LOCUS       NM_198182               3568 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens grainyhead like transcription factor 1 (GRHL1), mRNA.
ACCESSION   NM_198182 NM_014552
VERSION     NM_198182.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3568)
  AUTHORS   Taracha-Wisniewska,A., Parks,E.G.C., Miller,M.,
            Lipinska-Zubrycka,L., Dworkin,S. and Wilanowski,T.
  TITLE     Vitamin D Receptor Regulates the Expression of the Grainyhead-Like
            1 Gene
  JOURNAL   Int J Mol Sci 25 (14), 7913 (2024)
   PUBMED   39063155
  REMARK    GeneRIF: Vitamin D Receptor Regulates the Expression of the
            Grainyhead-Like 1 Gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3568)
  AUTHORS   Proft,S., Leiz,J., Heinemann,U., Seelow,D., Schmidt-Ott,K.M. and
            Rutkiewicz,M.
  TITLE     Discovery of a non-canonical GRHL1 binding site using deep
            convolutional and recurrent neural networks
  JOURNAL   BMC Genomics 24 (1), 736 (2023)
   PUBMED   38049725
  REMARK    GeneRIF: Discovery of a non-canonical GRHL1 binding site using deep
            convolutional and recurrent neural networks.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3568)
  AUTHORS   Grigolon,G., Araldi,E., Erni,R., Wu,J.Y., Thomas,C., La
            Fortezza,M., Laube,B., Pohlmann,D., Stoffel,M., Zarse,K.,
            Carreira,E.M., Ristow,M. and Fischer,F.
  TITLE     Grainyhead 1 acts as a drug-inducible conserved transcriptional
            regulator linked to insulin signaling and lifespan
  JOURNAL   Nat Commun 13 (1), 107 (2022)
   PUBMED   35013237
  REMARK    GeneRIF: Grainyhead 1 acts as a drug-inducible conserved
            transcriptional regulator linked to insulin signaling and lifespan.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3568)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3568)
  AUTHORS   Ming,Q., Roske,Y., Schuetz,A., Walentin,K., Ibraimi,I.,
            Schmidt-Ott,K.M. and Heinemann,U.
  TITLE     Structural basis of gene regulation by the Grainyhead/CP2
            transcription factor family
  JOURNAL   Nucleic Acids Res 46 (4), 2082-2095 (2018)
   PUBMED   29309642
  REMARK    GeneRIF: Structural basis of DNA target-site recognition by
            grainyhead-like 1.
REFERENCE   6  (bases 1 to 3568)
  AUTHORS   Henderson,Y.C., Frederick,M.J., Wang,M.T., Hollier,L.M. and
            Clayman,G.L.
  TITLE     LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from
            first-trimester human placental tissue and their transcriptional
            regulation
  JOURNAL   DNA Cell Biol 27 (2), 71-79 (2008)
   PUBMED   18004979
  REMARK    GeneRIF: LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter
            activity.
REFERENCE   7  (bases 1 to 3568)
  AUTHORS   Ting,S.B., Wilanowski,T., Cerruti,L., Zhao,L.L., Cunningham,J.M.
            and Jane,S.M.
  TITLE     The identification and characterization of human
            Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like
            family of developmental transcription factors
  JOURNAL   Biochem J 370 (Pt 3), 953-962 (2003)
   PUBMED   12549979
REFERENCE   8  (bases 1 to 3568)
  AUTHORS   Peters,L.M., Anderson,D.W., Griffith,A.J., Grundfast,K.M., San
            Agustin,T.B., Madeo,A.C., Friedman,T.B. and Morell,R.J.
  TITLE     Mutation of a transcription factor, TFCP2L3, causes progressive
            autosomal dominant hearing loss, DFNA28
  JOURNAL   Hum Mol Genet 11 (23), 2877-2885 (2002)
   PUBMED   12393799
  REMARK    GeneRIF: Includes a comparison to TFCP2L2, the GRHL1 protein.
REFERENCE   9  (bases 1 to 3568)
  AUTHORS   Wilanowski,T., Tuckfield,A., Cerruti,L., O'Connell,S., Saint,R.,
            Parekh,V., Tao,J., Cunningham,J.M. and Jane,S.M.
  TITLE     A highly conserved novel family of mammalian developmental
            transcription factors related to Drosophila grainyhead
  JOURNAL   Mech Dev 114 (1-2), 37-50 (2002)
   PUBMED   12175488
REFERENCE   10 (bases 1 to 3568)
  AUTHORS   Huang,N. and Miller,W.L.
  TITLE     Cloning of factors related to HIV-inducible LBP proteins that
            regulate steroidogenic factor-1-independent human placental
            transcription of the cholesterol side-chain cleavage enzyme,
            P450scc
  JOURNAL   J Biol Chem 275 (4), 2852-2858 (2000)
   PUBMED   10644752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312950.1, AC010969.11 and
            AA234992.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198182.2.
            
            Summary: This gene encodes a member of the grainyhead family of
            transcription factors. The encoded protein can exist as a homodimer
            or can form heterodimers with sister-of-mammalian grainyhead or
            brother-of-mammalian grainyhead. This protein functions as a
            transcription factor during development. [provided by RefSeq, Jun
            2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312950.1, AF198489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324907.14/ ENSP00000324693.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1998              AK312950.1         1-1998
            1999-3494           AC010969.11        171407-172902
            3495-3568           AA234992.1         13-86               c
FEATURES             Location/Qualifiers
     source          1..3568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..3568
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /note="grainyhead like transcription factor 1"
                     /db_xref="GeneID:29841"
                     /db_xref="HGNC:HGNC:17923"
                     /db_xref="MIM:609786"
     exon            1..161
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1998
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /note="transcription factor CP2-like 2; LBP protein 32;
                     mammalian grainyhead; transcription factor LBP-32;
                     grainyhead-like 1"
                     /codon_start=1
                     /product="grainyhead-like protein 1 homolog"
                     /protein_id="NP_937825.2"
                     /db_xref="CCDS:CCDS33144.2"
                     /db_xref="GeneID:29841"
                     /db_xref="HGNC:HGNC:17923"
                     /db_xref="MIM:609786"
                     /translation="MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAA
                     TKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQ
                     PLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTE
                     TQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFK
                     EGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNK
                     GQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQR
                     CIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLP
                     LNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLP
                     SHKRMDITVFKPFIDLDTQPVLFIPDVHFANLQRGTHVLPIASEELEGEGSVLKRGPY
                     GTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDV
                     PHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI"
     exon            162..348
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..419
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..810
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..887
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1044
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1156
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1251
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1410
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1462
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1602
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1640
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1732
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1818
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1883
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..3568
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /note="hexamer: ATTAAA"
     polyA_site      3568
                     /gene="GRHL1"
                     /gene_synonym="LBP32; MGR; NH32; TFCP2L2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgagaa aagcaaaccc aacccgtcgg ggccgccgct ccggacccgc agccgccgcc
       61 gccgcctcct ccccccggat cgggtgtact gtcccaaccc gaaagtccag ttctgcggcc
      121 cggcagcggc gagcgggcgc gatgacacag gagtacgaca acaaacggcc agtgttggtt
      181 cttcagaatg aagcacttta tccacagcgg cggtcctaca ctagtgagga tgaggcctgg
      241 aaatccttcc tggaaaaccc tctcactgca gcgaccaaag cgatgatgag catcaatgga
      301 gatgaagaca gcgccgctgc gctgggcctg ctctatgact actacaaggt tccaagagag
      361 agaaggtcat caacagcaaa gccagaggtg gagcaccctg agccagatca cagcaaaaga
      421 aacagcatac caattgtgac agagcagccc ctcatctctg ctggagaaaa cagagtgcaa
      481 gtactgaaaa atgtgccatt taacattgtc cttccccatg gcaaccagct gggcattgat
      541 aagagaggcc atctgacagc tccagatacg acagtcactg tctccatagc aacgatgcct
      601 acccactcca tcaagacaga aacccagcca catggcttcg ctgtgggaat ccccccagca
      661 gtgtatcatc ctgagcccac tgagcgggtg gtggttttcg atcggaatct caatactgac
      721 cagttcagct ctggtgctca agccccaaat gctcaaaggc gaactccaga ctcgaccttc
      781 tcagagacct tcaaggaagg cgttcaggag gttttcttcc cctcggatct cagtctgcgg
      841 atgcctggca tgaattcaga ggactatgtt tttgacagtg tttctgggaa caactttgaa
      901 tataccctag aagcttcaaa atcacttcga cagaagccag gagacagtac catgacgtac
      961 ctgaacaaag gccagttcta tcccatcacc ttgaaggagg tgagcagcag tgaaggaatc
     1021 catcatccca tcagcaaagt tcgaagtgtg atcatggtgg tttttgctga agacaaaagc
     1081 agagaagatc agttaaggca ttggaagtac tggcactccc ggcagcacac cgctaaacaa
     1141 agatgcattg acatagctga ctataaagaa agcttcaaca ctatcagtaa catcgaggag
     1201 attgcgtata acgccatttc cttcacatgg gacatcaacg atgaagcaaa ggttttcatc
     1261 tctgtgaact gcttaagcac agatttctct tcccagaagg gagtgaaggg gttgcctctt
     1321 aacattcaag ttgataccta tagttacaac aaccgcagca acaagcctgt gcaccgggcc
     1381 tactgccaga tcaaggtctt ctgtgacaag ggagctgagc ggaaaatcag ggatgaagaa
     1441 cgaaagcaaa gcaaaagaaa agtttctgat gttaaagtgc cactgcttcc ctctcacaag
     1501 cgaatggata tcacagtttt caaacccttc attgatctcg atactcagcc tgtcctcttc
     1561 attcctgacg tgcactttgc caacttgcag cggggcactc atgtccttcc cattgcctct
     1621 gaagaattgg agggtgaagg ctctgtcttg aaaagggggc cgtacggcac agaagatgac
     1681 tttgctgtcc ctccttctac caagctggcc cggatagaag aaccaaagag agtgctgctc
     1741 tacgttcgaa aggagtcaga agaagtcttt gatgccctga tgctcaaaac cccatctttg
     1801 aagggcttga tggaagctat ctcagacaaa tacgatgttc cccatgacaa gattgggaaa
     1861 atattcaaga agtgtaaaaa ggggatcctg gtgaacatgg acgacaacat tgtgaagcat
     1921 tactccaatg aggacacctt ccagctgcag attgaagaag ccggggggtc ttacaagctc
     1981 accctgacgg agatctaaag gcctgcgggc cacagctccc caggagttca gtgcaggtgt
     2041 ttctagatct tacggtttgg caactgcagg taaccccagt cagccatgtc gccagcacag
     2101 gtctatgtcg agggaatggg ttccttgcag gttggaggcg gggctgcatc tggcttggtg
     2161 gtagcattta atctattgca ttggtgtttt tcagatgaaa gagaaatcca tataccatta
     2221 tgtttgaatt tcctgatata tacaggattt aaagtgaaaa ctttattcca agagttaaca
     2281 gagtctctgg gaagctttag gacatctgct acgttattta tcaaaatatt gggatctctg
     2341 ccttgtgcct acagtgtcgt gggcctgctc gctagcagaa gtcagaaaag gcgataggct
     2401 tggctttaag gatttcgtgc ccttgcctga attcagtaca actccactgc ctcacgttag
     2461 cgggagcgca cctgaagagt acggggggag ccctctctcc cttaccctct cactctccac
     2521 cagatgttta ctaaacaggg catgttactg aaatcttcct ttgcgacttt ctcggacata
     2581 tcaactgcct ttctcatgaa gaattttaat gggttacagt atgaaatcag ttaagataaa
     2641 gctgcattgt atataagtgc aatatatttt tgaaggtctg taaatgtgta catacatgtc
     2701 ttatataaat atataatata taaatatggt gtctgtgtac atatagtgaa gatatgcagt
     2761 aagagctacc ttaaagactt tccctagaca aaggttaagt tattttttga tcgtgtatac
     2821 caagcagata gaatactgtg cttagtggaa cccgctaaaa acctttttct ctgtttttcc
     2881 aaacacaggc attctgtagc atagcaaaac cttctcaaat gacagagatt ctgtttgctg
     2941 ttgagaatgt tgttatttgg atttctgcac tgtttaacaa atgaagtaaa agaaaaacac
     3001 tactgcaatc acgtcttttg ttatgctagt atcagtcaga tgcacttaga gtgaagaaac
     3061 actgtaatta cagcacacag attgcaagta ttgcgtacca agtgatacaa ctcgaaatgc
     3121 agttctcatc ttcctgtttt gagaaatgat tattttatca cgcatcagag ccttcgtgct
     3181 ttgattatct tgtatgttaa caattctaga aaacattcat gaattcacaa aaatatgtta
     3241 ctatggcagg ggaacatttt gtacacattt aagtatataa aaatactaaa atatgtaatt
     3301 ttataacaaa gtcacgggta tctttaggtt cagggaacta gactaggtca ttcgtgtaaa
     3361 tggactggta gttacagtct taggttaaag tattctaatg aagtatggga actaaattgc
     3421 tggttttcta agataagata tgggatatgg gtcatataac ttttgtattt tttatgaagt
     3481 tgattttgtc ttgcgtgtta tttttaattg tatcattgaa gatgtatttt aaaccaaagg
     3541 aattaaattt tatatgtcta tttcgtaa
//
