LOCUS       NM_002088               4506 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor kainate type subunit 5
            (GRIK5), transcript variant 2, mRNA.
ACCESSION   NM_002088 XM_005258821
VERSION     NM_002088.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4506)
  AUTHORS   Xie,Z., Ke,Y., Li,Z., Chen,J., Lei,D., Chen,G., Wang,C., Chen,Y.,
            Ding,H. and Cheng,L.
  TITLE     GRIK5 stimulates colon cancer growth and metastasis through
            cAMP/PKA/CADM3 signaling
  JOURNAL   Cell Biol Int 47 (7), 1259-1266 (2023)
   PUBMED   36959746
  REMARK    GeneRIF: GRIK5 stimulates colon cancer growth and metastasis
            through cAMP/PKA/CADM3 signaling.
REFERENCE   2  (bases 1 to 4506)
  AUTHORS   Herbrechter,R., Hube,N., Buchholz,R. and Reiner,A.
  TITLE     Splicing and editing of ionotropic glutamate receptors: a
            comprehensive analysis based on human RNA-Seq data
  JOURNAL   Cell Mol Life Sci 78 (14), 5605-5630 (2021)
   PUBMED   34100982
REFERENCE   3  (bases 1 to 4506)
  AUTHORS   Unlu,G., Gamazon,E.R., Qi,X., Levic,D.S., Bastarache,L.,
            Denny,J.C., Roden,D.M., Mayzus,I., Breyer,M., Zhong,X.,
            Konkashbaev,A.I., Rzhetsky,A., Knapik,E.W. and Cox,N.J.
  TITLE     GRIK5 Genetically Regulated Expression Associated with Eye and
            Vascular Phenomes: Discovery through Iteration among Biobanks,
            Electronic Health Records, and Zebrafish
  JOURNAL   Am J Hum Genet 104 (3), 503-519 (2019)
   PUBMED   30827500
  REMARK    GeneRIF: Low GRIK5 expression is associated with eye diseases.
REFERENCE   4  (bases 1 to 4506)
  AUTHORS   Hong,X., Jeyifous,O., Ronilo,M., Marshall,J., Green,W.N. and
            Standley,S.
  TITLE     A novel function for the ER retention signals in the C-terminus of
            kainate receptor subunit, GluK5
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (3), 459-473 (2019)
   PUBMED   30339823
  REMARK    GeneRIF: Authors present evidence that the ER retention signals in
            the kainate receptors containing GluK5 impose a requirement for
            sorting into local dendritic secretory pathways in neurons, as
            opposed to traversing the somatic Golgi apparatus.
REFERENCE   5  (bases 1 to 4506)
  AUTHORS   Korytina,G.F., Akhmadishina,L.Z., Kochetova,O.V., Aznabaeva,Y.G.,
            Zagidullin,S.Z. and Victorova,T.V.
  TITLE     [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and
            Serotonin Receptor (HTR2A) Genes Are Associated with Chronic
            Obstructive Pulmonary Disease]
  JOURNAL   Mol Biol (Mosk) 51 (4), 603-614 (2017)
   PUBMED   28900078
  REMARK    GeneRIF: The AA genotype of GRIK5 had a protective effect against
            chronic obstructive pulmonary disease.
REFERENCE   6  (bases 1 to 4506)
  AUTHORS   Porter,R.H., Eastwood,S.L. and Harrison,P.J.
  TITLE     Distribution of kainate receptor subunit mRNAs in human
            hippocampus, neocortex and cerebellum, and bilateral reduction of
            hippocampal GluR6 and KA2 transcripts in schizophrenia
  JOURNAL   Brain Res 751 (2), 217-231 (1997)
   PUBMED   9099808
REFERENCE   7  (bases 1 to 4506)
  AUTHORS   Cauley,K., Kukekov,V. and Young,D.
  TITLE     Kainate/AMPA receptors expressed on human fetal astrocytes in
            long-term culture
  JOURNAL   J Neurosci Res 47 (3), 311-321 (1997)
   PUBMED   9039653
REFERENCE   8  (bases 1 to 4506)
  AUTHORS   Swanson,G.T., Feldmeyer,D., Kaneda,M. and Cull-Candy,S.G.
  TITLE     Effect of RNA editing and subunit co-assembly single-channel
            properties of recombinant kainate receptors
  JOURNAL   J Physiol 492 (Pt 1) (Pt 1), 129-142 (1996)
   PUBMED   8730589
REFERENCE   9  (bases 1 to 4506)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
REFERENCE   10 (bases 1 to 4506)
  AUTHORS   Kamboj,R.K., Schoepp,D.D., Nutt,S., Shekter,L., Korczak,B.,
            True,R.A., Zimmerman,D.M. and Wosnick,M.A.
  TITLE     Molecular structure and pharmacological characterization of
            humEAA2, a novel human kainate receptor subunit
  JOURNAL   Mol Pharmacol 42 (1), 10-15 (1992)
   PUBMED   1321949
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022515.5, AC020946.4 and
            AC010616.5.
            
            On or before Feb 10, 2021 this sequence version replaced
            XM_005258821.3, NM_002088.4.
            
            Summary: This gene encodes a protein that belongs to the
            glutamate-gated ionic channel family. Glutamate functions as the
            major excitatory neurotransmitter in the central nervous system
            through activation of ligand-gated ion channels and G
            protein-coupled membrane receptors. The protein encoded by this
            gene forms functional heteromeric kainate-preferring ionic channels
            with the subunits encoded by related gene family members.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3732808.1,
                                           ERR4352444.201206.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593562.6/ ENSP00000470251.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-966               AC022515.5         23650-24615
            967-1095            AC022515.5         28036-28164
            1096-1260           AC022515.5         28469-28633
            1261-1358           AC022515.5         31001-31098
            1359-1524           AC022515.5         31203-31368
            1525-1703           AC022515.5         34329-34507
            1704-1757           AC022515.5         36878-36931
            1758-1919           AC022515.5         37033-37194
            1920-2072           AC022515.5         39384-39536
            2073-2177           AC022515.5         39927-40031
            2178-2285           AC022515.5         40147-40254
            2286-2489           AC022515.5         51101-51304
            2490-2603           AC020946.4         14106-14219
            2604-2713           AC020946.4         14404-14513
            2714-2887           AC020946.4         14986-15159
            2888-3053           AC010616.5         167935-168100       c
            3054-3279           AC010616.5         167013-167238       c
            3280-3408           AC010616.5         164845-164973       c
            3409-3530           AC010616.5         164622-164743       c
            3531-4506           AC010616.5         159614-160589       c
FEATURES             Location/Qualifiers
     source          1..4506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..4506
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /note="glutamate ionotropic receptor kainate type subunit
                     5"
                     /db_xref="GeneID:2901"
                     /db_xref="HGNC:HGNC:4583"
                     /db_xref="MIM:600283"
     exon            1..966
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1095
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1017..3959
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; excitatory amino acid receptor 2; glutamate
                     receptor KA2; glutamate receptor ionotropic, kainate 5;
                     putative NMDtranscript(del_e13-e15); putative
                     NMDtranscript(altDon_e2)"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 5 isoform
                     2 precursor"
                     /protein_id="NP_002079.3"
                     /db_xref="CCDS:CCDS12595.1"
                     /db_xref="GeneID:2901"
                     /db_xref="HGNC:HGNC:4583"
                     /db_xref="MIM:600283"
                     /translation="MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLAL
                     ALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPAS
                     ASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS
                     ASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDA
                     NASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF
                     YPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLAC
                     TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWY
                     SNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDM
                     LRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREK
                     VIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAAR
                     LSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW
                     WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSR
                     YQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIG
                     GLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKG
                     LGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCR
                     KTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPG
                     PPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAG
                     PRELAEHE"
     exon            1096..1260
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1358
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1524
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1703
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1757
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1919
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2072
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2177
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2285
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2489
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2603
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2713
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2887
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3053
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3279
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3408
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3530
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..4506
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4483..4488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /note="hexamer: AATAAA"
     polyA_site      4506
                     /gene="GRIK5"
                     /gene_synonym="EAA2; GluK5; GRIK2; KA2"
                     /note="major polyA site"
ORIGIN      
        1 actgcgctcc aggacccagc gcaggcggca ggcgggcagg caggcggcgg cctcggaggg
       61 gagactgagc ggtggcggca gccagcggca gggaggcagg cccagccggg gactggagcc
      121 ggggactgga gccggctcct cacaggggac caggagtgtg tcgccaggcc ctcccactga
      181 ggcccagcac cgggagcccc tgggacaccc caccctcctc cgcctttctc ttccacctgc
      241 tcctctccat cctcctctcc ctcctcccta tctctccacc tcatttgccc ccttcttggc
      301 ctctccgggt ctcccagctc tccatcctcc ccagctctcc actcccgggc tctccccgcc
      361 cccagcatgc ttttcccgtg ggggctgagg gcttgaggac tccgggccct tgcctcaacc
      421 agggcagggc ccaggctcca ggggggaggg ggaaaggggg cggccccctc ccccagcagg
      481 ccctcccctc ccccacttct cctgatggcc ggcttccttt tctccaccca gtcctcgccc
      541 cctgtggccc ccccaggccg gcccggctag gggagggggc gggggccctt tcctgggcca
      601 gcttccccct cccccggctt tgcctgtgcc ccccccttcc gttttcacct tcctctcctc
      661 ctttcctccc tccttcccct ccatttgctc cttccccctc tcctctctcc ccttctctcc
      721 tccattttct cctttcccct tcctcccctc cccggcccgc cctctcctct tccacctgtc
      781 cttcctccct gctcctgtgg agccaccgtt ttggattagt tgggagccac caccggcggc
      841 gggggagggg gccctgtgga ctgccctctc cccccgccca gccccaccac cacccagcgc
      901 cagagcacct cccgctgtcg gtcttcgggc ctcgagggag cccagccctc cgtcccacca
      961 ggatccgtgg cgagtggggg ccgcggcagc tgcgtcccca tgaggagggg aggaagatgc
     1021 cggctgagct gctgctgctg ctgattgttg ccttcgccag ccccagctgc caggtgctct
     1081 catcactgcg catggctgca atcctggatg atcagacagt gtgtggccgc ggtgagcgtc
     1141 tggccttggc cttggcccgg gagcagatca acgggatcat cgaggtccca gccaaggccc
     1201 gagtggaagt agacatcttt gagctgcagc gggacagcca gtacgagacc acggacacca
     1261 tgtgtcagat cttacccaaa ggggttgtgt ctgtccttgg gccctcctct agcccagcat
     1321 ctgcctccac cgtgagccat atctgtggag agaaggagat cccccacatc aaggtgggtc
     1381 ccgaggagac accccgcctt cagtaccttc gcttcgcgtc tgtcagcctg taccccagta
     1441 acgaggacgt cagcttggcg gtctcccgaa tcctcaagtc cttcaactac ccctcggcca
     1501 gcctcatctg cgccaaggct gagtgcctgc tgcgattgga ggaactggtg cgtggcttcc
     1561 tcatctccaa ggagacgctg tcagtgagga tgttggacga cagccgggac cccacaccac
     1621 tgctcaagga gatccgtgat gacaaggtgt ccaccatcat catcgacgcc aacgcctcca
     1681 tctcccacct catcctccgt aaggcctcgg aactgggaat gacctcagcg ttttacaagt
     1741 acatcctcac caccatggac ttccccatcc tgcatctgga cggtattgtg gaggactcct
     1801 ccaacatcct gggcttctcc atgttcaaca cgtcccaccc cttctaccct gagtttgtcc
     1861 gcagcctcaa catgtcctgg agggagaact gtgaagccag cacctacctg ggccctgcgc
     1921 tgtcagccgc cctgatgttt gacgccgtgc acgtggtggt gagcgctgtc cgagagctga
     1981 accgcagcca ggagatcggt gtgaagcctc tggcctgtac atcggccaac atttggcccc
     2041 acgggaccag cctcatgaac tacctgcgca tggtagagta tgatgggctg accgggcggg
     2101 tcgagttcaa cagcaaaggg cagagaacca actacaccct gcgcatccta gaaaagtccc
     2161 ggcagggcca ccgtgagatt ggggtgtggt actctaaccg caccctggcc atgaatgcca
     2221 ccaccctgga catcaacctg tcgcagacac tggccaacaa gaccctggtg gtcacaacca
     2281 tcctggagaa cccatacgtc atgcgccggc ccaacttcca ggccctgtcg gggaacgaac
     2341 gcttcgaggg cttctgcgtg gacatgctgc gggagctggc cgagctgctg cgcttccgct
     2401 accgcctgcg gttggtggag gatgggctgt acggggcgcc cgagcccaac ggctcctgga
     2461 cgggcatggt tggcgagctc atcaaccgga aggcagacct ggctgtggcc gccttcacca
     2521 tcacagctga gcgggagaag gtcatcgact tttccaagcc ctttatgacc ctggggatca
     2581 gcatcctcta ccgagtgcac atgggccgca agcctggcta cttctccttc ctggacccct
     2641 tctcccctgc tgtgtggctc ttcatgcttc ttgcctacct ggctgtcagc tgcgtcctgt
     2701 ttctggctgc caggctgagc ccctatgagt ggtataaccc acacccatgc ctgcgggcac
     2761 gcccccacat cctggagaac cagtacacgc tgggcaacag cctgtggttt cccgtggggg
     2821 gcttcatgca gcagggctcg gagatcatgc cccgggcgct gtccacgcgc tgtgtcagcg
     2881 gagtctggtg ggccttcacc ttgatcatca tctcctccta cacggccaac ctggccgcct
     2941 tcctcaccgt gcagcgcatg gaggtgcctg tggagtcggc cgatgacctg gcagatcaga
     3001 ccaacatcga gtatggcacc atccacgccg gctccaccat gaccttcttc cagaattcac
     3061 ggtaccaaac gtaccagcgc atgtggaact acatgcagtc gaagcagccc agcgtgttcg
     3121 tcaagagcac agaagagggc attgcccgcg tcctcaactc ccgctacgcc ttcctgctcg
     3181 agtccaccat gaacgaatac caccggcgcc tcaactgcaa cctcacccag atcgggggac
     3241 tcctcgacac caagggctac ggcattggca tgccgctggg ctccccgttc cgggatgaga
     3301 tcacactggc catcctgcag cttcaggaga acaaccggct ggagatcctg aagcgcaagt
     3361 ggtgggaggg gggccggtgc cccaaggagg aggaccatcg agctaaaggt ttgggcatgg
     3421 agaacattgg tggcattttt atcgtgctca tctgtggcct catcattgct gtcttcgtgg
     3481 cggtcatgga attcatatgg tccacacgga ggtcagctga gtccgaggag gtgtcggtgt
     3541 gccaggagat gctgcaggag ctgcgccacg ccgtttcttg ccgcaagacg tcgcgttccc
     3601 gccggcgccg acgcccgggc ggcccgagcc gggccctgct gtcactgcgc gcggtccgcg
     3661 agatgcgcct cagcaacggc aagctctact cggccggcgc gggcggggat gcgggcagcg
     3721 cgcacggggg cccgcagcgc ctcctggacg acccggggcc ccccagcgga gcccgacccg
     3781 ccgcccccac cccctgcacc cacgtgcgcg tctgccagga gtgccggcgc atccaggcgc
     3841 tgcgggcctc gggggccggc gcgcctccgc gtggcctggg cgtccccgcc gaagccacca
     3901 gcccgccccg gccgcggcct ggccccgccg gcccccggga gctggcggag cacgagtgac
     3961 cacgggcggg gctgtgcggg cgcccggact gaccgaaggg acggggcccg ccccaggccc
     4021 cagcagtctc cgctcccgca gcgggcgcgg gacaggactt gtgcgccggc gccccggacg
     4081 ccgcgatttt gcctttggtt ccccgcgaag tccgaggcct ggctctggag cccgcctgcg
     4141 ccccccagtg gactcgcgag agggtgccgc gggcgagaag ggcgcaggaa ccgaggactc
     4201 caggggctgg ggacttcggg ggcggctctg ggaagcggaa agcagtcagc ggagaggacc
     4261 ccattctggg actgctcagg ctccccaaga cttgacgcag ccccccacgc ttctggaggt
     4321 ggggagggcc tctggacaga tgggtgtccc ctggtgcccc tccactcttc tcttcctctc
     4381 ttttttgggg ggagaaacct cggaatttct atgagacctc ccccagggag ggggtcagtt
     4441 gggcccccat ccctcccctt gccacatcgc agcccctgtt ggaataaaaa aaagaacaaa
     4501 acccca
//
