LOCUS       NM_001394787             592 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens galectin-related inter-fiber protein (GRIFIN), mRNA.
ACCESSION   NM_001394787
VERSION     NM_001394787.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 592)
  AUTHORS   Lin,X., Li,H., Yang,T., Liu,X., Fan,F., Zhou,X. and Luo,Y.
  TITLE     Transcriptomics Analysis of Lens from Patients with Posterior
            Subcapsular Congenital Cataract
  JOURNAL   Genes (Basel) 12 (12), 1904 (2021)
   PUBMED   34946854
  REMARK    GeneRIF: Transcriptomics Analysis of Lens from Patients with
            Posterior Subcapsular Congenital Cataract.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 592)
  AUTHORS   Barton,K.A., Hsu,C.D. and Petrash,J.M.
  TITLE     Interactions between small heat shock protein alpha-crystallin and
            galectin-related interfiber protein (GRIFIN) in the ocular lens
  JOURNAL   Biochemistry 48 (18), 3956-3966 (2009)
   PUBMED   19296714
REFERENCE   3  (bases 1 to 592)
  AUTHORS   Ogden,A.T., Nunes,I., Ko,K., Wu,S., Hines,C.S., Wang,A.F.,
            Hegde,R.S. and Lang,R.A.
  TITLE     GRIFIN, a novel lens-specific protein related to the galectin
            family
  JOURNAL   J Biol Chem 273 (44), 28889-28896 (1998)
   PUBMED   9786891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004840.4 and KF459637.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2467146 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000614228.2/ ENSP00000481185.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC004840.4         37397-37423
            28-107              AC004840.4         37796-37875
            108-267             KF459637.1         54-213              c
            268-434             AC004840.4         38487-38653
            435-592             AC004840.4         38909-39066
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..592
                     /gene="GRIFIN"
                     /note="galectin-related inter-fiber protein"
                     /db_xref="GeneID:402635"
                     /db_xref="HGNC:HGNC:4577"
                     /db_xref="MIM:619187"
     exon            1..27
                     /gene="GRIFIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..450
                     /gene="GRIFIN"
                     /note="putative grifin"
                     /codon_start=1
                     /product="grifin"
                     /protein_id="NP_001381716.1"
                     /db_xref="CCDS:CCDS94046.1"
                     /db_xref="GeneID:402635"
                     /db_xref="HGNC:HGNC:4577"
                     /db_xref="MIM:619187"
                     /translation="MAVQSKAFCAGGLAPGWKLLVQGHADSGEDRFETNFLLETGDIA
                     FHIKPRFSSATVVGNAFQYGRWGPEQVSSIFPLAPGEPFEIEVSWDAEHFHVYAPEHK
                     VLQFPCRQRPLGATTRVRVLSDHCLAQVELAKRGLSWGDRGY"
     exon            28..107
                     /gene="GRIFIN"
                     /inference="alignment:Splign:2.1.0"
     exon            108..267
                     /gene="GRIFIN"
                     /inference="alignment:Splign:2.1.0"
     exon            268..434
                     /gene="GRIFIN"
                     /inference="alignment:Splign:2.1.0"
     exon            435..592
                     /gene="GRIFIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      574..579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRIFIN"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="GRIFIN"
                     /note="major polyA site"
ORIGIN      
        1 agtggctggg agcagatggc agtgcagtct aaagccttct gtgcgggcgg cctggccccc
       61 ggctggaagc tgctggtcca gggacatgct gactctggag aggacaggtt cgagactaac
      121 ttcttgttgg agacggggga cattgccttc cacatcaagc cccggttctc cagcgccact
      181 gtggtgggca atgccttcca gtacggccgc tggggcccgg agcaggtgtc tagcatcttc
      241 ccgctggccc cgggggagcc ctttgagata gaggtcagct gggacgcgga gcacttccac
      301 gtctacgccc cggagcacaa ggtgctacag ttcccatgcc gtcagaggcc gctgggcgcc
      361 accaccaggg tgcgcgtgct gagtgaccac tgcctggccc aggtggagct ggccaagagg
      421 ggcctgagct ggggggaccg gggctactga gtgacacctg caccccagga gccagcctcg
      481 gcttgtccca tgtccagggt acctggagtc ccaccctggg gcagctgggt gagggggtct
      541 gtggtcctgt gtgctcctcg cagctccacc ttcaataaac tctgagaagg ct
//
