LOCUS       NM_000835               4271 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit 2C
            (GRIN2C), transcript variant 1, mRNA.
ACCESSION   NM_000835
VERSION     NM_000835.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4271)
  AUTHORS   Zhang,J., Zhang,M., Wang,Q., Wen,H., Liu,Z., Wang,F., Wang,Y.,
            Yao,F., Song,N., Kou,Z., Li,Y., Guo,F. and Zhu,S.
  TITLE     Distinct structure and gating mechanism in diverse NMDA receptors
            with GluN2C and GluN2D subunits
  JOURNAL   Nat Struct Mol Biol 30 (5), 629-639 (2023)
   PUBMED   36959261
REFERENCE   2  (bases 1 to 4271)
  AUTHORS   Chou,T.H., Kang,H., Simorowski,N., Traynelis,S.F. and Furukawa,H.
  TITLE     Structural insights into assembly and function of GluN1-2C,
            GluN1-2A-2C, and GluN1-2D NMDARs
  JOURNAL   Mol Cell 82 (23), 4548-4563 (2022)
   PUBMED   36309015
  REMARK    GeneRIF: Structural insights into assembly and function of
            GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
REFERENCE   3  (bases 1 to 4271)
  AUTHORS   Olajide,O.J. and Chapman,C.A.
  TITLE     Amyloid-beta (1-42) peptide induces rapid NMDA receptor-dependent
            alterations at glutamatergic synapses in the entorhinal cortex
  JOURNAL   Neurobiol Aging 105, 296-309 (2021)
   PUBMED   34144329
  REMARK    GeneRIF: Amyloid-beta (1-42) peptide induces rapid NMDA
            receptor-dependent alterations at glutamatergic synapses in the
            entorhinal cortex.
REFERENCE   4  (bases 1 to 4271)
  AUTHORS   Herbrechter,R., Hube,N., Buchholz,R. and Reiner,A.
  TITLE     Splicing and editing of ionotropic glutamate receptors: a
            comprehensive analysis based on human RNA-Seq data
  JOURNAL   Cell Mol Life Sci 78 (14), 5605-5630 (2021)
   PUBMED   34100982
REFERENCE   5  (bases 1 to 4271)
  AUTHORS   Kalsi,G., Whiting,P., Bourdelles,B.L., Callen,D., Barnard,E.A. and
            Gurling,H.
  TITLE     Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to
            19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the
            NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell
            hybrid and radiation hybrid mapping panels
  JOURNAL   Genomics 47 (3), 423-425 (1998)
   PUBMED   9480759
REFERENCE   6  (bases 1 to 4271)
  AUTHORS   Lin,Y.J., Bovetto,S., Carver,J.M. and Giordano,T.
  TITLE     Cloning of the cDNA for the human NMDA receptor NR2C subunit and
            its expression in the central nervous system and periphery
  JOURNAL   Brain Res Mol Brain Res 43 (1-2), 57-64 (1996)
   PUBMED   9037519
REFERENCE   7  (bases 1 to 4271)
  AUTHORS   Andersen,D.L., Tannenberg,A.E., Burke,C.J. and Dodd,P.R.
  TITLE     Developmental rearrangements of cortical glutamate-NMDA receptor
            binding sites in late human gestation
  JOURNAL   Brain Res Dev Brain Res 88 (2), 178-185 (1995)
   PUBMED   8665664
REFERENCE   8  (bases 1 to 4271)
  AUTHORS   Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
            Nath,A.
  TITLE     Human immunodeficiency virus type 1 tat activates
            non-N-methyl-D-aspartate excitatory amino acid receptors and causes
            neurotoxicity
  JOURNAL   Ann Neurol 37 (3), 373-380 (1995)
   PUBMED   7695237
REFERENCE   9  (bases 1 to 4271)
  AUTHORS   Takano,H., Onodera,O., Tanaka,H., Mori,H., Sakimura,K., Hori,T.,
            Kobayashi,H., Mishina,M. and Tsuji,S.
  TITLE     Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1
            subunit genes of the human NMDA receptor channel
  JOURNAL   Biochem Biophys Res Commun 197 (2), 922-926 (1993)
   PUBMED   8267632
REFERENCE   10 (bases 1 to 4271)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
  REMARK    GeneRIF: The authors identified and cloned sequences of NMDA
            receptor subunits 2A, 2B, and 2C from rat. They characterized the
            properties of the receptors composed of heteromeric 1-2A and
            heteromeric 1-2C and found that the latter had reduced sensitivity
            to magnesium and smaller conductance compared to the former.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087651.19 and AC068874.21.
            
            On Aug 31, 2019 this sequence version replaced NM_000835.5.
            
            Summary: This gene encodes a subunit of the N-methyl-D-aspartate
            (NMDA) receptor, which is a subtype of ionotropic glutamate
            receptor. NMDA receptors are found in the central nervous system,
            are permeable to cations and have an important role in
            physiological processes such as learning, memory, and synaptic
            development. The receptor is a tetramer of different subunits
            (typically heterodimer of subunit 1 with one or more of subunits
            2A-D), forming a channel that is permeable to calcium, potassium,
            and sodium, and whose properties are determined by subunit
            composition. Alterations in the subunit composition of the receptor
            are associated with pathophysiological conditions such as
            Parkinson's disease, Alzheimer's disease, depression, and
            schizophrenia. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77782.1, BC140801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293190.10/ ENSP00000293190.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC087651.19        6733-6874           c
            143-556             AC087651.19        1683-2096           c
            557-1155            AC068874.21        80516-81114
            1156-1270           AC068874.21        81436-81550
            1271-1482           AC068874.21        82360-82571
            1483-1648           AC068874.21        82756-82921
            1649-1802           AC068874.21        83194-83347
            1803-1928           AC068874.21        85150-85275
            1929-2158           AC068874.21        85590-85819
            2159-2319           AC068874.21        86207-86367
            2320-2507           AC068874.21        86874-87061
            2508-2740           AC068874.21        88619-88851
            2741-4271           AC068874.21        89574-91104
FEATURES             Location/Qualifiers
     source          1..4271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..4271
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="glutamate ionotropic receptor NMDA type subunit 2C"
                     /db_xref="GeneID:2905"
                     /db_xref="HGNC:HGNC:4587"
                     /db_xref="MIM:138254"
     exon            1..142
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            143..556
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            557..1155
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1270
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1482
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1648
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1802
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1928
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2158
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2319
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2507
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2740
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..4271
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4250..4255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="hexamer: ATTAAA"
     polyA_site      4271
                     /gene="GRIN2C"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="major polyA site"
ORIGIN      
        1 gcatcgcgag tgtccttgag ccgcgggtga cggtggctct cgctgctcgc gccccctcct
       61 cccgcggggg gagcctgatg ccacgttccc tatgaattat ttatcgccgg cctaaaaata
      121 ccccgaactt cacagcccga gtgaccctcc ggtggacatg ggtggggccc tggggccggc
      181 cctgttgctc acctcgctct tcggtgcctg ggcagggctg ggtccggggc agggcgagca
      241 gggcatgacg gtggccgtgg tgtttagcag ctcagggccg ccccaggccc agttccgtgc
      301 ccgcctcacc ccccagagct tcctggacct acccctggag atccagccgc tcacagttgg
      361 ggtcaacacc accaacccca gcagcctcct cacccagatc tgcggcctcc tgggtgctgc
      421 ccacgtccac ggcattgtct ttgaggacaa cgtggacacc gaggcggtgg cccagatcct
      481 tgacttcatc tcctcccaga cccatgtgcc catcctcagc atcagcggag gctctgctgt
      541 ggtcctcacc cccaaggagc cgggctccgc cttcctgcag ctgggcgtgt ccctggagca
      601 gcagctgcag gtgctgttca aggtgctgga agagtacgac tggagcgcct tcgccgtcat
      661 caccagcctg cacccgggcc acgcgctctt cctggagggc gtgcgcgccg tcgccgacgc
      721 cagccacgtg agttggcggc tgctggacgt ggtcacgctg gagctgggcc cgggagggcc
      781 gcgcgcgcgc acgcagcgcc tgctgcgcca gctcgacgcg cccgtgtttg tggcctactg
      841 ctcgcgcgag gaggccgagg tgctcttcgc cgaggcggcg caggccggtc tggtggggcc
      901 cggccacgtg tggctggtgc ccaacctggc gctgggcagc accgatgcgc cccccgccac
      961 cttccccgtg ggcctcatca gcgtcgtcac cgagagctgg cgcctcagcc tgcgccagaa
     1021 ggtgcgcgac ggcgtggcca ttctggccct gggcgcccac agctactggc gccagcatgg
     1081 aaccctgcca gccccggccg gggactgccg tgttcaccct gggcccgtca gccctgcccg
     1141 ggaggccttc tacaggcacc tactgaatgt cacctgggag ggccgagact tctccttcag
     1201 ccctggtggg tacctggtcc agcccaccat ggtggtgatc gccctcaacc ggcaccgcct
     1261 ctgggagatg gtggggcgct gggagcatgg cgtcctatac atgaagtacc ccgtgtggcc
     1321 tcgctacagt gcctctctgc agcctgtggt ggacagtcgg cacctgacgg tggccacgct
     1381 ggaagagcgg ccctttgtca tcgtggagag ccctgaccct ggcacaggag gctgtgtccc
     1441 caacaccgtg ccctgccgca ggcagagcaa ccacaccttc agcagcgggg acgtggcccc
     1501 ctacaccaag ctctgctgta agggattctg catcgacatc ctcaagaagc tggccagagt
     1561 ggtcaaattc tcctacgacc tgtacctggt gaccaacggc aagcatggca agcgggtgcg
     1621 cggcgtatgg aacggcatga ttggggaggt gtactacaag cgggcagaca tggccatcgg
     1681 ctccctcacc atcaatgagg aacgctccga gatcgtagac ttctctgtac cctttgtgga
     1741 gacgggcatc agtgtgatgg tggctcgcag caatggcacc gtctccccct cggccttctt
     1801 ggagccatat agccctgcag tgtgggtgat gatgtttgtc atgtgcctca ctgtggtggc
     1861 catcaccgtc ttcatgttcg agtacttcag ccctgtcagc tacaaccaga acctcaccag
     1921 aggcaagaag tccgggggcc cagctttcac tatcggcaag tccgtgtggc tgctgtgggc
     1981 gctggtcttc aacaactcag tgcccatcga gaacccgcgg ggcaccacca gcaagatcat
     2041 ggttctggtc tgggccttct ttgctgtcat cttcctcgcc agctacacgg ccaacctggc
     2101 cgccttcatg atccaagagc aatacatcga cactgtgtcg ggcctcagtg acaagaagtt
     2161 tcagcggcct caagatcagt acccaccttt ccgcttcggc acggtgccca acggcagcac
     2221 ggagcggaac atccgcagta actaccgtga catgcacacc cacatggtca agttcaacca
     2281 gcgctcggtg gaggacgcgc tcaccagcct caagatgggg aagctggatg ccttcatcta
     2341 tgatgctgct gtcctcaact acatggcagg caaggacgag ggctgcaagc tggtcaccat
     2401 tgggtctggc aaggtctttg ctaccactgg ctacggcatc gccatgcaga aggactccca
     2461 ctggaagcgg gccatagacc tggcgctctt gcagttcctg ggggacggag agacacagaa
     2521 actggagaca gtgtggctct cagggatctg ccagaatgag aagaacgagg tgatgagcag
     2581 caagctggac atcgacaaca tggcaggcgt cttctacatg ctgctggtgg ccatggggct
     2641 ggccctgctg gtcttcgcct gggagcacct ggtctactgg aagctgcgcc actcggtgcc
     2701 caactcatcc cagctggact tcctgctggc tttcagcagg ggcatctaca gctgcttcag
     2761 cggggtgcag agcctcgcca gcccaccgcg gcaggccagc ccggacctca cggccagctc
     2821 ggcccaggcc agcgtgctca agatgctgca ggcagcccgc gacatggtga ccacggcggg
     2881 cgtaagcagc tccctggacc gcgccactcg caccatcgag aattggggtg gcggccgccg
     2941 tgcgccccca ccgtccccct gcccgacccc gcggtctggc cccagcccat gcctgcccac
     3001 ccccgacccg cccccagagc cgagccccac gggctgggga ccgccagacg ggggtcgcgc
     3061 ggcgcttgtg cgcagggctc cgcagccccc gggccgcccc ccgacgccgg ggccgcccct
     3121 gtccgacgtc tcccgagtgt cgcgccgccc agcctgggag gcgcggtggc cggtgcggac
     3181 cgggcactgc gggaggcacc tctcggcctc cgagcggccc ctgtcgcccg cgcgctgtca
     3241 ctacagctcc tttcctcgag ccgaccgatc cggccgcccc ttcctcccgc tcttcccgga
     3301 gctggaggac ctgccgctgc tcggtccgga gcagctggcc cggcgggagg ccctgctgca
     3361 cgcggcctgg gcccggggct cgcgcccgcg tcacgcttcc ctgcccagct ccgtggccga
     3421 ggccttcgct cggcccagct cgctgcccgc tgggtgcacc ggccccgcct gcgcccgccc
     3481 cgacggccac tcggcctgca ggcgcttggc gcaggcgcag tcgatgtgct tgccgatcta
     3541 ccgggaggcc tgccaggagg gcgagcaggc aggggccccc gcctggcagc acagacagca
     3601 cgtctgcctg cacgcccacg cccacctgcc attttgctgg ggggctgtct gtcctcacct
     3661 tccaccctgt gccagccacg gctcctggct ctccggggcc tgggggcctc tggggcacag
     3721 gggcaggact ctggggctgg gcacaggcta cagagacagt gggggactgg acgagatcag
     3781 cagggtagcc cgtgggacgc aaggcttccc gggaccctgc acctggagac ggatctccag
     3841 tctggagtca gaagtgtgag ttatcagcca ctcaggctcc gagccagctg gattctctgc
     3901 ctgccactgt cagggttaag cggcaggcag gattgggctt ttctggcttc tgccatgaaa
     3961 tcctggccat gggaccccag tgacagatga tgtcttccat ggtcatcagt gacctcagta
     4021 gcctcaaatc atggtgaggg ctgggctttt gctgtcctct tctcacgcag agttctgcca
     4081 ggagggtgtg ctgtgggggt cagactcctg aggctctccc ttccctgggg ctagccagtt
     4141 actggtcatg gctgctgtgg gcatggaggc tggaacttgt ggttgaggca gggccatccc
     4201 gatccttgct ctacctggct agagtttctt ctcatcagag cactgggaca ttaaaccaac
     4261 cttttacaac a
//
