LOCUS       NP_937816                602 aa            linear   PRI 24-JUN-2024
DEFINITION  grainyhead-like protein 3 homolog isoform 2 [Homo sapiens].
ACCESSION   NP_937816
VERSION     NP_937816.1
DBSOURCE    REFSEQ: accession NM_198173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 602)
  AUTHORS   Lammert,F.C., Pannhausen,J., Noetzel,E., Friedland,F., Wirtz,J.,
            Herfs,Y., Leypold,S., Gan,L., Weiskirchen,R., Schnitzler,T.,
            Knuchel,R., Maurer,J., Jonigk,D.D., Rose,M. and Gaisa,N.T.
  TITLE     Dual role of GRHL3 in bladder carcinogenesis depending on
            histological subtypes
  JOURNAL   Mol Oncol 18 (6), 1397-1416 (2024)
   PUBMED   38429970
  REMARK    GeneRIF: Dual role of GRHL3 in bladder carcinogenesis depending on
            histological subtypes.
REFERENCE   2  (residues 1 to 602)
  AUTHORS   Hu,X.T., Wu,X.F., Sui,L.M., Ao,L.Q., Pu,C.X., Yuan,M., Xing,W. and
            Xu,X.
  TITLE     The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750
  JOURNAL   J Dermatol Sci 113 (3), 93-102 (2024)
   PUBMED   38383230
  REMARK    GeneRIF: The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750.
REFERENCE   3  (residues 1 to 602)
  AUTHORS   Slavec,L., Gersak,K., Eberlinc,A., Hovnik,T., Lovrecic,L.,
            Mlinaric-Rascan,I. and Karas Kuzelicki,N.
  TITLE     A Comprehensive Genetic Analysis of Slovenian Families with
            Multiple Cases of Orofacial Clefts Reveals Novel Variants in the
            Genes IRF6, GRHL3, and TBX22
  JOURNAL   Int J Mol Sci 24 (5), 4262 (2023)
   PUBMED   36901693
  REMARK    GeneRIF: A Comprehensive Genetic Analysis of Slovenian Families
            with Multiple Cases of Orofacial Clefts Reveals Novel Variants in
            the Genes IRF6, GRHL3, and TBX22.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 602)
  AUTHORS   Slavec,L., Karas Kuzelicki,N., Locatelli,I. and Gersak,K.
  TITLE     Genetic markers for non-syndromic orofacial clefts in populations
            of European ancestry: a meta-analysis
  JOURNAL   Sci Rep 12 (1), 1214 (2022)
   PUBMED   35075162
  REMARK    GeneRIF: Genetic markers for non-syndromic orofacial clefts in
            populations of European ancestry: a meta-analysis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 602)
  AUTHORS   Tan,L., Qu,W., Wu,D., Liu,M., Wang,Q., Ai,Q., Hu,H., Chen,M.,
            Chen,W. and Zhou,H.
  TITLE     GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in
            Colorectal Cancer
  JOURNAL   Anal Cell Pathol (Amst) 2021, 6004821 (2021)
   PUBMED   34888136
  REMARK    GeneRIF: GRHL3 Promotes Tumor Growth and Metastasis via the MEK
            Pathway in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 602)
  AUTHORS   Boglev,Y., Wilanowski,T., Caddy,J., Parekh,V., Auden,A., Darido,C.,
            Hislop,N.R., Cangkrama,M., Ting,S.B. and Jane,S.M.
  TITLE     The unique and cooperative roles of the Grainy head-like
            transcription factors in epidermal development reflect unexpected
            target gene specificity
  JOURNAL   Dev Biol 349 (2), 512-522 (2011)
   PUBMED   21081122
REFERENCE   7  (residues 1 to 602)
  AUTHORS   Caddy,J., Wilanowski,T., Darido,C., Dworkin,S., Ting,S.B., Zhao,Q.,
            Rank,G., Auden,A., Srivastava,S., Papenfuss,T.A., Murdoch,J.N.,
            Humbert,P.O., Parekh,V., Boulos,N., Weber,T., Zuo,J.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Epidermal wound repair is regulated by the planar cell polarity
            signaling pathway
  JOURNAL   Dev Cell 19 (1), 138-147 (2010)
   PUBMED   20643356
  REMARK    Erratum:[Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added]]
REFERENCE   8  (residues 1 to 602)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (residues 1 to 602)
  AUTHORS   Guardiola-Serrano,F., Haendeler,J., Lukosz,M., Sturm,K.,
            Melchner,Hv. and Altschmied,J.
  TITLE     Gene trapping identifies a putative tumor suppressor and a new
            inducer of cell migration
  JOURNAL   Biochem Biophys Res Commun 376 (4), 748-752 (2008)
   PUBMED   18814840
  REMARK    GeneRIF: GRHL3 strongly stimulated primary endothelial cell
            migration, suggesting that it is a putative tumor-angiogenesis
            factor.
REFERENCE   10 (residues 1 to 602)
  AUTHORS   Ting,S.B., Wilanowski,T., Cerruti,L., Zhao,L.L., Cunningham,J.M.
            and Jane,S.M.
  TITLE     The identification and characterization of human
            Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like
            family of developmental transcription factors
  JOURNAL   Biochem J 370 (Pt 3), 953-962 (2003)
   PUBMED   12549979
  REMARK    GeneRIF: Data report the identification of Sister-of-Mammalian
            Grainyhead (SOM), which is phylogenetically aligned with grainyhead
            protein, and like grainyhead encodes a highly conserved
            developmental transcription factor. [Sister-of-Mammalian
            Grainyhead]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA714132.1, AK315164.1,
            AY231160.1 and BC036890.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the grainyhead family of
            transcription factors. The encoded protein may function as a
            transcription factor during development, and has been shown to
            stimulate migration of endothelial cells. Multiple transcript
            variants encoding distinct isoforms have been identified for this
            gene.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2, also known as SOM2) differs in
            the 5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4109823.1, AK315164.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361548.9/ ENSP00000354943.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     Protein         1..602
                     /product="grainyhead-like protein 3 homolog isoform 2"
                     /note="transcription factor CP2-like 4; transcription
                     factor hSOM1; grainyhead-like protein 3 homolog; sister of
                     mammalian grainyhead"
                     /calculated_mol_wt=67565
     Region          215..421
                     /region_name="CP2"
                     /note="CP2 transcription factor; pfam04516"
                     /db_xref="CDD:461338"
     CDS             1..602
                     /gene="GRHL3"
                     /gene_synonym="SOM; TFCP2L4; VWS2"
                     /coded_by="NM_198173.3:196..2004"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS44088.1"
                     /db_xref="GeneID:57822"
                     /db_xref="HGNC:HGNC:25839"
                     /db_xref="MIM:608317"
ORIGIN      
        1 msneldfrsv rllkndpvnl qkfsytsede awktylenpl taatkammrv ngdddsvaal
       61 sflydyymgp kekrilssst ggrndqgkry yhgmeyetdl tplespthlm kfltenvsgt
      121 peypdllkkn nlmslegalp tpgkaaplpa gpskleagsv dsyllpttdm ydngslnslf
      181 esihgvpptq rwqpdstfkd dpqesmlfpd ilktspeppc pedypslksd feytlgspka
      241 ihiksgespm aylnkgqfyp vtlrtpaggk glalssnkvk svvmvvfdne kvpveqlrfw
      301 khwhsrqpta kqrvidvadc kenfntvehi eevaynalsf vwnvneeakv figvnclstd
      361 fssqkgvkgv plnlqidtyd cglgterlvh ravcqikifc dkgaerkmrd derkqfrrkv
      421 kcpdssnsgv kgcllsgfrg nettylrpet dletppvlfi pnvhfsslqr sggaapsagp
      481 sssnrlplkr tcspfteefe plpskqakeg dlqrvllyvr reteevfdal mlktpdlkgl
      541 rnaisekygf peeniykvyk kckrgilvnm dnniiqhysn hvaflldmge ldgkiqiilk
      601 el
//
