LOCUS       NP_001317923             949 aa            linear   PRI 27-APR-2025
DEFINITION  glutamate receptor ionotropic, kainate 1 isoform 8 precursor [Homo
            sapiens].
ACCESSION   NP_001317923 XP_006724054
VERSION     NP_001317923.1
DBSOURCE    REFSEQ: accession NM_001330994.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 949)
  AUTHORS   Chatterjee,M., Saha,S., Dutta,N., Sinha,S. and Mukhopadhyay,K.
  TITLE     Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1
            deficiency were detected in the Indian ADHD probands
  JOURNAL   Sci Rep 12 (1), 18449 (2022)
   PUBMED   36323684
  REMARK    GeneRIF: Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1
            deficiency were detected in the Indian ADHD probands.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 949)
  AUTHORS   Herbrechter,R., Hube,N., Buchholz,R. and Reiner,A.
  TITLE     Splicing and editing of ionotropic glutamate receptors: a
            comprehensive analysis based on human RNA-Seq data
  JOURNAL   Cell Mol Life Sci 78 (14), 5605-5630 (2021)
   PUBMED   34100982
REFERENCE   3  (residues 1 to 949)
  AUTHORS   Lam,J., DuBois,J.M., Rowley,J., Rousset,O.G.,
            Gonzalez-Otarula,K.A., Soucy,J.P., Massarweh,G., Hall,J.A.,
            Guiot,M.C., Zimmermann,M., Minuzzi,L., Rosa-Neto,P. and
            Kobayashi,E.
  TITLE     In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities
            are associated with temporal lobe epilepsy surgery outcomes
  JOURNAL   Epilepsia 62 (7), 1559-1568 (2021)
   PUBMED   34060082
  REMARK    GeneRIF: In vivo hippocampal cornu ammonis 1-3 glutamatergic
            abnormalities are associated with temporal lobe epilepsy surgery
            outcomes.
REFERENCE   4  (residues 1 to 949)
  AUTHORS   Hirbec,H., Francis,J.C., Lauri,S.E., Braithwaite,S.P., Coussen,F.,
            Mulle,C., Dev,K.K., Coutinho,V., Meyer,G., Isaac,J.T.,
            Collingridge,G.L. and Henley,J.M.
  TITLE     Rapid and differential regulation of AMPA and kainate receptors at
            hippocampal mossy fibre synapses by PICK1 and GRIP
  JOURNAL   Neuron 37 (4), 625-638 (2003)
   PUBMED   12597860
  REMARK    Erratum:[Neuron. 2003 May 22;38(4):673. Couthino V [corrected to
            Coutinho V]]
REFERENCE   5  (residues 1 to 949)
  AUTHORS   Barbon,A. and Barlati,S.
  TITLE     Genomic organization, proposed alternative splicing mechanisms, and
            RNA editing structure of GRIK1
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 236-239 (2000)
   PUBMED   10828597
REFERENCE   6  (residues 1 to 949)
  AUTHORS   Bortolotto,Z.A., Clarke,V.R., Delany,C.M., Parry,M.C., Smolders,I.,
            Vignes,M., Ho,K.H., Miu,P., Brinton,B.T., Fantaske,R., Ogden,A.,
            Gates,M., Ornstein,P.L., Lodge,D., Bleakman,D. and
            Collingridge,G.L.
  TITLE     Kainate receptors are involved in synaptic plasticity
  JOURNAL   Nature 402 (6759), 297-301 (1999)
   PUBMED   10580501
REFERENCE   7  (residues 1 to 949)
  AUTHORS   Clarke,V.R., Ballyk,B.A., Hoo,K.H., Mandelzys,A., Pellizzari,A.,
            Bath,C.P., Thomas,J., Sharpe,E.F., Davies,C.H., Ornstein,P.L.,
            Schoepp,D.D., Kamboj,R.K., Collingridge,G.L., Lodge,D. and
            Bleakman,D.
  TITLE     A hippocampal GluR5 kainate receptor regulating inhibitory synaptic
            transmission
  JOURNAL   Nature 389 (6651), 599-603 (1997)
   PUBMED   9335499
REFERENCE   8  (residues 1 to 949)
  AUTHORS   Nutt,S.L. and Kamboj,R.K.
  TITLE     RNA editing of human kainate receptor subunits
  JOURNAL   Neuroreport 5 (18), 2625-2629 (1994)
   PUBMED   7696618
REFERENCE   9  (residues 1 to 949)
  AUTHORS   Roche,K.W., Raymond,L.A., Blackstone,C. and Huganir,R.L.
  TITLE     Transmembrane topology of the glutamate receptor subunit GluR6
  JOURNAL   J Biol Chem 269 (16), 11679-11682 (1994)
   PUBMED   8163463
REFERENCE   10 (residues 1 to 949)
  AUTHORS   Gregor,P., O'Hara,B.F., Yang,X. and Uhl,G.R.
  TITLE     Expression and novel subunit isoforms of glutamate receptor genes
            GluR5 and GluR6
  JOURNAL   Neuroreport 4 (12), 1343-1346 (1993)
   PUBMED   8260617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000236.2, AP000237.3,
            AP000238.2, AP000239.2 and AA404271.1.
            
            On Sep 3, 2016 this sequence version replaced XP_006724054.1.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing (CAG->CGG; Q->R) within the second transmembrane domain,
            which is thought to alter the properties of ion flow. Alternative
            splicing, resulting in transcript variants encoding different
            isoforms, has been noted for this gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.196888.1,
                                           SRR1660809.135077.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327783.9/ ENSP00000327687.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            undergoes RNA editing  :: PMID: 7696618, 10828597
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     Protein         1..949
                     /product="glutamate receptor ionotropic, kainate 1 isoform
                     8 precursor"
                     /note="excitatory amino acid receptor 3; glutamate
                     receptor 5; glutamate receptor ionotropic, kainate 1;
                     GluK1(del_e2)"
                     /calculated_mol_wt=104386
     sig_peptide     1..30
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
                     /calculated_mol_wt=3510
     Region          38..431
                     /region_name="PBP1_iGluR_Kainate"
                     /note="N-terminal leucine-isoleucine-valine binding
                     protein (LIVBP)-like domain of the kainate receptors;
                     cd06382"
                     /db_xref="CDD:380605"
     Site            68
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            74
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            order(88..90,94,125,177,180,184,187,190..191,201..204)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:380605"
     Site            276
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            379
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            428
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            439
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Region          446..815
                     /region_name="Periplasmic_Binding_Protein_Type_2"
                     /note="Type 2 periplasmic binding fold superfamily;
                     cl21456"
                     /db_xref="CDD:473866"
     Site            446
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            561
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            577..597
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39086.1)"
     Site            654..674
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39086.1)"
     Site            725
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P39086.1)"
     Site            761
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P39086.1)"
     Site            766
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39086.1)"
     Site            835..855
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39086.1)"
     CDS             1..949
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /coded_by="NM_001330994.2:497..3346"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8"
                     /db_xref="CCDS:CCDS82659.1"
                     /db_xref="GeneID:2897"
                     /db_xref="HGNC:HGNC:4579"
                     /db_xref="MIM:138245"
ORIGIN      
        1 mehgtllaqp glwtrdtswa llyflcyilp qtapqvlrig gifetvenep vnveelafkf
       61 avtsinrnrt lmpnttltyd iqrinlfdsf easrracdql algvaalfgp shsssvsavq
      121 sicnalevph iqtrwkhpsv dnkdlfyinl ypdyaaisra ildlvlyynw ktvtvvyeds
      181 tglirlqeli kapsryniki kirqlpsgnk dakpllkemk kgkefyvifd cshetaaeil
      241 kqilfmgmmt eyyhyffttl dlfaldlely rysgvnmtgf rllnidnphv ssiiekwsme
      301 rlqapprpet glldgmmtte aalmydavym vaiashrasq ltvsslqchr hkpwrlgprf
      361 mnlikearwd gltghitfnk tnglrkdfdl diislkeegt ekaagevskh lykvwkkigi
      421 wnsnsglnmt dsnkdkssni tdslanrtli vttileepyv myrksdkply gndrfegycl
      481 dllkelsnil gfiydvklvp dgkygaqndk gewngmvkel idhradlava pltityvrek
      541 vidfskpfmt lgisilyrkp ngtnpgvfsf lnplspdiwm yvllaclgvs cvlfviarft
      601 pyewynphpc npdsdvvenn ftllnsfwfg vgalmqqgse lmpkalstri vggiwwfftl
      661 iiissytanl aafltverme spidsaddla kqtkieygav rdgstmtffk kskistyekm
      721 wafmssrqqt alvrnsdegi qrvlttdyal lmestsieyv tqrncnltqi gglidskgyg
      781 vgtpigspyr dkitiailql qeegklhmmk ekwwrgngcp eednkeasal gveniggifi
      841 vlaaglvlsv fvaigefiyk srknndieqk gkssrirfyf rnkvrfhgrk kqslgvekcl
      901 sfnaimeelg islknqkkik kksrtkgkss ftsiltchqr rtqrketva
//
