LOCUS       NM_001320616            3556 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor kainate type subunit 1
            (GRIK1), transcript variant 3, mRNA.
ACCESSION   NM_001320616 XM_005260943
VERSION     NM_001320616.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3556)
  AUTHORS   Chatterjee,M., Saha,S., Dutta,N., Sinha,S. and Mukhopadhyay,K.
  TITLE     Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1
            deficiency were detected in the Indian ADHD probands
  JOURNAL   Sci Rep 12 (1), 18449 (2022)
   PUBMED   36323684
  REMARK    GeneRIF: Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1
            deficiency were detected in the Indian ADHD probands.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3556)
  AUTHORS   Herbrechter,R., Hube,N., Buchholz,R. and Reiner,A.
  TITLE     Splicing and editing of ionotropic glutamate receptors: a
            comprehensive analysis based on human RNA-Seq data
  JOURNAL   Cell Mol Life Sci 78 (14), 5605-5630 (2021)
   PUBMED   34100982
REFERENCE   3  (bases 1 to 3556)
  AUTHORS   Lam,J., DuBois,J.M., Rowley,J., Rousset,O.G.,
            Gonzalez-Otarula,K.A., Soucy,J.P., Massarweh,G., Hall,J.A.,
            Guiot,M.C., Zimmermann,M., Minuzzi,L., Rosa-Neto,P. and
            Kobayashi,E.
  TITLE     In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities
            are associated with temporal lobe epilepsy surgery outcomes
  JOURNAL   Epilepsia 62 (7), 1559-1568 (2021)
   PUBMED   34060082
  REMARK    GeneRIF: In vivo hippocampal cornu ammonis 1-3 glutamatergic
            abnormalities are associated with temporal lobe epilepsy surgery
            outcomes.
REFERENCE   4  (bases 1 to 3556)
  AUTHORS   Hirbec,H., Francis,J.C., Lauri,S.E., Braithwaite,S.P., Coussen,F.,
            Mulle,C., Dev,K.K., Coutinho,V., Meyer,G., Isaac,J.T.,
            Collingridge,G.L. and Henley,J.M.
  TITLE     Rapid and differential regulation of AMPA and kainate receptors at
            hippocampal mossy fibre synapses by PICK1 and GRIP
  JOURNAL   Neuron 37 (4), 625-638 (2003)
   PUBMED   12597860
  REMARK    Erratum:[Neuron. 2003 May 22;38(4):673. Couthino V [corrected to
            Coutinho V]]
REFERENCE   5  (bases 1 to 3556)
  AUTHORS   Barbon,A. and Barlati,S.
  TITLE     Genomic organization, proposed alternative splicing mechanisms, and
            RNA editing structure of GRIK1
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 236-239 (2000)
   PUBMED   10828597
REFERENCE   6  (bases 1 to 3556)
  AUTHORS   Bortolotto,Z.A., Clarke,V.R., Delany,C.M., Parry,M.C., Smolders,I.,
            Vignes,M., Ho,K.H., Miu,P., Brinton,B.T., Fantaske,R., Ogden,A.,
            Gates,M., Ornstein,P.L., Lodge,D., Bleakman,D. and
            Collingridge,G.L.
  TITLE     Kainate receptors are involved in synaptic plasticity
  JOURNAL   Nature 402 (6759), 297-301 (1999)
   PUBMED   10580501
REFERENCE   7  (bases 1 to 3556)
  AUTHORS   Clarke,V.R., Ballyk,B.A., Hoo,K.H., Mandelzys,A., Pellizzari,A.,
            Bath,C.P., Thomas,J., Sharpe,E.F., Davies,C.H., Ornstein,P.L.,
            Schoepp,D.D., Kamboj,R.K., Collingridge,G.L., Lodge,D. and
            Bleakman,D.
  TITLE     A hippocampal GluR5 kainate receptor regulating inhibitory synaptic
            transmission
  JOURNAL   Nature 389 (6651), 599-603 (1997)
   PUBMED   9335499
REFERENCE   8  (bases 1 to 3556)
  AUTHORS   Nutt,S.L. and Kamboj,R.K.
  TITLE     RNA editing of human kainate receptor subunits
  JOURNAL   Neuroreport 5 (18), 2625-2629 (1994)
   PUBMED   7696618
REFERENCE   9  (bases 1 to 3556)
  AUTHORS   Roche,K.W., Raymond,L.A., Blackstone,C. and Huganir,R.L.
  TITLE     Transmembrane topology of the glutamate receptor subunit GluR6
  JOURNAL   J Biol Chem 269 (16), 11679-11682 (1994)
   PUBMED   8163463
REFERENCE   10 (bases 1 to 3556)
  AUTHORS   Gregor,P., O'Hara,B.F., Yang,X. and Uhl,G.R.
  TITLE     Expression and novel subunit isoforms of glutamate receptor genes
            GluR5 and GluR6
  JOURNAL   Neuroreport 4 (12), 1343-1346 (1993)
   PUBMED   8260617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296404.1, BC111793.1,
            AJ249208.1 and AA404271.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001320616.1.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing (CAG->CGG; Q->R) within the second transmembrane domain,
            which is thought to alter the properties of ion flow. Alternative
            splicing, resulting in transcript variants encoding different
            isoforms, has been noted for this gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296404.1, SRR1803614.181862.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            undergoes RNA editing :: PMID: 7696618, 10828597
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AK296404.1         2-393
            393-393             BC111793.1         6-6
            394-984             AK296404.1         395-985
            985-1012            AJ249208.1         614-641
            1013-2402           AK296404.1         1014-2403
            2403-2403           AJ249208.1         1987-1987
            2404-2617           AK296404.1         2405-2618
            2618-2618           AJ249208.1         2202-2202
            2619-3469           AK296404.1         2620-3470
            3470-3556           AA404271.1         11-97               c
FEATURES             Location/Qualifiers
     source          1..3556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..3556
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /note="glutamate ionotropic receptor kainate type subunit
                     1"
                     /db_xref="GeneID:2897"
                     /db_xref="HGNC:HGNC:4579"
                     /db_xref="MIM:138245"
     exon            1..614
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..3259
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; excitatory amino acid receptor 3; glutamate
                     receptor 5; glutamate receptor ionotropic, kainate 1;
                     GluK1(del_e2)"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 1 isoform
                     3 precursor"
                     /protein_id="NP_001307545.1"
                     /db_xref="CCDS:CCDS82658.1"
                     /db_xref="GeneID:2897"
                     /db_xref="HGNC:HGNC:4579"
                     /db_xref="MIM:138245"
                     /translation="MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFE
                     TVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLAL
                     GVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRA
                     ILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKE
                     MKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVN
                     MTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA
                     SHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDI
                     ISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLI
                     VTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN
                     DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG
                     VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLL
                     NSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP
                     IDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGI
                     QRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAIL
                     QLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGE
                     FIYKSRKNNDIEQCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQ
                     RKETVA"
     exon            615..782
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1040
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1222
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1276
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1450
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1594
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1702
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1747
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1861
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2065
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2289
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2408
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2626
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2852
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3103
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3556
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /note="hexamer: AATAAA"
     polyA_site      3556
                     /gene="GRIK1"
                     /gene_synonym="EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5"
                     /note="major polyA site"
ORIGIN      
        1 agttaacctg ctggagctca tcaggcttgc tcagagcccc tgcaccaact caccctgtac
       61 cctctctcct tcttcgttag tcttctttcc cccttttccc tcctctgtct gtgcctatcc
      121 cccgactttt gcatctgacc aaaggacgaa tgagggagac gttcctgcag atcggggcag
      181 caactttcct cagctggtct ctgggctccg ggagccagag agcgctgatc ctccgcggtc
      241 tgcggcccat ggaagaggag gaggaggagc cgtgatgggc tagcgacagc actgaggagc
      301 cccgagagag ctcagccttg ccagccagct ccgcggtccc acgcgggttc cctcgagctc
      361 gctccgtggg gagcgcgcag cgtgcttgga accggagcat ccagagagga tgaggcgggg
      421 acccggccca agttgggtgc atctctcggg cgtccggcag cggctgtatc tcggcatgaa
      481 ttaagaagct aggaagatgg agcacggcac actcctcgcc cagcccgggc tctggaccag
      541 ggacaccagc tgggcactcc tctatttcct ctgctatatc ctccctcaga ccgccccgca
      601 agtactcagg atcggaggga tttttgaaac agtggaaaat gagcctgtta atgttgaaga
      661 attagctttc aagtttgcag tcaccagcat taacagaaac cgaaccctga tgcctaacac
      721 cacattaacc tatgacatcc agagaattaa cctttttgat agttttgaag cctcgcggag
      781 agcatgtgac cagctggctc ttggtgtggc tgctctcttt ggcccttccc atagctcctc
      841 cgtcagtgct gtgcagtcta tttgcaatgc tctcgaagtt ccacacatac agacccgctg
      901 gaaacacccc tcggtggaca acaaagattt gttttacatc aacctttacc cagattatgc
      961 agctatcagc agggcgatcc tggatctggt cctctattac aactggaaaa cagtgacagt
     1021 ggtgtatgaa gacagcacag gtctaattcg tctacaagag ctcatcaaag ctccctccag
     1081 atataatatt aaaatcaaaa tccgccagct gccctctggg aataaagatg ccaagccttt
     1141 actcaaggag atgaagaaag gcaaggagtt ctatgtgata tttgattgtt cacatgaaac
     1201 agccgctgaa atccttaagc agattctgtt catgggcatg atgaccgagt actatcacta
     1261 ctttttcaca accctggact tatttgcttt ggatctggaa ctctataggt acagtggcgt
     1321 aaacatgacc gggtttcggc tgcttaacat tgacaaccct cacgtgtcat ccatcattga
     1381 gaagtggtcc atggagagac tgcaggcccc acccaggccc gagactggcc ttttggatgg
     1441 catgatgaca actgaagcgg ctctgatgta cgatgctgtg tacatggtgg ccattgcctc
     1501 gcaccgggca tcccagctga ccgtcagctc cctgcagtgc catagacata agccatggcg
     1561 cctcggaccc agatttatga acctgatcaa agaggcccgg tgggatggct tgactgggca
     1621 tatcaccttt aataaaacca atggcttgag gaaggatttt gatctggaca ttattagtct
     1681 caaagaggaa ggaactgaaa aggctgctgg cgaagtgtct aaacacttgt ataaagtgtg
     1741 gaagaagatt gggatttgga attccaacag tgggcttaac atgacggaca gcaacaaaga
     1801 caagtccagc aatatcactg attcattggc caacagaaca ctcattgtca ccaccattct
     1861 ggaagaaccc tatgttatgt acaggaaatc tgataagcct ctatatggaa atgacagatt
     1921 tgaaggatat tgcctagacc tgttgaaaga attgtcaaac atcctgggtt tcatttatga
     1981 tgttaaacta gttcccgatg gcaaatatgg ggcccagaat gacaaagggg agtggaacgg
     2041 gatggttaaa gaactcatag atcacagggc tgacctggca gtggctcctc ttaccatcac
     2101 ctacgtgcgg gagaaagtca ttgacttctc caaacccttc atgaccctag gcatcagcat
     2161 tctctaccgg aagcccaatg gtaccaatcc aggcgttttc tccttcctca accccctgtc
     2221 tccagatatt tggatgtatg tgctcttagc ctgcttggga gtcagctgtg tactctttgt
     2281 gattgcaagg tttacaccct acgagtggta taacccccac ccatgcaacc ctgactcaga
     2341 cgtggtggaa aacaatttta ctttactaaa tagtttctgg tttggagttg gagctctcat
     2401 gcagcaagga tcagagctga tgcccaaagc tctatcgacc agaatagttg gagggatatg
     2461 gtggtttttc accctaatca tcatttcatc ctacacggcc aatctggctg ccttcttgac
     2521 agtagagaga atggaatccc ccatagattc ggcagatgat ctggcaaagc aaaccaagat
     2581 agaatatggg gcggttagag atggatcaac aatgaccttc ttcaagaaat caaaaatctc
     2641 cacctatgag aagatgtggg ctttcatgag cagcaggcag cagaccgccc tggtaagaaa
     2701 cagtgatgag gggatccaga gagtgctcac cacagactac gcgctgctga tggagtccac
     2761 cagcattgag tatgtgacgc agagaaactg caacctcact cagatcgggg gcctcattga
     2821 ctccaaaggt tacggagtgg gaacacctat tggttctcct taccgggata aaattactat
     2881 tgctattctt caactccaag aagaagggaa gctgcatatg atgaaagaga agtggtggcg
     2941 tgggaatggc tgccccgagg aagacaacaa agaagccagt gccctgggag tggaaaatat
     3001 tggaggcatc ttcattgttc tggctgccgg actggtcctt tctgtatttg tagctattgg
     3061 agaattcata tacaaatcac ggaagaataa tgatattgaa cagtgtctct ctttcaacgc
     3121 tatcatggaa gaactgggaa tctcactgaa gaatcagaaa aaaataaaga aaaagtcaag
     3181 aactaagggg aaatcttcct tcacaagtat ccttacttgt catcagagac gaactcagag
     3241 aaaagagact gtggcgtgat ccaaggaaac gcctgtagga agaaaaagga tgcattccct
     3301 acagattttt ggagaaagga tttctgagga gtgtgtgatg tgtttccata tatctatatc
     3361 cataactctg attatgaata cagatataag aaatacaaaa gtttaaaaag ctcacataga
     3421 tatgacttgg gaagtgacac cagttctttt aaaataaatt tgtatgctca attattttgc
     3481 attttttctt tttccccaat aaattgttgt gtgtgctttc taaataataa taaaacaaca
     3541 gggttttttt ccagaa
//
