LOCUS       NM_198173               2834 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens grainyhead like transcription factor 3 (GRHL3),
            transcript variant 2, mRNA.
ACCESSION   NM_198173
VERSION     NM_198173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2834)
  AUTHORS   Lammert,F.C., Pannhausen,J., Noetzel,E., Friedland,F., Wirtz,J.,
            Herfs,Y., Leypold,S., Gan,L., Weiskirchen,R., Schnitzler,T.,
            Knuchel,R., Maurer,J., Jonigk,D.D., Rose,M. and Gaisa,N.T.
  TITLE     Dual role of GRHL3 in bladder carcinogenesis depending on
            histological subtypes
  JOURNAL   Mol Oncol 18 (6), 1397-1416 (2024)
   PUBMED   38429970
  REMARK    GeneRIF: Dual role of GRHL3 in bladder carcinogenesis depending on
            histological subtypes.
REFERENCE   2  (bases 1 to 2834)
  AUTHORS   Hu,X.T., Wu,X.F., Sui,L.M., Ao,L.Q., Pu,C.X., Yuan,M., Xing,W. and
            Xu,X.
  TITLE     The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750
  JOURNAL   J Dermatol Sci 113 (3), 93-102 (2024)
   PUBMED   38383230
  REMARK    GeneRIF: The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750.
REFERENCE   3  (bases 1 to 2834)
  AUTHORS   Slavec,L., Gersak,K., Eberlinc,A., Hovnik,T., Lovrecic,L.,
            Mlinaric-Rascan,I. and Karas Kuzelicki,N.
  TITLE     A Comprehensive Genetic Analysis of Slovenian Families with
            Multiple Cases of Orofacial Clefts Reveals Novel Variants in the
            Genes IRF6, GRHL3, and TBX22
  JOURNAL   Int J Mol Sci 24 (5), 4262 (2023)
   PUBMED   36901693
  REMARK    GeneRIF: A Comprehensive Genetic Analysis of Slovenian Families
            with Multiple Cases of Orofacial Clefts Reveals Novel Variants in
            the Genes IRF6, GRHL3, and TBX22.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2834)
  AUTHORS   Slavec,L., Karas Kuzelicki,N., Locatelli,I. and Gersak,K.
  TITLE     Genetic markers for non-syndromic orofacial clefts in populations
            of European ancestry: a meta-analysis
  JOURNAL   Sci Rep 12 (1), 1214 (2022)
   PUBMED   35075162
  REMARK    GeneRIF: Genetic markers for non-syndromic orofacial clefts in
            populations of European ancestry: a meta-analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2834)
  AUTHORS   Tan,L., Qu,W., Wu,D., Liu,M., Wang,Q., Ai,Q., Hu,H., Chen,M.,
            Chen,W. and Zhou,H.
  TITLE     GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in
            Colorectal Cancer
  JOURNAL   Anal Cell Pathol (Amst) 2021, 6004821 (2021)
   PUBMED   34888136
  REMARK    GeneRIF: GRHL3 Promotes Tumor Growth and Metastasis via the MEK
            Pathway in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2834)
  AUTHORS   Boglev,Y., Wilanowski,T., Caddy,J., Parekh,V., Auden,A., Darido,C.,
            Hislop,N.R., Cangkrama,M., Ting,S.B. and Jane,S.M.
  TITLE     The unique and cooperative roles of the Grainy head-like
            transcription factors in epidermal development reflect unexpected
            target gene specificity
  JOURNAL   Dev Biol 349 (2), 512-522 (2011)
   PUBMED   21081122
REFERENCE   7  (bases 1 to 2834)
  AUTHORS   Caddy,J., Wilanowski,T., Darido,C., Dworkin,S., Ting,S.B., Zhao,Q.,
            Rank,G., Auden,A., Srivastava,S., Papenfuss,T.A., Murdoch,J.N.,
            Humbert,P.O., Parekh,V., Boulos,N., Weber,T., Zuo,J.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Epidermal wound repair is regulated by the planar cell polarity
            signaling pathway
  JOURNAL   Dev Cell 19 (1), 138-147 (2010)
   PUBMED   20643356
  REMARK    Erratum:[Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added]]
REFERENCE   8  (bases 1 to 2834)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2834)
  AUTHORS   Guardiola-Serrano,F., Haendeler,J., Lukosz,M., Sturm,K.,
            Melchner,Hv. and Altschmied,J.
  TITLE     Gene trapping identifies a putative tumor suppressor and a new
            inducer of cell migration
  JOURNAL   Biochem Biophys Res Commun 376 (4), 748-752 (2008)
   PUBMED   18814840
  REMARK    GeneRIF: GRHL3 strongly stimulated primary endothelial cell
            migration, suggesting that it is a putative tumor-angiogenesis
            factor.
REFERENCE   10 (bases 1 to 2834)
  AUTHORS   Ting,S.B., Wilanowski,T., Cerruti,L., Zhao,L.L., Cunningham,J.M.
            and Jane,S.M.
  TITLE     The identification and characterization of human
            Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like
            family of developmental transcription factors
  JOURNAL   Biochem J 370 (Pt 3), 953-962 (2003)
   PUBMED   12549979
  REMARK    GeneRIF: Data report the identification of Sister-of-Mammalian
            Grainyhead (SOM), which is phylogenetically aligned with grainyhead
            protein, and like grainyhead encodes a highly conserved
            developmental transcription factor. [Sister-of-Mammalian
            Grainyhead]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA714132.1, AK315164.1,
            AY231160.1 and BC036890.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_198173.2.
            
            Summary: This gene encodes a member of the grainyhead family of
            transcription factors. The encoded protein may function as a
            transcription factor during development, and has been shown to
            stimulate migration of endothelial cells. Multiple transcript
            variants encoding distinct isoforms have been identified for this
            gene.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2, also known as SOM2) differs in
            the 5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4109823.1, AK315164.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361548.9/ ENSP00000354943.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               DA714132.1         36-198
            164-1380            AK315164.1         1-1217
            1381-1518           AY231160.1         1247-1384
            1519-2004           AK315164.1         1356-1841
            2005-2834           BC036890.2         1986-2815
FEATURES             Location/Qualifiers
     source          1..2834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2834
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /note="grainyhead like transcription factor 3"
                     /db_xref="GeneID:57822"
                     /db_xref="HGNC:HGNC:25839"
                     /db_xref="MIM:608317"
     exon            1..212
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2004
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor CP2-like 4; transcription factor
                     hSOM1; grainyhead-like protein 3 homolog; sister of
                     mammalian grainyhead"
                     /codon_start=1
                     /product="grainyhead-like protein 3 homolog isoform 2"
                     /protein_id="NP_937816.1"
                     /db_xref="CCDS:CCDS44088.1"
                     /db_xref="GeneID:57822"
                     /db_xref="HGNC:HGNC:25839"
                     /db_xref="MIM:608317"
                     /translation="MSNELDFRSVRLLKNDPVNLQKFSYTSEDEAWKTYLENPLTAAT
                     KAMMRVNGDDDSVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKRYYHGMEYETDLTP
                     LESPTHLMKFLTENVSGTPEYPDLLKKNNLMSLEGALPTPGKAAPLPAGPSKLEAGSV
                     DSYLLPTTDMYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESMLFPDILKTSPEP
                     PCPEDYPSLKSDFEYTLGSPKAIHIKSGESPMAYLNKGQFYPVTLRTPAGGKGLALSS
                     NKVKSVVMVVFDNEKVPVEQLRFWKHWHSRQPTAKQRVIDVADCKENFNTVEHIEEVA
                     YNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGLGTERLVHRA
                     VCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNSGVKGCLLSGFRGNETTYLRPET
                     DLETPPVLFIPNVHFSSLQRSGGAAPSAGPSSSNRLPLKRTCSPFTEEFEPLPSKQAK
                     EGDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENIYKVYKKCKRGI
                     LVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL"
     exon            213..399
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..461
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..807
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..881
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1035
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1147
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1242
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1401
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1480
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1614
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1649
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1738
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1824
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1889
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2834
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /note="hexamer: AATAAA"
     polyA_site      2834
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccggc acctgtacct gtagccaatc agcgccagcg ctgctgggaa cctacctgtc
       61 agcaaaatct cgacacccaa acctcaacat aaatcaaaca ctttcccggg cagagaatgt
      121 ctgtgtcagg caagaattag agacaagcgg tcagcagagc ctcagtgctg atcgtcggag
      181 cttgggagca ggaagatgtc gaatgaactt gatttcaggt ctgtgcggct gctaaagaac
      241 gacccagtca acttgcagaa attctcttac actagtgagg atgaggcctg gaagacgtac
      301 ctagaaaacc cgttgacagc tgccacaaag gccatgatga gagtcaatgg agatgatgac
      361 agtgttgcgg ccttgagctt cctctatgat tactacatgg gtcccaagga gaagcggata
      421 ttgtcctcca gcactggggg caggaatgac caaggaaaga ggtactacca tggcatggaa
      481 tatgagacgg acctcactcc ccttgaaagc cccacacacc tcatgaaatt cctgacagag
      541 aacgtgtctg gaaccccaga gtacccagat ttgctcaaga agaataacct gatgagcttg
      601 gagggggcct tgcccacccc tggcaaggca gctcccctcc ctgcaggccc cagcaagctg
      661 gaggccggct ctgtggacag ctacctgtta cccaccactg atatgtatga taatggctcc
      721 ctcaactcct tgtttgagag cattcatggg gtgccgccca cacagcgctg gcagccagac
      781 agcaccttca aagatgaccc acaggagtcg atgctcttcc cagatatcct gaaaacctcc
      841 ccggaacccc catgtccaga ggactacccc agcctcaaaa gtgactttga atacaccctg
      901 ggctccccca aagccatcca catcaagtca ggcgagtcac ccatggccta cctcaacaaa
      961 ggccagttct accccgtcac cctgcggacc ccagcaggtg gcaaaggcct tgccttgtcc
     1021 tccaacaaag tcaagagtgt ggtgatggtt gtcttcgaca atgagaaggt cccagtagag
     1081 cagctgcgct tctggaagca ctggcattcc cggcaaccca ctgccaagca gcgggtcatt
     1141 gacgtggctg actgcaaaga aaacttcaac actgtggagc acattgagga ggtggcctat
     1201 aatgcactgt cctttgtgtg gaacgtgaat gaagaggcca aggtgttcat cggcgtaaac
     1261 tgtctgagca cagacttttc ctcacaaaag ggggtgaagg gtgtccccct gaacctgcag
     1321 attgacacct atgactgtgg cttgggcact gagcgcctgg tacaccgtgc tgtctgccag
     1381 atcaagatct tctgtgacaa gggagctgag aggaagatgc gcgatgacga gcggaagcag
     1441 ttccggagga aggtcaagtg ccctgactcc agcaacagtg gcgtcaaggg ctgcctgctg
     1501 tcgggcttca ggggcaatga gacgacctac cttcggccag agactgacct ggagacgcca
     1561 cccgtgctgt tcatccccaa tgtgcacttc tccagcctgc agcgctctgg aggggcagcc
     1621 ccctcggcag gacccagcag ctccaacagg ctgcctctga agcgtacctg ctcgcccttc
     1681 actgaggagt ttgagcctct gccctccaag caggccaagg aaggcgacct tcagagagtt
     1741 ctgctgtatg tgcggaggga gactgaggag gtgtttgacg cgctcatgtt gaagacccca
     1801 gacctgaagg ggctgaggaa tgcgatctct gagaagtatg ggttccctga agagaacatt
     1861 tacaaagtct acaagaaatg caagcgagga atcttagtca acatggacaa caacatcatt
     1921 cagcattaca gcaaccacgt cgccttcctg ctggacatgg gggagctgga cggcaaaatt
     1981 cagatcatcc ttaaggagct gtaaggcctc tcgagcatcc aaaccctcac gacctgcaag
     2041 gggccagcag ggacgtggcc ccacgccaca cacaacctct ccacatgcct cagcgctgtt
     2101 acttgaatgc cttccctgag ggaagaggcc cttgagtcac agacccacag acgtcagggc
     2161 cagggagaga cctagggggt cccctggcct ggatccccat ggtatgcttg aatctgctcc
     2221 ctgaacttcc tgccagtgcc tccccgtacc ccaaaacaat gtcaccatgg ttaccaccta
     2281 cccagaagac tgttccctcc tcccaagacc cttgtctgca gtggtgctcc tgcaggctgc
     2341 ccgttaagat ggtggcggca cacgctccct cccgcagcac cacgccagct ggtgcggccc
     2401 ccactctctg tcttccttca acttcagaca aaggatttct caacctttgg tcagttaact
     2461 tgaaaactct tgattttcag tgcaaatgac ttttaaaaga cactatattg gagtctcttt
     2521 ctcagacttc ctcagcgcag gatgtaaata gcactaacga tcgactggaa caaagtgacc
     2581 gctgtgtaaa actactgcct tgccactcac tgttgtatac atttcttatt tacgattttc
     2641 atttgttata tatatatata aatatactgt atatatatgc aacattttat atttttcatg
     2701 gatatgtttt tatcatttca aaaaatgtgt atttcacatt tcttggactt tttttagctg
     2761 ttattcagtg atgcattttg tatactcacg tggtatttag taataaaaat ctatctatgt
     2821 attacgtcac atta
//
