal injury in neonatal rats
  JOURNAL   Neuroscience 88 (2), 585-597 (1999)
   PUBMED   10197777
REFERENCE   7  (bases 1 to 7838)
  AUTHORS   New,D.R., Maggirwar,S.B., Epstein,L.G., Dewhurst,S. and
            Gelbard,H.A.
  TITLE     HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha
            and activation of non-N-methyl-D-aspartate receptors by a
            NFkappaB-independent mechanism
  JOURNAL   J Biol Chem 273 (28), 17852-17858 (1998)
   PUBMED   9651389
REFERENCE   8  (bases 1 to 7838)
  AUTHORS   Das,S., Sasaki,Y.F., Rothe,T., Premkumar,L.S., Takasu,M.,
            Crandall,J.E., Dikkes,P., Conner,D.A., Rayudu,P.V., Cheung,W.,
            Chen,H.S., Lipton,S.A. and Nakanishi,N.
  TITLE     Increased NMDA current and spine density in mice lacking the NMDA
            receptor subunit NR3A
  JOURNAL   Nature 393 (6683), 377-381 (1998)
   PUBMED   9620802
REFERENCE   9  (bases 1 to 7838)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   10 (bases 1 to 7838)
  AUTHORS   Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
            Nath,A.
  TITLE     Human immunodeficiency virus type 1 tat activates
            non-N-methyl-D-aspartate excitatory amino acid receptors and causes
            neurotoxicity
  JOURNAL   Ann Neurol 37 (3), 373-380 (1995)
   PUBMED   7695237
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356516.12, BC167432.1,
            AF416558.1 and AL591377.4.
            
            On Jul 15, 2019 this sequence version replaced NM_133445.2.
            
            Summary: This gene encodes a subunit of the N-methyl-D-aspartate
            (NMDA) receptors, which belong to the superfamily of
            glutamate-regulated ion channels, and function in physiological and
            pathological processes in the central nervous system. This subunit
            shows greater than 90% identity to the corresponding subunit in
            rat. Studies in the knockout mouse deficient in this subunit
            suggest that this gene may be involved in the development of
            synaptic elements by modulating NMDA receptor activity. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167432.1, AB075853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361820.6/ ENSP00000355155.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AL356516.12        59030-59096         c
            68-3169             BC167432.1         1-3102
            3170-3597           AF416558.1         2515-2942
            3598-3789           BC167432.1         3531-3722
            3790-7838           AL591377.4         30946-34994         c
FEATURES             Location/Qualifiers
     source          1..7838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..7838
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /note="glutamate ionotropic receptor NMDA type subunit 3A"
                     /db_xref="GeneID:116443"
                     /db_xref="HGNC:HGNC:16767"
                     /db_xref="MIM:606650"
     exon            1..1367
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..4016
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /note="glutamate [NMDA] receptor subunit 3A;
                     N-methyl-D-aspartate receptor subtype 3A; glutamate
                     receptor ionotropic, NMDA 3A; glutamate receptor,
                     ionotropic, N-methyl-D-aspartate 3A"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 3A
                     precursor"
                     /protein_id="NP_597702.2"
                     /db_xref="CCDS:CCDS6758.1"
                     /db_xref="GeneID:116443"
                     /db_xref="HGNC:HGNC:16767"
                     /db_xref="MIM:606650"
                     /translation="MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRI
                     GHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTL
                     HGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGD
                     LPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHI
                     PVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNI
                     TDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMES
                     IRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDA
                     MELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIR
                     VKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ
                     HPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSND
                     TVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGT
                     AHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIF
                     VALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCW
                     TGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVR
                     ESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSID
                     ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCG
                     KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYW
                     LHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFS
                     DEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQV
                     IRQELQLAVSRKTELEEYQRTSRTCES"
     exon            1368..1972
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..3020
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3166
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3282
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3434
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3599
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3676
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..7838
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7814..7819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /note="hexamer: AATAAA"
     polyA_site      7838
                     /gene="GRIN3A"
                     /gene_synonym="GluN3A; NMDAR-L; NMDAR3A; NR3A"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgttg ctcctccgag gaagcaagcg gcggtggcga ctcggtggaa aaataacgaa
       61 agaaaggcag agaggaagta gcgagagaag agagaaaatg aagtcggcgc tgggggagcc
      121 tgcaggaggg tggccaacag tggaggaagg tggatttggc ttcttttccg caccccgggc
      181 gtgaaagccc tctccaacgc gaccccagga aataagtggg tctcgcctgg gcagaaaagg
      241 aaaagaatcc aggcgagagc gcgtcgctcc tctgtcactg ctgcccccga ggaactccgg
      301 ctgcttctca tcccggccgc ctcgcggggc cggacgcagt gcccgaggcg ccctgcagat
      361 ggggcgggca gggaacgggc gctccagctg cgggtgacag gcgccggccc gcccgcctgc
      421 ctgctcagcg cagtgaccgg gcgggcagag gatgccaggc ggagggacct gggagcggga
      481 tctgagactg ccggaggcgc gctacgctcc aacttgcatg gcctagagac cgctccagct
      541 cctgggaccg cttcaccgag tggagtgaag ctgcgcgcgg gacctggagg cggagacctc
      601 aggcagcggc tgcagagggg cgagccgggc gcaggagggg gcgcgctttc tccctgcggg
      661 tctcagtaat gaggagactg agtttgtggt ggctgctgag cagggtctgt ctgctgttgc
      721 cgccgccctg cgcactggtg ctggccgggg tgcccagctc ctcctcgcac ccgcagccct
      781 gccagatcct caagcgcatc gggcacgcgg tgagggtggg cgcggtgcac ttgcagccct
      841 ggaccaccgc cccccgcgcg gccagccgcg ctccggacga cagccgagca ggagcccaga
      901 gggatgagcc ggagccaggg actaggcggt ccccggcgcc ctcgccgggc gcacgctggt
      961 tggggagcac cctgcatggc cgggggccgc cgggctcccg taagcccggg gagggcgcca
     1021 gggcggaggc cctgtggcca cgggacgccc tcctatttgc cgtggacaac ctgaaccgcg
     1081 tggaagggct gctaccctac aacctgtctt tggaagtagt gatggccatc gaggcaggcc
     1141 tgggcgatct gccacttttg cccttctcct cccctagttc gccatggagc agtgaccctt
     1201 tctccttcct gcaaagtgtg tgccataccg tggtggtgca aggggtgtcg gcgctgctcg
     1261 ccttccccca gagccagggc gaaatgatgg agctcgactt ggtcagctta gtcctgcaca
     1321 ttccagtgat cagcatcgtg cgccacgagt ttccacggga gagtcagaat ccccttcacc
     1381 tacaactgag tttagaaaat tcattaagtt ctgatgctga tgtcactgtc tcaatcctga
     1441 ccatgaacaa ctggtacaat tttagcttgt tgctgtgcca ggaagactgg aacatcaccg
     1501 acttcctcct ccttacccag aataattcca agttccacct tggttctatc atcaacatca
     1561 ccgctaacct cccctccacc caggacctct tgagcttcct acagatccag cttgagagta
     1621 ttaagaacag cacacccaca gtggtgatgt ttggctgcga catggaaagt atccggcgga
     1681 ttttcgaaat tacaacccag tttggggtca tgccccctga acttcgttgg gtgctgggag
     1741 attcccagaa tgtggaggaa ctgaggacag agggtctgcc cttagggctc attgctcatg
     1801 gaaaaacaac acagtctgtc tttgagcact acgtacaaga tgctatggag ctggtcgcaa
     1861 gagctgtagc cacagccacc atgatccaac cagaacttgc tctcattccc agcacgatga
     1921 actgcatgga ggtggaaact acaaatctca cttcaggaca atatttatca aggtttctag
     1981 ccaataccac tttcagaggc ctcagtggtt ccatcagagt aaaaggttcc accatcgtca
     2041 gctcagaaaa caactttttc atctggaatc ttcaacatga ccccatggga aagccaatgt
     2101 ggacccgctt gggcagctgg caggggggaa agattgtcat ggactatgga atatggccag
     2161 agcaggccca gagacacaaa acccacttcc aacatccaag taagctacac ttgagagtgg
     2221 ttaccctgat tgagcatcct tttgtcttca caagggaggt agatgatgaa ggcttgtgcc
     2281 ctgctggcca actctgtcta gaccccatga ctaatgactc ttccacattg gacagccttt
     2341 ttagcagcct ccatagcagt aatgatacag tgcccattaa attcaagaag tgctgctatg
     2401 gatattgcat tgatctgctg gaaaagatag cagaagacat gaactttgac ttcgacctct
     2461 atattgtagg ggatggaaag tatggagcat ggaaaaatgg gcactggact gggctagtgg
     2521 gtgatctcct gagagggact gcccacatgg cagtcacttc ctttagcatc aatactgcac
     2581 ggagccaggt gatagatttc accagccctt tcttctccac cagcttgggc atcttagtga
     2641 ggacccgaga tacagcagct cccattggag ccttcatgtg gccactccac tggacaatgt
     2701 ggctggggat ttttgtggct ctgcacatca ctgccgtctt cctcactctg tatgaatgga
     2761 agagtccatt tggtttgact cccaaggggc gaaatagaag taaagtcttc tccttttctt
     2821 cagccttgaa catctgttat gccctcttgt ttggcagaac agtggccatc aaacctccaa
     2881 aatgttggac tggaaggttt ctaatgaacc tttgggccat tttctgtatg ttttgccttt
     2941 ccacatacac ggcaaacttg gctgctgtca tggtaggtga gaagatctat gaagagcttt
     3001 ctggaataca tgaccccaag ttacatcatc cttcccaagg attccgcttt ggaactgtcc
     3061 gagaaagcag tgctgaagat tatgtgagac aaagtttccc agagatgcat gaatatatga
     3121 gaaggtacaa tgttccagcc acccctgatg gagtggagta tctgaagaat gatccagaga
     3181 aactagacgc cttcatcatg gacaaagccc ttctggatta tgaagtgtca atagatgctg
     3241 actgcaaact tctcactgtg gggaagccat ttgccataga aggatacggc attggcctcc
     3301 cacccaactc tccattgacc gccaacatat ccgagctaat cagtcaatac aagtcacatg
     3361 ggtttatgga tatgctccat gacaagtggt acagggtggt tccctgtggc aagagaagtt
     3421 ttgctgtcac ggagactttg caaatgggca tcaaacactt ctctgggctc tttgtgctgc
     3481 tgtgcattgg atttggtctg tccattttga ccaccattgg tgagcacata gtatacaggc
     3541 tgctgctacc acgaatcaaa aacaaatcca agctgcaata ctggctccac accagccaga
     3601 gattacacag agcaataaat acatcattta tagaggaaaa gcagcagcat ttcaagacca
     3661 aacgtgtgga aaagaggtct aatgtgggac cccgtcagct taccgtatgg aatacttcca
     3721 atctgagtca tgacaaccga cggaaataca tctttagtga tgaggaagga caaaaccagc
     3781 tgggcatccg gatccaccag gacatccccc tccctccaag gagaagagag ctccctgcct
     3841 tgcggaccac caatgggaaa gcagactccc taaatgtatc tcggaactca gtgatgcagg
     3901 aactctcaga gctcgagaag cagattcagg tgatccgtca ggagctgcag ctggctgtga
     3961 gcaggaaaac ggagctggag gagtatcaaa ggacaagtcg gacttgtgag tcctaggtga
     4021 ccacactgct tccctttctc agttcctgac cttcctctga gcccttgaga cactttgtaa
     4081 tgctcttttg taactatcga caaaggtgtg gggaagctga ggtctaggtc ttcttaaagg
     4141 tcaagtctgc tctccctcgc ctaaagtgca gcagcagctc ctctcaagct cactctctag
     4201 gtctccaggg taggagtgtt tttctagcaa gaatcttagt caggagtaag ctctgtgcga
     4261 gagatctgtg aataaccaga taaccccagc tgccgttaac cttttcacca ggtgccacag
     4321 taatatttct ggtttttagc cctttctctg cactaccaac aagagataaa attgttactc
     4381 acacttatgt cttactgggt tgctggtttt catcgtaaca cagaacgagg ttatctaggg
     4441 ttgtagcttt tgatacaact ccccgatcta gatttattcc tacattctga atggggagca
     4501 ggtaagagca gagcacctcc cactgggggt ggggtattta aaaattaact cattagtatc
     4561 ataaacgtca aggattgatt ggaccaggca agagccatgt ttttgagaag gttctggatc
     4621 tctgactcca tcctgactgt ttagtaagag catgcttaca ccctactgtg aaaaggggag
     4681 gggatgtggt aagcggaaac agaagacagg cagcagaggc attaaaaatg cataccatgc
     4741 tttcagaaca aaagctctgg gccagaaagg caatttggct aaaaaatgaa taagactact
     4801 tctaatgtaa ctaagcatct ccactatggt gtgtgccttt tataaaggaa aagagagaaa
     4861 aaggcaaagc aaggttgtgg ccttaggttg gacctggaat atcccttatt gcctataatg
     4921 gaatatgtga cactgtgggt gaaatgttct acacaccaca cactaggcca ttttcagatc
     4981 agcagtcacc catcgcttag catagaaatc ccaaaacctc cagcccggga acactataag
     5041 cttcgaccat tcaggaatct gccctgcact ttgcatatct gtatagaaaa tcaagtcaat
     5101 cccccatcct cacacccact catctctgag gagctatgaa ctggttttgg tccctctaat
     5161 gatcctccag cctcatctaa tgccccccaa agactgatac aagtaacctc ccctctgctt
     5221 aggtgtcact ttctcagcat atcaagttta ggcagcaagg gaaaggaata tgggtcagtt
     5281 ctcaaatgtc aatgtagata agagtcatct agtagagaac tcatcagagt gcggattgcc
     5341 aagacccttc tccagagatt atggggttgg gggtggaggt ctagaggtga gctcagaaac
     5401 ctactgttaa ccaacacccc caagtgactg acacaggtgg tctaaaaatt acttttctag
     5461 aaacaccatt ctggaagttt ggctgcccac aggcaggagg agaagcatga agagaaaacc
     5521 tgtttgagaa gttttgtttt gttttgtttt gctttttaat aattttagca cacatctgct
     5581 gactctcctt caacatcctc acccccaccc ctgggcacca tttaggacaa gacttcctta
     5641 tttatcaatt acttgattta tcttctcagg actcattgtt ccacccccaa ccaatttgaa
     5701 tgcctacaat aagttcagga gctgtgccaa gcactttcct cttttacagc tggagatcac
     5761 tggaaaggtg tctcagtcac aaaacttctc cctctactac tggatgaaat gtctgcattt
     5821 ccaccaaaat ctacccagtc acccagggaa taacaactta agctgtagtt agataacacc
     5881 tagtgattaa ttggctgaga aaaccctgga gtggagggag gctcagagat actgatatgg
     5941 atgtgggagg gctctaaagt tagaggtcac caactccaca gatgaaacag ttcaataatg
     6001 aggaaacagg tgagccctga aaacacaaaa ggacagttct gtgttgaaac accccatccc
     6061 ctcacgttct caccccaggc ccagaagtag gttgcaactg cctttggaag attttgcccc
     6121 ttagccatcc ccacccactt gtaccagcta agaatgctgg agactctgcc accatgctct
     6181 gcgtgcccct gaacctctgt gcagcccgga aggctgatgt acaggtgtac ctcaatccac
     6241 attacagcca tgctcctaat gtacatggac atttttgtaa ctcagctcat attctgactg
     6301 tatttgagaa gctggctgtt taagggaacc cagaagtgaa ttcttttgta aagtaaagca
     6361 cccttttgta atgcaattaa ttatccctta atgtatctgt tttgtaagtc tgcatttttg
     6421 tatatcggat ttaccttaag cttctctagt gaggcattct gagcagtggt gatcacatgc
     6481 cagatcgccc tgcctatcca caaagtagat gaccaatgca cgctcctcaa acatctttgg
     6541 aggaactacc tggccaaaac actggccagg atgcagcaag cagcagcagg ggctgacagc
     6601 aggcttactg ccatcaacat tgcttgaaat gcctctatgt tctgaataaa gaaaaaccat
     6661 aattgcttgt ggtgaaacga agcagtcttc atgttaagta gcaatggtta tttttattgg
     6721 tagtaactga acagtgtttt gcaatttgtg aaacagtgta ttgtgttttg taaaatgatg
     6781 tcatgaaatg gtgggtcctt ggaaacctcc tttccgttca gctctgcctc tgttctttca
     6841 actcctttga ggctcaaaaa aaacacaaag atcagaagcc ttcagataga gggtggtatt
     6901 ctggtaaaga agaaagagat aagggacgct accttgcttt tctggcacag gaagcacatg
     6961 ataaagcatg ctcagatgag ctggaacaga tatagctacc tggttcgtgt aaataagaat
     7021 aatcaaggcc ccagagtgtg tatgcttcca ggtggaggag aaaggggaat ctcccaaaat
     7081 ttaaaaacaa attggaagaa taaccaggac agccaagtga agcagccaca gggacccaag
     7141 cagtcgaggt ctttaatgtg cctggagatg actctctgct attcatgaat cttgctattg
     7201 cacaaaccct atcaagagct gctgcttccc ttccagccag aaaagtggta agcggagcaa
     7261 gtgccaagca gaacagacct tatcatctgg gtaacagact tctcagtgtt ggtgctgtgt
     7321 ctgttagagc cttagagcaa gttaagcact tccttggtgt gggtaaagaa taaaggggaa
     7381 agaaactact ttagagcctc tttttctccc aactcatatt tttgatagga aaaacagaaa
     7441 acccatccag ttcttcagaa attgctttct aggcattaat actactttac tatctatact
     7501 gtttagttat tcctttcttt acccacctaa actatccatc taatccagga ttccctcact
     7561 cttttttttt agttactaat cattttatga aaataatgta tttataagta ttttcttaag
     7621 gtttgtgaag agtatttgca ttgtgtcttc attttaatgt gtttgcaatc gctccgctcc
     7681 aggaagaacg gaaatgctgt cttgtgagca tgaagtgaac gggctgtttt gctccagcca
     7741 cttttcttgt acaaccacat ggatggatta gatgtcctca ggtcttttcc atcttcagtt
     7801 tctatgactg tggaataaat gttcagatag aaacttca
//
