LOCUS       XM_024447716            1605 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens glyoxylate and hydroxypyruvate reductase
            (GRHPR), transcript variant X1, mRNA.
ACCESSION   XM_024447716
VERSION     XM_024447716.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024447716.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..1605
                     /gene="GRHPR"
                     /gene_synonym="GLXR; GLYD; PH2"
                     /note="glyoxylate and hydroxypyruvate reductase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 28 ESTs, 107 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9380"
                     /db_xref="HGNC:HGNC:4570"
                     /db_xref="MIM:604296"
     CDS             16..1305
                     /gene="GRHPR"
                     /gene_synonym="GLXR; GLYD; PH2"
                     /codon_start=1
                     /product="glyoxylate reductase/hydroxypyruvate reductase
                     isoform X1"
                     /protein_id="XP_024303484.1"
                     /db_xref="GeneID:9380"
                     /db_xref="HGNC:HGNC:4570"
                     /db_xref="MIM:604296"
                     /translation="MRPWTGYCPLSPGALIPQWHEAHPPTHTQGHCVGSLLLSLPEHA
                     QSPLSRNPALPLAKPHPLRTPRATSLPPTPAWPRPGPATFPGQLLYCQVRVGGCTADE
                     TGATHEGVRHPQDTRRGCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILD
                     AAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLP
                     EAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGR
                     QPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINI
                     SRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCDGPEFCHFEIMCY
                     SISATKNHYPGMFLIPSLVPHQGRDKQNPVVTMALES"
     polyA_site      1605
                     /gene="GRHPR"
                     /gene_synonym="GLXR; GLYD; PH2"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 aaaagcaggg ctcccatgag gccttggacg ggatactgcc ccctctcccc cggggccctg
       61 attccccagt ggcacgaggc gcaccccccc acacacacac aaggacactg tgtagggtca
      121 ctgttactgt cactccccga gcacgcacag tcaccgctca gccgcaaccc ggcgctccct
      181 ctcgcgaagc cacaccccct gcgcacgccg cgcgcgacgt ctctcccgcc cactccagcc
      241 tggccccgcc ccggcccagc tacattcccg ggccagcttc tgtactgcca ggtccgggtc
      301 ggcggctgca ctgcggatga gaccggtgcg actcatgaag gtgttcgtca cccgcaggat
      361 acccgccgag gctgtgaggt ggagcagtgg gactcggatg agcccatccc tgccaaggag
      421 ctagagcgag gtgtggcggg ggcccacggc ctgctctgcc tcctctccga ccacgtggac
      481 aagaggatcc tggatgctgc aggggccaat ctcaaagtca tcagcaccat gtctgtgggc
      541 atcgaccact tggctttgga tgaaatcaag aagcgtggga tccgagttgg ctacacccca
      601 gatgtcctga cagataccac cgccgaactc gcagtctccc tgctacttac cacctgccgc
      661 cggttgccgg aggccatcga ggaagtgaag aatggtggct ggacctcgtg gaagcccctc
      721 tggctgtgtg gctatggact cacgcagagc actgtcggca tcatcgggct ggggcgcata
      781 ggccaggcca ttgctcggcg tctgaaacca ttcggtgtcc agagatttct gtacacaggg
      841 cgccagccca ggcctgagga agcagcagaa ttccaggcag agtttgtgtc tacccctgag
      901 ctggctgccc aatctgattt catcgtcgtg gcctgctcct taacacctgc aaccgaggga
      961 ctctgcaaca aggacttctt ccagaagatg aaggaaacag ctgtgttcat caacatcagc
     1021 aggggcgacg tcgtaaacca ggacgacctg taccaggcct tggccagtgg taagattgca
     1081 gctgctggac tggatgtgac gagcccagaa ccactgccta caaaccaccc tctcctgacc
     1141 ctgaagaact gtgatggccc tgaattttgc cactttgaaa taatgtgcta ctcaatctca
     1201 gcaaccaaaa accattatcc aggaatgttt cttattcctt cacttgtccc tcaccaagga
     1261 cgggacaaac agaacccagt tgtgaccatg gcacttgaat cttgatacct agaccatcag
     1321 gaaaattaag gagcacttcc agaaaaggag ttaactggaa gaaatgagaa ctaggtaagg
     1381 acgtaactct tattttggtc agaacgatta gaggtaggtg ggtttaattt taaaattagt
     1441 ttcagcacct acacatattg ttccctttgc ccattctgtc cccccagccc ctccctgccc
     1501 ccaggtggat tttttttttt tttaatcacc accttaccca cttctctcca aggtcaggcc
     1561 acagcactgc cattgccaat gccttgctct gtgctcaagg aatca
//
