LOCUS       NM_001510               5783 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens glutamate ionotropic receptor delta type subunit 2
            (GRID2), transcript variant 1, mRNA.
ACCESSION   NM_001510
VERSION     NM_001510.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5783)
  AUTHORS   Allen,J.P., Garber,K.B., Perszyk,R., Khayat,C.T., Kell,S.A.,
            Kaneko,M., Quindipan,C., Saitta,S., Ladda,R.L., Hewson,S.,
            Inbar-Feigenberg,M., Prasad,C., Prasad,A.N., Olewiler,L., Mu,W.,
            Rosenthal,L.S., Scala,M., Striano,P., Zara,F., McCullock,T.W.,
            Jauss,R.T., Lemke,J.R., MacLean,D.M., Zhu,C., Yuan,H., Myers,S.J.
            and Traynelis,S.F.
  TITLE     Clinical features, functional consequences, and rescue pharmacology
            of missense GRID1 and GRID2 human variants
  JOURNAL   Hum Mol Genet 33 (4), 355-373 (2024)
   PUBMED   37944084
  REMARK    GeneRIF: Clinical features, functional consequences, and rescue
            pharmacology of missense GRID1 and GRID2 human variants.
REFERENCE   2  (bases 1 to 5783)
  AUTHORS   Grigorenko,A.P., Protasova,M.S., Lisenkova,A.A., Reshetov,D.A.,
            Andreeva,T.V., Garcias,G.L., Martino Roth,M.D.G.,
            Papassotiropoulos,A. and Rogaev,E.I.
  TITLE     Neurodevelopmental Syndrome with Intellectual Disability, Speech
            Impairment, and Quadrupedia Is Associated with Glutamate Receptor
            Delta 2 Gene Defect
  JOURNAL   Cells 11 (3), 400 (2022)
   PUBMED   35159210
  REMARK    GeneRIF: Neurodevelopmental Syndrome with Intellectual Disability,
            Speech Impairment, and Quadrupedia Is Associated with Glutamate
            Receptor Delta 2 Gene Defect.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5783)
  AUTHORS   Ceylan,A.C., Acar Arslan,E., Erdem,H.B., Kavus,H., Arslan,M. and
            Topaloglu,H.
  TITLE     Autosomal recessive spinocerebellar ataxia 18 caused by homozygous
            exon 14 duplication in GRID2 and review of the literature
  JOURNAL   Acta Neurol Belg 121 (6), 1457-1462 (2021)
   PUBMED   32170608
  REMARK    GeneRIF: Autosomal recessive spinocerebellar ataxia 18 caused by
            homozygous exon 14 duplication in GRID2 and review of the
            literature.
            Review article
REFERENCE   4  (bases 1 to 5783)
  AUTHORS   Zhang,Q., Huang,X., Chen,X.Z., Li,S.Y., Yao,T. and Wu,J.
  TITLE     Association of Gene Variations in Ionotropic Glutamate Receptor and
            Attention-Deficit/Hyperactivity Disorder in the Chinese Population:
            A Two-Stage Case-Control Study
  JOURNAL   J Atten Disord 25 (10), 1362-1373 (2021)
   PUBMED   32065002
  REMARK    GeneRIF: Association of Gene Variations in Ionotropic Glutamate
            Receptor and Attention-Deficit/Hyperactivity Disorder in the
            Chinese Population: A Two-Stage Case-Control Study.
REFERENCE   5  (bases 1 to 5783)
  AUTHORS   Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T.
  TITLE     The protein-tyrosine phosphatase PTPMEG interacts with glutamate
            receptor delta 2 and epsilon subunits
  JOURNAL   J Biol Chem 275 (21), 16167-16173 (2000)
   PUBMED   10748123
REFERENCE   6  (bases 1 to 5783)
  AUTHORS   Roche,K.W., Ly,C.D., Petralia,R.S., Wang,Y.X., McGee,A.W.,
            Bredt,D.S. and Wenthold,R.J.
  TITLE     Postsynaptic density-93 interacts with the delta2 glutamate
            receptor subunit at parallel fiber synapses
  JOURNAL   J Neurosci 19 (10), 3926-3934 (1999)
   PUBMED   10234023
REFERENCE   7  (bases 1 to 5783)
  AUTHORS   Hu,W., Zuo,J., De Jager,P.L. and Heintz,N.
  TITLE     The human glutamate receptor delta 2 gene (GRID2) maps to
            chromosome 4q22
  JOURNAL   Genomics 47 (1), 143-145 (1998)
   PUBMED   9465309
REFERENCE   8  (bases 1 to 5783)
  AUTHORS   Araki,K., Meguro,H., Kushiya,E., Takayama,C., Inoue,Y. and
            Mishina,M.
  TITLE     Selective expression of the glutamate receptor channel delta 2
            subunit in cerebellar Purkinje cells
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1267-1276 (1993)
   PUBMED   7506541
REFERENCE   9  (bases 1 to 5783)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
REFERENCE   10 (bases 1 to 5783)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112695.3, AB209318.1,
            BC099653.3, AC104077.2 and AW295056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001510.3.
            
            Summary: The protein encoded by this gene is a member of the family
            of ionotropic glutamate receptors which are the predominant
            excitatory neurotransmitter receptors in the mammalian brain. The
            encoded protein is a multi-pass membrane protein that is expressed
            selectively in cerebellar Purkinje cells. A point mutation in the
            mouse ortholog, associated with the phenotype named 'lurcher', in
            the heterozygous state leads to ataxia resulting from selective,
            cell-autonomous apoptosis of cerebellar Purkinje cells during
            postnatal development. Mice homozygous for this mutation die
            shortly after birth from massive loss of mid- and hindbrain neurons
            during late embryogenesis. This protein also plays a role in
            synapse organization between parallel fibers and Purkinje cells.
            Alternate splicing results in multiple transcript variants encoding
            distinct isoforms. Mutations in this gene cause cerebellar ataxia
            in humans. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.9675.1,
                                           SRR1660809.116011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282020.9/ ENSP00000282020.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AC112695.3         22704-23136
            434-893             AB209318.1         1-460
            894-3715            BC099653.3         203-3024
            3716-3984           AB209318.1         3283-3551
            3985-5472           AC104077.2         76564-78051
            5473-5773           AW295056.1         15-315              c
            5774-5783           AC104077.2         78353-78362
FEATURES             Location/Qualifiers
     source          1..5783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1-q22.2"
     gene            1..5783
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /note="glutamate ionotropic receptor delta type subunit 2"
                     /db_xref="GeneID:2895"
                     /db_xref="HGNC:HGNC:4576"
                     /db_xref="MIM:602368"
     exon            1..779
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     CDS             692..3715
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutamate receptor delta-2 subunit; gluR
                     delta-2 subunit; glutamate receptor, ionotropic, delta 2"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, delta-2 isoform 1
                     precursor"
                     /protein_id="NP_001501.2"
                     /db_xref="CCDS:CCDS3637.1"
                     /db_xref="GeneID:2895"
                     /db_xref="HGNC:HGNC:4576"
                     /db_xref="MIM:602368"
                     /translation="MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVF
                     RTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSA
                     GSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVV
                     TEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIE
                     ELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRR
                     SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL
                     ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGG
                     NPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLE
                     EPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGL
                     VGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFD
                     LSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVP
                     YTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTV
                     LDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFV
                     WDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMD
                     ILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWN
                     KRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQ
                     ALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNG
                     GFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI"
     exon            780..935
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1220
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1426
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1480
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1654
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1816
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1936
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2038
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2236
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2549
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2688
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2884
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3051
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3292
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..5783
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5755..5760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /note="hexamer: AATAAA"
     polyA_site      5783
                     /gene="GRID2"
                     /gene_synonym="GluD2; SCAR18"
                     /note="major polyA site"
ORIGIN      
        1 aaaccggctc cccgggcccg cctcgccaag ctgcgttccg cgcctcacgc agaaagggaa
       61 ttttctctgc attactatct gcattacctt gaagttcact ttttctaccc ctcttggaga
      121 gggctttttt cccccctccc tggtggaatc tggctgctcc gtttggaatc tcctaatctt
      181 tcctttccac ttagattctg gcagcgaaga ccagtgattc tctgcgggct gtaggggcgg
      241 gggcgggggt cttttttggt ccgagagggt gcggggaagg gggcacatcc ggcgtgaggg
      301 gggtgttgga agttgcagcg gagctgggac cggagacccg cggcccccgc gcagcgatgg
      361 gtctgatctg agccccagcc tctccccctg cccaagagca gtagaggctg gatatatttt
      421 tcaaaagcca aactgcaaac aactctggcg atgccaaaat tcccctccaa gtgacacggc
      481 tttgcgaagg aggtttcctc aggctgggct ctttctgtca ttcccttctg cctttctcgg
      541 cgacgataaa aggctttgct ctggcaatag gaatttagaa aaaaagaaaa agctgcgcta
      601 aactccaccg tgacctcaaa ctctttggac tgtttgaaaa aaaaaaaatt ggaagaaaat
      661 ccatcctcca agagaatcgg cataggagga gatggaagtt ttcccctttc tcttggtttt
      721 gtccgtctgg tggtctcgaa cctgggactc ggcgaatgcg gattcgatca ttcacatcgg
      781 agcaattttt gatgaatctg ccaaaaagga tgatgaggta tttcgcactg cggttggtga
      841 ccttaaccag aatgaggaga tcttacagac tgagaaaatc acattttcag tgacgtttgt
      901 tgatggcaac aaccctttcc aagcagttca agaagcctgt gaacttatga atcaaggcat
      961 cttggccctg gtcagctcca ttggctgcac gtcagcagga tccctccagt ctttggcaga
     1021 cgccatgcat atcccccacc tcttcattca gcgctcaaca gctgggaccc caaggagtgg
     1081 ctgtggactc acccggagca acaggaatga tgactacact ctctcagttc gcccacctgt
     1141 ctacttgcat gatgttatcc taagagtggt cacagagtat gcctggcaga aattcattat
     1201 attctatgat agtgaatacg atatccgtgg aatacaggag ttcttggaca aagtctctca
     1261 gcagggaatg gatgttgcac ttcagaaggt agaaaacaac atcaataaaa tgattaccac
     1321 tctctttgac accatgagaa tagaagaact gaatcgctat cgagacactc ttaggcgagc
     1381 gatccttgtt atgaatcctg ctacagccaa atccttcatt actgaggttg tggagactaa
     1441 tttggttgct tttgactgtc actggatcat tataaatgag gaaataaacg atgtggacgt
     1501 acaggaactt gtaagaaggt caattggaag gttaacgatt attcggcaga catttccagt
     1561 tccccagaac ataagtcagc ggtgtttccg tggcaaccat cgaatatctt caacattgtg
     1621 tgatccaaag gatccatttg ctcagaatat ggagatttcc aacctttaca tatatgacac
     1681 ggtgcttctg cttgctaatg cttttcataa gaagctggag gaccgaaagt ggcacagcat
     1741 ggcaagtctg tcatgtatca gaaagaactc aaagccctgg cagggtgggc gctccatgtt
     1801 ggagaccatc aagaagggtg gagttagtgg gttgactgga gagctagaat ttggagaaaa
     1861 tggaggcaat cccaatgtcc actttgaaat ccttggaacc aactatggag aagagcttgg
     1921 cagaggtgtt cgaaaacttg gttgctggaa tcctgtcaca ggtctgaatg ggtcactgac
     1981 tgacaagaaa ttggagaata acatgcgtgg agtggttcta cgtgtagtaa ctgttctgga
     2041 agaacctttt gtgatggtct ctgaaaatgt cttgggtaag ccgaagaaat accagggctt
     2101 ctccattgat gttttggatg ccttatctaa ctacctgggt tttaactacg aaatttacgt
     2161 agcaccggat cacaaatacg gaagcccaca agaagatggg acatggaatg gcttggtagg
     2221 agaacttgtc tttaagagag ccgacatagg gatttctgct ttaaccatca ctccagatcg
     2281 tgaaaatgtg gtggacttta cgacacgtta catggactac tcagtggggg tactacttcg
     2341 aagggctgaa aagacagtgg atatgtttgc ctgtcttgca ccatttgatc tctctctatg
     2401 ggcttgcatt gctggcacag tccttctggt gggtctactg gtctacctct tgaactggct
     2461 taatccccca cgattacaaa tgggatcaat gacgtctact actctctaca actccatgtg
     2521 gtttgtgtat ggatcttttg tacaacaagg cggggaagtc ccgtacacga ctctggctac
     2581 ccgaatgatg atgggggctt ggtggctatt tgctttgatt gttatctcat cttacacggc
     2641 aaacctcgct gctttcctca ctattacacg cattgaaagt tccatccagt ctctccagga
     2701 cctttccaag caaacagaaa tcccttatgg cacagtccta gactctgcgg tatatgagca
     2761 tgtccgcatg aaaggactga atccttttga gagggacagc atgtattccc aaatgtggcg
     2821 gatgatcaac cgaagcaatg gatcggagaa caatgttctg gagtcccagg caggcattca
     2881 aaaggtaaaa tatggaaatt atgctttcgt atgggatgca gctgtattgg aatatgtggc
     2941 tatcaatgac ccagattgtt ccttttacac cattggaaat actgttgctg atcggggata
     3001 tggaattgca ttacaacatg gcagtcctta ccgagatgtt ttttcacaaa ggatcctgga
     3061 gcttcagcag aatggtgaca tggacatcct gaagcacaaa tggtggccta agaatggcca
     3121 gtgtgacctg tactcgtcag tggacacaaa gcagaaagga ggcgccctgg acataaagag
     3181 ctttgcaggg gtcttttgta tcctggctgc tggaattgtc ctctcctgct tcatagccat
     3241 gctggagacg tggtggaaca agaggaaagg ctcccgggtt ccatcaaaag aggatgacaa
     3301 ggaaattgac ctggagcacc tccatagacg tgtaaatagc ttgtgcacag atgacgacag
     3361 cccccataaa cagttttcca cctcgtcaat tgatttgacc cctctggaca ttgacacttt
     3421 gccaacacga caagcactgg agcaaatcag tgatttcagg aacactcata ttaccacaac
     3481 aacctttatc ccagagcaga tccagactct tagccgcaca ctgtcagcta aagctgcttc
     3541 tggtttcact tttggcaacg tgcctgagca ccgaactggc ccttttaggc acagggcacc
     3601 taatgggggc tttttcagga gtcctataaa aacaatgtca tctattcctt atcaaccaac
     3661 tcctaccctg gggctcaatc tgggtaatga tccagaccga ggcacctcca tatgagcatc
     3721 aaacaaatct cttcactgtt tcttttttag gactcccttt gcaaggagca actgtaatat
     3781 tgtgggacta acatggatgt aacgtttaaa aaaaagatca ggattattag taacaattct
     3841 agttttttcc tcccaccttc tccctctcct ctctcctcta tgattttctc tctttccccc
     3901 tcccttcctg tacattttcc tccacttttt ttcattactc aacttgttcc ccaagaaggt
     3961 agtgtactag gatcctatta gtctgctttt catatactgt acatcaagta taggaaatgt
     4021 gcactgagta tactaaaagt atatgcagga ttaattttac ataaaggcct cttctgtaac
     4081 atttctctat tttttgaaat acaattgcaa taacttcagt ctttttacat tcttctgctg
     4141 catccataca atgctccact gctgttgagt gtcctttaac tgtggaccaa aggcaacccc
     4201 tgcagtgttt ataaaacaat tttaagacca ttcaggccac ataagatgag aatgcaattt
     4261 tgtaggatta caaaaaagcc attaatatgc cagtcaagac tacagttaaa actactcttg
     4321 cactgcaaca gtgcatatga cctttatgtg attgtacagt attaaaagtt ttttcttatg
     4381 tacagtaaac tttatcatat ggcagaagcc tctattgtgt taaataaatt agtatttcat
     4441 atatatacat atatatgcac ctatataatg tgtatatata taaaaaggca gccattgcta
     4501 ttgcaattca tttaataaag ctttagttta aacaaaagta ttgtatacag gaactatgta
     4561 tagtgcaggg gttcttttca gttagaaaag gcaggttgct ttaatgttat tctgactcgc
     4621 attgtttgcc aacagaaaat attttatact tttgttatta aagcatccag ggcaatttaa
     4681 tatttgttcc tagatgtaac tcatttgaat aggttttgca tttgttattc agcagtgtat
     4741 aaagctaacc ttgataattt tacttttaat taattatcta aatgaaaaat gctattagct
     4801 gaaccacatc cacaacagca catagagctc tagaagagtt gaaacataga tcattgaagg
     4861 ttaaaaatcc tcttccaaag cagcaagtca atcaatacaa taatgatatt tggggagggg
     4921 tgggagccct taagaactat tgatgtggcc ttaaattact gtcatttatt atcctaaaga
     4981 agaaaacata ataaccataa tgggctctca actcaactcc cttttttatt tagttctatt
     5041 tggaggagtt atgtattttt tacattagtg ccaagtatat agaaggatga cagcaaaaac
     5101 agtgcctctt tgtgcacaat ccttttaaag tagcattctt acttgttaga aatgtagaat
     5161 gaactttgtt tgtaatcctt aaattaaaat gtggtaagta ggaagcaaga acttattctg
     5221 tgtttttacg cagccataca cttactttaa tctaactcat tctgtggcta ggattgatat
     5281 aggaatcaac ctatgtgatt tgctttagga gaaattaaaa ggtatattct taagatatat
     5341 tatattttga tgctaattct gttctgggga gcatcttgta ttgtcactgt tttgtactaa
     5401 atcttcaaat attgtctact gtgtaaggca gaaaaatttc ttatcatgca aaaaccattt
     5461 tgtttccagg gtaacaagta actaagtgca tgcacaactt gttttccctt gtaacattca
     5521 tgatctcatt tacaactctg attttaaaac aaaaaaatct ttacaacaag ctatataggg
     5581 acataccaga tgttgcagtg attttagcta tcaacaaact gttaaccatg tacaatattt
     5641 aaaataggct tattttgatg tatcgcctat tatacaaaca cacaaaacat ttttggaggc
     5701 ctcagttatg agtgacagag ctttctgtgt ataatttgtc taaataattt gtctaataaa
     5761 aatgttttct aaacttgctc tca
//
