LOCUS       NM_001142966            9344 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens GREB1 like retinoic acid receptor coactivator
            (GREB1L), transcript variant 2, mRNA.
ACCESSION   NM_001142966 XM_005258343 XR_040952 XR_040953 XR_040954
VERSION     NM_001142966.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9344)
  AUTHORS   Xie,F., Zhou,L., Luo,P., Xi,H., Yu,W., Ma,N., Wang,D. and Peng,Y.
  TITLE     Whole exome sequencing reveals two novel mutations in GREB1L in two
            Chinese families with renal agenesis
  JOURNAL   QJM 117 (6), 462-464 (2024)
   PUBMED   38410081
  REMARK    GeneRIF: Whole exome sequencing reveals two novel mutations in
            GREB1L in two Chinese families with renal agenesis.
REFERENCE   2  (bases 1 to 9344)
  AUTHORS   Zhao,E., Bomback,M., Khan,A., Krishna Murthy,S., Solowiejczyk,D.,
            Vora,N.L., Gilmore,K.L., Giordano,J.L., Wapner,R.J.,
            Sanna-Cherchi,S., Lyford,A., Jelin,A.C., Gharavi,A.G. and Hays,T.
  TITLE     The expanded spectrum of human disease associated with GREB1L
            likely includes complex congenital heart disease
  JOURNAL   Prenat Diagn 44 (3), 343-351 (2024)
   PUBMED   38285371
  REMARK    GeneRIF: The expanded spectrum of human disease associated with
            GREB1L likely includes complex congenital heart disease.
REFERENCE   3  (bases 1 to 9344)
  AUTHORS   Dong,K., Geng,C., Zhan,X., Sun,Z., Pu,Q., Li,P., Song,H., Zhao,G.
            and Gao,H.
  TITLE     GREB1L overexpression is associated with good clinical outcomes in
            breast cancer
  JOURNAL   Eur J Med Res 28 (1), 510 (2023)
   PUBMED   37964281
  REMARK    GeneRIF: GREB1L overexpression is associated with good clinical
            outcomes in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9344)
  AUTHORS   Jolly,A., Du,H., Borel,C., Chen,N., Zhao,S., Grochowski,C.M.,
            Duan,R., Fatih,J.M., Dawood,M., Salvi,S., Jhangiani,S.N.,
            Muzny,D.M., Koch,A., Rouskas,K., Glentis,S., Deligeoroglou,E.,
            Bacopoulou,F., Wise,C.A., Dietrich,J.E., Van den Veyver,I.B.,
            Dimas,A.S., Brucker,S., Sutton,V.R., Gibbs,R.A., Antonarakis,S.E.,
            Wu,N., Coban-Akdemir,Z.H., Zhu,L., Posey,J.E. and Lupski,J.R.
  TITLE     Rare variant enrichment analysis supports GREB1L as a contributory
            driver gene in the etiology of Mayer-Rokitansky-Kuster-Hauser
            syndrome
  JOURNAL   HGG Adv 4 (3), 100188 (2023)
   PUBMED   37124138
  REMARK    GeneRIF: Rare variant enrichment analysis supports GREB1L as a
            contributory driver gene in the etiology of
            Mayer-Rokitansky-Kuster-Hauser syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9344)
  AUTHORS   Wu,S., Wang,X., Dai,S., Zhang,G., Zhou,J. and Shen,Y.
  TITLE     A novel missense mutation in GREB1L identified in a
            three-generation family with renal hypodysplasia/aplasia-3
  JOURNAL   Orphanet J Rare Dis 17 (1), 413 (2022)
   PUBMED   36371238
  REMARK    GeneRIF: A novel missense mutation in GREB1L identified in a
            three-generation family with renal hypodysplasia/aplasia-3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9344)
  AUTHORS   Adadey,S.M., Aboagye,E.T., Esoh,K., Acharya,A., Bharadwaj,T.,
            Lin,N.S., Amenga-Etego,L., Awandare,G.A., Schrauwen,I., Leal,S.M.
            and Wonkam,A.
  TITLE     A novel autosomal dominant GREB1L variant associated with
            non-syndromic hearing impairment in Ghana
  JOURNAL   BMC Med Genomics 15 (1), 237 (2022)
   PUBMED   36357908
  REMARK    GeneRIF: A novel autosomal dominant GREB1L variant associated with
            non-syndromic hearing impairment in Ghana.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9344)
  AUTHORS   De Tomasi,L., David,P., Humbert,C., Silbermann,F., Arrondel,C.,
            Tores,F., Fouquet,S., Desgrange,A., Niel,O., Bole-Feysot,C.,
            Nitschke,P., Roume,J., Cordier,M.P., Pietrement,C., Isidor,B., Khau
            Van Kien,P., Gonzales,M., Saint-Frison,M.H., Martinovic,J.,
            Novo,R., Piard,J., Cabrol,C., Verma,I.C., Puri,R., Journel,H.,
            Aziza,J., Gavard,L., Said-Menthon,M.H., Heidet,L., Saunier,S. and
            Jeanpierre,C.
  TITLE     Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and
            Mice
  JOURNAL   Am J Hum Genet 101 (5), 803-814 (2017)
   PUBMED   29100091
REFERENCE   8  (bases 1 to 9344)
  AUTHORS   Sanna-Cherchi,S., Khan,K., Westland,R., Krithivasan,P., Fievet,L.,
            Rasouly,H.M., Ionita-Laza,I., Capone,V.P., Fasel,D.A., Kiryluk,K.,
            Kamalakaran,S., Bodria,M., Otto,E.A., Sampson,M.G., Gillies,C.E.,
            Vega-Warner,V., Vukojevic,K., Pediaditakis,I., Makar,G.S.,
            Mitrotti,A., Verbitsky,M., Martino,J., Liu,Q., Na,Y.J., Goj,V.,
            Ardissino,G., Gigante,M., Gesualdo,L., Janezcko,M., Zaniew,M.,
            Mendelsohn,C.L., Shril,S., Hildebrandt,F., van Wijk,J.A.E.,
            Arapovic,A., Saraga,M., Allegri,L., Izzi,C., Scolari,F., Tasic,V.,
            Ghiggeri,G.M., Latos-Bielenska,A., Materna-Kiryluk,A., Mane,S.,
            Goldstein,D.B., Lifton,R.P., Katsanis,N., Davis,E.E. and
            Gharavi,A.G.
  TITLE     Exome-wide Association Study Identifies GREB1L Mutations in
            Congenital Kidney Malformations
  JOURNAL   Am J Hum Genet 101 (5), 789-802 (2017)
   PUBMED   29100090
  REMARK    Erratum:[Am J Hum Genet. 2017 Dec 7;101(6):1034. doi:
            10.1016/j.ajhg.2017.11.003.. PMID: 29220675]
REFERENCE   9  (bases 1 to 9344)
  AUTHORS   Brophy,P.D., Rasmussen,M., Parida,M., Bonde,G., Darbro,B.W.,
            Hong,X., Clarke,J.C., Peterson,K.A., Denegre,J., Schneider,M.,
            Sussman,C.R., Sunde,L., Lildballe,D.L., Hertz,J.M., Cornell,R.A.,
            Murray,S.A. and Manak,J.R.
  TITLE     A Gene Implicated in Activation of Retinoic Acid Receptor Targets
            Is a Novel Renal Agenesis Gene in Humans
  JOURNAL   Genetics 207 (1), 215-228 (2017)
   PUBMED   28739660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022809.6, AC015878.7 and AC011774.9.
            
            On Aug 14, 2020 this sequence version replaced NM_001142966.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.13764.1,
                                           SRR14038197.2697567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424526.7/ ENSP00000412060.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC022809.6         143488-143649
            163-272             AC015878.7         77748-77857         c
            273-438             AC015878.7         60209-60374         c
            439-636             AC015878.7         59481-59678         c
            637-813             AC015878.7         48323-48499         c
            814-990             AC015878.7         42558-42734         c
            991-1113            AC015878.7         39890-40012         c
            1114-1230           AC015878.7         4247-4363           c
            1231-1350           AC015878.7         3496-3615           c
            1351-1488           AC015878.7         2347-2484           c
            1489-1674           AC011774.9         157616-157801       c
            1675-2001           AC011774.9         152189-152515       c
            2002-2130           AC011774.9         150874-151002       c
            2131-2265           AC011774.9         149808-149942       c
            2266-2463           AC011774.9         147462-147659       c
            2464-2644           AC011774.9         128814-128994       c
            2645-2837           AC011774.9         124669-124861       c
            2838-2971           AC011774.9         116272-116405       c
            2972-3311           AC011774.9         111674-112013       c
            3312-3427           AC011774.9         106240-106355       c
            3428-3672           AC011774.9         105327-105571       c
            3673-4250           AC011774.9         101719-102296       c
            4251-4353           AC011774.9         101383-101485       c
            4354-4509           AC011774.9         96458-96613         c
            4510-4649           AC011774.9         96076-96215         c
            4650-4811           AC011774.9         93746-93907         c
            4812-5016           AC011774.9         93434-93638         c
            5017-5182           AC011774.9         88039-88204         c
            5183-5410           AC011774.9         86381-86608         c
            5411-5552           AC011774.9         85271-85412         c
            5553-5753           AC011774.9         83791-83991         c
            5754-5889           AC011774.9         81202-81337         c
            5890-9344           AC011774.9         75913-79367         c
FEATURES             Location/Qualifiers
     source          1..9344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.1-q11.2"
     gene            1..9344
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="GREB1 like retinoic acid receptor coactivator"
                     /db_xref="GeneID:80000"
                     /db_xref="HGNC:HGNC:31042"
                     /db_xref="MIM:617782"
     exon            1..162
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..272
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            273..438
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..6053
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     GREB1-like protein; growth regulation by estrogen in
                     breast cancer-like; growth regulation by estrogen in
                     breast cancer 1-like protein; growth regulation by
                     estrogen in breast cancer 1 like"
                     /codon_start=1
                     /product="GREB1-like protein isoform 2"
                     /protein_id="NP_001136438.1"
                     /db_xref="CCDS:CCDS45836.1"
                     /db_xref="GeneID:80000"
                     /db_xref="HGNC:HGNC:31042"
                     /db_xref="MIM:617782"
                     /translation="MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDP
                     DQHPFSSADVKPKVEDLDKDLVNRYTQNGSLDFSNNLTVNEMEDDEDDEEMSDSNSPP
                     IPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVC
                     AVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYY
                     LVRSSQGVLSKGPLICWKECRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQ
                     TDAANGNSSHGGKGSASSSTPAHTGNYSLSPRPSYASGDQATMFISGPPKKRHRGWYP
                     GSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPAGETVIVPENLLS
                     NSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSV
                     ENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRERALQIGAQCVPVSPGQLP
                     WLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRLPDYVVVICASKIRGN
                     EFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLL
                     EKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLL
                     SQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGT
                     AHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSE
                     PSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQLDTGEDVG
                     CEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQ
                     YSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAK
                     ERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDG
                     LPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGP
                     TVALDLSGKEQERAAVSENDSDELLIDLERPQSNSSAVTGTSGSIMENGVSSSSTADK
                     SQKQSLTPSFQSPATSLGLDEGVSASSAGAGAGETLKQECDSLGPQMASSTTSKPSSS
                     SSGPRTLPWPGQPIRGCRGPQAALPPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADV
                     AWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQLDPASGTRNFHPRRLLLTG
                     PPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTDHNESSEVSQSEGEPWPDIES
                     FSKMPFDVSVHDPKYSLMSLVYTEKLAGVKQEVIKESKVEEPRKRETVSIMLTKYAAY
                     NTFHHCEQCRQYMDFTSASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSK
                     QGKHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHLHLLVVKEY
                     EMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCV
                     WPFIVMMDDSCVLWNIHSVQEPSSQPMEVGVSSKNVSLKTVLQHIEATPKIVHYAILG
                     IQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNVQYDFNRYFCEDADFNLRTNSSG
                     LLICRFNNFSLMKKHVQVGGQRDFIIKPKIMVSESLAPILPLQYICAPDSEHTLLAAP
                     AQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEVAICYISSRPHSSNVNCE
                     GVFFSGLLLYLCDSFVGADLKKFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRL
                     RDEFQTANSSDDKPLYFLTGRHV"
     exon            439..636
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..813
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..990
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1113
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1230
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1350
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1488
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1674
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..2001
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2130
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2265
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2463
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2644
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2837
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2971
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3311
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3427
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3672
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..4250
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4353
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4509
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            4510..4649
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4811
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..5016
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5182
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5410
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5411..5552
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5553..5753
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5754..5889
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     exon            5890..9344
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8626..8631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="hexamer: ATTAAA"
     polyA_site      8655
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="major polyA site"
     regulatory      8769..8774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="hexamer: ATTAAA"
     polyA_site      8791
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
     regulatory      9075..9080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
                     /note="hexamer: AATAAA"
     polyA_site      9096
                     /gene="GREB1L"
                     /gene_synonym="C18orf6; DFNA80; KIAA1772; RHDA3"
ORIGIN      
        1 agagagacgc cagccgccgg cggcgctagc acctcggagt cgggcggccg gagcagcgga
       61 gcgcagcgcg gcgcagggaa cggcactggg ggtggggaga ccagcccggc cgagccgagg
      121 gccaccccct ggtcctctgc cctcgcgccc cgctagggcc aggtgcacaa aaagctttaa
      181 acaagttaaa atctaggcaa cagactccct gaagtgttga ctgcccaact taatcatgac
      241 tgtgattcaa aaatgttaat aaataaacca aggtgtagat catggggaat tcatatgctg
      301 ggcaactgaa atctgctcga tttgaggaag ctctccacaa ctccatagaa gcctccctca
      361 gatgtagtag tgtggtacca cggccaattt tttcccagct atacctggac cctgaccagc
      421 atcctttctc atctgcagat gtcaaaccca aggtggagga tctggacaaa gatttggtaa
      481 accgctacac tcaaaatgga agtctggatt tttctaacaa tctaacagtt aatgaaatgg
      541 aagatgatga agacgatgaa gaaatgtctg attcaaacag cccaccaatt ccctattcac
      601 aaaaacctgc cccagaagga tcttgcacta cagatggttt ttgtcaagca ggaaaggatt
      661 tgcgtttggt atcactgtgt atggaacaaa ttgacatccc agcaggattc ctcctggtgg
      721 gggccaagtc tcccaatctg cctgaacaca tcctagtttg tgctgtggac aagcgatttc
      781 taccagatga tcatggaaaa aatgcacttt tagggttttc tggaaattgt atcggctgtg
      841 gagaaagagg atttcgatat ttcacggaat tttccaacca cattaacttg aagctcacca
      901 ctcagccaaa gaagcagaag cacttaaagt actacctagt cagaagctcc cagggtgtac
      961 tgtctaaagg acctcttatc tgctggaaag aatgtagaag ccgacaatcc tctgcttctt
     1021 gccactctat taagccaagc tcttcagtgt cgtcaactgt gaccccagaa aatgggacaa
     1081 ctaatggata caaatcagga ttcactcaga cagatgctgc taatggaaac agtagccatg
     1141 gagggaaggg cagtgcatcc agctccactc cagcccacac agggaattac tctttgtcac
     1201 cacgacctag ctatgcatca ggagatcaag ctaccatgtt catttctggg ccaccaaaga
     1261 aacgacaccg gggatggtat cctgggtcac ctctccccca acctggctta gttgtacctg
     1321 tccctacagt tcgccctctt tcaagaacgg agcccctttt atctgcccca gttccacaga
     1381 ccccactaac tggaatttta caacccaggc ccattcctgc aggggaaact gtaattgttc
     1441 ctgaaaacct gctgagtaac tcaggagtta gaccagtaat tctgataggc tatggcactt
     1501 taccctattt ctatggaaat gttggtgaca ttgttgtgag tcctctgctg gtgaattgct
     1561 acaagattcc acagttggaa aacaaagatt tggaaaaatt agggttgacc ggcagccaat
     1621 ttctgagcgt ggaaaacatg attcttctga cgatacagta tcttgtgcgg ctgggtcctg
     1681 atcaggtacc tctcagggaa gaatttgagc aaattatgct gaaagctatg caagaattta
     1741 ctctgagaga aagagccctg cagataggtg ctcagtgtgt ccctgtgtca ccaggacaac
     1801 tcccctggct tgctagatta attgccagcg tatctcaaga cttggttcat gtggttgtga
     1861 cccagaactc tttggcggag ggcatttcag agaccttaag gactctcagt gaaatgagac
     1921 actatcaaag gctgccagat tatgtggtgg taatttgtgc atcgaaaatc agaggaaatg
     1981 aattttgtgt ggtagtgtta ggtcagcacc agtcccgagc tctggcagag agcatgctca
     2041 ccacaagtga gtttttgaaa gaaattagtt atgagcttat cacaggaaag gtcagtttcc
     2101 tggcatcaca tttcaaaacc acatcattag gcgatgacct agacaagctg ctggaaaaaa
     2161 tgcaacaaag aagaggagac agtgtggtta cccctttcga tggagacctt aatgaatgtg
     2221 tgtcacccca ggaggctgct gctatgattc ccacacaaaa cctggattta gataatgaaa
     2281 ccttccacat ttatcaaccg cagctaacag ttgccagaaa actcttatcc caggtgtgtg
     2341 ctatagcgga cagtggcagc cagagcctgg acctcggtca cttcagcaaa gtagacttca
     2401 tcatcattgt tcccagatcg gaggtgttgg ttcagcaaac tcttcagcgg attcgacaat
     2461 caggtgtcct tgtagacttg ggtctggagg aaaatgggac agcccatcag agagcagaaa
     2521 aatatgttgt tcgtctagac aatgagattc aaaccaagtt tgaagttttt atgaggagag
     2581 tgaaacagaa cccgtacaca ctgtttgtgc tagttcatga caactcccat gtggaactaa
     2641 cgagtgtcat ttcaggctct ttgtcacata gcgaacccag tcatgggcta gctgatagag
     2701 tcattaattg cagagaagtt ctggaagctt tcaacctcct ggtgctccag gtcagctcct
     2761 tcccatacac tctgcagacc caacagtccc gcattagctc tagcaatgag gttcactgga
     2821 tacagctgga tactggggag gacgtgggct gcgaggagaa gctgtacttt ggcttgagtg
     2881 agtacagcaa gtctctgcag tgggggatca cgagcccact tctgagatgt gacgagactt
     2941 ttgaaaaaat ggtgaacaca ctcttggaga ggtaccccag gctgcacagc atggtcgtcc
     3001 gctgctatct tctcatccag cagtactctg aggccctgat ggctctcacc accatggcgt
     3061 cactccgcga ccacagcaca ccagaaacac tcagcattat ggatgacctc atcagctccc
     3121 caggcaaaaa caaaagtggg aggggacaca tgctcattat cagggtgccc tcggtgcagc
     3181 tggcgatgtt agccaaggag cggctacagg aggtgcgcga caaactgggt ctgcagtatc
     3241 ggtttgagat catccttggg aacccggcca ccgaactcag tgttgcaact cactttgtgg
     3301 cgcgattaaa gagttggaga ggaaatgaac cagaagagtg gatccctcgg acataccaag
     3361 atttagacgg tctaccttgt attgtgatat taactggcaa agatcctctt ggagaaacct
     3421 ttcccaggtc tttgaagtac tgtgacctcc ggttaattga ctcaagctat ttaactcgca
     3481 cggccttgga gcaggaggtg ggtctggcat gctgctatgt ctcaaaagag gtcatccggg
     3541 gacccactgt tgccctggac ctcagcggga aggagcagga gagagctgct gtcagtgaga
     3601 atgactccga tgagctgctc atcgacctgg agcggcccca gagcaacagc agcgctgtca
     3661 cagggacctc gggttccatc atggagaatg gagtgagctc ttccagcaca gctgacaagt
     3721 cccagaagca gtccctgacc cccagctttc agagcccagc caccagcttg gggctggatg
     3781 aaggggtctc cgccagctca gctggagccg gagccgggga gactctgaag caggaatgtg
     3841 actccctggg cccccagatg gcgagcagca ccacctccaa gccgtcatca tcatcctcag
     3901 gacccaggac cctcccatgg ccgggacagc ccatcagagg ctgccggggc ccacaggcag
     3961 ccctgccacc agtggtgatc ctatccaaag cggcctacag tctcctgggc tcccagaaga
     4021 gtggcaagct gccatcctcc tcctccctgc tgccccacgc cgacgtggcc tgggtgagct
     4081 ccctgcggcc actcctgaac aaggacatga gcagtgagga gcagtccctc tactacaggc
     4141 agtggacctt ggcccggcag caccacgctg actatagcaa ccagctggac ccggcctctg
     4201 gcacccgaaa cttccacccc cgacggctcc tgctgacagg gcccccacag gtgggaaaga
     4261 cgggctccta tttacagttc ctcaggatcc tcttccgcat gctcatcagg ctcctggagg
     4321 tggacgtgta tgatgaggag gagatcaaca ccgatcacaa tgaaagcagt gaagtgagcc
     4381 agtcagaggg agagccctgg cctgacatcg agagcttcag taaaatgcct tttgatgtca
     4441 gtgtgcatga ccccaagtac agtttgatga gcctggtgta tactgagaag ctggcagggg
     4501 tcaaacaaga agtgataaag gaatccaaag ttgaagagcc caggaaacgg gaaactgtat
     4561 ccataatgct gaccaaatat gcagcctata acacctttca ccactgtgaa cagtgccgcc
     4621 agtacatgga cttcacctct gcctcccaga tgtctgactc cacccttcat gccttcacat
     4681 tctcttcttc tatgctggga gaagaggttc agctctattt catcattccc aaatccaaag
     4741 agagtcattt tgtcttcagc aagcagggca agcacctgga gagcatgcgg ctgcccctgg
     4801 tttcagacaa gaatttgaat gcagtcaaga gccctatttt cactccttcc agtggtcgac
     4861 atgagcacgg actcctaaac cttttccacg ccatggaggg catcagccac cttcacctcc
     4921 tggtggtcaa agagtatgag atgcctctgt accgcaagta ctggcccaac cacatcatgc
     4981 tggtgcttcc cggcatgttc aataatgcag gcgtgggtgc tgccaggttc ctcatcaagg
     5041 agctatcata tcacaaccta gaattggaga gaaaccgcct ggaggagcta ggcattaaac
     5101 gccagtgtgt ctggcctttc atcgtcatga tggatgactc atgtgtccta tggaacattc
     5161 acagtgttca ggagccatcc agccagccca tggaagtagg agtttccagt aagaatgtgt
     5221 ccttgaagac tgtcttgcag cacattgaag ccacaccaaa aattgtccac tatgcaatct
     5281 tgggcataca gaaatggagc agcaagctga cttctcagag cctaaaggcc ccattctcta
     5341 ggtgtcacgt gcatgatttc attctcctca acacagactt gactcagaat gtgcagtatg
     5401 acttcaacag gtatttctgt gaagatgctg actttaatct gagaacaaac agtagtggcc
     5461 tgctcatctg ccgctttaat aacttcagtc tcatgaagaa acatgttcag gttggagggc
     5521 aaagggactt tatcattaaa ccaaagatca tggtgtcaga gagcttagca cccatcttgc
     5581 cccttcaata catctgtgct cccgacagtg aacacacact actggcagcc cctgcacagt
     5641 ttctcctgga gaaattcctt cagcacgcct catataaact cttccccaaa gccatccata
     5701 acttcaggag tcctgtgctg gccattgact gctaccttaa cattggacca gaggtggcca
     5761 tatgctatat cagctccaga ccccactcca gcaatgtcaa ctgtgaaggg gtgtttttca
     5821 gtggactcct tttgtacctc tgtgactctt ttgtaggtgc tgatcttaag aaatttaaat
     5881 ttctaaaagg tgctacactg tgtgtcatct gccaagacag aagttccttg cgccaaacaa
     5941 ttgtccgctt agagctagaa gatgagtggc agttccgcct ccgggacgag tttcaaactg
     6001 ctaacagcag tgatgacaag cctctctact ttcttactgg acgtcatgta tgagcttttg
     6061 aagagaccaa aacagcaaaa agatgcctag gtgggatggg acagaaacaa tttgggattt
     6121 ttctttttcc tttaaagtac aatcactgtg gagcaaagtg caacatattt gtctaaattc
     6181 tccaaagaac tccccaaatc tgatccaggt ctttggggac atcactttcc ttcagttcca
     6241 attacaggac ccttaaattc aggtaaactc tatcctaggc agttatgcaa ttacttaaga
     6301 tacggtctgc ccatgggatc ctgaggagga tatactttgg agagtgaata tggagtttgc
     6361 attatttttt tctattacta tgttaggggg aaactgactg tcaggattaa ctagcctgaa
     6421 tgtgttacat gagactcatg ccattggtgt ggaatcaatt gaagattaac gtttgaggcc
     6481 tgaaccctca gtttctcttc agatctgtac tttggtacag tattactcag gggtttgaaa
     6541 tgatagaatg tagacgatat ttgtatttaa aaaaagaagt agctttgtct ttctctgtgc
     6601 agtgttagtt taagatttat aatcttctat gtattgaaac ttttggcaaa atttccacag
     6661 gagttagaag tttactattt aaactgaaca aacaaatcag taaatgcaga gcaggcattg
     6721 tgtgcattta tgcatcttct cctagcctaa ttcctttgct ttacccactc tttaaatgtg
     6781 tttccagtct ttaagaatat cttatctatg agactatgga acagtgatta atcttttgca
     6841 agaacttaag tcagttaaga agctttcagc aggtaacctg cacccaccgt ttggttggaa
     6901 ttaagcagtt ggcaccagca aacctaaatg tcaggctgag gttctgttgc agagtgaaac
     6961 tagtttgttt cctttcaggg actcaagcaa agcttccttt aaaagatgca ctaaatatta
     7021 ccaccttaca ctgacaacgc cacagaaatt gccgaattgg gaaattgagc catagaaaga
     7081 gaaatgtttt tttacttaat cttaccagtg actcttgtga ggagtaagga agactccatt
     7141 aagagtcttt ttgattcatt aaaatcagca gggggtgttt gtccagtatc ggcaatggga
     7201 ggcatatgtt tctacagatt tctcaaatat tttaatcaaa aacattattt ttagaaagtg
     7261 ttctagataa aactaagtct tagaagttta ctcttaaatt actccagttc tcatcattga
     7321 acaatctctt gagagttttc tcattagccc atatttacta ctttatcccc acttaaaatg
     7381 gccattttta cttgaatcaa tcttgtttgt gacctgaaac tactgagggg cctactaagc
     7441 ctgcatttac ttagaacaaa tagtgttaat tgaccagctt tattatctta tgacaacaag
     7501 gagtttacaa agctagtgaa aaaatggaat gtattagact aaaaatggtt tgcagatctc
     7561 ttggttttaa tatagctact tataatgctt taactgtatt ttgaagtgaa caattccttt
     7621 taaccccatt tttaattgtc cttcaaagag gacctgcctt atatatgctt taaaaaatac
     7681 tccttaattt tagtacagca gaatttttgg taaagaggta tgttttgaag caatttggtt
     7741 taaatatgaa tgtatttcac ttgttcctgt tttgttgaaa gggcctaatg caaataatac
     7801 caagaaaccc actgtctgtg caatattcca ataacattta catagggcaa ataaaatact
     7861 tgaaagaatt ctgaaacaat tgtacctggg gtggatggcc tctcagggtt tcttctggct
     7921 ttatgacttc atagtttaaa gaactttttt tttaagtagt tacatcagat gcaggtactc
     7981 cattagttag ggctgcactc tgaaaattca aattattatt atgagctctt aaatactatt
     8041 taactctgga agagatatgc cagaataaag ccaaaagacc atcaccccta taatggagaa
     8101 attgatctgc ctattctttt caaagcctat cttactaatg tttggatctt ttaaaatcat
     8161 cttatcatca gtataattct tgagtatgtt aggtccttct ttaaggataa aattgcacaa
     8221 gcacaggaca ccatgatttg tgtgtatata tatatatatc ctagtgtgtt cagctttaag
     8281 ctttgcaatc ccttaggaca ctgatgtggg atgaatggat tcgctaggcc cacacagtaa
     8341 ctcacctgta gacctgctga acctcagcat gtatgacagt tcacacaggt taatactgaa
     8401 tgtaaacgaa aaactagaag acaattgtta taattttttt tggctgtaat ttatgcaatt
     8461 gctttttgtg atttttagaa aatggggcac ccgtgttatt actgtaaaat gttcttaacc
     8521 aaaatttggt gaatttcact agtctacctc acattttgtt aatgattcaa aattgtcttg
     8581 tgtctactgt tatatttttg tcctttgatt taatttgctt aatgtattaa agttatctcc
     8641 caccccctcc aaaaagttat tttttcttta tagttttctg gcatgtttgt taagaaaaca
     8701 agctccctga ctctggcaat gtcctaaaaa ggctggaagt cagtcacatt ataggttgga
     8761 caaccaagat taaagaggtg ttgaaaacat acatagtaga taccaatctt ttatttgaca
     8821 gattgcaact acactcactt tgatgtcctt ctggaaacag aacaactttg ggttgctaaa
     8881 actaatacaa ggtgtttgtt attgttaatc tccagttaaa acttctcaaa ctttttgaga
     8941 gtgtctcaaa gttgctagaa ctatgtagta tgaagatgct gttattgtag tatgaattat
     9001 atcttcttaa aaaattttac caacttttga gaataacaac tttgttgtcc cagaaaaatg
     9061 gctttcaatc tattaataaa gtgtagtaaa ttaaaagaat ttgacataga ttccatgaaa
     9121 acaatcttct aggccaaagg accctcagga agggcaataa atatttgtaa gtgtaatgac
     9181 agactttcag aggaaagtaa agactactgg tgttccacta tacattccaa agcagctgcc
     9241 ttgaaaagac tattaattaa ctgtgaaact gactgctgca acatcacact aaactactta
     9301 ggcctgaaac aacatccaga gaacgaacat ttatcaagct tctc
//
