LOCUS       NM_000831               9491 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor kainate type subunit 3
            (GRIK3), mRNA.
ACCESSION   NM_000831
VERSION     NM_000831.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9491)
  AUTHORS   Fang,G., Wu,Y. and Zhang,X.
  TITLE     CircASXL1 knockdown represses the progression of colorectal cancer
            by downregulating GRIK3 expression by sponging miR-1205
  JOURNAL   World J Surg Oncol 19 (1), 176 (2021)
   PUBMED   34127015
  REMARK    GeneRIF: CircASXL1 knockdown represses the progression of
            colorectal cancer by downregulating GRIK3 expression by sponging
            miR-1205.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9491)
  AUTHORS   Xiao,B., Kuang,Z., Zhang,W., Hang,J., Chen,L., Lei,T., He,Y.,
            Deng,C., Li,W., Lu,J., Qu,J., Zhou,Q., Hao,W., Sun,Z. and Li,L.
  TITLE     Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3)
            promotes epithelial-mesenchymal transition in breast cancer cells
            by regulating SPDEF/CDH1 signaling
  JOURNAL   Mol Carcinog 58 (7), 1314-1323 (2019)
   PUBMED   30977227
  REMARK    GeneRIF: Mechanically, GRIK3 influenced a range of signaling
            pathways and key signal transducers, including two
            epithelial-mesenchymal transition regulators, SPDEF and CDH1.
            Moreover, overexpression of GRIK3 increased the expression of
            mesenchymal markers and decreased the expression of epithelial
            markers, resulting in the translocation of beta-catenin into the
            nucleus and the increased beta-catenin transcriptional activity.
REFERENCE   3  (bases 1 to 9491)
  AUTHORS   Gong,B., Li,Y., Cheng,Z., Wang,P., Luo,L., Huang,H., Duan,S. and
            Liu,F.
  TITLE     GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph
            node metastasis, and poor prognosis of GC
  JOURNAL   Tumour Biol 39 (6), 1010428317704364 (2017)
   PUBMED   28631555
  REMARK    GeneRIF: additional experiment showed that the lymph node
            metastasis tissues had higher GRIK3 expression than their matched
            primary gastric cancer (GC) tissues. These findings suggested that
            elevated GRIK3 expression could serve as an independent prognostic
            biomarker and a novel potential treatment target for patients with
            GC.
REFERENCE   4  (bases 1 to 9491)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: GRIK3 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 9491)
  AUTHORS   Takenouchi,T., Hashida,N., Torii,C., Kosaki,R., Takahashi,T. and
            Kosaki,K.
  TITLE     1p34.3 deletion involving GRIK3: Further clinical implication of
            GRIK family glutamate receptors in the pathogenesis of
            developmental delay
  JOURNAL   Am J Med Genet A 164A (2), 456-460 (2014)
   PUBMED   24449200
  REMARK    GeneRIF: 1p34.3 deletion involving GRIK3: Further clinical
            implication of GRIK family glutamate receptors in the pathogenesis
            of developmental delay.
            Review article
REFERENCE   6  (bases 1 to 9491)
  AUTHORS   Ripellino,J.A., Neve,R.L. and Howe,J.R.
  TITLE     Expression and heteromeric interactions of non-N-methyl-D-aspartate
            glutamate receptor subunits in the developing and adult cerebellum
  JOURNAL   Neuroscience 82 (2), 485-497 (1998)
   PUBMED   9466455
REFERENCE   7  (bases 1 to 9491)
  AUTHORS   Flor,P.J., Van Der Putten,H., Ruegg,D., Lukic,S., Leonhardt,T.,
            Bence,M., Sansig,G., Knopfel,T. and Kuhn,R.
  TITLE     A novel splice variant of a metabotropic glutamate receptor, human
            mGluR7b
  JOURNAL   Neuropharmacology 36 (2), 153-159 (1997)
   PUBMED   9144652
REFERENCE   8  (bases 1 to 9491)
  AUTHORS   Roche,K.W., Raymond,L.A., Blackstone,C. and Huganir,R.L.
  TITLE     Transmembrane topology of the glutamate receptor subunit GluR6
  JOURNAL   J Biol Chem 269 (16), 11679-11682 (1994)
   PUBMED   8163463
REFERENCE   9  (bases 1 to 9491)
  AUTHORS   Nutt,S.L., Hoo,K.H., Rampersad,V., Deverill,R.M., Elliott,C.E.,
            Fletcher,E.J., Adams,S.L., Korczak,B., Foldes,R.L. and Kamboj,R.K.
  TITLE     Molecular characterization of the human EAA5 (GluR7) receptor: a
            high-affinity kainate receptor with novel potential RNA editing
            sites
  JOURNAL   Recept Channels 2 (4), 315-326 (1994)
   PUBMED   7719709
REFERENCE   10 (bases 1 to 9491)
  AUTHORS   Puranam,R.S., Eubanks,J.H., Heinemann,S.F. and McNamara,J.O.
  TITLE     Chromosomal localization of gene for human glutamate receptor
            subunit-7
  JOURNAL   Somat Cell Mol Genet 19 (6), 581-588 (1993)
   PUBMED   8128318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355386.9, DR003075.1,
            AJ249210.1, U16127.1, AW898512.1, AC117945.2, BG818719.1,
            DT217951.1, BQ446793.1 and BG057125.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000831.3.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. It is not certain if the subunit encoded by this gene is
            subject to RNA editing as the other 2 family members (GRIK1 and
            GRIK2). A Ser310Ala polymorphism has been associated with
            schizophrenia, and there are conflicting reports of its association
            with the pathogenesis of delirium tremens in alcoholics. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.159793.1, U16127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373091.8/ ENSP00000362183.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AL355386.9         26643-26914
            273-396             DR003075.1         185-308
            397-2972            AJ249210.1         11-2586
            2973-3172           U16127.1           2584-2783
            3173-3419           AW898512.1         247-493
            3420-8076           AC117945.2         33369-38025         c
            8077-8793           BG818719.1         1-717
            8794-9010           DT217951.1         467-683
            9011-9486           BQ446793.1         13-488              c
            9487-9491           BG057125.1         7-11                c
FEATURES             Location/Qualifiers
     source          1..9491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..9491
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /note="glutamate ionotropic receptor kainate type subunit
                     3"
                     /db_xref="GeneID:2899"
                     /db_xref="HGNC:HGNC:4581"
                     /db_xref="MIM:138243"
     exon            1..522
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..3167
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /note="excitatory amino acid receptor 5; glutamate
                     receptor 7; dJ1090M5.1 (glutamate receptor, ionotropic,
                     kainate 3 (GLUR7)); gluR-7; glutamate receptor ionotropic,
                     kainate 3"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 3
                     precursor"
                     /protein_id="NP_000822.2"
                     /db_xref="CCDS:CCDS416.1"
                     /db_xref="GeneID:2899"
                     /db_xref="HGNC:HGNC:4581"
                     /db_xref="MIM:138243"
                     /translation="MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEY
                     ADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQL
                     ALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLS
                     HAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLL
                     KEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSG
                     VNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVS
                     VCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL
                     DIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR
                     KSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELI
                     DHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIW
                     MYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQ
                     GSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI
                     EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMES
                     TTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
                     WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQR
                     SFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSL
                     APVFP"
     exon            523..699
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            700..957
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1139
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1193
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1367
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1511
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1619
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1733
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1937
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2161
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2280
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2498
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2721
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2972
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..9491
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9467..9472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /note="hexamer: AATAAA"
     polyA_site      9491
                     /gene="GRIK3"
                     /gene_synonym="EAA5; GLR7; GluK3; GLUR7; GluR7a"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgagccc gggcgatagc atcggcggcg gctggaggag gagcggccgg agacgcgtgc
       61 agcccgcccg ccagagcccg gcagccgggg caggtgggag cccgcgcggg agccgagccg
      121 acgcgagtcg gagccggagc cgagtccgag cggagtccgg gcggagccca ggagcctcgc
      181 tcgcgggcag cccgtgggcg gcagccaggc ggggcgggcg ccggcggggc ggccccccag
      241 taagatgtgc gcggcgccgc ggggcgcccc ccacttgcag cggcgctcgg gagccgggcg
      301 gctgggccag gcggcgcctt cggggctgct gcgcgcccgc gcctagagct gccgccccag
      361 ggagcccgcc acggccgcgc cccgggcacg ctcggcggcg cccaacgatg accgctccct
      421 ggcggcgcct ccggagtctg gtttgggaat actgggccgg gctcctcgtg tgcgccttct
      481 ggatcccgga ctcgcgcggg atgccccacg tcatccggat cggaggaatc ttcgagtatg
      541 cggacggccc caacgcccag gtcatgaatg ccgaggagca tgcctttcga ttttctgcca
      601 acatcatcaa caggaacagg actctgctgc ccaacacaac cttgacctat gacatacaga
      661 ggattcactt ccatgacagc ttcgaggcga ccaaaaaggc ctgtgaccag ctggcactgg
      721 gcgtggtggc gatcttcggc ccatcacagg gctcctgcac caatgccgtc cagtccatct
      781 gcaatgccct ggaggtgccc cacatccagc tgcgttggaa gcaccacccg ctggacaaca
      841 aggacacctt ctacgtgaac ctctaccccg actacgcctc gctcagccat gccatcctcg
      901 acctggtcca gtacctcaag tggcggtcag ccaccgtggt ctatgacgac agtacagggc
      961 tcatccgact gcaggagctc atcatggccc catcaagata caacatccgc ctgaagatcc
     1021 gtcagctccc catcgactct gacgactcgc gccccttgct caaggagatg aagcgaggcc
     1081 gggaattccg cattatcttc gactgcagcc acactatggc ggcccagatc ctcaagcagg
     1141 ccatggccat gggcatgatg actgagtact accacttcat cttcaccact ctggatctct
     1201 acgctttaga cctggagccc taccgctact caggcgtgaa cctgacagga ttccggattc
     1261 tcaatgtgga caacccacac gtctcggcca ttgtggagaa gtggtccatg gagcggctgc
     1321 aggcagctcc ccggtccgag tctggcctgc tggatggagt gatgatgact gatgcagcct
     1381 tactgtacga cgccgtccat atcgtgtccg tgtgctacca gcgggcacca cagatgaccg
     1441 tgaactccct gcagtgccat cggcacaagg cctggcgctt tggcggccgc ttcatgaact
     1501 tcatcaagga ggctcaatgg gaaggattaa ctggacgaat tgttttcaac aaaactagtg
     1561 gcttgcggac ggattttgat ctggacatca tcagcctgaa agaggatggc ctggagaagg
     1621 ttggggtgtg gagtcctgcc gacgggctca acatcactga ggttgccaaa ggccgaggcc
     1681 ctaatgtcac cgactctctg acaaacagat cactcattgt caccacagtg ctggaggagc
     1741 ccttcgtcat gtttcggaaa tcagacagga cgctatacgg gaatgaccgg ttcgagggct
     1801 actgcatcga cctgctaaag gagctggccc acatccttgg tttctcctat gagatccggc
     1861 tggtggagga cggcaagtac ggggcacagg atgacaaggg ccagtggaac ggcatggtca
     1921 aggagctcat cgaccacaag gcagatctgg ccgtggcccc cctgaccatc acccatgttc
     1981 gagagaaggc catcgacttc tccaagccct tcatgacact tggtgtgagc atcctgtatc
     2041 gaaagcccaa tggcaccaac cccagcgtct tctccttcct caatcccctg tccccagaca
     2101 tctggatgta tgttctcctc gcctacctgg gggtcagctg tgtcctcttc gtcatcgcca
     2161 ggttcagccc ttatgagtgg tacgatgctc acccctgcaa ccctggctcc gaggtggtgg
     2221 aaaataactt cactctgctt aacagcttct ggtttggaat gggatccctg atgcagcaag
     2281 ggtctgagct gatgcccaaa gccctgtcca cacgcatcat tggtggcatc tggtggttct
     2341 tcacgctcat catcatctct tcctacacgg ccaacctggc tgcctttctg accgtggagc
     2401 gcatggaatc acccattgac tctgctgatg acctggccaa gcaaaccaaa atcgagtatg
     2461 gggctgtcaa ggatggggcc accatgacct tcttcaagaa atccaagatc tccaccttcg
     2521 agaagatgtg ggccttcatg agcagcaagc catcggcgct ggtgaagaac aacgaggagg
     2581 gcatccagag ggccctgacg gccgactacg cgctgctcat ggagtccacc accatcgagt
     2641 acgtcacgca gaggaactgc aacctcaccc agatcggggg cctcattgac tccaagggct
     2701 acggcatcgg cacgcccatg ggctccccat accgggacaa gatcaccatc gccatcctgc
     2761 agcttcagga ggaggacaag ctgcatatca tgaaggagaa gtggtggcgg ggcagcgggt
     2821 gtcctgagga ggaaaacaaa gaggccagtg ccctggggat ccagaagatc gggggcatct
     2881 tcattgtcct ggccgccggg ctggtcctct ctgtgctggt ggccgtgggc gagtttgtgt
     2941 acaagctccg caaaacagca gagagagagc agcgttcctt ctgcagcacc gtggccgatg
     3001 agatccgttt ctcccttacc tgccagcgtc gagtcaagca caagcctcag cctcccatga
     3061 tggtcaagac tgacgccgtc atcaacatgc acacattcaa tgaccgccgg cttcccggca
     3121 aggacagcat ggcctgcagc acatccttag cccctgtgtt cccctaggca cagctggggt
     3181 ggggacctca ggcctggggg ctgggcagag gaaagcaaag gagattggaa ggaacgtccc
     3241 ctgtccccgc actgggcttg gggaccagag ctgccacctg cctgttgggc caggagcctc
     3301 ctgcccttac ctgccaggaa gccagcaggc tctcaggcca gctgcttggg cttcatcctc
     3361 ctcagatctt ctgtgggttt ctaaagctgc cagccgagat agccaaggcc aaaggaagca
     3421 catgcctctc tcaggccaaa ctcacctgcc cctcaactct cctccagagt cagaagtttc
     3481 tgccgcagcc ctgcagaggg cacagaaaat ggaagacagc tcttatattg ccatttcttc
     3541 cacaagagcc caggcctcct acagcttgac cgtgaggcca gagacacaag ccttcggcgc
     3601 cttaaggatg ttctagcatg gctgccaatg ggagctcatg gtgagggata cccatcccat
     3661 atgcctgggc agaaggaaga cttcatccct ctggggctgt tcacgtggtc ctaatcttct
     3721 gaacttggcg ctgcccctgg cagcccctgt tctggcagag ttgaagacag agctacacag
     3781 gggaaaagag gagtttgggg tatgggagag aagagaatgc acaaacagag gccgccattt
     3841 tggattctta tggacaatga cccagtggtt cctaatcctc taggaggtct ctaagaatat
     3901 aagtggggga gtggccacag aaaattcttc tccactttct agccagagga gagaggaccc
     3961 cctgaatttc tcacaaagga tgcccaaaga tgcagccggt atttgaagcc cagcagagga
     4021 aaagcagatt ccatggaagt cccaccggct cttgtgccaa tggatctcac tttcctggtt
     4081 agcaagctgt tgtctaaacc ctgttcacat ttggaaacct gggctctttg ccatcttctc
     4141 atcaacaact ccccattcct ggctggttga ccttggcctc actctgtctt tttgaaagaa
     4201 gagttggttg aagtgaaagt caagttgtcc ctcctcaaaa aaggagttag tgtcctacta
     4261 cacagactaa ctttgggcta ggtgagggaa accagaagag accaaaagaa cttctggtct
     4321 cctggactta ccaaacctag agatgctccc caggaaaaga aagtttccag ggacataata
     4381 tcatagctgg cagaggcccc aagggtgggg aggaagaagc tgcctcctgg agaattaacc
     4441 aaagacccca cacagagaca tgaggccatc ctggcccctt gtctgttgtc cagagcagct
     4501 atggcattgt ggggcttggg gaagacagca gagaagtagc agcaggttgg gtaccagcca
     4561 gggggtggac ctatgagttc cagcttgctg tgatgaatgc tctagaggtc tgtgacttta
     4621 agagtcttgg aaaagaatga gacatgaagg attaggaaca aagtgtcctt aaagagaaca
     4681 tgatgggcca gcagggttac catggccaag gatggagggg caggttttga acaggggagg
     4741 gaggttctgg ggattctgga tgagaactgg ggcataccag ccactcccct cccacctctg
     4801 tcccatgctg cttgggaagc ccggttaggg aagagcttca tttggatctc aagggctttc
     4861 tcatctgggt gaagggcaat ctctagcaaa gcaggagacc acagtgggct catgtgataa
     4921 acactgtccc tcctccagac tgtgagctgc aggaccaaac cagcaggttc ccagaatcct
     4981 agcagctctg actggctatg tacattggac gagggagagg agggctagac atacaccaaa
     5041 gccccatgca tgtaatgtta ggaaaagcca tgctgtcata agcttcaggg tacagagggc
     5101 gtgtgcatgt gtgtctgtgt ctttgtgttt gtatgtgtga gcttcggggg ctggggcaca
     5161 ggacagatct ggacatataa catagtccag ggcatgcaat aataggtgaa tccttgggga
     5221 tctgatgtgt gcatatgcgt gcgtatgtgt atctgagtga attggggacg agggagacaa
     5281 atatgtgaag cagcaaggcc ccatatatgt aaaaacagga gaagccatgt cataatgggg
     5341 ccctggtggg tatgcatatg taagcatgca tgcatgcata ggtgtgtgca tgctggtgtg
     5401 tgtgtgtgca catgtacact gaatggcata ggatggagat caggatctta cctgcagcta
     5461 gccaaatatg cgtaaaagga gaagccatgt caccaagggg tccatgtctg agtgcatgtg
     5521 aacacatgtg tacaggcatg tgtgcacagt ggggagcggg gggaaggcca ggaccagaga
     5581 gtcgtgtgac atgggtcaat gcatgctgta gacaagaagc cacgtggagt tgaagtttcc
     5641 gagtgtgtgg gacacacaca tatgttccag gtcacagtgg aagcaaagac agacaatcag
     5701 gaaggccggg caccagggtc tgtttgcact tctgtcatgg gagagatcat ttgtcacaga
     5761 gaggttccaa ggttgcatgg gcacacttgc caggagacgg gggcacaacc cttcaggggc
     5821 tcatgctgct gatgcctttg ctgtggacat catgtcctgt ttgaagggaa aactcttttt
     5881 tgtaattccc aggtaacagg attctaatga aggtatttgc caatttgctg tcagcaaaca
     5941 caatcattaa gcgccgtctt actttgtcca gtatagtttc agagcacgtg cctcattctt
     6001 gctcttgtct cacacatgtg ttgtgtgtgt gatgctacat gagcatgttc ttcagaggct
     6061 atgcatatat gtggattgtg acaggaggaa gaagaagtgg tgagaatttt tataaaacga
     6121 acaaagaata gtggataaat agaggcagaa ttcaattcga gaaacccccc aaaatgtacc
     6181 gactggtctt tagactcctg tgtggaagca ggagggcatg ctgcctcatc tcctctccca
     6241 ggcaaacctt gcgtcctgat gttcaggtgt tgtcggtgtg gctgatattt ggcttctggc
     6301 caatatcctg catttgtcct agagaccagc ctagtgttca aagtgcagtg gggaccacag
     6361 ctgcccaagc atgagctctg tctctcccgg ggcactgaaa atgatgctac atctgtgagg
     6421 tgggacggag tggggaggtg ttttcagtga ggcagatctt gtgttttttt aagtttaggt
     6481 ctgtcctgcc agtgggcatg gagctgagct ggggcaggtg catgcgtgtg tgtgtatgtg
     6541 tgtgtatgca tgtgtagtgt gtgtgcacac acgcaggcac tgagaggtga tgggaagcat
     6601 gaaagcttgc ttggatggag cagaagaagg aacctgcctg agcagatgct ggactgtccc
     6661 tgcgtggtgc cacatgccag ccctgaacag aagaatgtcc ccactgcatc cccaaatgca
     6721 agtgcctcct ctccacctgc tcaagctggc caagttgagg ggcagtggta agaagacacc
     6781 aaccccaccg cccctgccga ggccctggga ctaaggacag tgagccctcc caatcactct
     6841 ccccttgtcc tgctgctggt ttctctgctc tggacagaag aaaatcctga aagcgttgtc
     6901 aatgttcaag tggccccatg ctgcaagagt ctctcgcgag gggtgacgcc cccttggcca
     6961 gtgtgctgga ctttgagtgt ctgaggggta agagggccac cccctcctca cagccgagac
     7021 tctatctaac ctggaagcac actctggctc cacccccaac ccctgccatg ccctaggccc
     7081 tggaagatgg gaatcctggc ccaggccagg gtaaagggcc aaacaggtta gaagttgctc
     7141 ccctccacca ggcgtgcact caccaagaac gatcaaaagc tccctttctg cctacttttc
     7201 caggggtact gggtgtgggg ggtgggtcac agctcctgct tcatcactca gcatgaagtt
     7261 ggtccctccc tgagccactc ccagctacat gcacaaacat ctgaaagtag gctggcctct
     7321 ctggctcaca tctggagtgg tcctgtgtgg atacccatct gcaaaggggc tagaggtttg
     7381 gacaaacagc tgcatggact tatcatctgg gatgggccca gcctcatgga cagatacaag
     7441 aaatgagccc aactctgtgg gcaggtctct ggattagaca catctgaaag ttgcaggtca
     7501 agtggacaca tctggaagtg gcccggctgc tggctgccat ggaagggccg tgccctctgt
     7561 ccccatggca gtttaaatca ggccttccct tcagtcctgg atttgccctg gagtaaaaat
     7621 ttcagagctg aggtcatacg tgagtcacaa aacttttagg tagaaggtta atgttctgta
     7681 caatatatat atgaatgtaa aatatatata tatactgtat atatatatat atatgcacag
     7741 tgtatatatg acctgtagcc catgtgtata caaccctttc ctgcacgtct gcacacggag
     7801 tgtacagaac ccagccagca cgggtgagga ccagatgaga gatgggggct gcagcagcaa
     7861 agtctgggac ggaggtctca gagagcccct tggggtggcg aaggccctcc acacatcaga
     7921 gctccagacc ctgaagaaga gggcagagct acatggtgct gccaggtgag tcctgcaccg
     7981 ccagggcctc ctgtgggagg ggcaggaatg gccaacggac ctcatctcca tccgagcctg
     8041 tctgaggcag gacagctggg tgtgtctgag aagcaatgtc atgctagtac tcagcccctg
     8101 tgccaatatt acattctagt tctggggcaa ttcatcagga gcagaagggc tgggaaagag
     8161 caggccactc cccaggcctg ttctcacacc tgcctgcaga atcacaggta ggtttcaggc
     8221 tccatctagg ataccctaga aggcggggct attctaggta gcaaaagcct ctgcctctga
     8281 ttctcaccca catgcagaag cagtcacaac ttgcacacaa cacagctcac aactagggaa
     8341 agcacttgtt aaagagaatg cccccagggc atggccagca tgccgataca gtgttcccat
     8401 gcccctgtta ctgatcctgt cctcctgcct tctagaacag tggacctcac atcacctccc
     8461 agattgtctc cattttatgg attgaaactc tgaggcctcc agacatgaag aagcagccat
     8521 agattcagtc aaatgccagc caagggtttg ccttgcctca gacaacctcc ccagccccat
     8581 ttgacccaga gaccagctgt cagggagcga cctcagagcc agaggggtga aagatgagag
     8641 gcaagaaggt agctcctatc ctagcacagc ccaggctcca tctgtctgcc tttctctccc
     8701 ctgcggcatc ctggcagggc agttggcaga gtgccccctc cccaggaggc tgcagatctc
     8761 tgtccctggc tcacccagat cggtctgttc tctgcagttc cattccttta gcctctttcg
     8821 caggtctgag catctctgga gcatgcaggg gaggagatat ctgaggtggg cttccgtgca
     8881 gtcagcagcc tgccccagct tcagcctcag gcgtcaggct ggtctgcact gaactctggg
     8941 tctgcctctg gggccctgac caagcacgcc tgactccagc cccatgagga gcatcctgtc
     9001 ttggttccgt agggatcatg ggtcctctta ccactgtgcg ccaagccccc agcccacctc
     9061 tgcctgggcc gacttcctgg ttgggcctcc catggtaggg gcctcagttc ccaggctctg
     9121 ggctgagccc ccagggagca ccatgggcct ctgagaccct agacctgtcc caccacccag
     9181 accagagtgc ctggacgccc cccactccca ctcaacatgg ttcccacaca ctggtctctg
     9241 ggccattcag gggatgccct ttgtggacat gcagaatttc tatgaatata gttttttgta
     9301 aacattttgt aacaatttgg gtttcatagt aactgtgtta cttgccaatc attctaggct
     9361 gatgtaaata aatttccaaa caaatctgat tattttcctt tttaagacac tgtgatatat
     9421 caaagtgcac agtttgctgt atgaagtaat atggttttaa attttaaata aaatgtttct
     9481 agaaaacagg g
//
