LOCUS       NM_000836               5511 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D
            (GRIN2D), mRNA.
ACCESSION   NM_000836
VERSION     NM_000836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5511)
  AUTHORS   Wang,L.L., Li,J., Xue,H., Zhang,L., Yu,D.Y., Yang,N., Yun,W.J.,
            Zhao,M.Z. and Zheng,H.C.
  TITLE     The promoting effects of Grin2d expression in tumorigenesis and the
            aggressiveness of esophageal cancer
  JOURNAL   Histol Histopathol 39 (5), 659-670 (2024)
   PUBMED   37982578
  REMARK    GeneRIF: The promoting effects of Grin2d expression in
            tumorigenesis and the aggressiveness of esophageal cancer.
REFERENCE   2  (bases 1 to 5511)
  AUTHORS   Neumann,A., Ohlei,O., Kucukali,F., Bos,I.J., Timsina,J., Vos,S.,
            Prokopenko,D., Tijms,B.M., Andreasson,U., Blennow,K.,
            Vandenberghe,R., Scheltens,P., Teunissen,C.E., Engelborghs,S.,
            Frisoni,G.B., Blin,O., Richardson,J.C., Bordet,R., Lleo,A.,
            Alcolea,D., Popp,J., Marsh,T.W., Gorijala,P., Clark,C.,
            Peyratout,G., Martinez-Lage,P., Tainta,M., Dobson,R.J.B.,
            Legido-Quigley,C., Van Broeckhoven,C., Tanzi,R.E., Ten Kate,M.,
            Lill,C.M., Barkhof,F., Cruchaga,C., Lovestone,S., Streffer,J.,
            Zetterberg,H., Visser,P.J., Sleegers,K. and Bertram,L.
  CONSRTM   EMIF-AD & ADNI study group
  TITLE     Multivariate GWAS of Alzheimer's disease CSF biomarker profiles
            implies GRIN2D in synaptic functioning
  JOURNAL   Genome Med 15 (1), 79 (2023)
   PUBMED   37794492
  REMARK    GeneRIF: Multivariate GWAS of Alzheimer's disease CSF biomarker
            profiles implies GRIN2D in synaptic functioning.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5511)
  AUTHORS   Vinnakota,C., Hudson,M.R., Jones,N.C., Sundram,S. and Hill,R.A.
  TITLE     Potential Roles for the GluN2D NMDA Receptor Subunit in
            Schizophrenia
  JOURNAL   Int J Mol Sci 24 (14), 11835 (2023)
   PUBMED   37511595
  REMARK    GeneRIF: Potential Roles for the GluN2D NMDA Receptor Subunit in
            Schizophrenia.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5511)
  AUTHORS   Chen,Z., Song,Y., Li,P. and Gao,W.
  TITLE     GRIN2D knockdown suppresses the progression of lung adenocarcinoma
            by regulating the E2F signalling pathway
  JOURNAL   Cell Signal 107, 110685 (2023)
   PUBMED   37084840
  REMARK    GeneRIF: GRIN2D knockdown suppresses the progression of lung
            adenocarcinoma by regulating the E2F signalling pathway.
REFERENCE   5  (bases 1 to 5511)
  AUTHORS   Zhang,J., Zhang,M., Wang,Q., Wen,H., Liu,Z., Wang,F., Wang,Y.,
            Yao,F., Song,N., Kou,Z., Li,Y., Guo,F. and Zhu,S.
  TITLE     Distinct structure and gating mechanism in diverse NMDA receptors
            with GluN2C and GluN2D subunits
  JOURNAL   Nat Struct Mol Biol 30 (5), 629-639 (2023)
   PUBMED   36959261
REFERENCE   6  (bases 1 to 5511)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   7  (bases 1 to 5511)
  AUTHORS   Akbarian,S., Sucher,N.J., Bradley,D., Tafazzoli,A., Trinh,D.,
            Hetrick,W.P., Potkin,S.G., Sandman,C.A., Bunney,W.E. Jr. and
            Jones,E.G.
  TITLE     Selective alterations in gene expression for NMDA receptor subunits
            in prefrontal cortex of schizophrenics
  JOURNAL   J Neurosci 16 (1), 19-30 (1996)
   PUBMED   8613785
REFERENCE   8  (bases 1 to 5511)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   9  (bases 1 to 5511)
  AUTHORS   Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
            Nath,A.
  TITLE     Human immunodeficiency virus type 1 tat activates
            non-N-methyl-D-aspartate excitatory amino acid receptors and causes
            neurotoxicity
  JOURNAL   Ann Neurol 37 (3), 373-380 (1995)
   PUBMED   7695237
REFERENCE   10 (bases 1 to 5511)
  AUTHORS   Platzer,K., Krey,I. and Lemke,J.R.
  TITLE     GRIN2D-Related Developmental and Epileptic Encephalopathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35914066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011527.4, U77783.1,
            AB209292.1 and AW139866.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 29, 2020 this sequence version replaced NM_000836.3.
            
            Summary: N-methyl-D-aspartate (NMDA) receptors are a class of
            ionotropic glutamate receptors. NMDA channel has been shown to be
            involved in long-term potentiation, an activity-dependent increase
            in the efficiency of synaptic transmission thought to underlie
            certain kinds of memory and learning. NMDA receptor channels are
            heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and
            1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B
            (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by
            RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U77783.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA2145743,
                                    SAMEA2154665 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000263269.4/ ENSP00000263269.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC011527.4         5295-5495
            202-418             AC011527.4         6285-6501
            419-3275            U77783.1           1-2857
            3276-3647           AB209292.1         882-1253
            3648-3794           U77783.1           3230-3376
            3795-4648           AB209292.1         1401-2254
            4649-4716           U77783.1           4231-4298
            4717-5510           AB209292.1         2323-3116
            5511-5511           AW139866.1         17-17               c
FEATURES             Location/Qualifiers
     source          1..5511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..5511
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /note="glutamate ionotropic receptor NMDA type subunit 2D"
                     /db_xref="GeneID:2906"
                     /db_xref="HGNC:HGNC:4588"
                     /db_xref="MIM:602717"
     exon            1..201
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            202..480
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            481..971
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..4517
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /note="estrogen receptor binding CpG island;
                     N-methyl-d-aspartate receptor subunit 2D; glutamate [NMDA]
                     receptor subunit epsilon-4; glutamate receptor ionotropic,
                     NMDA 2D; N-methyl D-aspartate receptor subtype 2D;
                     glutamate receptor, ionotropic, N-methyl D-aspartate 2D"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2D
                     precursor"
                     /protein_id="NP_000827.2"
                     /db_xref="CCDS:CCDS12719.1"
                     /db_xref="GeneID:2906"
                     /db_xref="HGNC:HGNC:4588"
                     /db_xref="MIM:602717"
                     /translation="MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGG
                     LGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQ
                     LCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGST
                     FLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHR
                     GALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVG
                     PQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQAL
                     LRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISL
                     TRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADP
                     ISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLV
                     TNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVA
                     RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGG
                     STFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMI
                     QEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPR
                     VEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR
                     WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAM
                     GLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQP
                     LPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQG
                     LGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSP
                     PAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGG
                     APAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLG
                     PPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDG
                     GWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDL
                     PPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
                     GTRRGSAHFSSLESEV"
     exon            972..1591
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1706
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1918
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2087
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2241
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2367
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2597
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2758
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2946
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3179
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..5511
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5485..5490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /note="hexamer: AATAAA"
     polyA_site      5511
                     /gene="GRIN2D"
                     /gene_synonym="DEE46; EB11; EIEE46; GluN2D; NMDAR2D; NR2D"
                     /note="major polyA site"
ORIGIN      
        1 atcccgagtg agtgtgtgtg tgcgagaaca cagcgagtgt gtgagtccct cccgctccag
       61 ctcctccaag ccgcggccgc cgccgccacc ctcgcccgca gcctcccgca gcctccctcg
      121 gccaccggtg cctgctgggg gtgttgcctg ggtaggtcgg cccggccccc aggggtctct
      181 cgagcgtctg ccatctgccc gagcaacatg tgtagccacg tcctcgccta gtccaggtgg
      241 ccgcaacctt gggggagaga cagggcagga caggaccaag gaagaggaag gagagacgga
      301 gccagggaca gacaggaggt ccgggctgcc gctgctgccg ccaccaccac tgccgccgcc
      361 ccggggcctg ccccccgaca tcggctctct gagccctcct cggaatcttg gggtcgctgg
      421 acgccgggtt ccggtcctgg cccccccgcc atccccccaa cagaacaggg tcatgaaaag
      481 aggccgcccg gcggggcccg caggcgatgc gcggcgccgg tggcccccgc ggccctcggg
      541 gccccgctaa gatgctgctg ctgctggcgc tggcctgcgc cagcccgttc ccggaggagg
      601 cgccggggcc gggcggggcc ggtgggcccg gcggcggcct cggcggggcg cggccgctca
      661 acgtggcgct cgtgttctcg gggcccgcgt acgcggccga ggcggcacgc ctgggcccgg
      721 ccgtggcggc ggcggtgcgc agcccgggcc tagacgtgcg gcccgtggcg ctggtgctca
      781 acggctcgga cccgcgcagc ctcgtgctgc agctctgcga cctgctgtcg gggttgcgcg
      841 tgcacggcgt ggtcttcgaa gacgactcgc gcgcgcccgc cgtcgcgccc atcctcgact
      901 tcctgtcggc gcagacctcg ctgcccatcg tggccgtgca cggcggcgcc gcgctcgtgc
      961 tcacgcccaa ggagaagggc tccaccttcc tgcagctggg ctcttccacc gagcaacagc
     1021 ttcaggtcat ctttgaggtg ctggaggagt atgactggac gtcctttgta gccgtgacca
     1081 ctcgtgcccc tggccaccgg gccttcctgt cctacattga ggtgctgact gacggtagtc
     1141 tggtgggctg ggagcaccgc ggagcgctga cgctggaccc tggggcgggc gaggccgtgc
     1201 tcagtgccca gctccgcagt gtcagcgcgc agatccgcct gctcttctgc gcccgagagg
     1261 aggccgagcc cgtgttccgc gcagctgagg aggctggcct cactggatct ggctacgtct
     1321 ggttcatggt ggggccccag ctggctggag gcgggggctc tggggcccct ggtgagcccc
     1381 ctcttctgcc aggaggcgcc cccctgcctg ccgggctgtt tgcagtgcgc tcggctggct
     1441 ggcgggatga cctggctcgg cgagtggcag ctggcgtggc cgtagtggcc agaggtgccc
     1501 aggccctgct gcgtgattat ggtttccttc ctgagctcgg ccacgactgt cgcgcccaga
     1561 accgcaccca ccgcggcgag agtctgcata ggtacttcat gaacatcacg tgggataacc
     1621 gggattactc cttcaatgag gacggcttcc tagtgaaccc ctccctggtg gtcatctccc
     1681 tcaccagaga caggacgtgg gaggtggtgg gcagctggga gcagcagacg ctccgcctca
     1741 agtacccgct gtggtcccgc tatggtcgct tcctgcagcc agtggacgac acgcagcacc
     1801 tcacggtggc cacgctggag gaaaggccgt ttgtcatcgt ggagcctgca gaccctatca
     1861 gcggcacctg catccgagac tccgtcccct gccggagcca gctcaaccga acccacagcc
     1921 ctccaccgga tgccccccgc ccggaaaagc gctgctgcaa gggtttctgc atcgacattc
     1981 tgaagcggct ggcgcatacc atcggcttca gctacgacct ctacctggtc accaatggca
     2041 agcacggaaa gaagatcgat ggcgtctgga acggcatgat cggggaggtg ttctaccagc
     2101 gcgcagacat ggccatcggc tccctcacca tcaacgagga gcgctccgag atcgtggact
     2161 tctccgtccc cttcgtggag accggcatca gcgtcatggt ggcgcgcagc aatggcacgg
     2221 tgtccccctc ggccttcctc gagccctaca gccccgccgt gtgggtgatg atgttcgtca
     2281 tgtgcctcac tgtggtcgcc gtcactgttt tcatcttcga gtacctcagt cctgttggtt
     2341 acaaccgcag cctggccacg ggcaagcgcc ctggcggttc aaccttcacc attgggaaat
     2401 ccatctggct gctctgggcc ctggtgttca ataattcggt gcccgtggag aacccccggg
     2461 gaaccaccag caaaatcatg gtgctggtgt gggccttctt cgccgtcatc ttcctcgcca
     2521 gctacacagc caacctggcc gccttcatga tccaggagga gtacgtggat actgtgtctg
     2581 ggctcagtga ccgcaagttc cagaggcccc aggagcagta cccgcccctg aagtttggga
     2641 ccgtgcccaa cggctccacg gagaagaaca tccgcagcaa ctatcccgac atgcacagct
     2701 acatggtgcg ctacaaccag ccccgcgtag aggaagcgct cactcagctc aaggcaggga
     2761 agctggacgc cttcatctac gatgctgcag tgctcaatta catggcccgc aaggacgagg
     2821 gctgcaagct tgtcaccatc ggctccggca aggtcttcgc cacgacaggc tatggcatcg
     2881 ccctgcacaa gggctcccgc tggaagcggc ccatcgacct ggcgttgctg cagttcctgg
     2941 gggatgatga gatcgagatg ctggagcggc tgtggctctc tgggatctgc cacaatgaca
     3001 aaatcgaggt gatgagcagc aagctggaca tcgacaacat ggcgggcgtc ttctacatgc
     3061 tcctggtggc catgggcctg tccctgctgg tcttcgcctg ggagcacctg gtgtactggc
     3121 gcctgcggca ctgcctgggg cccacccacc gcatggactt cctgctggcc ttctccaggg
     3181 gcatgtacag ctgctgcagc gctgaggccg ccccaccgcc cgccaagccc ccgccgccgc
     3241 cacagcccct gcccagcccc gcgtaccccg cgccgcggcc ggctcccggg cccgcacctt
     3301 tcgtgccccg cgagcgcgcc tcagtggacc gctggcgccg gaccaagggc gcggggccgc
     3361 cggggggcgc gggcctggcc gacggcttcc accgctacta cggccccatc gagccgcagg
     3421 gcctaggcct cggcctgggc gaagcgcgcg cggcaccgcg gggcgcagcc gggcgcccgc
     3481 tgtccccgcc ggccgctcag cccccgcaga agccgccgcc ctcctatttc gccatcgtac
     3541 gcgacaagga gccagccgag ccccccgccg gcgccttccc cggcttcccg tcgccgcccg
     3601 cgccccccgc cgccgcggcc accgccgtcg ggccgccact ctgccgcttg gccttcgagg
     3661 acgagagccc gccggcgccc gcgcggtggc cgcgctcgga ccccgagagc caacccctgc
     3721 tggggccagg cgcgggcggc gcggggggca cggggggcgc aggcggagga gccccggccg
     3781 ctccgccccc gtgccgcgcc gcgccgcccc cgtgccctta cctcgatctc gagccgtcgc
     3841 cgtcggactc ggaggactcg gagagcctgg gcggcgcgtc gctgggcggc ctggagccct
     3901 ggtggttcgc cgacttccct tacccgtatg ccgagcgcct cgggccgccg cccggccgct
     3961 actggtcggt cgacaagctc gggggctggc gcgccgggag ctgggactac ctgcccccgc
     4021 gcagcggtcc ggccgcctgg cactgtcggc actgcgccag cctggagctg ctgccgccgc
     4081 cgcgccatct cagctgctcg cacgatggcc tggacggcgg ctggtgggcg ccaccgcctc
     4141 caccctgggc cgccgggccc ctgccccgac gccgggcccg ctgcgggtgc ccgcggtcgc
     4201 acccgcaccg cccgcgggcc tcgcaccgca cgcccgccgc cgccgcgccc caccaccaca
     4261 ggcaccggcg cgccgctggg ggctgggacc tcccgccgcc cgcgcccacc tcgcgctcgc
     4321 tcgaggacct cagctcgtgc cctcgcgccg cccctgcgcg caggcttacc gggccctccc
     4381 gccacgctcg caggtgtccg cacgccgcgc actgggggcc gccgctgccc acagcttccc
     4441 accggagaca ccggggcggg gacctgggca cccgcagggg ctcggcgcac ttctctagcc
     4501 tcgagtccga ggtatgacgc ggccccgggg gccccaccgc ccccttggtc agcgcaggcc
     4561 acggcccgag ggggcgcccg cagtggacag gacccgcgtg ggttgggaag gaaagcagtg
     4621 gaactggccg gaccccgcct ggagcagcgt cctgcgcccc ctggttctgg aggaaccgca
     4681 agccggagag gatttggtcc ctcaactatc acccagcctg agaacgaggg ggcgggggcc
     4741 ttggagccca ccggactttt ttttaaaccc gacaagggct ttttaacgtc accagatggg
     4801 gcgggaggtg gggggttcac gccactcccg cgtcccacct ccacgcccgg ggccgtggcc
     4861 cccacatcac tgtgcagctc cccggcccca gccgcgcctc cggggaagcc cgtttttaac
     4921 ctttcatcca ttgggactca aaactgtgag acgcgttcgc caaactgtga ccccagacct
     4981 tggccccgcc acacagaaac ccctgaccca gactgtgaca tccgactcct aaaatggtca
     5041 tccgactcca gactgtgacc cctgacccca aactgtgacc cgaaccccag actgtgcccc
     5101 gaccagactg tgacccttga catcaaaccg tgacaccccc tcctcctctt ccaccctcgg
     5161 tcgcttttcc ctactctgac ctaggacacg tccccaacgg aagccccgcc ttcccttgca
     5221 ccgcgatgaa cccaacctcc ctgaagccaa aacttcccac cctgccgcac ctccggacca
     5281 ccccacttgc caccaagcac atcctctcca aatccaaccc ttatttgcga cccttcagtg
     5341 atgacccagc agacctccaa aaagcctcct ctgcccagat ctccagccgg gtctggggct
     5401 gggttgcgga ggggagggtc tgggagtcca cacttctcca ccaacttccc ttcccactct
     5461 cttattccac attgcagtgt ttggaataaa ccatgttttt atgcctcctc a
//
