LOCUS       NM_021956               4722 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens glutamate ionotropic receptor kainate type subunit 2
            (GRIK2), transcript variant 1, mRNA.
ACCESSION   NM_021956 XM_005266945
VERSION     NM_021956.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4722)
  AUTHORS   Peng,J., Zhang,Q., Lin,F., Ke,C., Deng,W., Yang,A. and Su,X.
  TITLE     Epigenetic signature discriminates lymphatic metastasis in BRAF
            wild-type thyroid carcinoma: methylation role of GRIK2
  JOURNAL   Epigenomics 15 (21), 1101-1119 (2023)
   PUBMED   37990886
  REMARK    GeneRIF: Epigenetic signature discriminates lymphatic metastasis in
            BRAF wild-type thyroid carcinoma: methylation role of GRIK2.
REFERENCE   2  (bases 1 to 4722)
  AUTHORS   Gorlewicz,A., Barthet,G., Zucca,S., Vincent,P., Griguoli,M.,
            Grosjean,N., Wilczynski,G. and Mulle,C.
  TITLE     The Deletion of GluK2 Alters Cholinergic Control of Neuronal
            Excitability
  JOURNAL   Cereb Cortex 32 (14), 2907-2923 (2022)
   PUBMED   34730179
  REMARK    GeneRIF: The Deletion of GluK2 Alters Cholinergic Control of
            Neuronal Excitability.
REFERENCE   3  (bases 1 to 4722)
  AUTHORS   He,L., Sun,J., Gao,Y., Li,B., Wang,Y., Dong,Y., An,W., Li,H.,
            Yang,B., Ge,Y., Zhang,X.C., Shi,Y.S. and Zhao,Y.
  TITLE     Kainate receptor modulation by NETO2
  JOURNAL   Nature 599 (7884), 325-329 (2021)
   PUBMED   34552241
  REMARK    GeneRIF: Kainate receptor modulation by NETO2.
REFERENCE   4  (bases 1 to 4722)
  AUTHORS   Stolz,J.R., Foote,K.M., Veenstra-Knol,H.E., Pfundt,R., Ten
            Broeke,S.W., de Leeuw,N., Roht,L., Pajusalu,S., Part,R., Rebane,I.,
            Ounap,K., Stark,Z., Kirk,E.P., Lawson,J.A., Lunke,S.,
            Christodoulou,J., Louie,R.J., Rogers,R.C., Davis,J.M., Innes,A.M.,
            Wei,X.C., Keren,B., Mignot,C., Lebel,R.R., Sperber,S.M.,
            Sakonju,A., Dosa,N., Barge-Schaapveld,D.Q.C.M.,
            Peeters-Scholte,C.M.P.C.D., Ruivenkamp,C.A.L., van Bon,B.W.,
            Kennedy,J., Low,K.J., Ellard,S., Pang,L., Junewick,J.J., Mark,P.R.,
            Carvill,G.L. and Swanson,G.T.
  TITLE     Clustered mutations in the GRIK2 kainate receptor subunit gene
            underlie diverse neurodevelopmental disorders
  JOURNAL   Am J Hum Genet 108 (9), 1692-1709 (2021)
   PUBMED   34375587
  REMARK    GeneRIF: Clustered mutations in the GRIK2 kainate receptor subunit
            gene underlie diverse neurodevelopmental disorders.
            Erratum:[Am J Hum Genet. 2021 Nov 4;108(11):2206. doi:
            10.1016/j.ajhg.2021.09.018.. PMID: 34739836]
REFERENCE   5  (bases 1 to 4722)
  AUTHORS   Sander,T., Janz,D., Ramel,C., Ross,C.A., Paschen,W., Hildmann,T.,
            Wienker,T.F., Bianchi,A., Bauer,G., Sailer,U. et al.
  TITLE     Refinement of map position of the human GluR6 kainate receptor gene
            (GRIK2) and lack of association and linkage with idiopathic
            generalized epilepsies
  JOURNAL   Neurology 45 (9), 1713-1720 (1995)
   PUBMED   7675232
REFERENCE   6  (bases 1 to 4722)
  AUTHORS   Nutt,S.L. and Kamboj,R.K.
  TITLE     RNA editing of human kainate receptor subunits
  JOURNAL   Neuroreport 5 (18), 2625-2629 (1994)
   PUBMED   7696618
REFERENCE   7  (bases 1 to 4722)
  AUTHORS   Paschen,W., Hedreen,J.C. and Ross,C.A.
  TITLE     RNA editing of the glutamate receptor subunits GluR2 and GluR6 in
            human brain tissue
  JOURNAL   J Neurochem 63 (5), 1596-1602 (1994)
   PUBMED   7523595
REFERENCE   8  (bases 1 to 4722)
  AUTHORS   Paschen,W., Blackstone,C.D., Huganir,R.L. and Ross,C.A.
  TITLE     Human GluR6 kainate receptor (GRIK2): molecular cloning,
            expression, polymorphism, and chromosomal assignment
  JOURNAL   Genomics 20 (3), 435-440 (1994)
   PUBMED   8034316
REFERENCE   9  (bases 1 to 4722)
  AUTHORS   Hoo,K.H., Nutt,S.L., Fletcher,E.J., Elliott,C.E., Korczak,B.,
            Deverill,R.M., Rampersad,V., Fantaske,R.P. and Kamboj,R.K.
  TITLE     Functional expression and pharmacological characterization of the
            human EAA4 (GluR6) glutamate receptor: a kainate selective channel
            subunit
  JOURNAL   Recept Channels 2 (4), 327-337 (1994)
   PUBMED   7536611
REFERENCE   10 (bases 1 to 4722)
  AUTHORS   Raymond,L.A., Blackstone,C.D. and Huganir,R.L.
  TITLE     Phosphorylation and modulation of recombinant GluR6 glutamate
            receptors by cAMP-dependent protein kinase
  JOURNAL   Nature 361 (6413), 637-641 (1993)
   PUBMED   8094892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002528.1, AP002529.1 and
            AP002530.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 14, 2020 this sequence version replaced
            XM_005266945.2, NM_021956.4.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing at multiple sites within the first and second transmembrane
            domains, which is thought to alter the structure and function of
            the receptor complex. Alternatively spliced transcript variants
            encoding different isoforms have also been described for this gene.
            Mutations in this gene have been associated with autosomal
            recessive cognitive disability. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). RNA editing changes Ile567Val, Tyr571Cys and Gln621Arg.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK014576.1, SRR1660803.221685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369134.9/ ENSP00000358130.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            undergoes RNA editing  :: PMID: 7696618, 7523595
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AP002528.1         164611-164740
            131-538             AP002528.1         169888-170295
            539-706             AP002529.1         92857-93024
            707-964             AP002529.1         97288-97545
            965-1146            AP002529.1         147531-147712
            1147-1200           AP002529.1         153461-153514
            1201-1374           AP002529.1         157088-157261
            1375-1518           AP002529.1         270556-270699
            1519-1626           AP002529.1         273239-273346
            1627-1740           AP002529.1         289278-289391
            1741-1947           AP002530.2         30195-30401
            1948-2171           AP002530.2         60548-60771
            2172-2290           AP002530.2         95509-95627
            2291-2508           AP002530.2         99323-99540
            2509-2734           AP002530.2         206249-206474
            2735-2985           AP002530.2         226238-226488
            2986-4722           AP002530.2         239255-240991
FEATURES             Location/Qualifiers
     source          1..4722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.3"
     gene            1..4722
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="glutamate ionotropic receptor kainate type subunit
                     2"
                     /db_xref="GeneID:2898"
                     /db_xref="HGNC:HGNC:4580"
                     /db_xref="MIM:138244"
     exon            1..130
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            131..538
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..3150
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; excitatory amino acid receptor 4; bA487F5.1;
                     glutamate receptor 6; glutamate receptor form B; glutamate
                     receptor form C; glutamate receptor form D; glutamate
                     receptor form E; glutamate receptor form A; gluR-6;
                     glutamate receptor ionotropic, kainate 2;
                     GluK2(alt_5'UTR); putative NMDtranscript(cassette_171nt)"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 2 isoform
                     1 precursor"
                     /protein_id="NP_068775.1"
                     /db_xref="CCDS:CCDS5048.1"
                     /db_xref="GeneID:2898"
                     /db_xref="HGNC:HGNC:4580"
                     /db_xref="MIM:138244"
                     /translation="MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEY
                     VESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLG
                     VAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAI
                     LDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM
                     KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM
                     TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV
                     QQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVI
                     SLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSD
                     KPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDH
                     KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMY
                     ILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGS
                     ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY
                     GAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMEST
                     TIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKW
                     WRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRS
                     FCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA"
     exon            539..706
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            707..964
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1146
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1200
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1374
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1518
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1626
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1740
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1947
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2171
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2290
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2508
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2734
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2985
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..4722
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="hexamer: ATTAAA"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="hexamer: ATTAAA"
     polyA_site      4705
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="major polyA site"
     polyA_site      4722
                     /gene="GRIK2"
                     /gene_synonym="EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
                     NEDLAS"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgctc ggcgccggcg gctgcgctgg tcggtctggt agctggggac ttttccgccc
       61 gacctcctcc ggctgctcct ccccgaggac caccccaccc cctccccgcc cacctcaccc
      121 ctagctccag gctcgcgcgg ccggacattg tgggtgtgcg tgctggattt ctcccggatg
      181 ctctccgact aacatggatg tcccaccatt ccttgcagtg gaaggttgtt ccttggcgca
      241 gtgagtgaag aacatgcagc gattgctaat gggtttggga agcggagact ccttcctctc
      301 tctatgacca tgccgtgatc gtgtctgcgg tcaccactcg acgcatcctc atttctaccc
      361 gaacccagga gccgaacgct agatcgggga agtgggtgcc gtgcgtgtgg gcacagaaac
      421 accatgaaga ttattttccc gattctaagt aatccagtct tcaggcgcac cgttaaactc
      481 ctgctctgtt tactgtggat tggatattct caaggaacca cacatgtatt aagatttggt
      541 ggtatttttg aatatgtgga atctggccca atgggagctg aggaacttgc attcagattt
      601 gctgtgaaca caattaacag aaacagaaca ttgctaccca atactaccct tacctatgat
      661 acccagaaga taaaccttta tgatagtttt gaagcatcca agaaagcctg tgatcagctg
      721 tctcttgggg tggctgccat cttcgggcct tcacacagct catcagcaaa cgcagtgcag
      781 tccatctgca atgctctggg agttccccac atacagaccc gctggaagca ccaggtgtca
      841 gacaacaaag attccttcta tgtcagtctc tacccagact tctcttcact cagccgtgcc
      901 attttagacc tggtgcagtt tttcaagtgg aaaaccgtca cggttgtgta tgatgacagc
      961 actggtctca ttcgtttgca agagctcatc aaagctccat caaggtataa tcttcgactc
     1021 aaaattcgtc agttacctgc tgatacaaag gatgcaaaac ccttactaaa agaaatgaaa
     1081 agaggcaagg agtttcatgt aatctttgat tgtagccatg aaatggcagc aggcatttta
     1141 aaacaggcat tagctatggg aatgatgaca gaatactatc attatatctt taccactctg
     1201 gacctctttg ctcttgatgt tgagccctac cgatacagtg gtgttaacat gacagggttc
     1261 agaatattaa atacagaaaa tacccaagtc tcctccatca ttgaaaagtg gtcgatggaa
     1321 cgattgcagg cacctccgaa acccgattca ggtttgctgg atggatttat gacgactgat
     1381 gctgctctaa tgtatgatgc tgtgcatgtg gtgtctgtgg ccgttcaaca gtttccccag
     1441 atgacagtca gttccttgca gtgtaatcga cataaaccct ggcgcttcgg gacccgcttt
     1501 atgagtctaa ttaaagaggc acattgggaa ggcctcacag gcagaataac tttcaacaaa
     1561 accaatggct tgagaacaga ttttgatttg gatgtgatca gtctgaagga agaaggtcta
     1621 gaaaagattg gaacgtggga tccagccagt ggcctgaata tgacagaaag tcaaaaggga
     1681 aagccagcga acatcacaga ttccttatcc aatcgttctt tgattgttac caccattttg
     1741 gaagagcctt atgtcctttt taagaagtct gacaaacctc tctatggtaa tgatcgattt
     1801 gaaggctatt gcattgatct cctcagagag ttatctacaa tccttggctt tacatatgaa
     1861 attagacttg tggaagatgg gaaatatgga gcccaggatg atgccaatgg acaatggaat
     1921 ggaatggttc gtgaactaat tgatcataaa gctgaccttg cagttgctcc actggctatt
     1981 acctatgttc gagagaaggt catcgacttt tccaagccct ttatgacact tggaataagt
     2041 attttgtacc gcaagcccaa tggtacaaac ccaggcgtct tctccttcct gaatcctctc
     2101 tcccctgata tctggatgta tattctgctg gcttacttgg gtgtcagttg tgtgctcttt
     2161 gtcatagcca ggtttagtcc ttatgagtgg tataatccac acccttgcaa ccctgactca
     2221 gacgtggtgg aaaacaattt taccttgcta aatagtttct ggtttggagt tggagctctc
     2281 atgcagcaag gttctgagct catgcccaaa gcactgtcca ccaggatagt gggaggcatt
     2341 tggtggtttt tcacacttat catcatttct tcgtatactg ctaacttagc cgcctttctg
     2401 acagtggaac gcatggaatc ccctattgac tctgctgatg atttagctaa acaaaccaag
     2461 atagaatatg gagcagtaga ggatggtgca accatgactt ttttcaagaa atcaaaaatc
     2521 tccacgtatg acaaaatgtg ggcctttatg agtagcagaa ggcagtcagt gctggtcaaa
     2581 agtaatgaag aaggaatcca gcgagtcctc acctctgatt atgctttcct aatggagtca
     2641 acaaccatcg agtttgttac ccagcggaac tgtaacctga cacagattgg cggccttata
     2701 gactctaaag gttatggcgt tggcactccc atgggttctc catatcgaga caaaattacc
     2761 atagcaattc ttcagctgca agaggaaggc aaactgcata tgatgaagga gaaatggtgg
     2821 aggggcaatg gttgcccaga agaggagagc aaagaggcca gtgccctggg ggttcagaat
     2881 attggtggca tcttcattgt tctggcagcc ggcttggtgc tttcagtttt tgtggcagtg
     2941 ggagaatttt tatacaaatc caaaaaaaac gctcaattgg aaaagaggtc cttctgtagt
     3001 gccatggtag aagaattgag gatgtccctg aagtgccagc gtcggttaaa acataagcca
     3061 caggccccag ttattgtgaa aacagaagaa gttatcaaca tgcacacatt taacgacaga
     3121 aggttgccag gtaaagaaac catggcataa agctgggagg ccaaacaccc aagcacaaac
     3181 tgtcgtcttt ttccaaacaa tttagccaga atgtttcctg tggaaatatg caacctgtgc
     3241 aaaataaaat gagttacctc atgccgctgt gtctatgaac tagagactct gtgatctaag
     3301 cagttgcaat gatcagactt gatttacaag catcatggat caaccaagtt acacggggtt
     3361 acactgttaa tcatgggttc ctcccttctt ctgagtgaat gttaacatgc gcattttgtg
     3421 gctgatttca aatgcagtcc agtgagaaat tacaggttcc ttttgaagct caactgttgc
     3481 caggagatgg aatatcaatg cccaacaggg caaccaataa aagtgtcact aagaatataa
     3541 atatttggaa tcagcaaaaa ctgtagtgtt acaggaaaca gtacagtctt ctgaacaccc
     3601 agatcataga ggtgatgatg ttactagccc ccaactactc agtataatta ttgtctgaat
     3661 gcaaagtatg tgtttatagg atgtgaaaaa atgtaatgca aaacaaattt gaatcccatg
     3721 gcagttggaa tataaagcag atgttcatca cttattttcc ttttttcttt tcttattttt
     3781 ttttttgaca gtctgtgtca ctgattgaga tagaaatgcc aattatcaag gaaataatgt
     3841 tttcttaagt tccctaaggc agaagattta acatgcaatt ctaccagatc ccttcctatt
     3901 cccccaacac cttttctcta acccccatat cccaaataat aataataata ataataataa
     3961 taataataat aataataaaa gcagttggtt cagtgattct gaattaaaag gataatgttt
     4021 tgcaatgttc aagttgtaaa aactggccga gtattggctg tgtggaagac taaagctttc
     4081 attctaacat tcagacatag caatccaaac ccttgttcct gctgtaaatg aacttgatgg
     4141 agcatgggca gatttcagtg atacgagaaa ggggactggt catctataga aaaatctgtg
     4201 agagaacttg gaagtggact gcgtttatca atacagtcac aatgttaaat gaacaaaatt
     4261 cttgaacagt tttttttcaa aaaatgttca ggtttatttg tggaaatgca agatttctat
     4321 gaaaatagtt tttgtatgga aatttttgta atacttttta tcaacaaaac aagaacatgt
     4381 gttcctgtca ggggtgtgat gtcaagcatg aatggtagtg cgtgtgcacc accaacgttt
     4441 ggtgaaaact atttttatca agaaaaaagg aatcatagaa gagaaatatt ttcaagttag
     4501 ataatataaa agctaggtgc actaccacca ctgcttacca tgccacaccc ctggtttcca
     4561 cgaggctgac aacatactgt aatgaacaat tgtgtgtaaa atggtaaaag acacagacct
     4621 cttgacaaca ttgtgataac agttgagtgc acacagtttg ctgtttgaat ccaatgcaca
     4681 aaattaaaaa aaatcattaa aactatgttc attttacttt ca
//
