LOCUS       NM_007327               4379 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor NMDA type subunit 1
            (GRIN1), transcript variant GluN1-1a, mRNA.
ACCESSION   NM_007327
VERSION     NM_007327.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4379)
  AUTHORS   Korinek,M., Candelas Serra,M., Abdel Rahman,F., Dobrovolski,M.,
            Kuchtiak,V., Abramova,V., Fili,K., Tomovic,E., Hrcka Krausova,B.,
            Krusek,J., Cerny,J., Vyklicky,L., Balik,A. and Smejkalova,T.
  TITLE     Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes:
            Insights into NMDA Receptor Structure, Function, and
            Pathophysiology
  JOURNAL   Physiol Res 73 (Suppl 1), S413-S434 (2024)
   PUBMED   38836461
  REMARK    GeneRIF: Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B
            genes: Insights into NMDA Receptor Structure, Function, and
            Pathophysiology.
            Review article
REFERENCE   2  (bases 1 to 4379)
  AUTHORS   Michalski,K. and Furukawa,H.
  TITLE     Structure and function of GluN1-3A NMDA receptor excitatory glycine
            receptor channel
  JOURNAL   Sci Adv 10 (15), eadl5952 (2024)
   PUBMED   38598639
REFERENCE   3  (bases 1 to 4379)
  AUTHORS   Xu,Y., Song,R., Perszyk,R.E., Chen,W., Kim,S., Park,K.L.,
            Allen,J.P., Nocilla,K.A., Zhang,J., XiangWei,W., Tankovic,A.,
            McDaniels,E.D., Sheikh,R., Mizu,R.K., Karamchandani,M.M., Hu,C.,
            Kusumoto,H., Pecha,J., Cappuccio,G., Gaitanis,J., Sullivan,J.,
            Shashi,V., Petrovski,S., Jauss,R.T., Lee,H.K., Bozarth,X.,
            Lynch,D.R., Helbig,I., Pierson,T.M., Boerkoel,C.F., Myers,S.J.,
            Lemke,J.R., Benke,T.A., Yuan,H. and Traynelis,S.F.
  TITLE     De novo GRIN variants in M3 helix associated with neurological
            disorders control channel gating of NMDA receptor
  JOURNAL   Cell Mol Life Sci 81 (1), 153 (2024)
   PUBMED   38538865
  REMARK    GeneRIF: De novo GRIN variants in M3 helix associated with
            neurological disorders control channel gating of NMDA receptor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4379)
  AUTHORS   Ragnarsson,L., Zhang,Z., Das,S.S., Tran,P., Andersson,A., des
            Portes,V., Desmettre Altuzarra,C., Remerand,G., Labalme,A.,
            Chatron,N., Sanlaville,D., Lesca,G., Anggono,V., Vetter,I. and
            Keramidas,A.
  TITLE     GRIN1 variants associated with neurodevelopmental disorders reveal
            channel gating pathomechanisms
  JOURNAL   Epilepsia 64 (12), 3377-3388 (2023)
   PUBMED   37734923
  REMARK    GeneRIF: GRIN1 variants associated with neurodevelopmental
            disorders reveal channel gating pathomechanisms.
REFERENCE   5  (bases 1 to 4379)
  AUTHORS   McNearney,T.A. and Westlund,K.N.
  TITLE     Pluripotential GluN1 (NMDA NR1): Functional Significance in
            Cellular Nuclei in Pain/Nociception
  JOURNAL   Int J Mol Sci 24 (17), 13196 (2023)
   PUBMED   37686003
  REMARK    GeneRIF: Pluripotential GluN1 (NMDA NR1): Functional Significance
            in Cellular Nuclei in Pain/Nociception.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4379)
  AUTHORS   Zimmer,M., Fink,T.M., Franke,Y., Lichter,P. and Spiess,J.
  TITLE     Cloning and structure of the gene encoding the human
            N-methyl-D-aspartate receptor (NMDAR1)
  JOURNAL   Gene 159 (2), 219-223 (1995)
   PUBMED   7622053
REFERENCE   7  (bases 1 to 4379)
  AUTHORS   Younkin,D.P., Tang,C.M., Hardy,M., Reddy,U.R., Shi,Q.Y.,
            Pleasure,S.J., Lee,V.M. and Pleasure,D.
  TITLE     Inducible expression of neuronal glutamate receptor channels in the
            NT2 human cell line
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2174-2178 (1993)
   PUBMED   7681588
REFERENCE   8  (bases 1 to 4379)
  AUTHORS   Karp,S.J., Masu,M., Eki,T., Ozawa,K. and Nakanishi,S.
  TITLE     Molecular cloning and chromosomal localization of the key subunit
            of the human N-methyl-D-aspartate receptor
  JOURNAL   J Biol Chem 268 (5), 3728-3733 (1993)
   PUBMED   7679115
REFERENCE   9  (bases 1 to 4379)
  AUTHORS   Platzer,K. and Lemke,J.R.
  TITLE     GRIN1-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31219694
REFERENCE   10 (bases 1 to 4379)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL929554.20 and D13515.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007327.3.
            
            Summary: The protein encoded by this gene is a critical subunit of
            N-methyl-D-aspartate receptors, members of the glutamate receptor
            channel superfamily which are heteromeric protein complexes with
            multiple subunits arranged to form a ligand-gated ion channel.
            These subunits play a key role in the plasticity of synapses, which
            is believed to underlie memory and learning. Cell-specific factors
            are thought to control expression of different isoforms, possibly
            contributing to the functional diversity of the subunits.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (GluN1-1a, also known as NR1-3)
            represents the longest transcript and encodes protein isoform
            GluN1-1a (also known as isoform NR1-3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13268.1, D13515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371561.8/ ENSP00000360616.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL929554.20        52417-52578
            163-3271            D13515.1           1-3109
            3272-4379           AL929554.20        80912-82019
FEATURES             Location/Qualifiers
     source          1..4379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4379
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /note="glutamate ionotropic receptor NMDA type subunit 1"
                     /db_xref="GeneID:2902"
                     /db_xref="HGNC:HGNC:4584"
                     /db_xref="MIM:138249"
     exon            1..591
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..3150
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /note="isoform GluN1-1a precursor is encoded by transcript
                     variant GluN1-1a; N-methyl-D-aspartate receptor channel,
                     subunit zeta-1; glutamate [NMDA] receptor subunit zeta-1;
                     N-methyl-D-aspartate receptor subunit NR1; glutamate
                     receptor ionotropic, NMDA 1; glutamate receptor,
                     ionotropic, N-methyl D-aspartate 1; putative
                     NMDtranscript(altAcc_e2)"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 1 isoform
                     GluN1-1a precursor"
                     /protein_id="NP_015566.1"
                     /db_xref="CCDS:CCDS7031.1"
                     /db_xref="GeneID:2902"
                     /db_xref="HGNC:HGNC:4584"
                     /db_xref="MIM:138249"
                     /translation="MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFRE
                     AVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHF
                     TPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSW
                     NHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARV
                     IILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKN
                     ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGV
                     TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGY
                     QMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHT
                     VPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSG
                     QADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLV
                     GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAP
                     RSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYA
                     TVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA
                     SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC
                     DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVN
                     VWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKD
                     TVLPRRAIEREEGQLQLCSRHRES"
     exon            592..726
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..903
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1004
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1126
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1301
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1446
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1530
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1672
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1800
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1965
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2084
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2197
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2346
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2504
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2666
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2776
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2922
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3033
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..4379
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4379
                     /gene="GRIN1"
                     /gene_synonym="DEE101; GluN1; hNR1; MRD8; NDHMSD; NDHMSR;
                     NMD-R1; NMDA1; NMDAR1; NR1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgccg cagcgtccgg accggaacca gcgccgtccg cggagccgcc gccgccgccg
       61 ccgggccctt tccaagccgg gcgctcggag ctgtgcccgg ccccgcttca gcaccgcgga
      121 cagcgccggc cgcgtggggc tgagccccga gcccccgcgc acgcttcagc gccccttccc
      181 tcggccgacg tcccgggacc gccgctccgg gggagacgtg gcgtccgcag cccgcggggc
      241 cgggcgagcg caggacggcc cggaagcccc gcgggggatg cgccgagggc cccgcgttcg
      301 cgccgcgcag agccaggccc gcggcccgag cccatgagca ccatgcgcct gctgacgctc
      361 gccctgctgt tctcctgctc cgtcgcccgt gccgcgtgcg accccaagat cgtcaacatt
      421 ggcgcggtgc tgagcacgcg gaagcacgag cagatgttcc gcgaggccgt gaaccaggcc
      481 aacaagcggc acggctcctg gaagattcag ctcaatgcca cctccgtcac gcacaagccc
      541 aacgccatcc agatggctct gtcggtgtgc gaggacctca tctccagcca ggtctacgcc
      601 atcctagtta gccatccacc tacccccaac gaccacttca ctcccacccc tgtctcctac
      661 acagccggct tctaccgcat acccgtgctg gggctgacca cccgcatgtc catctactcg
      721 gacaagagca tccacctgag cttcctgcgc accgtgccgc cctactccca ccagtccagc
      781 gtgtggtttg agatgatgcg tgtctacagc tggaaccaca tcatcctgct ggtcagcgac
      841 gaccacgagg gccgggcggc tcagaaacgc ctggagacgc tgctggagga gcgtgagtcc
      901 aaggcagaga aggtgctgca gtttgaccca gggaccaaga acgtgacggc cctgctgatg
      961 gaggcgaaag agctggaggc ccgggtcatc atcctttctg ccagcgagga cgatgctgcc
     1021 actgtatacc gcgcagccgc gatgctgaac atgacgggct ccgggtacgt gtggctggtc
     1081 ggcgagcgcg agatctcggg gaacgccctg cgctacgccc cagacggcat cctcgggctg
     1141 cagctcatca acggcaagaa cgagtcggcc cacatcagcg acgccgtggg cgtggtggcc
     1201 caggccgtgc acgagctcct cgagaaggag aacatcaccg acccgccgcg gggctgcgtg
     1261 ggcaacacca acatctggaa gaccgggccg ctcttcaaga gagtgctgat gtcttccaag
     1321 tatgcggatg gggtgactgg tcgcgtggag ttcaatgagg atggggaccg gaagttcgcc
     1381 aactacagca tcatgaacct gcagaaccgc aagctggtgc aagtgggcat ctacaatggc
     1441 acccacgtca tccctaatga caggaagatc atctggccag gcggagagac agagaagcct
     1501 cgagggtacc agatgtccac cagactgaag attgtgacga tccaccagga gcccttcgtg
     1561 tacgtcaagc ccacgctgag tgatgggaca tgcaaggagg agttcacagt caacggcgac
     1621 ccagtcaaga aggtgatctg caccgggccc aacgacacgt cgccgggcag cccccgccac
     1681 acggtgcctc agtgttgcta cggcttttgc atcgacctgc tcatcaagct ggcacggacc
     1741 atgaacttca cctacgaggt gcacctggtg gcagatggca agttcggcac acaggagcgg
     1801 gtgaacaaca gcaacaagaa ggagtggaat gggatgatgg gcgagctgct cagcgggcag
     1861 gcagacatga tcgtggcgcc gctaaccata aacaacgagc gcgcgcagta catcgagttt
     1921 tccaagccct tcaagtacca gggcctgact attctggtca agaaggagat tccccggagc
     1981 acgctggact cgttcatgca gccgttccag agcacactgt ggctgctggt ggggctgtcg
     2041 gtgcacgtgg tggccgtgat gctgtacctg ctggaccgct tcagcccctt cggccggttc
     2101 aaggtgaaca gcgaggagga ggaggaggac gcactgaccc tgtcctcggc catgtggttc
     2161 tcctggggcg tcctgctcaa ctccggcatc ggggaaggcg cccccagaag cttctcagcg
     2221 cgcatcctgg gcatggtgtg ggccggcttt gccatgatca tcgtggcctc ctacaccgcc
     2281 aacctggcgg ccttcctggt gctggaccgg ccggaggagc gcatcacggg catcaacgac
     2341 cctcggctga ggaacccctc ggacaagttt atctacgcca cggtgaagca gagctccgtg
     2401 gatatctact tccggcgcca ggtggagctg agcaccatgt accggcatat ggagaagcac
     2461 aactacgaga gtgcggcgga ggccatccag gccgtgagag acaacaagct gcatgccttc
     2521 atctgggact cggcggtgct ggagttcgag gcctcgcaga agtgcgacct ggtgacgact
     2581 ggagagctgt ttttccgctc gggcttcggc ataggcatgc gcaaagacag cccctggaag
     2641 cagaacgtct ccctgtccat cctcaagtcc cacgagaatg gcttcatgga agacctggac
     2701 aagacgtggg ttcggtatca ggaatgtgac tcgcgcagca acgcccctgc gacccttact
     2761 tttgagaaca tggccggggt cttcatgctg gtagctgggg gcatcgtggc cgggatcttc
     2821 ctgattttca tcgagattgc ctacaagcgg cacaaggatg ctcgccggaa gcagatgcag
     2881 ctggcctttg ccgccgttaa cgtgtggcgg aagaacctgc aggatagaaa gagtggtaga
     2941 gcagagcctg accctaaaaa gaaagccaca tttagggcta tcacctccac cctggcttcc
     3001 agcttcaaga ggcgtaggtc ctccaaagac acgagcaccg ggggtggacg cggcgctttg
     3061 caaaaccaaa aagacacagt gctgccgcga cgcgctattg agagggagga gggccagctg
     3121 cagctgtgtt cccgtcatag ggagagctga gactccccgc ccgccctcct ctgccccctc
     3181 ccccgcagac agacagacag acggacggga cagcggcccg gcccacgcag agccccggag
     3241 caccacgggg tcgggggagg agcaccccca gcctccccca ggctgcgcct gcccgcccgc
     3301 cggttggccg gctggccggt ccaccccgtc ccggccccgc gcgtgccccc agcgtggggc
     3361 taacgggcgc cttgtctgtg tatttctatt ttgcagcagt accatcccac tgatatcacg
     3421 ggcccgctca acctctcaga tccctcggtc agcaccgtgg tgtgaggccc ccggaggcgc
     3481 ccacctgccc agttagcccg gccaaggaca ctgatgggtc ctgctgctcg ggaaggcctg
     3541 agggaagccc acccgcccca gagactgccc accctgggcc tcccgtccgt ccgcccgccc
     3601 accccgctgc ctggcgggca gcccctgctg gaccaaggtg cggaccggag cggctgagga
     3661 cggggcagag ctgagtcggc tgggcagggc cgcagggcgc tccggcagag gcagggccct
     3721 ggggtctctg agcagtgggg agcgggggct aactggcccc aggcggaggg gcttggagca
     3781 gagacggcag ccccatcctt cccgcagcac cagcctgagc cacagtgggg cccatggccc
     3841 cagctggctg ggtcgcccct cctcgggcgc ctgcgctcct ctgcagcctg agctccaccc
     3901 tcccctcttc ttgcggcacc gcccacccac accccgtctg ccccttgacc ccacacgccg
     3961 gggctggccc tgccctcccc cacggccgtc cctgacttcc cagctggcag cgcctcccgc
     4021 cgcctcgggc cgcctcctcc agactcgaga gggctgagcc cctcctctcc tcgtccggcc
     4081 tgcagcccag aacgggcctc cccgggggtc cccggacgct ggctcgggac tgtcttcaac
     4141 cctgccctgc accttgggca cgggagagcg ccacccgccc gcccccgccc tcgctccggg
     4201 tgcgtgaccg gcccgccacc ttgtacagaa ccagcactcc cagggcccga gcgcgtgcct
     4261 tccccgtgcg gcccgtgcgc agccgcgctc tgcccctccg tccccagggt gcaggcgcgc
     4321 accgcccaac ccccacctcc cggtgtatgc agtggtgatg cctaaaggaa tgtcacgca
//
