LOCUS       NM_001396456            1685 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  Homo sapiens glycine rich extracellular protein 1 (GREP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001396456
VERSION     NM_001396456.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Zhu,Y., Wu,H., Yang,X., Xiong,Z., Zhao,T. and Gan,X.
  TITLE     LINC00514 facilitates cell proliferation, migration, invasion, and
            epithelial-mesenchymal transition in non-small cell lung cancer by
            acting on the Wnt/beta-catenin signaling pathway
  JOURNAL   Bioengineered 13 (5), 13654-13666 (2022)
   PUBMED   35653786
  REMARK    GeneRIF: LINC00514 facilitates cell proliferation, migration,
            invasion, and epithelial-mesenchymal transition in non-small cell
            lung cancer by acting on the Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Wang,X., Liu,H., Zhang,Q., Zhang,X., Qin,Y., Zhu,G., Dang,J.,
            Wang,F., Yang,X. and Fan,R.
  TITLE     LINC00514 promotes lipogenesis and tumor progression in esophageal
            squamous cell carcinoma by sponging miR-378a-5p to enhance SPHK1
            expression
  JOURNAL   Int J Oncol 59 (5) (2021)
   PUBMED   34533201
  REMARK    GeneRIF: LINC00514 promotes lipogenesis and tumor progression in
            esophageal squamous cell carcinoma by sponging miR378a5p to enhance
            SPHK1 expression.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Prensner,J.R., Enache,O.M., Luria,V., Krug,K., Clauser,K.R.,
            Dempster,J.M., Karger,A., Wang,L., Stumbraite,K., Wang,V.M.,
            Botta,G., Lyons,N.J., Goodale,A., Kalani,Z., Fritchman,B.,
            Brown,A., Alan,D., Green,T., Yang,X., Jaffe,J.D., Roth,J.A.,
            Piccioni,F., Kirschner,M.W., Ji,Z., Root,D.E. and Golub,T.R.
  TITLE     Noncanonical open reading frames encode functional proteins
            essential for cancer cell survival
  JOURNAL   Nat Biotechnol 39 (6), 697-704 (2021)
   PUBMED   33510483
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Yuan,L., Li,J., Yang,Y., Chen,Y., Bu,Y., Ye,M., Mao,X., Ma,T.,
            Yu,L. and Nan,Y.
  TITLE     LINC00514 promotes gastric cancer cell growth and EMT progression
            via miR-204-3p/KRAS
  JOURNAL   Aging (Albany NY) 13 (8), 12007-12015 (2021)
   PUBMED   33888645
  REMARK    GeneRIF: LINC00514 promotes gastric cancer cell growth and EMT
            progression via miR-204-3p/KRAS.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Han,Q., Li,J., Xiong,J. and Song,Z.
  TITLE     Long noncoding RNA LINC00514 accelerates pancreatic cancer
            progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b
            expression
  JOURNAL   J Exp Clin Cancer Res 39 (1), 151 (2020)
   PUBMED   32771045
  REMARK    GeneRIF: Long noncoding RNA LINC00514 accelerates pancreatic cancer
            progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b
            expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Li,X., Zhong,W., Xu,Y., Yu,B. and Liu,H.
  TITLE     Silencing of lncRNA LINC00514 inhibits the malignant behaviors of
            papillary thyroid cancer through miR-204-3p/CDC23 axis
  JOURNAL   Biochem Biophys Res Commun 508 (4), 1145-1148 (2019)
   PUBMED   30553447
  REMARK    GeneRIF: LINC00514 promoted CDC23 expression via restraining
            miR-204-3p activity, leading to papillary thyroid cancer
            progression.
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Ramnarine,V.R., Alshalalfa,M., Mo,F., Nabavi,N., Erho,N.,
            Takhar,M., Shukin,R., Brahmbhatt,S., Gawronski,A., Kobelev,M.,
            Nouri,M., Lin,D., Tsai,H., Lotan,T.L., Karnes,R.J., Rubin,M.A.,
            Zoubeidi,A., Gleave,M.E., Sahinalp,C., Wyatt,A.W., Volik,S.V.,
            Beltran,H., Davicioni,E., Wang,Y. and Collins,C.C.
  TITLE     The long noncoding RNA landscape of neuroendocrine prostate cancer
            and its clinical implications
  JOURNAL   Gigascience 7 (6) (2018)
   PUBMED   29757368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004233.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968832
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 33510483
            MANE Ensembl match        :: ENST00000715180.1/ ENSP00000520374.1
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC004233.1         15905-15983
            80-112              AC004233.1         16233-16265
            113-142             AC004233.1         17166-17195
            143-175             AC004233.1         17617-17649
            176-211             AC004233.1         17730-17765
            212-247             AC004233.1         18195-18230
            248-301             AC004233.1         18691-18744
            302-361             AC004233.1         19021-19080
            362-397             AC004233.1         20046-20081
            398-427             AC004233.1         20448-20477
            428-460             AC004233.1         20574-20606
            461-490             AC004233.1         22341-22370
            491-523             AC004233.1         22449-22481
            524-559             AC004233.1         22570-22605
            560-592             AC004233.1         22927-22959
            593-628             AC004233.1         23262-23297
            629-661             AC004233.1         23382-23414
            662-697             AC004233.1         24139-24174
            698-730             AC004233.1         24316-24348
            731-763             AC004233.1         24696-24728
            764-796             AC004233.1         25446-25478
            797-829             AC004233.1         25999-26031
            830-859             AC004233.1         26137-26166
            860-991             AC004233.1         26491-26622
            992-1033            AC004233.1         27545-27586
            1034-1066           AC004233.1         27729-27761
            1067-1180           AC004233.1         28357-28470
            1181-1234           AC004233.1         28924-28977
            1235-1685           AC004233.1         29204-29654
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1685
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /note="glycine rich extracellular protein 1"
                     /db_xref="GeneID:283875"
                     /db_xref="HGNC:HGNC:27549"
     exon            1..79
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1260
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; long intergenic non-protein coding RNA 514"
                     /codon_start=1
                     /product="glycine-rich extracellular protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001383385.1"
                     /db_xref="GeneID:283875"
                     /db_xref="HGNC:HGNC:27549"
                     /translation="MGAWAFPAALFLLCLTSESLQGLPLLPPGLGKVYGPHSGLGAGY
                     DGGVKPQKPGFVVRHGLGTQPGFRTFAGAAAQPGYGNGLGAAAFPVAGAQSGLGSRSG
                     LGAGTLPGAGTPPGYNNGNGPGTQPGPAAQNGFGPGFGGGGKPQKPGPTTQNGYRPGY
                     VGAVKPQKPGFQYRIGLGAQPGFRGDMKAQEPVLTAQNRFGFGAGLGGNVKPLKPEYG
                     HGNGPGVQPGLGAGMKPQMPGYLGVMKAQKPGAGEGMKPQKPGLRGTLKPQKSGHGHE
                     NGPWPGPCNARVAPMLLPRLPTPGVPSDKEGGWGLKSQPPSAVQNGKLPGHQPPNGYG
                     PGAEPGFNGGLEPQKIGQAGVLWNSRWPTLQAWGAGLKPGYQAGDEYAEARSQPGGPD
                     VKRGSNGQLGNGYGGRCPLGKC"
     exon            80..112
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            113..142
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            143..175
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            176..211
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            212..247
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            248..301
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            302..361
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            362..397
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            398..427
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            428..460
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            461..490
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            491..523
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            524..559
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            560..592
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            593..628
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            629..661
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            662..697
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            698..730
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            731..763
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            764..796
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            797..829
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            830..859
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            860..991
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1033
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1066
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1180
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1234
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1685
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /note="hexamer: ATTAAA"
     polyA_site      1685
                     /gene="GREP1"
                     /gene_synonym="G029442; LA16c-380H5.1; LA16c-380H5.3;
                     LINC00514"
                     /note="major polyA site"
ORIGIN      
        1 actctgccta gagtcatggg cgcctgggcc ttccccgcag cccttttcct tctctgcctg
       61 acttccgaga gcctgcaagg gctgcccctt ctgcctcctg gcctggggaa agtctatggc
      121 ccccacagtg gcctgggagc aggctatgat gggggcgtga agccacagaa gccaggattc
      181 gtggtcaggc atgggctggg aacccagcca gggttcagga ccttcgcagg tgctgcagcc
      241 cagccaggat atggaaacgg gctgggagca gcggccttcc cagtggccgg agcccagtca
      301 ggattgggga gcagaagtgg tttgggcgct ggcactcttc caggggcagg aaccccacca
      361 ggatacaaca atggaaacgg accgggaacc cagccaggtc ctgccgctca aaatggcttt
      421 ggaccaggct ttggaggggg tggaaaaccc cagaagccag gccccaccac tcaaaatggc
      481 tatagaccag gctatgtggg ggccgtcaaa ccccagaagc caggattcca gtacagaatt
      541 gggctgggag cccagccagg ctttagaggg gacatgaagg cacaggagcc agtcttgaca
      601 gcccagaacc gatttggatt tggagcaggc cttggaggga atgtgaagcc tctgaagcca
      661 gaatatggcc atggaaatgg accgggagtc cagccaggcc taggagcggg gatgaagcct
      721 cagatgccag gctatttggg ggttatgaag gcccagaagc caggtgctgg agagggcatg
      781 aaacctcaga agccaggcct gcgagggacc ttgaagcctc agaagtcagg acacggccat
      841 gaaaatgggc cctggccagg tccctgcaat gcgagggtcg ctccgatgct cctccccagg
      901 cttcccactc caggggtccc ttcggacaaa gagggtggct ggggcctgaa atcccagccc
      961 ccttccgcag tgcagaatgg caagttacca gggcaccagc ctccaaatgg ctatggaccg
     1021 ggagcagaac caggttttaa tggtggcctc gagccacaga aaattgggca ggccggggtg
     1081 ctgtggaact ctcgctggcc caccctccag gcctgggggg ccggcttgaa gcctggatat
     1141 caggctggag atgaatatgc tgaggccagg agccagccag ggggccccga cgtgaagaga
     1201 ggcagcaatg gccagctggg gaatggctac ggaggccgct gccctctggg gaaatgctga
     1261 gcactgcaat gcccctcgcc tgcccagcaa ggaagacaga cccttgggct tggcctctgg
     1321 tgctgcctgg ccgggggtct cctccatgct agaaccacaa acgtgcttcc ctgcttgcct
     1381 ccgcgtgcca tgcaaggggc ttgctgacca gggtgggagt ggcatgggcc tgcagccacc
     1441 acccagcacc tcattcattc atttggcaaa catcaatgag gccatgtgcc agggaccatg
     1501 ttcccaacag gagaaatcat gagaagaaaa cagactcgat caacgcctgc cctcagggag
     1561 ggcatcactt ggtgaccgcc tagcggggga accacatcca agttaggggc cttgtgcatg
     1621 gaaaagaaca cttcattctt tgtgttttca tttataatcg atttattaaa gttgttagat
     1681 aaaaa
//
