LOCUS       NM_014668               8555 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens growth regulating estrogen receptor binding 1 (GREB1),
            transcript variant a, mRNA.
ACCESSION   NM_014668 XM_005246191
VERSION     NM_014668.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8555)
  AUTHORS   Shinzawa,K., Matsumoto,S., Sada,R., Harada,A., Saitoh,K., Kato,K.,
            Ikeda,S., Hirayama,A., Yokoi,K., Tanemura,A., Nimura,K., Ikawa,M.,
            Soga,T. and Kikuchi,A.
  TITLE     GREB1 isoform 4 is specifically transcribed by MITF and required
            for melanoma proliferation
  JOURNAL   Oncogene 42 (42), 3142-3156 (2023)
   PUBMED   37658191
  REMARK    GeneRIF: GREB1 isoform 4 is specifically transcribed by MITF and
            required for melanoma proliferation.
REFERENCE   2  (bases 1 to 8555)
  AUTHORS   Shin,E.M., Huynh,V.T., Neja,S.A., Liu,C.Y., Raju,A., Tan,K.,
            Tan,N.S., Gunaratne,J., Bi,X., Iyer,L.M., Aravind,L. and
            Tergaonkar,V.
  TITLE     GREB1: An evolutionarily conserved protein with a
            glycosyltransferase domain links ERalpha glycosylation and
            stability to cancer
  JOURNAL   Sci Adv 7 (12) (2021)
   PUBMED   33731348
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8555)
  AUTHORS   Haines,C.N., Klingensmith,H.D., Komara,M. and Burd,C.J.
  TITLE     GREB1 regulates PI3K/Akt signaling to control hormone-sensitive
            breast cancer proliferation
  JOURNAL   Carcinogenesis 41 (12), 1660-1670 (2020)
   PUBMED   32894276
  REMARK    GeneRIF: GREB1 regulates PI3K/Akt signaling to control
            hormone-sensitive breast cancer proliferation.
REFERENCE   4  (bases 1 to 8555)
  AUTHORS   Kochi,M., Hinoi,T., Niitsu,H., Miguchi,M., Saito,Y., Sada,H.,
            Sentani,K., Sakamoto,N., Oue,N., Tashiro,H., Sotomaru,Y., Yasui,W.
            and Ohdan,H.
  TITLE     Oncogenic mutation in RAS-RAF axis leads to increased expression of
            GREB1, resulting in tumor proliferation in colorectal cancer
  JOURNAL   Cancer Sci 111 (10), 3540-3549 (2020)
   PUBMED   32629543
  REMARK    GeneRIF: Oncogenic mutation in RAS-RAF axis leads to increased
            expression of GREB1, resulting in tumor proliferation in colorectal
            cancer.
REFERENCE   5  (bases 1 to 8555)
  AUTHORS   Schrauwen,I., Liaqat,K., Schatteman,I., Bharadwaj,T., Nasir,A.,
            Acharya,A., Ahmad,W., Van Camp,G. and Leal,S.M.
  TITLE     Autosomal Dominantly Inherited GREB1L Variants in Individuals with
            Profound Sensorineural Hearing Impairment
  JOURNAL   Genes (Basel) 11 (6), 687 (2020)
   PUBMED   32585897
  REMARK    GeneRIF: Autosomal Dominantly Inherited GREB1L Variants in
            Individuals with Profound Sensorineural Hearing Impairment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8555)
  AUTHORS   Deschenes,J., Bourdeau,V., White,J.H. and Mader,S.
  TITLE     Regulation of GREB1 transcription by estrogen receptor alpha
            through a multipartite enhancer spread over 20 kb of upstream
            flanking sequences
  JOURNAL   J Biol Chem 282 (24), 17335-17339 (2007)
   PUBMED   17463000
  REMARK    GeneRIF: Data show that the induction of the gene regulated in
            breast cancer 1 (GREB1) is mediated by binding of estrogen receptor
            alpha to three consensus estrogen response elements spread over
            approximately 20 kb of upstream flanking sequences.
REFERENCE   7  (bases 1 to 8555)
  AUTHORS   Rae,J.M., Johnson,M.D., Cordero,K.E., Scheys,J.O., Larios,J.M.,
            Gottardis,M.M., Pienta,K.J. and Lippman,M.E.
  TITLE     GREB1 is a novel androgen-regulated gene required for prostate
            cancer growth
  JOURNAL   Prostate 66 (8), 886-894 (2006)
   PUBMED   16496412
  REMARK    GeneRIF: GREB1 is expressed in proliferating prostatic tissue and
            prostate cancer, is regulated by androgens, and suppression of
            GREB1 blocks androgen-induced growth suggesting GREB1 may be
            critically involved in prostate cancer proliferation.
REFERENCE   8  (bases 1 to 8555)
  AUTHORS   Rae,J.M., Johnson,M.D., Scheys,J.O., Cordero,K.E., Larios,J.M. and
            Lippman,M.E.
  TITLE     GREB 1 is a critical regulator of hormone dependent breast cancer
            growth
  JOURNAL   Breast Cancer Res Treat 92 (2), 141-149 (2005)
   PUBMED   15986123
  REMARK    GeneRIF: GREB1 is critically involved in the estrogen induced
            growth of breast cancer cells.
REFERENCE   9  (bases 1 to 8555)
  AUTHORS   Bourdeau,V., Deschenes,J., Metivier,R., Nagai,Y., Nguyen,D.,
            Bretschneider,N., Gannon,F., White,J.H. and Mader,S.
  TITLE     Genome-wide identification of high-affinity estrogen response
            elements in human and mouse
  JOURNAL   Mol Endocrinol 18 (6), 1411-1427 (2004)
   PUBMED   15001666
  REMARK    GeneRIF: Estrogen receptors are recruited at several proximal and
            distal estrogen response elements upstream of the GREB1
            transcription unit.
REFERENCE   10 (bases 1 to 8555)
  AUTHORS   Ghosh,M.G., Thompson,D.A. and Weigel,R.J.
  TITLE     PDZK1 and GREB1 are estrogen-regulated genes expressed in
            hormone-responsive breast cancer
  JOURNAL   Cancer Res 60 (22), 6367-6375 (2000)
   PUBMED   11103799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011994.10 and AC110754.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014668.3.
            
            Summary: This gene is an estrogen-responsive gene that is an early
            response gene in the estrogen receptor-regulated pathway. It is
            thought to play an important role in hormone-responsive tissues and
            cancer. Three alternatively spliced transcript variants encoding
            distinct isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142853,
                              SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381486.7/ ENSP00000370896.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC011994.10        109331-109401       c
            72-210              AC011994.10        109192-109330       c
            211-528             AC011994.10        86675-86992         c
            529-648             AC011994.10        80864-80983         c
            649-825             AC011994.10        76790-76966         c
            826-1008            AC011994.10        66911-67093         c
            1009-1143           AC011994.10        65015-65149         c
            1144-1272           AC011994.10        62614-62742         c
            1273-1386           AC011994.10        58172-58285         c
            1387-1530           AC011994.10        57541-57684         c
            1531-1716           AC011994.10        54515-54700         c
            1717-2067           AC011994.10        50320-50670         c
            2068-2196           AC011994.10        48067-48195         c
            2197-2325           AC011994.10        47207-47335         c
            2326-2523           AC011994.10        45468-45665         c
            2524-2704           AC011994.10        44586-44766         c
            2705-2900           AC011994.10        42451-42646         c
            2901-3037           AC011994.10        40904-41040         c
            3038-3377           AC011994.10        32419-32758         c
            3378-3493           AC011994.10        30836-30951         c
            3494-3693           AC011994.10        28156-28355         c
            3694-3783           AC011994.10        26726-26815         c
            3784-4415           AC011994.10        24527-25158         c
            4416-4518           AC011994.10        22439-22541         c
            4519-4677           AC011994.10        18134-18292         c
            4678-4820           AC011994.10        16342-16484         c
            4821-4982           AC011994.10        13337-13498         c
            4983-5187           AC011994.10        11333-11537         c
            5188-5362           AC011994.10        10383-10557         c
            5363-5581           AC011994.10        9097-9315           c
            5582-5717           AC011994.10        8041-8176           c
            5718-5918           AC011994.10        5530-5730           c
            5919-6057           AC011994.10        4637-4775           c
            6058-7219           AC011994.10        1994-3155           c
            7220-8553           AC110754.3         1-1334
            8554-8555           AC110754.3         1335-1336
FEATURES             Location/Qualifiers
     source          1..8555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..8555
                     /gene="GREB1"
                     /note="growth regulating estrogen receptor binding 1"
                     /db_xref="GeneID:9687"
                     /db_xref="HGNC:HGNC:24885"
                     /db_xref="MIM:611736"
     exon            1..210
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..528
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..6221
                     /gene="GREB1"
                     /note="isoform a is encoded by transcript variant a;
                     protein GREB1; gene regulated by estrogen in breast
                     cancer; gene regulated in breast cancer 1 protein; growth
                     regulation by estrogen in breast cancer 1"
                     /codon_start=1
                     /product="protein GREB1 isoform a"
                     /protein_id="NP_055483.2"
                     /db_xref="CCDS:CCDS42655.1"
                     /db_xref="GeneID:9687"
                     /db_xref="HGNC:HGNC:24885"
                     /db_xref="MIM:611736"
                     /translation="MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPIFSQLYLEA
                     EQQLAALEGGSRVDNEEEEEEGEGGLETNGPPNPFQLHPLPEGCCTTDGFCQAGKDLR
                     LVSISNEPMDVPAGFLLVGVKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGC
                     GKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGTLTKGPLICWKGSEFRSRQ
                     IPASTCSSSLFPALESTAAFPSEPVPGTNPSILMGAQQAGPASDHPSLNAAMGPAVFN
                     GKDSPKCQQLAKNNLLALPRPSALGILSNSGPPKKRHKGWSPESPSAPDGGCPQGGGN
                     RAKYESAGMSCVPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFP
                     YLCGNLNDVVVSPLLYTCYQNSQSVSRAYEQYGASAIQPISEEMQLLLTVYYLVQLAA
                     DQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPAPSAAAPVTSAQLPWLASLA
                     ASSCNDSVHVIECAYSLAEGLSEMFRLLVEGKLAKTNYVVIICACRSAAIDSCIAVTG
                     KYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQ
                     GHISSSLAASSVTKAASLDVSGTPVCTSYNLEPHSIRPFQLAVAQKLLSHVCSIADSS
                     TQNLDLGSFEKVDFLICIPPSEVTYQQTLLHVWHSGVLLELGLKKEHMTKQRVEQYVL
                     KLDTEAQTKFKAFLQNSFQNPHTLFVLIHDHAHWDLVSSTVHNLYSQSDPSVGLVDRL
                     LNCREVKEAPNIVTLHVTSFPYALQTQHTLISPYNEIHWPASCSNGVDLYHENKKYFG
                     LSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAALMAV
                     SGLPQMKNYTSVETLEITQNLLNSPKQCPCGHGLMVLLRVPCSPLAVVAYERLAHVRA
                     RLALEEHFEIILGSPSSGVTVGKHFVKQLRMWQKIEDVEWRPQTYLELEGLPCILIFS
                     GMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSNEVPLEKGARNEALE
                     SDAEKLSSTDNEDEELGTEGSTSEKRSPMKRERSRSHDSASSSLSSKASGSALGGESS
                     AQPTALPQGEHARSPQPRGPAEEGRAPGEKQRPRASQGPPSAISRHSPGPTPQPDCSL
                     RTGQRSVQVSVTSSCSQLSSSSGSSSSSVAPAAGTWVLQASQCSLTKACRQPPIVFLP
                     KLVYDMVVSTDSSGLPKAASLLPSPSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRP
                     SHMDYGNRAEGRVDGFHPRRLLLSGPPQIGKTGAYLQFLSVLSRMLVRLTEVDVYDEE
                     EININLREESDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHYQGIKSED
                     RGMSRKPEDLYVRRQTARMRLSKYAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAF
                     SYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTG
                     RHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHF
                     LIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVNSAGERSREFSW
                     SERNVSLKHIMQHIEAAPDIMHYALLGLRKWSSKTRASEVQEPFSRCHVHNFIILNVD
                     LTQNVQYNQNRFLCDDVDFNLRVHSAGLLLCRFNRFSVMKKQIVVGGHRSFHITSKVS
                     DNSAAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHLFFPLSLKNHDHPVLSVDC
                     YLNLGSQISVCYVSSRPHSLNISCSDLLFSGLLLYLCDSFVGASFLKKFHFLKGATLC
                     VICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAREDRPLFFLTGRHI"
     exon            529..648
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..825
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1008
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1143
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1272
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1386
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1530
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1716
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2067
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2196
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2325
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2523
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2704
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2900
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3037
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3377
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3493
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3693
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3783
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..4415
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4518
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4677
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4820
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4982
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5187
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5362
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5363..5581
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5582..5717
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5718..5918
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5919..6057
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6058..8555
                     /gene="GREB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8398..8403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREB1"
                     /note="hexamer: AATAAA"
     polyA_site      8424
                     /gene="GREB1"
     regulatory      8534..8539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GREB1"
                     /note="hexamer: AATAAA"
     polyA_site      8555
                     /gene="GREB1"
                     /note="major polyA site"
ORIGIN      
        1 gctaaatggt taagagatac ataaatactg cagtagagat gggattttac ctcaaagtgc
       61 aaaggtaaat gaaataaagt tttttcaatg gaaggcttgc agctcttgag gacctgccaa
      121 atggaagaag gacagagacc tggagcccta tggaaagttc tgacaccatg tgtggaagga
      181 catggctttt aacacgtgtg gtgactggag tagctgcagc tgaggacagc caccctttct
      241 tcgtctctgc tgagcgaagg ctacacggcc cttcctcctt gcagctgttt caccttctac
      301 cttgcgtgga gccaggcttt tgcaccgaat ctgagatgcc attttaaaca gaagactcca
      361 tcctcttgaa gatgggaaat tcttacgctg gacagctgaa gacgacacgc tttgaagagg
      421 tcttgcacaa ttccatcgag gcatccctgc ggtccaacaa cctggtgccc aggcccatct
      481 tttcccagct gtacctggaa gctgagcagc agcttgccgc tctagaaggt ggtagccgag
      541 tggacaatga ggaagaggaa gaagagggag aaggagggct ggaaacaaat ggccccccaa
      601 accctttcca gctgcaccct ctgcctgaag gatgctgtac cacagacggg ttttgccagg
      661 ccgggaagga cctgcgcctt gtctccattt ccaacgagcc catggatgtc cctgcgggct
      721 ttctcctcgt gggggtcaag tcccccagcc tgccggacca tctcctggtg tgcgccgttg
      781 acaagaggtt cttgccagat gacaatggcc acaatgctct tcttggtttc tctgggaatt
      841 gtgttggctg tggaaagaaa ggcttctgtt acttcacgga attctccaat catataaatc
      901 tgaaactgac cactcaaccc aagaagcaga aacacttgaa gtattacctg gtccgtaatg
      961 cacaagggac tctaaccaaa ggacctttaa tctgttggaa aggctcagag tttagaagcc
     1021 ggcagatccc cgccagtact tgttccagtt ccctcttccc agccctggag agcacggctg
     1081 ccttccccag cgagcccgtt cctgggacga accccagcat cctgatggga gctcagcagg
     1141 caggaccagc ttctgatcac ccctcactaa acgcagcaat gggtccggct gttttcaacg
     1201 gcaaagattc cccgaagtgc caacaactgg caaagaataa cctgttggcc ctgccgcgac
     1261 catcggcttt aggtatcttg tcaaactccg ggccccccaa aaaacgccac aaagggtggt
     1321 ctccagaatc tccatcagct ccagatggtg gctgccccca aggtggtggg aacagagcta
     1381 agtatgagag cgcaggcatg tcctgcgtgc cgcaggttgg cttggtggga ccagcttcag
     1441 tcacctttcc agtggtggcc tctggagaac cagtgtctgt tcctgacaac ttgctgaaaa
     1501 tatgcaaggc caagccagtg atatttaaag gccatgggaa cttcccttac ctctgtggga
     1561 acctgaatga cgtcgtggtc agccccctct tgtacacgtg ctaccagaat tcccagtctg
     1621 tctcacgggc atacgagcag tacggcgcct ctgccatcca gcccatctcc gaggagatgc
     1681 agctcctgct taccgtctac tacctggtcc agctggccgc ggaccaggtg cccttgatgg
     1741 aggacctgga gcagatcttc ctgcgctctt ggcgcgagtc gcacctgacc gagatccggc
     1801 agtaccagca ggcgccgccg cagcccttcc cgcccgcgcc cagcgccgcg gcacccgtga
     1861 cctccgcgca gctgccctgg ctggccagcc tggccgccag ctcctgcaac gacagcgtgc
     1921 acgtcatcga gtgtgcttac tccctggccg agggcctctc cgagatgttc cggctgttgg
     1981 tcgagggcaa gcttgccaag accaactacg tggtcatcat ctgcgcctgc cgcagcgcgg
     2041 ccatcgactc ctgcatcgcc gtcaccggaa aataccaagc ccggattctt tccgagagcc
     2101 ttctcactcc tgcggagtac cagaaggaag tcaattacga gctggttacg gggaaggtag
     2161 actcgctggg ggccttcttt agcaccctct gtccagaggg tgacattgac attttgctgg
     2221 acaaatttca ccaggaaaat caaggccata tttcttcctc actcgctgcc tcttctgtca
     2281 ctaaagcagc atccctggat gtcagtggga caccggtgtg cacaagttac aatctggagc
     2341 cacacagcat ccggcccttc cagctggcag tagcgcagaa gctcctctcc catgtgtgtt
     2401 ccattgcgga ttccagcacc caaaatctgg acctgggatc ctttgagaag gtggactttc
     2461 tcatttgcat tcccccctca gaagtgacct accagcagac tctgctccat gtgtggcatt
     2521 caggggtttt gctggagctt ggtctgaaga aagagcacat gacgaagcag agggtggaac
     2581 agtatgttct gaagctagac acggaggcac agacaaaatt taaggctttt ctgcaaaact
     2641 ccttccagaa cccgcataca ctttttgtcc taatccatga ccatgcgcac tgggatcttg
     2701 tgagtagcac tgttcataac ctctattctc aaagtgaccc gtcggtggga ttggtggacc
     2761 gattgctcaa ctgcagggag gtgaaggagg cccccaacat tgtgacactt cacgtgacct
     2821 ccttcccgta tgcactgcag acacagcaca ccctcatcag cccctacaac gagatccact
     2881 ggcctgcctc ctgcagtaat ggagtggact tatatcatga aaataagaag tacttcgggc
     2941 tgtcggagtt tattgaatcc accctttcag gacacagcct ccccttgctc agatacgata
     3001 gctcctttga ggccatggtc actgcattag gaaaaaggtt cccccgcctg cacagcgcgg
     3061 tgatcaggac ctttgttctc gtgcagcact acgcggccgc cctgatggcc gtaagcggcc
     3121 tcccgcagat gaagaactac acgtcggtgg agacgctgga gatcacgcag aacctcctca
     3181 actccccgaa gcagtgcccc tgcggccacg ggctcatggt cctgctgcgg gtgccctgtt
     3241 cgcccctggc ggtggtggcc tatgagcggc tggcccacgt gcgggcccgg ctggcgctgg
     3301 aggagcactt tgagatcatc ctgggcagtc ccagctcagg cgtcaccgtg gggaagcact
     3361 tcgtaaagca gctcaggatg tggcagaaaa ttgaggatgt ggagtggaga ccccagactt
     3421 acttggagct ggagggtctg ccttgcatcc tgatcttcag tgggatggac ccgcatgggg
     3481 agtccttgcc gaggtctttg aggtactgtg acctgcgatt gataaactcc tcctgcttgg
     3541 tgagaacagc cttggagcag gagctgggcc tggctgccta ctttgtgagc aacgaggttc
     3601 ccttggagaa gggggctagg aacgaggcct tggagagtga tgctgagaag ctgagcagca
     3661 cagacaacga ggatgaggag ctggggacag aaggctctac ctcggagaag agaagcccca
     3721 tgaaaaggga gaggtcccgc tcccacgact cagcatcctc atccctctcc tccaaggctt
     3781 ccggttcagc gctcggtggc gagtcctcgg ctcagcccac agcactcccc cagggagagc
     3841 atgccaggtc gccccagccc cgtggccccg cagaggaggg cagagcccct ggtgagaaac
     3901 agaggccccg ggcaagtcag gggccaccct cggccatcag caggcacagt cccgggccga
     3961 cgccccagcc cgactgtagc ctcaggaccg gccagaggag cgtccaggtg tcggtcacct
     4021 cgtcgtgctc ccagctgtcc tcctcctcgg gctcatcctc ctcatccgtg gcgcccgctg
     4081 ccggcacgtg ggtcctgcag gcctcccagt gctccttgac caaggcctgc cgccagccac
     4141 ccattgtctt cttgcccaag ctcgtgtacg acatggttgt gtccactgac agcagtggcc
     4201 tgcccaaggc cgcctccctc ctgccctccc cctcggtcat gtgggccagc tctttccgcc
     4261 ccctgctcag caagaccatg acatccaccg agcagtccct ctactaccgg cagtggacgg
     4321 tgccccggcc cagccacatg gactacggca accgggccga gggccgcgtg gacggcttcc
     4381 acccccgcag gctgctgctc agcggccccc ctcagatcgg gaagacaggt gcctacctgc
     4441 agttcctcag tgtcctgtcc aggatgcttg ttcggctcac agaagtggat gtctatgacg
     4501 aggaggagat caatatcaac ctcagagaag aatctgactg gcattatctc cagcttagcg
     4561 acccctggcc agacctggag ctgttcaaga agttgccctt tgactacatc attcacgacc
     4621 cgaagtatga agatgccagc ctgatttgtt cgcactatca gggtataaag agtgaagaca
     4681 gagggatgtc ccggaagccg gaggaccttt atgtgcggcg tcagacggca cggatgagac
     4741 tgtccaagta cgcagcgtac aacacttacc accactgtga gcagtgccac cagtacatgg
     4801 gcttccaccc ccgctaccag ctgtatgagt ccaccctgca cgcctttgcc ttctcttact
     4861 ccatgctagg agaggagatc cagctgcact tcatcatccc caagtccaag gagcaccact
     4921 ttgtcttcag ccaacctgga ggccagctgg agagcatgcg actacccctc gtgacagaca
     4981 agagccatga atatataaaa agtccgacat tcactccaac caccggccgt cacgaacatg
     5041 ggctctttaa tctgtaccac gcaatggacg gtgccagcca tttgcacgtg ctggttgtca
     5101 aggaatacga gatggcaatt tataagaaat attggcccaa ccacatcatg ctggtgctcc
     5161 ccagtatctt caacagtgct ggagttggtg ctgctcattt cctcatcaag gagctgtcct
     5221 accataacct ggagctcgag cggaaccggc aggaggagct gggaatcaag ccgcaggaca
     5281 tctggccttt cattgtgatc tctgatgact cctgcgtgat gtggaacgtg gtggatgtca
     5341 actctgctgg ggagagaagc agggagttct cctggtcgga aaggaacgtg tctttgaagc
     5401 acatcatgca gcacatcgag gcggcccccg acatcatgca ctacgccctg ctgggcctgc
     5461 ggaagtggtc cagcaagacc cgggccagcg aggtgcaaga gcccttctcc cgctgccacg
     5521 tgcacaactt catcatcctg aacgtggacc tgacccagaa cgtgcagtac aaccagaacc
     5581 ggttcctgtg tgacgatgta gacttcaacc tgcgggtgca cagcgccggc ctcctgctct
     5641 gccggttcaa ccgcttcagc gtgatgaaga agcagatcgt ggtgggcggc cacaggtcct
     5701 tccacatcac atccaaggtg tctgataact ctgccgcggt cgtgccggcc cagtacatct
     5761 gtgccccgga cagcaagcac acgttcctcg cagcgcccgc ccagctcctg ctggagaagt
     5821 tcctgcagca ccacagccac ctcttcttcc cgctgtccct gaagaaccat gaccacccag
     5881 tgctgtctgt cgactgttac ctgaacctgg gatctcagat ttctgtttgc tatgtgagct
     5941 ccaggcccca ctctttaaac atcagctgct cggacttgct gttcagtggg ctgctgctgt
     6001 acctctgtga ctcttttgtg ggagctagct ttttgaaaaa gtttcatttt ctgaaaggtg
     6061 cgacgttgtg tgtcatctgt caggaccgga gctcactgcg ccagacggtc gtccgcctgg
     6121 agctcgagga cgagtggcag ttccggctgc gcgatgagtt ccagaccgcc aatgccaggg
     6181 aagaccggcc gctctttttt ctgacgggac gacacatctg aggaagacag cggcgagttt
     6241 tctgaagaga tgagtgctca gagccctcat gctgttgagg ctaaagggag gcctggaacg
     6301 gtggggcgtt tgactggaat ggaccccagg gactgtccag gtgcagcccc tcctagtaca
     6361 catgggcccc cgaggccgtg gtcctgggag ccaggaagac tccgcagtgg gtgagaatga
     6421 aaacttgaga ctcccaagtt ctgggccagc ccattgctct gggctgtttt aaagcccatt
     6481 tcacgaggaa caaagattta cttcctgtcc tgccattcgt gtgcttccat ggacaaacct
     6541 gatttttttc tcttagttct aaagaatctt gggttatttt gtagcggtgc cagtatttca
     6601 gtagatggga tttcagccaa gtaggttccc ctgtaacctc ctacaaagca atattccaaa
     6661 ggaacatttt aactgtaaag gctggagaca agaaaaaata agtagatcgt tttaataaca
     6721 attatttaat tgcctataag tttgctgttt cagaggctag cccaaaggca tcaaatttaa
     6781 taaagttaaa caaattgatt tacttcagag caaatatgat cctattaaaa taatataggg
     6841 taaataccct acctcttaga aagggcaaaa atgcaaagaa gctttcttta aaactaaaag
     6901 ggttttttgg ggggggagtt ggcggggagg aaataaggct aacagaggtt gacctaaaat
     6961 tagccttaca aaggagaaag gaccacattg cttacttgaa acagacaatg aaaacaacca
     7021 aagtgatata taaaatagtt gatgagaact agacttatga ctgtagttta ctagagttta
     7081 gttttcagtt gctgaagtag ctcattttct cttactaatg tttggttcct cagggaagaa
     7141 tctcacttga ctagagagga ggtgggaaca gaagagagaa ggaggcaggg agatgtattt
     7201 cttagggctc accccttcac agactgacag aatggttttg ttttgttttg ttttgttttg
     7261 ttttgttttt gagatggact ctagctctgt cacccaggct ggagtgcagt ggtgcgatct
     7321 cggctcactg caagctccgc ctcccgggtt ctcaccattc tcctgcctca gcctcccgag
     7381 tagctgggac tacaggcgcc caccaccacg cccggctaat tttttgtatt ttttagtaga
     7441 gacggggttt caccatgtta gccaggatgg tctcgatctc ctgacctcgt gatccgcccg
     7501 cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgtgcctgc cccagaatgg
     7561 tttttaaagc cacagttgag aggccaccca ttgcccggcg cctggacagt gatcatcttg
     7621 ttcatcttgt tcagtccttt cttgtgtgat tggaattatt catccccttt gaaagatgag
     7681 aaggttgaga tgcaaagagt ctacctttcc aagttctcac tgctggaaag agctagaagc
     7741 acagttcaaa gttctggctt ctggactctg cagtccaggt ctcccttctc ccacttgcct
     7801 accctcaatg ccacactgtt tttgaagtgg cccataactt gaaggaaaag tttaaagaca
     7861 gttcaattta atcatcagaa tgcattcttt tttttttcgg agacggagtt tcactcttgc
     7921 tgcccaggct ggagtgcaat ggtgcaatga cctcggctca ctgcaacctc tgcctcctgg
     7981 gttcaagtga ttctccagcc tcagcctccc gagtagctgg gattatgggc gcccaccacc
     8041 atgcccagct aatttttgta tttttttttt ttagtagaga tggggtttcg ccaggttggc
     8101 caggctggtc ttgtgaactc ctggcctcag gtgatctgcc cacctcatcc tccaaaagtg
     8161 ctgggattac aggcatgagc cactgcgcct ggcctcagaa tgcattctta cacatctatc
     8221 ctagacattt ataagcactc taatggataa caatccaaga ataaatgatt gtaaaagatg
     8281 atgccgaaga gttgatgtca atcttttttt cctaagaaaa aaagtccgcg agtattaaat
     8341 atttagatca atgtttataa aatgattact ttgtatatct cattattcct attttggaat
     8401 aaaaactgac cttctttaat catatacttg tcttttgtaa atagcagctt ttgtgtcatt
     8461 ctccccactt tattagttaa tttaaattgg aaaaaaccct caaactaata ttcttgtctg
     8521 ttccagtctt ataaataaaa cttataatgc atgta
//
