LOCUS       NM_000834              30609 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit 2B
            (GRIN2B), transcript variant 1, mRNA.
ACCESSION   NM_000834 XM_011520628
VERSION     NM_000834.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 30609)
  AUTHORS   Korinek,M., Candelas Serra,M., Abdel Rahman,F., Dobrovolski,M.,
            Kuchtiak,V., Abramova,V., Fili,K., Tomovic,E., Hrcka Krausova,B.,
            Krusek,J., Cerny,J., Vyklicky,L., Balik,A. and Smejkalova,T.
  TITLE     Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes:
            Insights into NMDA Receptor Structure, Function, and
            Pathophysiology
  JOURNAL   Physiol Res 73 (Suppl 1), S413-S434 (2024)
   PUBMED   38836461
  REMARK    GeneRIF: Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B
            genes: Insights into NMDA Receptor Structure, Function, and
            Pathophysiology.
            Review article
REFERENCE   2  (bases 1 to 30609)
  AUTHORS   Raich,I., Lillo,J., Rebassa,J.B., Capo,T., Cordomi,A.,
            Reyes-Resina,I., Pallas,M. and Navarro,G.
  TITLE     Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's
            Disease
  JOURNAL   Int J Mol Sci 25 (9), 4757 (2024)
   PUBMED   38731978
  REMARK    GeneRIF: Dual Role of NMDAR Containing NR2A and NR2B Subunits in
            Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 30609)
  AUTHORS   Iacobucci,G.J. and Popescu,G.K.
  TITLE     NMDA receptors: linking physiological output to biophysical
            operation
  JOURNAL   Nat Rev Neurosci 18 (4), 236-249 (2017)
   PUBMED   28303017
  REMARK    Review article
REFERENCE   4  (bases 1 to 30609)
  AUTHORS   Hu,C., Chen,W., Myers,S.J., Yuan,H. and Traynelis,S.F.
  TITLE     Human GRIN2B variants in neurodevelopmental disorders
  JOURNAL   J Pharmacol Sci 132 (2), 115-121 (2016)
   PUBMED   27818011
  REMARK    GeneRIF: In this review, mutations in GRIN2B were described as
            distributed throughout the entire gene in patients with
            neuropsychiatric and developmental disorders.
            Review article
            Erratum:[J Pharmacol Sci. 2017 Apr;133(4):280. doi:
            10.1016/j.jphs.2017.04.001.. PMID: 28434657]
REFERENCE   5  (bases 1 to 30609)
  AUTHORS   Hess,S.D., Daggett,L.P., Crona,J., Deal,C., Lu,C.C., Urrutia,A.,
            Chavez-Noriega,L., Ellis,S.B., Johnson,E.C. and Velicelebi,G.
  TITLE     Cloning and functional characterization of human heteromeric
            N-methyl-D-aspartate receptors
  JOURNAL   J Pharmacol Exp Ther 278 (2), 808-816 (1996)
   PUBMED   8768735
REFERENCE   6  (bases 1 to 30609)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   7  (bases 1 to 30609)
  AUTHORS   Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
            Nath,A.
  TITLE     Human immunodeficiency virus type 1 tat activates
            non-N-methyl-D-aspartate excitatory amino acid receptors and causes
            neurotoxicity
  JOURNAL   Ann Neurol 37 (3), 373-380 (1995)
   PUBMED   7695237
REFERENCE   8  (bases 1 to 30609)
  AUTHORS   Mandich,P., Schito,A.M., Bellone,E., Antonacci,R., Finelli,P.,
            Rocchi,M. and Ajmar,F.
  TITLE     Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to
            chromosome 12p12
  JOURNAL   Genomics 22 (1), 216-218 (1994)
   PUBMED   7959773
REFERENCE   9  (bases 1 to 30609)
  AUTHORS   Platzer,K. and Lemke,J.R.
  TITLE     GRIN2B-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29851452
REFERENCE   10 (bases 1 to 30609)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007916.10, U90278.1,
            U88963.1, AC007535.3 and AC007527.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jan 27, 2020 this sequence version replaced
            XM_011520628.2, NM_000834.4.
            
            Summary: This gene encodes a member of the N-methyl-D-aspartate
            (NMDA) receptor family within the ionotropic glutamate receptor
            superfamily. The encoded protein is a subunit of the NMDA receptor
            ion channel which acts as an agonist binding site for glutamate.
            The NMDA receptors mediate a slow calcium-permeable component of
            excitatory synaptic transmission in the central nervous system. The
            NMDA receptors are heterotetramers of seven genetically encoded,
            differentially expressed subunits including NR1 (GRIN1), NR2
            (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The
            early expression of this gene in development suggests a role in
            brain development, circuit formation, synaptic plasticity, and
            cellular migration and differentiation. Naturally occurring
            mutations within this gene are associated with neurodevelopmental
            disorders including autism spectrum disorder, attention deficit
            hyperactivity disorder, epilepsy, and schizophrenia. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U11287.1, U90278.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145743, SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609686.4/ ENSP00000477455.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC007916.10        111106-111366
            262-499             AC007916.10        112352-112589
            500-1073            U90278.1           1-574
            1074-1119           U88963.1           545-590
            1120-4206           U90278.1           621-3707
            4207-19850          AC007535.3         145452-161095
            19851-30609         AC007527.6         75934-86692         c
FEATURES             Location/Qualifiers
     source          1..30609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..30609
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="glutamate ionotropic receptor NMDA type subunit 2B"
                     /db_xref="GeneID:2904"
                     /db_xref="HGNC:HGNC:4586"
                     /db_xref="MIM:138252"
     exon            1..261
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..690
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1119
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1718
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1833
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2036
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2208
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2362
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2488
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2718
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2879
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3067
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3306
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..30609
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      25702..25707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="hexamer: AATAAA"
     polyA_site      25723
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="major polyA site"
     polyA_site      27549
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="major polyA site"
     regulatory      27553..27558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="hexamer: ATTAAA"
     polyA_site      27578
                     /gene="GRIN2B"
                     /gene_synonym="DEE27; EIEE27; GluN2B; hNR3; MRD6; NMDAR2B;
                     NR2B; NR3"
                     /note="major polyA site"
ORIGIN      
        1 acttcctccg gcttcttcac ctctaggaaa tctcggggct tcgctctatc gagagtgctc
       61 gtcaagggtg attcttgatc accaccatcc agtagtgctg gcgtccgaat gcatatcctt
      121 ttgccttgca aagaagagtc atgaacttca aaacccccga gacggatcat taatcctgct
      181 ttgcaggaaa ggaaaaccct ccattcccag ccaccggcca cccctctccg cagactgcaa
      241 ccgcggaggc gctcggagcc ggaaggggac gctttgggaa tgaccatgct ccaccgaggg
      301 acggagccgg cccccagctt ctccacacag agcctcctcc actaacgctc caaaaaccaa
      361 aaaccgtaat tgccagaaga agcgttaaaa atctattcca gccactaacc tcacatgcac
      421 acggaataat tactctggat tctgcattgt gagctgctct ccataccctg aattaccttt
      481 gaattaaatc tttttttttt tgaatttgca tctcttcaag acacaagatt aaaacaaaat
      541 ttacgctaaa ttggatttta aattatcttc cgttcattta tccttcgtct ttcttatgtg
      601 gatatgcaag cgagaagaag ggactggaca ttcccaacat gctcactccc ttaatctgtc
      661 cgtctagagg tttggcttct acaaaccaag ggagtcgacg agttgaagat gaagcccaga
      721 gcggagtgct gttctcccaa gttctggttg gtgttggccg tcctggccgt gtcaggcagc
      781 agagctcgtt ctcagaagag cccccccagc attggcattg ctgtcatcct cgtgggcact
      841 tccgacgagg tggccatcaa ggatgcccac gagaaagatg atttccacca tctctccgtg
      901 gtaccccggg tggaactggt agccatgaat gagaccgacc caaagagcat catcacccgc
      961 atctgtgatc tcatgtctga ccggaagatc cagggggtgg tgtttgctga tgacacagac
     1021 caggaagcca tcgcccagat cctcgatttc atttcagcac agactctcac ccccatcctg
     1081 ggcatccacg ggggctcctc tatgataatg gcagataagg atgaatcctc catgttcttc
     1141 cagtttggcc catcaattga acagcaagct tccgtaatgc tcaacatcat ggaagaatat
     1201 gactggtaca tcttttctat cgtcaccacc tatttccctg gctaccagga ctttgtaaac
     1261 aagatccgca gcaccattga gaatagcttt gtgggctggg agctagagga ggtcctccta
     1321 ctggacatgt ccctggacga tggagattct aagatccaga atcagctcaa gaaacttcaa
     1381 agccccatca ttcttcttta ctgtaccaag gaagaagcca cctacatctt tgaagtggcc
     1441 aactcagtag ggctgactgg ctatggctac acgtggatcg tgcccagtct ggtggcaggg
     1501 gatacagaca cagtgcctgc ggagttcccc actgggctca tctctgtatc atatgatgaa
     1561 tgggactatg gcctccccgc cagagtgaga gatggaattg ccataatcac cactgctgct
     1621 tctgacatgc tgtctgagca cagcttcatc cctgagccca aaagcagttg ttacaacacc
     1681 cacgagaaga gaatctacca gtccaatatg ctaaataggt atctgatcaa tgtcactttt
     1741 gaggggagga atttgtcctt cagtgaagat ggctaccaga tgcacccgaa actggtgata
     1801 attcttctga acaaggagag gaagtgggaa agggtgggga agtggaaaga caagtccctg
     1861 cagatgaagt actatgtgtg gccccgaatg tgtccagaga ctgaagagca ggaggatgac
     1921 catctgagca ttgtgaccct ggaggaggca ccatttgtca ttgtggaaag tgtggaccct
     1981 ctgagtggaa cctgcatgag gaacacagtc ccctgccaaa aacgcatagt cactgagaat
     2041 aaaacagacg aggagccggg ttacatcaaa aaatgctgca aggggttctg tattgacatc
     2101 cttaagaaaa tttctaaatc tgtgaagttc acctatgacc tttacctggt taccaatggc
     2161 aagcatggga agaaaatcaa tggaacctgg aatggtatga ttggagaggt ggtcatgaag
     2221 agggcctaca tggcagtggg ctcactcacc atcaatgagg aacgatcgga ggtggtcgac
     2281 ttctctgtgc ccttcataga gacaggcatc agtgtcatgg tgtcacgcag caatgggact
     2341 gtctcacctt ctgccttctt agagccattc agcgctgacg tatgggtgat gatgtttgtg
     2401 atgctgctca tcgtctcagc cgtggctgtc tttgtctttg agtacttcag ccctgtgggt
     2461 tataacaggt gcctcgctga tggcagagag cctggtggac cctctttcac catcggcaaa
     2521 gctatttggt tgctctgggg tctggtgttt aacaactccg tacctgtgca gaacccaaag
     2581 gggaccacct ccaagatcat ggtgtcagtg tgggccttct ttgctgtcat cttcctggcc
     2641 agctacactg ccaacttagc tgccttcatg atccaagagg aatatgtgga ccaggtttct
     2701 ggcctgagcg acaaaaagtt ccagagacct aatgacttct cacccccttt ccgctttggg
     2761 accgtgccca acggcagcac agagagaaat attcgcaata actatgcaga aatgcatgcc
     2821 tacatgggaa agttcaacca gaggggtgta gatgatgcat tgctctccct gaaaacaggg
     2881 aaactggatg ccttcatcta tgatgcagca gtgctgaact atatggcagg cagagatgaa
     2941 ggctgcaagc tggtgaccat tggcagtggg aaggtctttg cttccactgg ctatggcatt
     3001 gccatccaaa aagattctgg gtggaagcgc caggtggacc ttgctatcct gcagctcttt
     3061 ggagatgggg agatggaaga actggaagct ctctggctca ctggcatttg tcacaatgag
     3121 aagaatgagg tcatgagcag ccagctggac attgacaaca tggcaggggt cttctacatg
     3181 ttgggggcgg ccatggctct cagcctcatc accttcatct gcgaacacct tttctattgg
     3241 cagttccgac attgctttat gggtgtctgt tctggcaagc ctggcatggt cttctccatc
     3301 agcagaggta tctacagctg catccatggg gtggcgatcg aggagcgcca gtctgtaatg
     3361 aactccccca ccgcaaccat gaacaacaca cactccaaca tcctgcgcct gctgcgcacg
     3421 gccaagaaca tggctaacct gtctggtgtg aatggctcac cgcagagcgc cctggacttc
     3481 atccgacggg agtcatccgt ctatgacatc tcagagcacc gccgcagctt cacgcattct
     3541 gactgcaaat cctacaacaa cccgccctgt gaggagaacc tcttcagtga ctacatcagt
     3601 gaggtagaga gaacgttcgg gaacctgcag ctgaaggaca gcaacgtgta ccaagatcac
     3661 taccaccatc accaccggcc ccatagtatt ggcagtgcca gctccatcga tgggctctac
     3721 gactgtgaca acccaccctt caccacccag tccaggtcca tcagcaagaa gcccctggac
     3781 atcggcctcc cctcctccaa gcacagccag ctcagtgacc tgtacggcaa attctccttc
     3841 aagagcgacc gctacagtgg ccacgacgac ttgatccgct ccgatgtctc tgacatctca
     3901 acccacaccg tcacctatgg gaacatcgag ggcaatgccg ccaagaggcg taagcagcaa
     3961 tataaggaca gcctgaagaa gcggcctgcc tcggccaagt cccgcaggga gtttgacgag
     4021 atcgagctgg cctaccgtcg ccgaccgccc cgctcccctg accacaagcg ctacttcagg
     4081 gacaaggaag ggctacggga cttctacctg gaccagttcc gaacaaagga gaactcaccc
     4141 cactgggagc acgtagacct gaccgacatc tacaaggagc ggagtgatga ctttaagcgc
     4201 gactccgtca gcggaggagg gccctgtacc aacaggtctc acatcaagca cgggacgggc
     4261 gacaaacacg gcgtggtcag cggggtacct gcaccttggg agaagaacct gaccaacgtg
     4321 gagtgggagg accggtccgg gggcaacttc tgccgcagct gtccctccaa gctgcacaac
     4381 tactccacga cggtgacggg tcagaactcg ggcaggcagg cgtgcatccg gtgtgaggct
     4441 tgcaagaaag caggcaacct gtatgacatc agtgaggaca actccctgca ggaactggac
     4501 cagccggctg ccccagtggc ggtgacgtca aacgcctcca ccactaagta ccctcagagc
     4561 ccgactaatt ccaaggccca gaagaagaac cggaacaaac tgcgccggca gcactcctac
     4621 gacaccttcg tggacctgca gaaggaagaa gccgccctgg ccccgcgcag cgtaagcctg
     4681 aaagacaagg gccgattcat ggatgggagc ccctacgccc acatgtttga gatgtcagct
     4741 ggcgagagca cctttgccaa caacaagtcc tcagtgccca ctgccggaca tcaccaccac
     4801 aacaaccccg gcggcgggta catgctcagc aagtcgctct accctgaccg ggtcacgcaa
     4861 aaccctttca tccccacttt tggggacgac cagtgcttgc tccatggcag caaatcctac
     4921 ttcttcaggc agcccacggt ggcgggggcg tcgaaagcca ggccggactt ccgggccctt
     4981 gtcaccaaca agccggtggt ctcggccctt catggggccg tgccagcccg tttccagaag
     5041 gacatctgta tagggaacca gtccaacccc tgtgtgccta acaacaaaaa ccccagggct
     5101 ttcaatggct ccagcaatgg gcatgtttat gagaaacttt ctagtattga gtctgatgtc
     5161 tgagtgaggg aacagagagg ttaaggtggg tacgggaggg taaggctgtg ggtcgcgtga
     5221 tgcgcatgtc acggagggtg acgggggtga acttggttcc catttgctcc tttcttgttt
     5281 taatttattt atgggatcct ggagttctgg ttcctactgg gggcaaccct ggtgaccagc
     5341 accatctctc ctccttttca cagttctctc cttcttcccc ccgctgtcag ccattcctgt
     5401 tcccatgaga tgatgccatg ggccctctca gcaggggagg gtagagcgga gaaaggaagg
     5461 gctgcatgcg ggcttcctcc tggtgtggaa gagctccttg atatcctctt tgagtgaagc
     5521 tgggagaacc aaaaagaggc tatgtgagca caaaggtagc ttttcccaaa ctgatctttt
     5581 catttaggtg aggaagcaaa agcatctatg tgagaccatt tagcacactg cttgtgaaag
     5641 gaaagaggct ctggctaaat tcatgctgct tagatgacat ctgtctagga atcatgtgcc
     5701 aagcagaggt tgggaggcca tttgtgttta tatataagcc aaaaaatgct tgcttcaacc
     5761 ccatgagact cgatagtggt ggtgaacaga acaaaaggtc attggtggca gagtggattc
     5821 ttgaacaaac tggaaagtac gttatgatag tgtcccacgg tgccttgggg acaagagcag
     5881 gtggattgtg cgtgcatgtg tgttcatgca cacttgcacc catgtgtagt caggtgcctc
     5941 aagagaaggc aaccttgact ctttctattg tttctttcaa tatccccaag cagtgtgatt
     6001 gtttggctta tatacagaca gagatggcca tgtattacct gaattttggc tgtgtctccc
     6061 ttcatccttc tggaataagg agaatgaaaa ttcttgataa agaagattct gtggtctaaa
     6121 caaaaaaagg cggtgagcaa tcctgcaaga acaaggtaca taaacaagtc ctcagtggtt
     6181 ggcaattgtt tcaaccagtt tgaaccaaga actttccagg aaggctaaag ggaaaccgaa
     6241 ttttcacagc catgattctt ttgcccacac ttgggagcaa aagattctac aaagctcttt
     6301 tgagcattta gactctcgac tggccaaggt ttggggaaga acgaagccac ctttgaagaa
     6361 gtaaggagtc gtgtatggta gggtaagtga gagaggggga tgtttccaat gctttgatcc
     6421 cttcttactt aacctgaagc tagacgagca ggcttcttcc ccccaaaact gattacaact
     6481 gctacagagc agacagttaa gagaaatgag cttgaccttt aagagaaatg agctgcactc
     6541 catgagtgca gctctggagg tacgaaaaga ggggaagaga cttggaaatg ggagacgggg
     6601 gcagagaggg accctccacc acctctttgg gcctggctcc ctgggaatgt gacttgagcc
     6661 cagagtgaac actcttggta gaagcccttc taccttcctg caacaccttg tttccctctc
     6721 agattgtacc attgaggaat aaaaaaagat atacatgtat aaaactccag ggatgagggt
     6781 accagcagaa ctgatgctcc cttcacttaa cattggaaaa ttgagaaggg aaatgaatat
     6841 gtatcactgc cggtcctgaa acttgcggta gggctattta ttctatgggt cagttccact
     6901 gtcctgccat cctcccctac acagggtggc atccagagag ccccaggtct gtgtggaagc
     6961 ttgactgcag gatcgccatg ttgcacacag gacacataaa ccagaaaggt gctcatcctc
     7021 ctctggaagg aagctgccat gtctcttcaa gtcactccct ccagggctgc tcttcgcccc
     7081 tgtttgccct cactcgtgac ccttcctcat cccgcccttg actgctgtcc ccaaccctcc
     7141 tccttgattt ttacctcagt atctttcatt ttaaagccaa ctgaaggcct tgtaaagctt
     7201 tgttttcttt ctaaaatgaa catgggggca aggggctgaa cctctcacag atttggtgag
     7261 aggagcacgg agtgctttac cttagataac agaaaagact gagagaggac agagggcatg
     7321 aggcacctcc aggaggaaga aggcgaaggg ccacgtaaac actgcttcgc cctgactctg
     7381 tccaggggtc agggactcat cccctcatct tcctcttacc tcaccccttt caaacaaaaa
     7441 aaccaaacca actaacctag cgaacagcaa tctagaacca agggagctct ttcagtctcc
     7501 gctggcaaca gaaatcaaga tggtgtttat ttcatatgta aatattttgt tttctaattt
     7561 tgtatagata aagtgttctc ttgtgagtat tcagggtgtt gggctggagg gagtggggtg
     7621 gtgatgggaa tgagagggaa aaagtgtttt gttatgggtt ttcatttccc attgggggaa
     7681 ttgttttgta tggctttttt gcttcagggt gtctggaaaa agcgaatgct catggaggcc
     7741 actatggtga aaaagccagg ggaaagtaat tgtgtccatc ccccccagaa aaccagtctt
     7801 cttactggtt tgtgagaaat gttcatgcac tttggccagg gttttacata gggttcaatt
     7861 tggctctaag caaaccccag gtctgactcc tatcttctag gtagacccta ggttaccaca
     7921 ttccacacaa agacaggctg gtggcaccat atttcctctg tcagtaccta gggtaggaaa
     7981 gattcccaaa agggcttaaa cagaattaag gtcaaattaa cttcccattc ttggcgtgac
     8041 tgaaaggttt caggaagctc aatcctgaga aatctcccag cggcctcctc tgatgctgaa
     8101 acaatcgtct cagtcatctg agtcttttct tctttaggac ctgggcgctg actcactccc
     8161 tgccccatct ccaccctcag aagtcagcct ggcaaacaca cgtggaaaaa tctccactaa
     8221 ctctactttt tgaagcatgt gatatctggt cacagagagg tagtgctgga tatgtgtctt
     8281 acaaatttgc atgcttttct agaaaagatg atgggatcca ctagaaactc agtggtgaga
     8341 tgattccctt agcaagattg ctgaagttag gtttagacgt gggagggtgg gtatgtgagc
     8401 aatggtgcca atagcggctc tttatttgcc ttgtcctcat tactgccatc aggaaggtgc
     8461 tactggcctc gagccaggtg ttcataatct ggccttgggt taaccagaca aatagaactt
     8521 cttttcctag actgttggct ttgtggaggt tggcagcctc tatcacagga taaaatttcc
     8581 aaatccattt acccagtata ttcactacat tttttcctat cctcccatca taaaagctgt
     8641 tagctggaca attttatttt tctaaactta tttggcccca gttggttgct tttcttcaac
     8701 tggatatttg cactgggact aagttactca tggtctgctt aagaaaactt aaagaaagga
     8761 aggctgggca ttgttaaaat ctagatgtta cttaattcca gaataacaag caagtaaaat
     8821 gcatgaggaa gaattcagct ataagcccaa tctatatcac agatgggtat gaaacaacac
     8881 ccaatccatc caaaactgtg agattccgca gataccctca ggagcaccta atattcccat
     8941 gttcttcaga atccatgctt tctcgctttg taccctctat cattcccttc cattgcagaa
     9001 gtggttggtg agtgtggtcc tgtatgaact cctttcagtg gcaatgctta aatctcagca
     9061 tttccactga caataatctg acccttgaat ttgcctgagt cgagactttg cacacccttc
     9121 aaagtgatgc atgtacagtg gactttgtta tttcaaaatc tgtcactgtg tatcctcagc
     9181 cagaacttgg gaaacatcct tcatatgtat ttccctgcac tggccacagc catgttgtga
     9241 ttgaggggaa aatcccaaat gattccatta aatgttgctg gtgtcagtag tgccaaaaac
     9301 gcatgtatga catgatacag taggagttgt ctatacagtt aagtgactat cactcacccg
     9361 gtcttccgtg gccatcagga gttgcccaag ggagaattct ctgcagagtg ctggtcacct
     9421 gcacatgtca ctaagaacta ggtttctttg gttcattttt tttttttttt tggtcggttt
     9481 ttagttagtt agttcaagat ttacagatag aataaccaga ttgtttgggc aataagcttt
     9541 tggaaaaact attccagaac tcactttatt ctttcaatca tcatctctct aaaaaggccc
     9601 tgtcattgct tgacaccctg tgaatgtctg tttttgtatg ttaggaatga ttcagatgtg
     9661 tgcataaatg atgtcactgc agtgatattg atgaatgcat tcagcatttc cagggactgt
     9721 ggccatacct tatgtgctct ctgagcccaa agccatatag gaaatacatg ctcagtaggc
     9781 tgctacacac tacagcagag cttttgcttt cttcacttgg gtgtcagaga cttttcctcc
     9841 tgtttaagga gctcttcatg gaggagaagc agctgaaagt gaatagtcac actgggatgg
     9901 gtctggcctt atgtatgcta tgtggtccat ggtgtgttga aggtcctgaa aaggtctttt
     9961 tcatttccca ccccactgca actaccacct tcccacacag atttgttgct ttagcactga
    10021 gctgagctgt ctgtcattcg aatgaaagta atcccaggaa aggtgacata ttaagccata
    10081 ttagggatgt atacatttaa tcacctaatt tacattagga atctcactcc ttttcctggg
    10141 aataagttat gatacaagag aagaggaagg gagcagagag cactgagagc aatagagtag
    10201 ggaacaagga tacaggttct agatggcaaa gacatttaaa ccatattttg gcctccgcct
    10261 gcttttattt aagcctcatt tgacacctaa ataggactcc tggttaggaa ttattttcaa
    10321 tacacaatca tatgagtgta taatttatga atttctaaat tcagtatctt gtagggcagg
    10381 ttgagaacta tgattctttc catagaaaat agaagagtga tgcttctcct ccattacatg
    10441 ttactgagta ggcagctaga aaaatcaaat tgaattagtg atacaataaa atttactgtc
    10501 attgtctggt ttctgtccca gtttaattaa tcttccaatt agctgagttg gtctatatcc
    10561 tatactttcc acctccatag ggggtgccct gttatctggt aaaagagcca cttatgacct
    10621 caggtgctac ttaacctggg gggcaattgt ttcttaggcc tagcagatgt ttgggatgac
    10681 actaaaatgg cagattagtc agtctgagaa tgtctaatat tgatctgaat ctaggattct
    10741 attctagttt ggggggtggg gttgcagtat tgtataaaat cataggatat ctgagaacat
    10801 cccaccctca actcattcca accacattga ttcagtcaca cagtggccct gtgagctcta
    10861 tgacttagaa gagatagcct atctattcct atgacaaagg ccctcaccca aaaccttaaa
    10921 ttgaaagcca gtgctgctac tttcatgcct tggagagaac tgtgacgttt agggcttctc
    10981 atttacaata ttgaagcaag aaaaaagaat tttgttcaga gtaatgggtt agaatagcag
    11041 tactgggaat aagtagggaa agttagaaat cttccacatt tctctctaca tctctcaaga
    11101 gctctgtaca gtgagtttct ggagctgctt catgctttga atataattgc tggggtgatt
    11161 atgtggttaa gggctcctga aagaactgaa ggtgaaaagc agagtagatg agtagaattc
    11221 ctcagagcct tggcactctg gtgtgtagaa tctgtgtttt ggagaaggtg aaagaactca
    11281 gtgcaagaat taaggtacaa ttaaaaagca caacactaag cccaatttaa actgttattt
    11341 taaagattag gtttccacac tttaaacctg aactctttta tcggtaatta ttttaatgtt
    11401 gtgatttagg aggtggagca gattctagta ctatgcagga gaaaaaaata aaagctctct
    11461 ggttaaatat gtgagtttaa ttaaaccaac gtctattgtg cacgtactat gtccctaggc
    11521 tagttctgtg aatgatataa aaggtttcaa aatggagtat attgtactca cgtagaatat
    11581 atgaaagcat aagtataaaa tatgtaaatg tatgtataaa taggtatgca tacatttgta
    11641 tgattataca tgcaagttta atattttctg gtttcagggt aggagtcaaa gatatccatt
    11701 atgctatttg aaaaaacatt gcagagattc agcttcccat gtcatggcca ggcctggact
    11761 tattcttttg aaattattac acctcccaga gctaaaactc tgggatttcc tctctaacca
    11821 caaccttgcc ttttctatat cttccttcct tcaagacccc tctgttgttc tggtccataa
    11881 atccatcagg cctcattgaa ttccctcttt ggtctaaccc tgtatttacc cacattagca
    11941 atattctcac cggcaattcc tttttcctct tgccatctca ctacaccaac catgcttagc
    12001 taactgcatc ccatcccctt gtcattcatt gcatccccaa gaagagcaag tcttaaacct
    12061 acgtgaagag cacaaattca atcaatttaa cctcacctga agcctactca cttggacttt
    12121 ttaatttctc caatgttgac tcagtgtcac attctgtgct tgataaattt gttttatttt
    12181 cctttcatgt tcatgtcctg tctttcaaca ggcaatcttt cctactgtgt ttgcaagaaa
    12241 atctgattat tgaatcctca catatgctgt cctctctgcc tttagatttc tcttgtcttt
    12301 cacacatctt ttccatcctt tctcccaacc aagtgctcct cttccctatg ctctgacctc
    12361 ttctgaggtg ctctccagcc aattgtattt ctctcttttg catctttaat tccttccaca
    12421 catctacctg caactatctc aaaaacaccc gtcctacaac tatctctaaa gacaaatctc
    12481 tcaatccaat ttgactcttg aatttctgtc ctatcgctat cttttcactt cccaacttct
    12541 caaaagggta gtctttcttt ctccacttcc tcaccttatg ctcatggctt catcaatggg
    12601 ctacacccta ccactcttct gaaactactc tcaggcaacg ttccaatgaa gttcttgtta
    12661 caaaagtcaa tagccttttt tctttactta ccctgctctt caacctcatt gacaattacc
    12721 attgggaggc aatacattct ggttttaatc ttagttctct ggtcctctaa cctcattggt
    12781 tcctgctctt cctcttatct ccttagcatt gacttgccat ggtatatctg agcttgaccc
    12841 tcttctcctt atcttaatgc ttctgtagca atctttctgt cttctatgat ttcaataact
    12901 ctttgaatga agatgaatcc caaatcttca cttttagccc ctaccttttg cttttccttc
    12961 atacacatac ttccagtcac cttctgaaca ctcaacttca tcttgactca aatatccaaa
    13021 accattgctg caaaccaaca taatcaccaa cttcctcctt ttgcttaatg gtatcaccat
    13081 gtcttccgtc accgaactca agcttttcag gcacttttgc ctcctccatt ttcttcatcc
    13141 tgcatatcta aaaatttgaa aagcctacta attcttcccc ctaaggtttc cagtctttcc
    13201 ttttcattca gacccttcct tctagtctgg attatttcag cgtcttttag cattgttcca
    13261 atattttata tttgaatcta ctcttgtcag tactcacttc ctacatataa atcagatgtc
    13321 attcttcaga tcaagaaaca accttcagtg ggcttcactt gccgtagtct gccagcaata
    13381 atttcttgtt acttgactat gtgtgtgtcc cataatccag acaagctgaa taacatttgt
    13441 ttcacctttc cctaccagct tgttttccca cttgcgtctt cccttaaact gttccctttg
    13501 tccaaaatac tctccttcct atctcccatc tcactccctt cttgaataat atccattccc
    13561 tctatataag tcttcaaaga ccagaacaac ttctttatct tccattcaga aaataatttt
    13621 aggcatttta tgaatgccca taacactttc gttgtttctc cctagtggca gctatcatgg
    13681 gccatcttat ttcataggta tttggttata catctcatct ctcctgctac agcataagct
    13741 ccctgtgttc agggccatgt atttttaaat ctttttatct cctgtagcac taaacagagt
    13801 gccttgtata tgaaaggcat tagtaaatat ttgatattat tataaattat aattgagaag
    13861 gagtcacttt attttgccca tttgtatctg cagtagcacc taaggatgaa tccccccagt
    13921 ttctctatat atatctgcac acacaatcac atgtatatac tacatgtata cagttcatta
    13981 tttcaaatgg aatctggatt tttctaagtg ctttgtcctt tttctaagtg ctttgtcctt
    14041 tgaagttgtt ttggactgtt ttatggttag gaaagtgtac ttggaacact acatgtgttc
    14101 aagtaagtga cagagggaga aactatgaag gatattgatc aaattttagg tatcagcttt
    14161 tcagatgctt tgggtagagc ttgtatccag acactttact accaagattg agtctctaat
    14221 aacctgatcc atgctgggac tgatctgtga tccaatattt agcttctttt ttaacacttt
    14281 cagcaccaaa agaaccttgt cacagttctg gctcactaat cacacagcct tgtagacccc
    14341 aggtggtggt ccaacaggac cactgtattt caccacacgc tacttccaca tttgtggcct
    14401 tgggggaact gtctgtgctg gtcaccacct tgtctttata tttctttcct gagttctttg
    14461 gcttctcacc ctttctgagg ctttgtctac aggatcactt ctcccaaagg gaggataaga
    14521 gttgaggtaa ttgagcactt tacctcttat ctgtatattt acaatgaaag taagttagga
    14581 tttgaatgag ctggctcaga gagaatgcta gtctctaaac tactcctttc tctgtaaata
    14641 taaagggatt cattacctca gggggagaca acatcacttc tgaccttatg gccctccctt
    14701 atcctctggt ccctgtattc ttgaagccct gttaaccctt cctcctcctc tcttggctct
    14761 acttagcaat ctatcaatca ttctttctag ccagtgtcag tctctgtccc tctgaagaaa
    14821 ctcttggagc tcgtactgtc ctttcacttc agctgctctg gtaaccgata atgttttcgt
    14881 tccttctccc ggccagcctt ctctgtaaat ctcattatgc cattggctat gaattattcc
    14941 cctttgggag gcatcttctg ccactgtgtg ctaatttaaa gcatactata gagaactgaa
    15001 ctcaaataag ttacaggcag tgacaagtct ctttttttaa aaaaaaagtg aagaaagtcc
    15061 actcttcatt gagacaggag tgggtaggac aattattatt ggcaaggtag ggcaaaactt
    15121 gtgacaactt gggagatacc tagtgaaaat taaaatataa gtctagagag ataattttgc
    15181 ttttcaaaag tcctatgggg tctagatagc cttgctcctg aaaatgagaa tagttaatat
    15241 tttagagcaa aacccatttc attatactat gagacttttt tttttagctg atgaaacaaa
    15301 ttatctggta aacagctggt gggagggtag gaagacagcc atcctcatga aggacgttca
    15361 tgaatctcat ttgggccaat aaatggacca aaattctagg cattttagcc atgaactgtt
    15421 catgtcaatt attttgccta caaataccca taaaaggaaa gggaggatat gaggaaggaa
    15481 aagaacagga agtctacact ggagcttcct tttgtgtcac caataaagcc agaagctgac
    15541 atgtgaggca catggttccc ccttggttac tggcttcaat gatagcttcg gaaagtaggg
    15601 aaacttgaaa gagcaaggac caaagcggag atgagtgagg aacctgaatg caaccttatg
    15661 tgtgaggtcc tgatatccac aaggaacctg gccccatgtc attcctgccc aggtccttca
    15721 gattacagca cccaaggagc ccttgatcat caccctgggc agagggagtg acttatcaca
    15781 ccacccttac ccacagaatt taggccacca ggctgtgact ccatctgtcc cccttgcagt
    15841 aagagattca tagtctctga aatctgacag gagaacagca tcaggggaag gggccacagg
    15901 aatgcgaatt tgttgagctg cctgctcctc taggataagt atattacctg tttccagagg
    15961 ggattgtttt tttttcgaaa tgaaacaaaa catgcctgcc taaaacttca gccctattca
    16021 gaacagtctt gcagttaact gtcattgtca cattttaatt gtaattgatt ttcttttgaa
    16081 atccatggct attttaatgc tccctttgac catgacataa gaaccctctg caaaccagag
    16141 acctggccat taggttgcct ctggctgagt tatactctca gtagtttata ctttgctctc
    16201 agatattcac ctgaacagca caactacaca gaatttgatc tctttgccat gagcattctg
    16261 atgcctatgt acctccctaa tgcacacaca caatcttaac aaatagatcc aaatttccta
    16321 tgtcaatcat gttatggtag atgaaagtgt tcatttagaa tgggataaag agacatatca
    16381 taatttatgc agccagtgtt ttctctttgc tctacctggc ttgtggatca ttgatccctc
    16441 aaggtttgac agaaatattc aggcttcatg tgaaggcagc atgttctttg tgatgaaaca
    16501 acctagttat cgtctccatt ttcccatttt accctatgga atccatgtgg ccttctaagg
    16561 tcctgttgat ggactggtac taagaggatg gagaagcaga agccagtccc cctgagaaca
    16621 gacagtcctg ttgcttagat acatacatat tcgcacatgt gcccacatct cttcttggaa
    16681 acatcatgag cagaggtgga gaggtctgtt ctcaatggga ggaataaggg taggagaatt
    16741 ccttgagaat ccctattctc aaggaatagg gataaatgcc ttcacggatt caataattta
    16801 tctgttctct ctctcccagg gtcaggagca agaaaaatat caaggtttca cataggcagg
    16861 aagcaaggag gatagtgaag catctaggtg gaggtggaac tcttactgag aaaaacatga
    16921 agtagtaaaa tcaccctttc tttgatataa atgcatttag aagtcaatga gggcacttac
    16981 agctgtgttt cccttcacta acttttcatc tcttgcattc tttacttctc tttctcaatt
    17041 tattcatctt gaggtatact tatcctgagt tgactctgag cagcccatcc tcaaaacaca
    17101 aacaatgtta ggatgagaag ttgagtgagc acagagctcg aacacgtgca tggtacttaa
    17161 tgtttccaaa ctcgagccca atcagtctag cacagtcaat cccactgcat tttaatgact
    17221 aggatggggc ctgctgtaca tagctggaca tcttggatta cagaaaagag gctttatgtg
    17281 aaggcagcat tttctttgtg gtagagcaac atagttatcc tgctaactgt cctatttgac
    17341 ctgatggaat ccataaggtc ctgttgatgg gttggttcta agaggatgga gaagcagaag
    17401 tcattctact gagaacagac agtcctgttg cttagataca tacatattct ttatgacaga
    17461 attcctcctg agactcttgc acaccttcag tgatcagcgc attcactttg gttatttctt
    17521 ggtaacaggc acgagaaatg ggtcacatag aaatctgaag agtcatttct cgagcatttt
    17581 tagcttattc ccatgtaaag aggcactgag ctcctgcagt tctagcctgc ctctgctccc
    17641 ctccttgggg aatggtggag tttctaggat aaccagcaac ccattaggct ccaccacact
    17701 tagcctatgg tacattctga gtaaatcaca gtagttggta tgtgaataca gaagaattta
    17761 ccataaccac ttctccaaat aacctccttt gacttggaaa taagatcatc tttcagtttt
    17821 acagatgaga agtcaaagca caaaattgga taattagcca aaagtaagat tatacagaaa
    17881 attcttgaca gaaccaaaac ttggctgaac caaaacttgt ccaaatttct aactctcagt
    17941 ctagctcagc gagtaatgct gcctgaattg tctgccccca ctgtaggttt tcagcatcta
    18001 gcagtggaga aaagtcacga aatctaggca gctgatttag ccagatctta tctatgaaat
    18061 ttccctttgt agacacacac acactccaca tacatctaca gagacaagtc aaaaagagca
    18121 agaagaaagc aaaaatttga aaatcagaaa ggttagagag gtttccacgg tgaagaaaac
    18181 ttggtcaaat aaaaatgttt ttgaattcta tagggtaaga tattgtgaat aattttttat
    18241 tattaaaaat tttttttagg tagcatgtaa tccacataaa taaaaaactc aagaataaac
    18301 tgggacagag gatttcttcc agagtgctac atggcaaaag agccttcagg aacgtgtgca
    18361 ggggtgtcat gatactccga aggtgtcagt agttttggtc agcccacagt gagcagggca
    18421 gcctcaaggg agagcccctt acatcctttt ctgggcacct ctgtctaatt aagttcaaac
    18481 atacaagcct gattctagga ttaaggcata agttagttct gaacagaaaa atataaggca
    18541 gttcacatac acaatgaatt cttgaagaaa gaacctatag cccccagacc gataataaat
    18601 aattactgcc tgccaaaatc ctgaagaaag ggaagcatgg gggctccaaa attaatagtc
    18661 tcctgagaat acttatgaga ccttgatttt gtcacaaggt tgcaatggtg aattatttat
    18721 taagcacccg cagatcagag aatcttgcaa caaccttctc ttacaaccca cctgttcact
    18781 tatgaatgat atcaagctca ggatataatc catctttcca aagattttag tatctttagt
    18841 ttgggctgca gaagaaattt tggctcacag cattatgctt aaaccaaaaa cagtgaaaga
    18901 gctctagtgt cctgcttaat gtagagtaac tttttttttt tatcagtcct tcctagccct
    18961 agagggaaga taggagagga ggtaggaaga tggaaaagtc cttagatgaa tgagtgagga
    19021 gacttctata ccatcaactt cagagtgtac tgatccccgg agcctggttc aggaggctag
    19081 tttcagatga tcggaggaaa tggaggaggt agcttttatt cccatgcatg aagatggggg
    19141 gaggaggtgg gcactagact aattttttaa tctaaaaaaa atcaagccta ttacaaatct
    19201 catttttccc ttgtcctttt gcctcccaat aattcacata aaatcgtgtt atcatagtaa
    19261 gctaagagag aggggcagta gctatttcta ccttgactcc gtggtgactt catctttttc
    19321 atgagtgtca ttacagatac ctggatcatg atgatcctga aaaacaggtc acagggccaa
    19381 cagctgatga gtatttggag catcttattc ccccaagatg accactccct gtcttctgct
    19441 acacctatat tcatcggggg ggggaggtgg gaaaatagca ggattcttgg ggactctgag
    19501 ggcatgaatg gagaattatt tgattgaaac cacagagctc ttgtacttag tattaaatat
    19561 taaaatagaa atgaaaagtt cagcttttct gagctgtacc atagcggcca atggaggaag
    19621 tcttacaaag aaaatctata tctgcacaag actgaagcca ctaaaccgag tatacacaac
    19681 ataaagatat cttcctattt caagtatccc ttagggggca tgggtgctta gctatcctat
    19741 gaaagacaga gaagataagc tcaattttag agcccagagc ttgctccgga acagcaagat
    19801 ccacatgaac ttaaactctt tcccactgag cctaggggtg gaatgtaatt cctctgatgg
    19861 ttttgattta tttccaagct agacttctct atttgatcat tggcaccttg gcagctcaca
    19921 catctccgtg gtctcttctg tagctttcag aaaaaaaaaa aaaatatata tatatatata
    19981 tatatacaca cacatacata catacataca tatacataac cctgtttggg taaggcctat
    20041 tgacagaagc cagatatctg ggtggaagtt agaagatggg caaggaattc ttatctcaga
    20101 gtttcaacac tgcgacaatg tggagagaag tctcctggga aaatgcagat gcccaataac
    20161 ttccaaaaga atcagggaag ttggagtatt tttgagattt acagtgtctt tacttcagta
    20221 aaacaagcca tagcaacatt atgctctgca gagtcttctg ttcacctttg gatggaaaag
    20281 agctgcttct cctagggaga caactaagac caagaacaaa actcccatct cctaggccaa
    20341 ttattgtttt ctcctttcct ttctttttta ttctctttgt tacataatgg tgaaatctac
    20401 ctggccattg ccagtcaaac attctaattg ctaaatatca tacagaaatt catgaaaaaa
    20461 gagtagaatc agcagatttc atttaatccc aagggtcttt gcagttttca tcctctccct
    20521 caaagttatc tcttctttga gacacatgat cacccctttc ctcttctggg tggccatgat
    20581 tccaaaatga acttcagtgg ttggtgcttc acaaaaggaa agacagctat aatataaaat
    20641 agaccaaaat acttatattt ttagccactg caaagtgggt tttatcgttg agaacaacct
    20701 tccaagctcc ttacttggaa acccttcctc acctcccagc ctcctggcag ctctcctggt
    20761 tccccttcat gtttttggct cccctccccg actttccttt cctatgaaaa tgggatatat
    20821 cccttaaact gtattcttat ctaaactatc agactgttaa aagaaaccct tgacagtaat
    20881 ttttcatggt tttctcatca ttttttaact taggaagttg gagaaagaat gacaagcagg
    20941 caaatgaggt cttgttcctg agtgcttcaa ctcaagatca agtgctggga tagtgagtgg
    21001 ctcttagtgg agagggatgt gctctggaat attaagccac ctctgagcat gtgtcctggt
    21061 gctctggtca agatgcctgt tgtgtatgtg gaggtatttt gtggcttttc ttgttctctc
    21121 tttttaaatt tatttcaagg cacaagccct ttgtgatgga ggatgtctag cttgaacatg
    21181 ctggtaatgt gacactatcc tcagctcccc ttggccctgg gttcatagga ggcaagtgtt
    21241 tctaaatttc tcgcccagtg agttgttgca tgttattttt aaccattaat attgtgtgtc
    21301 tattggaatg agaaacagaa ggttgaatgg gaaatagatt cagtgacaag cagacaaaaa
    21361 gcttggttct gagaaatgtt cttcactgag ttgaaaaaaa aataatctag aaacaaagaa
    21421 gagggaaatt ggggtagaat ggtttggtgg tgaagagacg atgacaccca catccagatg
    21481 ctctggtgta ttccctcaga gatttgtcat tccctgtgag ctctggcaga aggagaggct
    21541 gtgctgccat tgatggctca gaaatggtga caggctggct ttagaaagag acgtaggctt
    21601 tcttccagac agacattgat aagcattgta gctcgattct tcaaaacctt gtctacaaac
    21661 ctttagggca gcccctctcc aatgatttcc attctccagt caagaagatt ctgagtggaa
    21721 gagccttgtg tgcattgtga ttacattgac ttaaattggg aagccaaggg gcactgagaa
    21781 ctgaatatat caggggaatg gagttagctg aacctttttt tttcaatatt ggaatgattt
    21841 tggatcacaa agttaggtca cctctgagag agaaaatctg ttaaataaaa ttatatcttc
    21901 ccatctccag tgaaatcact aggttgttaa tgtgattact gtttacttca gaaagaaaat
    21961 tgctagattc gattacaaat aggcatttta cagattgatt taatcctgag tcttacacat
    22021 attaacatgg aatttactga ctcagacatg atcttctaag ctataaaata ttactggcgg
    22081 gtagtagatc atatgttcta agcaaaccag gaaagctaaa acgttaagta atcctcccaa
    22141 atattcagcg tctgtgtatt tcactatagc tgaaggggat ttgggagtta ggccgcaggg
    22201 gagaggaggg acaaagtgcc atagattaat gaaactcgga gtaacttttt tcttacctat
    22261 taaaaataat aattaaccca aggacaattc tcaaaccaga aaaatcatga aaagtgagct
    22321 ctgcacttgc cattggttaa aatttagaaa cacttagaat aaatatccag gttttggggg
    22381 aggagttgtt tccttgcttg cattgttttg tttactggag ctcttatttt ggggatattt
    22441 ggtctgtggc ttcagagcat gttttggata aatgacttat ccatgttgat atttattgag
    22501 tggaaaccca tgccaggctg ttctaggtgc tggaatataa gaacgaacca cacaaagtcc
    22561 ataccctctt gaagtttgta tgttgatgag aggaaatgga caaaaaagca aatcaataga
    22621 tctcatgtca gatagtgcaa agtgtcatgc agaaaaatga ggcagattaa gggggataga
    22681 tgataggatg ggtgtggggt tgctattttt gagtaagcaa agatgacatt taagtaaagg
    22741 tttggaggaa atgagggagt gagacttggg gctttctatg caaaggcaaa gagaaagcaa
    22801 ttgcaaaggc cctgctgtca aaccaaatgc ttggcaaact tgaggaagag ccgggaggcc
    22861 aatgagggag gaggagagta tgagaggtga ggtcagagag ggggcaataa cgcaagtcag
    22921 gtagggcctt gtaggacact gtcaggattt ggcttttacc aagagcaaga tgagaagttg
    22981 ctagaaggtt cggagcatag agtgatatga tctgacttca gttgaagagg aagctttggg
    23041 actgctgtgt tgagagtata ccctgagagg gcagacaatg gaagcggctg aaagaccggt
    23101 taggaagctc ttgcaataat cctggtaaga gatcatagtt gcttgggcca tgatgttagc
    23161 aggggaggtg ataagaagca gttggattcc agaaatgttt taaagaatcg atatcacaca
    23221 gtttgctgat gaattagaca ttgaataaga gaaagaaaaa tcttaagaat aaccttagaa
    23281 tgtttggcct gagctattga aagtttggag ttgccatcag tgtaagacag gaatcctgca
    23341 ggtgaggctg actgggaagg aaagccttat agtttaaggt gtctacagat gttgcaagta
    23401 gaaatgatga ttaggcaatt agatatatgg acctggagtt cagggaaaat gtatagcctg
    23461 aagatacata tttaaaattt gtatgcgttt ggttggtatt tgaagccatg atactggaac
    23521 tagagaatga gtagcgacag aagaggattc tctagactga ggcccagggt ggaggattgt
    23581 tcaaagctcc aggagatgag aagggaccag caatgggagg agtggttaat gggtaaagca
    23641 agtactatta ttgagtagga taagactatc tggaaacatg gaggtcatcc cattgatgac
    23701 ctggaagaga gctgtttcag tggactggtg ggggcaaaag catgatgggg tggattcaag
    23761 aaagagggga aggagaggag gtagagacaa caggaatagg caacgcttta ggagtttggc
    23821 tgtaaagagg acatggaaat agcagatcat agagaatgtg acgcccaggg agggacttct
    23881 ttttttaaga tgggaaaaat aacagcccat tttatgttga caagactaat ccaggagaaa
    23941 ggaaaaattg atgatgccta gggagagagg acaattgctg gagtaatgtc tttgatgaag
    24001 tgagagggca tgggattcaa tacaaacata gagggactgg cttcagggga ctaaccaggt
    24061 ttgtttgtat taatagcagg gagatagtgc atttgggcac agatgcaagt gggctggtaa
    24121 atgggataat gggagtatgc tttttctgat tgatttttag taaactatga aaggagttca
    24181 tcagttaaga gtgagtatag gggaagagta ttggaggttt tggaaggaag aaagcatgaa
    24241 tgagtcatat agccatccgg caggaagagt gagaacaaaa atgtcggaga caccaaaaat
    24301 ataggagaca tgctaggggg cataaaggaa ttatttgagt ttttatgatt atgagtttaa
    24361 agaaatttgt tttcttcagt caccttcagc tgcttaaaca gggtggcaag ttagattgga
    24421 acagggttgg ggtataacca ggtgaatata atgaaagcaa gagatgtgga gtcaagggca
    24481 actgcagtgt gttaactata atgtttggtc atggaatcta agctgggtgt agaggaaagt
    24541 gaggattttt agggaaggag gaacaatgaa gcatattaga ggcagaggat tgagattcaa
    24601 gctgggatca ctcagttagt gagtcagaag caataacgta gaaattagga ggtgggttgg
    24661 agaggtggat gcttgaggtt atggagggct tgcagttatt ggtggtttgg ggtctgttgt
    24721 tggggtggtg ggctgagata agatagagga aaaggttata gaaggagcag gggtcaagga
    24781 actgagaggc caggatatgg gaattatata gatattgaag tcaacaaaat gttgacttcc
    24841 atatgatagg aatgtaaatt atgacaggaa tgagggagag tgattcgaga acatttcaat
    24901 cattgcatca agtaaggggt gcagctagcc tagtctgatg tgcatcaaag ctggatttta
    24961 tggttgttgc atgttatttt tttttaaaaa ggagggagga tggtctggaa tggcaatgag
    25021 gggcaagaag ggcatctcca cctccaggcc ccagggcatg aggaaggtgc aagtggaaat
    25081 gctcaccacc tgggagtgat tcagggtcct caaagaggag ccaggtttct gtaagagcaa
    25141 gaggaaagga attgccaggg ttgtggctgg tgatgaacca ctgattctta ggcaggattt
    25201 gggagttggt aaaggaaggg aaatgagctg agatgggaga tgtgcatggg tatctgggga
    25261 tgaaagtcca agtgataaga gggactgggg gtcttgggct tctcgtggtg attgccctaa
    25321 gcgaggctgt gggcatttgg ggttggccct aattgtctct atgtcagatt gaggtggtga
    25381 tgctgcaagt gcccggggca gggacttgat ggcagcacat ggaactctgg tacctcttcc
    25441 tcagtcctga tatttgcttt tttaacttct actaaaaacc ccactgctaa ctgtgatagg
    25501 ccacaacatg tttttataga tgtcaacaaa tgttatcctg gattgagacc acattttgac
    25561 tatttatcct ggaaagtaca cattttcaca ggaaatcttg tcctttctaa ggttcccaac
    25621 taagctagtc tcgttgtggg ggggtcataa ttatttgttc ttacttacct tactccttgt
    25681 tcatctttaa aaaaaaaatc aaataaaaag gattggaaag caactttgct tctgcccaat
    25741 tctgctaaat gaaagttttc tctgacagat cattttgatt ttgtattttc ttttgtgaca
    25801 gaaacagtgg gacaggagca tggaaatgaa tgaaagtctt taaaagcctt gagagagcgt
    25861 tttcaaggat caggagaggg cttagaaaga aaaggactct gagtggggct gcatgaaaag
    25921 ggggtaagtg aggactcttg gggagggtct gaaaaaaaca agtagtttgg caaggagagc
    25981 agaaaaataa aattccactg tgtaggcatt tggagattta gcaagagcaa cctagagtct
    26041 gcccccagag acactgcacg ttgtttctga cacagaggat gcactaattc tatttcctgt
    26101 gccacctgaa aaaatcataa tttgagaaga gaaactgtta ggccatttct agtgaactat
    26161 ttttccaaac cctcacggaa ccctgaacag ggtgtgaatg agatcacaac tactgctgct
    26221 gctggttcag cctctctgtc cactaataaa ggcaaaccct tcagcatggt catatcctgc
    26281 cagccgtttt cccccaaaag attaaattat gttcatcttg gctcatctaa cgccacatct
    26341 tgagttctta aggtatcaca gccaactcag tcatacctta ctttatgcac tgagtacgca
    26401 ttaaactcta tttaggaagg aagagggaag caaaggaagc cagggatggt tttgtcatga
    26461 cctctctttg ctttctgacc tcccggaatc cactctttgg aagatgtgca gaaaacaatg
    26521 tgacttccat ttaccctgcc tcagatctcc cctccttcag actggctccc acccctggtt
    26581 aatggggtaa cctgggtacg cctatttgtt aaaggaattt gtgggaagtg aggggcaaaa
    26641 ttgttggagc agagggaata gatttatggg agctttgtta cccagtgact atcccagcat
    26701 taatacttca gagtagccct gacgcttgtg gaaacatttc aagggagcta gaggcaatgt
    26761 tacagtggag atcagagaag ggatggggca gtgagctctt gtccctaggg gaaatctctt
    26821 ttcctccacg tgacaggagc cagtgctcca acagcatcag aattacactt agccacaatg
    26881 actgatgcgt gtgtgtgcct gtgcacatgt gtgtgagcgt gtgtgtgagc gcacgtgtgt
    26941 aagggggtga tgatggaaac atgatatgca tccactatgg ggttgcgttg caaattcaca
    27001 gctgcacccc tcccaaagtc acatggcaga ggggaaatgg tcatagcttt cctgtgtgat
    27061 gtcctctcca gggagcaccg acgactcagg cttgcctcag ctctgcgagg cccagactcc
    27121 acactcctcc ctggggccgg ctctccttcc tcttgactct cagatcccca gcccatccac
    27181 ctccaagttc tttttttgtt tatttgtttt gcttctgttt tctgtaaata tctatttctt
    27241 attttggaca tgcagggatc aattgagatt ctggagtggg gggaggggcg gatgactggg
    27301 tctttttatt ttttcctttc tctcttggat tttggtgttt gaacttgaaa aaaataatta
    27361 caagtatata tataagcaaa tgacttacct ttaaacaaaa gaaataagtt gatttcattc
    27421 ttttgattta tcttgtttct cattggggtc gggtgggggt ggggggtctt ttgggtggag
    27481 ggcttttttg tgagctgtat agatttccag tttggacttg ttcaaatgat gcaggaacaa
    27541 aaattaaaac gaattaaaaa aaagacaaca taaaaaaaca agaaaaactt tgtgatgtat
    27601 aaaagctgta aatagtcaaa gattctttct cttttctaat ggcaaattat ttctgtcact
    27661 ttatattcaa aaaataaaga aacctaccac aaattatcag ggttaaaaaa aatccagaat
    27721 cagagttttt ttcttggtct ttgtgctttc tttactgtga ttccaaaaag attgttaaaa
    27781 gtgctgtttg ggaaaaaccc cttgcccagt tggtttccaa ttgttggtag gagtcttgga
    27841 ctggcgaatc tacttgggtt gggatctgtt tctactatag ctggtgctgg agcccttggt
    27901 tacactcatc tccccctcat gtattattct gaaacaaatc ccataattat atggtttcat
    27961 ctgtaaacat tacagtatat atctctttta ctaaggactc ttttttagtt taacaatacc
    28021 attgtgacat cataaggtag ccataattcc ttgataagaa atatccagtg ttcactaatt
    28081 gtctcaaatg taatactgtt ttatggggtg gtggtgggtt tttttcccat aagtcataag
    28141 gtccatacaa ttagttgcta tttctcaaat gtattttaaa tctaaagatt tgctttctaa
    28201 ctttttcttg acatatactt gttaaaggaa tagagcactt tatcctttag aggttcccac
    28261 agttggattt tgctggttct tcccaatatt aatgaagaca atgtaaattg gtaattgttt
    28321 tactctttaa tgcatacttc cattgcttgg aggtgtcaga aaagcaaacc agcccttgtt
    28381 ttgctgattg tttcccaccc cactcccagt cccagtcctg ttactggctt tatatatgga
    28441 ttctaaatga tctctctttc tataccttga ttgctaaatt atccaagtta aataatagta
    28501 tctccccctt agctatcttg gtaagaaaat agcatagaca tatttagctt ttcacatgcc
    28561 aatcatgagg cacatttcaa catcacttta ttaaaagcca catgctcctc ctatagtcct
    28621 agtactggaa aggaccttct agagaccatt tagaagaact ctgtctcatg gccaaggagc
    28681 ctgggtgagc tcatgtatgg cagccctggc tagaagccag cagggctaat ccctagttcc
    28741 aggaatctcc caggataatg tattgttatc tctttgaagt tactgtctca gagagattat
    28801 ctgtgagggt ctctcttgta ctttcctttg tactgaacaa aaattcttgt ttctccctga
    28861 acattccaga aagtagcaag ctctaacata aagccagatt cttcccagat atagtgattc
    28921 tctttacttc tggagatact tccttaaacc ccaaattttt tttggacaac agaactgctt
    28981 taacaataat ctgaaaatta tacagtaagt ttgatttgaa aatctgagat ttgtttaaaa
    29041 aaaaaagggg gaagacaaga cttgaaatct tggctctgat ttttctgttg tttttgtttt
    29101 tttgtttgtt ttttttttgt ttgtttgttt tttaagaggg tcttgctctg tcatccaggc
    29161 tggagtggag aggtatgatt acggctcact gcagccttga cctcccaggc tcaagtgatt
    29221 ctaccacctc cgcctcctgt gtagctgggt actactggtg cataccacca cactgggctg
    29281 attttgtatt ttttgtagag acggggtttc accatgttgt ccaggctgat tctgaactcc
    29341 tgggttcaag tgatctgcct gcctcggctt cctatgatgc taggattaca ggtgtgagcc
    29401 actgtgccca tcttggctct agttttaaat aaggaagctt gcgagtattt atctggatta
    29461 tggtgggaac ctccagtagg atatcatgaa agctttgatc atgatcacaa caccttcaat
    29521 aaaacaaaga ctccaatgac aagggtgagt gccagaactt cctgagacta tgccaagtgt
    29581 ctgttcttta tacagcctgc ctcacccaca cctggaatct cttaaatgga ttagctcaga
    29641 gcacctgtgt cctacatgcc cttgtgccac cctgaagtcc actgcaaggg actatcagta
    29701 agaccagtct aatgaaaggc tgagggagca cccggttgtg tccccatcag ccaactgttc
    29761 cggaaagatg agcctccttg gctgtcccag gattgacact cttcccctgc atacatcact
    29821 aggaaggtag aacctaccct gaacacttga tttgaatatt tctattcccc tattctttta
    29881 caaatgcaaa ctaattcttt caaaaatata aatgatcctc tgaaagaaat ttcttgtgga
    29941 attctggaat gaccaagaag atgggaagag accaccagaa aagtggttct gagagtctgc
    30001 agggcctgtc aaaaaaatta tgccaaagct atcatttgtg gcctgcatca aatcatctag
    30061 acttccgttt tcttatcttg aaacccagat gttggtctat ctgccctccc catcaaaggt
    30121 tacctggagc agtagttctc agttttacat agtggagtca tctgagtatt tctgaaatgc
    30181 tgatgcctga gtctcatccc ctagagagtc tcattcaatt gtcctgggtg gctggagggg
    30241 ttaggggttg aaaacttgcc caggtgattt taatatacag ccagaatgtg aaccactatg
    30301 tatgtgcatc tggggaaagc gggcctccta tttacttcta atcccattat atgtggcagc
    30361 tgtttgttgt cactctcctc tcaccatgga caactattca cagcacagac agtcaccctt
    30421 tggaactcca ggacctcttt cctcttccat ttggagctga agaatggaca taacggaagc
    30481 accattttat gattacagcc tcgttctcta attctgccta tccccagcat acacggctag
    30541 atatagacat actgcaaagc tcctctatgt aaaggaaatt ctacacataa aatttaaact
    30601 tggaatcga
//
