LOCUS       NM_001145118            4657 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens Grid2 interacting protein (GRID2IP), transcript
            variant 1, mRNA.
ACCESSION   NM_001145118 XR_017146 XR_018117 XR_041837 XR_041838
VERSION     NM_001145118.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Zhao,J., Quan,J., Chen,W. and Xie,X.
  TITLE     Grid2 interacting protein is a potential biomarker related to
            immune infiltration in colorectal cancer
  JOURNAL   Eur J Med Res 28 (1), 511 (2023)
   PUBMED   37964339
  REMARK    GeneRIF: Grid2 interacting protein is a potential biomarker related
            to immune infiltration in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Silkworth,W.T., Kunes,K.L., Nickel,G.C., Phillips,M.L.,
            Quinlan,M.E. and Vizcarra,C.L.
  TITLE     The neuron-specific formin Delphilin nucleates nonmuscle actin but
            does not enhance elongation
  JOURNAL   Mol Biol Cell 29 (5), 610-621 (2018)
   PUBMED   29282276
  REMARK    GeneRIF: Delphilin is an actin nucleator that does not accelerate
            elongation. Delphilin exhibits a preference for actin isoforms,
            nucleating nonmuscle actin but not muscle actin.
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Ek,W.E., Reznichenko,A., Ripke,S., Niesler,B., Zucchelli,M.,
            Rivera,N.V., Schmidt,P.T., Pedersen,N.L., Magnusson,P.,
            Talley,N.J., Holliday,E.G., Houghton,L., Gazouli,M.,
            Karamanolis,G., Rappold,G., Burwinkel,B., Surowy,H., Rafter,J.,
            Assadi,G., Li,L., Papadaki,E., Gambaccini,D., Marchi,S.,
            Colucci,R., Blandizzi,C., Barbaro,R., Karling,P., Walter,S.,
            Ohlsson,B., Tornblom,H., Bresso,F., Andreasson,A., Dlugosz,A.,
            Simren,M., Agreus,L., Lindberg,G., Boeckxstaens,G., Bellini,M.,
            Stanghellini,V., Barbara,G., Daly,M.J., Camilleri,M., Wouters,M.M.
            and D'Amato,M.
  TITLE     Exploring the genetics of irritable bowel syndrome: a GWA study in
            the general population and replication in multinational
            case-control cohorts
  JOURNAL   Gut 64 (11), 1774-1782 (2015)
   PUBMED   25248455
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Sonoda,T., Mochizuki,C., Yamashita,T., Watanabe-Kaneko,K.,
            Miyagi,Y., Shigeri,Y., Yazama,F., Okuda,K. and Kawamoto,S.
  TITLE     Binding of glutamate receptor delta2 to its scaffold protein,
            Delphilin, is regulated by PKA
  JOURNAL   Biochem Biophys Res Commun 350 (3), 748-752 (2006)
   PUBMED   17027646
  REMARK    GeneRIF: Thus, phosphorylation of -2T and/or -1S of GluRdelta2
            C-terminus by PKA may regulate the binding of GluRdelta2 to its
            scaffolding protein, Delphilin.
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Matsuda,K., Matsuda,S., Gladding,C.M. and Yuzaki,M.
  TITLE     Characterization of the delta2 glutamate receptor-binding protein
            delphilin: Splicing variants with differential palmitoylation and
            an additional PDZ domain
  JOURNAL   J Biol Chem 281 (35), 25577-25587 (2006)
   PUBMED   16835239
  REMARK    GeneRIF: delphilin isoforms with differential palmitoylation and
            clustering capabilities may provide two separate intracellular and
            surface GluRdelta2 pools and may control GluRdelta2 signaling in
            Purkinje cells
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human GRID2IP gene and rat
            Grid2ip gene in silico
  JOURNAL   Int J Mol Med 12 (6), 1015-1019 (2003)
   PUBMED   14612983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC072052.6.
            
            On May 5, 2021 this sequence version replaced NM_001145118.1.
            
            Summary: Glutamate receptor delta-2 (GRID2; MIM 602368) is
            predominantly expressed at parallel fiber-Purkinje cell
            postsynapses and plays crucial roles in synaptogenesis and synaptic
            plasticity. GRID2IP1 interacts with GRID2 and may control GRID2
            signaling in Purkinje cells (Matsuda et al., 2006 [PubMed
            16835239]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457091.3/ ENSP00000397351.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC072052.6         110551-111004       c
            455-609             AC072052.6         99261-99415         c
            610-858             AC072052.6         86064-86312         c
            859-944             AC072052.6         85767-85852         c
            945-1014            AC072052.6         81431-81500         c
            1015-1109           AC072052.6         80972-81066         c
            1110-1293           AC072052.6         80121-80304         c
            1294-1448           AC072052.6         73918-74072         c
            1449-1580           AC072052.6         70451-70582         c
            1581-1678           AC072052.6         70152-70249         c
            1679-1796           AC072052.6         69826-69943         c
            1797-2152           AC072052.6         68501-68856         c
            2153-2569           AC072052.6         67528-67944         c
            2570-2657           AC072052.6         65363-65450         c
            2658-2735           AC072052.6         64336-64413         c
            2736-2932           AC072052.6         63034-63230         c
            2933-3088           AC072052.6         62551-62706         c
            3089-3175           AC072052.6         62329-62415         c
            3176-3305           AC072052.6         61532-61661         c
            3306-3424           AC072052.6         61324-61442         c
            3425-3589           AC072052.6         57607-57771         c
            3590-4657           AC072052.6         56321-57388         c
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..4657
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /note="Grid2 interacting protein"
                     /db_xref="GeneID:392862"
                     /db_xref="HGNC:HGNC:18464"
                     /db_xref="MIM:610639"
     exon            1..454
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3661
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutamate receptor, ionotropic, delta 2 (Grid2)
                     interacting protein 1; glutamate receptor, ionotropic,
                     delta 2-interacting protein 1"
                     /codon_start=1
                     /product="delphilin isoform 1"
                     /protein_id="NP_001138590.1"
                     /db_xref="CCDS:CCDS47537.1"
                     /db_xref="GeneID:392862"
                     /db_xref="HGNC:HGNC:18464"
                     /db_xref="MIM:610639"
                     /translation="MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLR
                     PGDQILEVEGLAVGGLSRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVL
                     RAPRCGRGLALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFA
                     ALKQFAAEQRVDDLVWTLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKL
                     CRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGA
                     RRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSH
                     DKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQ
                     GRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQ
                     LLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLR
                     SQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSS
                     FKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSS
                     SESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRF
                     LDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSL
                     TYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPP
                     PPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYD
                     KLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSP
                     AELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLS
                     VPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYL
                     NDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTV
                     PLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRAL
                     DGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGLRSSG
                     MVSPLAW"
     exon            455..609
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            610..858
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            859..944
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1014
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1109
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1293
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1448
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1580
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1678
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1796
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2152
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2569
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2657
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2735
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2932
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3088
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3175
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3305
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3424
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3589
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..4657
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /note="hexamer: ATTACA"
     polyA_site      4000
                     /gene="GRID2IP"
                     /gene_synonym="DELPHILIN"
                     /note="major polyA site"
ORIGIN      
        1 ctgttctgtc tccagttcta ggtgcatggc caccactgcc acgccggcca cgaaccaggg
       61 ctggccagag gactttggct tccggctagg tggctctggc ccctgcttcg tcctggaggt
      121 ggccaagggg agcagcgcgc atgccggagg actgcggcca ggagaccaga tcctggaggt
      181 ggaggggctg gcggtgggcg gtctgagccg cgagcgcctc gtgcgcctgg cacggcgctg
      241 cccacgtgtg ccgcccagtc tgggcgtgct cccggctccc gacggtggcc ccggcccagg
      301 atccggcccc gcggccccga ccacagtctt gcgggccccg cggtgcggcc gcggcctagc
      361 tctgggccgt gagctgcttc gcctggccgg ccgcaagcgc ccggacgcgg tgcaccgaga
      421 gcgcaggcgc aaggcccaag agttcagccg caaggtggat gaaatcttgg gggaccagcc
      481 aactgccaag gagcaggtgt tcgctgcact gaagcagttt gcagctgagc agcgggtgga
      541 tgatctggtg tggactctca ccctggcgct gccccgagag gcctgcgggc cactcctgga
      601 caacctcagg atcttcatcc ccaagaagca ccgggcgcgc ttcgacgagg tggtgtctca
      661 gggcctcctg ggcaagctgt gccgcgcacg ccgggcccag ggcgcgcagc gactgcgccg
      721 gagccgcagc gaggagcggc cggagcgcct cctggtgtcc acgcgcgcca gcgccccgcc
      781 gcgccgcccc gatgagccgc ccccgcgcag ggcctccttg ctggtgggcg gcctcgccgg
      841 ccccgggggc gcgcgcagga ctgtccgagt ctacaaaggc aacaagagct tcggcttcac
      901 acttcgcggc cacgggcctg tctggatcga gtctgtcctg cctgggagcc cagctgacaa
      961 tgctgccctc aagtcaggtg accggatcct cttcctcaat ggactggaca tgaggaactg
     1021 ctcccacgac aaggtggtgt ccatgctgca gggcagtggt gccatgccca cgctggtggt
     1081 ggaggaaggg ctcgtcccat ttgccagtga ctccgattct ctggactcac ccaacccgtc
     1141 gtcggcgctc acctccctgc agtgggtggc ggagatcctg ccgtccagca tccgggtcca
     1201 agggaggacc ttcagccagc agctggagca cctactcaca cctcctgagc gctatggggt
     1261 ctgccgggcc ctcgagagct tcttccagca caggaacatc gacaccctca tcgttgacgt
     1321 ctaccctgtg ctggacaccc ctgccaagca ggtcctgtgg cagttcatct accagctgct
     1381 gacctatgag gagcaggagc tctgtcagga gaaaatcgca tgcttcctgg gctacacggc
     1441 catgacagca gagccggagc ctgagctgga cctggagtcc gagcccacgc ctgagcccca
     1501 gccgcggagc tccctgcggg cttcctccat gtgccgccgc agcctccggt cccagggcct
     1561 ggaggccggc ctcagctgcg gtcccagcga gtgccctgag atgcctcttc ccctgatccc
     1621 aggcgagcgc caggcaggcg acggcacgtc cctccctgag acccccaacc ccaagatgat
     1681 gtcagccgtc tatgcagagc ttgagtctcg actgaacagc agcttcaaag ggaagatggg
     1741 gaccgtgtcc aaatcccggg cttcccctcc aggccccagc ccagcagtca ccacagggcc
     1801 caggaccctg tccggcgtct catggcccag cgagcgactc ttgccctccc cctgctacca
     1861 cccgctgtgt tcggggggtc tggcctcccc cagcagctct gagtcccacc cctacgccag
     1921 cctggacagc agcagggcac cctccccaca gccaggcccc gggcccatct gccccgacag
     1981 ccccccaagc ccggacccca cccgcccgcc cagccgcagg aagctcttca ccttctccca
     2041 ccctgtgcga agccgcgata ctgaccgctt cctggacgtg ctgagcgagc agctgggccc
     2101 ccgggtcacc atcgtggatg atttcctgac cccggagaac gactacgagg agatgagctt
     2161 ccatgatgac cagggcagct tcgtaaccaa tgagcggagc agcgccagcg actgcatcag
     2221 cagcagtgaa gaaggcagct ccctgaccta ctcctccatc tctgaccaca tccccccacc
     2281 cccgctcagc cccccaccac cgccacccct gcctttccat gacgctaagc ccagctcccg
     2341 cagctctgat ggttcccggg gccctgctca ggcgctggcc aagcccctca cccaactcag
     2401 ccacccagtc cctccaccac ccccaccgcc cctgccccca cccgtgccct gtgcaccccc
     2461 catgctgtcc cggggcctgg gccaccggcg cagtgagacc agccacatga gcgtcaagcg
     2521 cttgcggtgg gaacaggtgg agaactcaga aggcaccatc tggggtcagc tcggggaaga
     2581 ctctgactac gataagctga gtgacatggt gaaatacctc gacctggagc tccacttcgg
     2641 cacccagaaa cctgctaaac cggtgccggg gccggagccc ttccggaaga aggaggtggt
     2701 ggagatcctg tcccataaga aggcctacaa cacctccatc ctcttggcac acctgaagct
     2761 gagccccgcg gagctgcgcc aggtgctgat gagcatggag ccccggcgcc tggagcccgc
     2821 acatctcgcg cagctgctgc tcttcgcgcc cgacgccgac gaggagcagc gctaccaggc
     2881 cttccgcgag gcgcccggcc gcctcagcga gccggaccag ttcgtcctgc agatgctgtc
     2941 agttcccgaa tacaagacac gcctgcgcag cctccacttc caggccaccc tccaggagaa
     3001 gacagaggag atccgaggca gccttgaatg cttgcgccag gcctccctgg agctcaaaaa
     3061 cagtcggaag ctcgccaaga tcctggagtt tgtgttggcc atgggcaact atctcaacga
     3121 tggacagccc aaaaccaaca agactacggg cttcaagatc aactttctga cagagctgaa
     3181 ctccaccaag acagtggatg ggaagtccac cttcctgcac atccttgcca aatcgctgag
     3241 ccagcacttc cctgaactcc tgggctttgc tcaggacctg cccaccgtgc ccctggctgc
     3301 caaagtgaac caacgggccc tgaccagtga cctggctgac ctccatggca ctatcagcga
     3361 gatacaggat gcctgccaga gcatttcccc ctctagcgag gacaagtttg caatggtcat
     3421 gtcgtccttc ctggagacgg cccagccagc acttcgggcg ctcgacgggc tgcagcgcga
     3481 ggccatggag gagctgggca aggcgctggc cttctttggg gaggattcca aggccaccac
     3541 ctctgaggct ttcttcggca tctttgcaga gttcatgagc aaattcgagc gagcgctgag
     3601 tgacctgcag gccggggagg gcctgcgcag ctccgggatg gtttcacccc tggcctggtg
     3661 acagtggcca caccgcgtcc tctgcggcct gagcagggag atggaggccg agagggcagc
     3721 ccagacactg ccgaggtccg gggccactgt gccccgggct ctgagcacac cgccagcctc
     3781 tcctgcagct acctcagccg ccgagctgtg gtcgggccct cctctgccag cccttgttcc
     3841 tacccccagg cccagagcca gatgctgtag gagcaggtgc tgagtgtgcc tgcacatgga
     3901 ggaccgtgct ctgtcggctt cttgggccca cttcccactt cgctcccagg ctgtcagggg
     3961 ggcctggagg gtggattaca aagtggccac attcctggga catgtggacc ttttttctga
     4021 tcctgctcct agtgggtccc tgtgaggggg ccgacaccct tgagcacgac cctgcaggca
     4081 ggcgcgagac gcgagagggc agaaagccgg atgtagaggg gccctgggga tgtgcacgcc
     4141 cagcctgggc cttggaagct ggcttcaggg acacaggaag agagaagcct gggagagacg
     4201 cagggaagga aggactggag aaggaagacc ccctatgtca gactgcggaa ttgaggtttc
     4261 atgcagtgga caaacccaaa cctgtgtaga ggtggcccaa ttggaagtgg ggagcctggg
     4321 agtggaatag gtgtggtcaa ggtagagcag acagaatggg gaggtgttga ggcaggaggt
     4381 gagcaggatc tggtggccaa ctgccagact tctcacctgg acggatggtg atgttccctg
     4441 gagcaagtca tgagaccggg gcaggtgtgg gggcagatga cacaatctgg gatgtgtttg
     4501 ggacccaaat ggtcatttta catgtgccta ggcatatagc aggagttacc tggataccag
     4561 gagcaggagc aggtggcgtg gtgggcaggg agggagggtg tgtgaactgt ttcacctttt
     4621 ttaaaattct ctgattgaca gatccttgga tcagaca
//
