LOCUS       NM_005310               2233 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens growth factor receptor bound protein 7 (GRB7),
            transcript variant 1, mRNA.
ACCESSION   NM_005310
VERSION     NM_005310.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Zhu,G., Cai,H., Xiao,Q., Zeng,S., Jiang,X. and Liu,D.
  TITLE     GRB7 plays a promoting role in the progression of gastric cancer
  JOURNAL   BMC Cancer 23 (1), 1262 (2023)
   PUBMED   38129809
  REMARK    GeneRIF: GRB7 plays a promoting role in the progression of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Xu,Q., Liu,Z., Zhu,Z.Q., Fan,Y., Chen,R., Xie,X.H. and Cheng,M.
  TITLE     Knockdown of growth factor receptor bound protein 7 suppresses
            angiogenesis by inhibiting the secretion of vascular endothelial
            growth factor A in ovarian cancer cells
  JOURNAL   Bioengineered 12 (2), 12179-12190 (2021)
   PUBMED   34783299
  REMARK    GeneRIF: Knockdown of growth factor receptor bound protein 7
            suppresses angiogenesis by inhibiting the secretion of vascular
            endothelial growth factor A in ovarian cancer cells.
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Gotovac,J.R., Liu,D.S., Yates,M.J., Milne,J.V., Macpherson,A.A.,
            Simpson,K.J., Eslick,G.D., Mitchell,C., Duong,C.P., Phillips,W.A.
            and Clemons,N.J.
  TITLE     GRB7 is an oncogenic driver and potential therapeutic target in
            oesophageal adenocarcinoma
  JOURNAL   J Pathol 252 (3), 317-329 (2020)
   PUBMED   32737994
  REMARK    GeneRIF: GRB7 is an oncogenic driver and potential therapeutic
            target in oesophageal adenocarcinoma.
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Zheng,Y., Pei,Y., Yang,L., Zeng,Z., Wang,J., Xie,G., Wang,L. and
            Yuan,J.
  TITLE     Upregulated GRB7 promotes proliferation and tumorigenesis of
            Bladder Cancer via Phospho-AKT Pathway
  JOURNAL   Int J Biol Sci 16 (16), 3221-3230 (2020)
   PUBMED   33162827
  REMARK    GeneRIF: Upregulated GRB7 promotes proliferation and tumorigenesis
            of Bladder Cancer via Phospho-AKT Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Tang,H., Yang,P., Yang,X., Peng,S., Hu,X. and Bao,G.
  TITLE     Growth factor receptor bound protein-7 regulates proliferation,
            cell cycle, and mitochondrial apoptosis of thyroid cancer cells via
            MAPK/ERK signaling
  JOURNAL   Mol Cell Biochem 472 (1-2), 209-218 (2020)
   PUBMED   32577949
  REMARK    GeneRIF: Growth factor receptor bound protein-7 regulates
            proliferation, cell cycle, and mitochondrial apoptosis of thyroid
            cancer cells via MAPK/ERK signaling.
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Janes,P.W., Lackmann,M., Church,W.B., Sanderson,G.M.,
            Sutherland,R.L. and Daly,R.J.
  TITLE     Structural determinants of the interaction between the erbB2
            receptor and the Src homology 2 domain of Grb7
  JOURNAL   J Biol Chem 272 (13), 8490-8497 (1997)
   PUBMED   9079677
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   Tanaka,S., Mori,M., Akiyoshi,T., Tanaka,Y., Mafune,K., Wands,J.R.
            and Sugimachi,K.
  TITLE     Coexpression of Grb7 with epidermal growth factor receptor or
            Her2/erbB2 in human advanced esophageal carcinoma
  JOURNAL   Cancer Res 57 (1), 28-31 (1997)
   PUBMED   8988034
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Yokote,K., Margolis,B., Heldin,C.H. and Claesson-Welsh,L.
  TITLE     Grb7 is a downstream signaling component of platelet-derived growth
            factor alpha- and beta-receptors
  JOURNAL   J Biol Chem 271 (48), 30942-30949 (1996)
   PUBMED   8940081
REFERENCE   9  (bases 1 to 2233)
  AUTHORS   Pandey,A., Liu,X., Dixon,J.E., Di Fiore,P.P. and Dixit,V.M.
  TITLE     Direct association between the Ret receptor tyrosine kinase and the
            Src homology 2-containing adapter protein Grb7
  JOURNAL   J Biol Chem 271 (18), 10607-10610 (1996)
   PUBMED   8631863
REFERENCE   10 (bases 1 to 2233)
  AUTHORS   Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
            Skolnik,E., Ullrich,A. and Schlessinger,J.
  TITLE     High-efficiency expression/cloning of epidermal growth
            factor-receptor-binding proteins with Src homology 2 domains
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8894-8898 (1992)
   PUBMED   1409582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079199.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_005310.4.
            
            Summary: The product of this gene belongs to a small family of
            adapter proteins that are known to interact with a number of
            receptor tyrosine kinases and signaling molecules. This gene
            encodes a growth factor receptor-binding protein that interacts
            with epidermal growth factor receptor (EGFR) and ephrin receptors.
            The protein plays a role in the integrin signaling pathway and cell
            migration by binding with focal adhesion kinase (FAK). Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (a) is
            shorter at the N-terminus compared to isoform b. Variants 1, 2, and
            3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43772.1, AK222870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309156.9/ ENSP00000310771.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC079199.9         82397-82592
            197-401             AC079199.9         86711-86915
            402-552             AC079199.9         87025-87175
            553-709             AC079199.9         87357-87513
            710-831             AC079199.9         87639-87760
            832-909             AC079199.9         87852-87929
            910-1047            AC079199.9         88529-88666
            1048-1158           AC079199.9         89012-89122
            1159-1257           AC079199.9         89345-89443
            1258-1338           AC079199.9         89702-89782
            1339-1455           AC079199.9         89881-89997
            1456-1516           AC079199.9         90187-90247
            1517-1604           AC079199.9         90372-90459
            1605-1698           AC079199.9         90568-90661
            1699-2233           AC079199.9         91210-91744
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2233
                     /gene="GRB7"
                     /note="growth factor receptor bound protein 7"
                     /db_xref="GeneID:2886"
                     /db_xref="HGNC:HGNC:4567"
                     /db_xref="MIM:601522"
     exon            1..196
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            197..401
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1845
                     /gene="GRB7"
                     /note="isoform a is encoded by transcript variant 1; B47;
                     GRB7 adapter protein; epidermal growth factor receptor
                     GRB-7"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 7 isoform
                     a"
                     /protein_id="NP_005301.2"
                     /db_xref="CCDS:CCDS11345.1"
                     /db_xref="GeneID:2886"
                     /db_xref="HGNC:HGNC:4567"
                     /db_xref="MIM:601522"
                     /translation="MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQP
                     LLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPH
                     VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLED
                     HESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHED
                     LIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVA
                     DVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFR
                     LFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREAL
                     SVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGL
                     VDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQL
                     VEFHQLNRGILPCLLRHCCTRVAL"
     exon            402..552
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            553..709
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            710..831
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            832..909
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1047
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1158
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1257
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1338
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1455
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1516
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1604
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1698
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2233
                     /gene="GRB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRB7"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="GRB7"
                     /note="major polyA site"
ORIGIN      
        1 agtttccttg ggcctggaat ctggacacac agggctcccc cccgcctctg acttctctgt
       61 ccgaagtcgg gacaccctcc taccacctgt agagaagcgg gagtggatct gaaataaaat
      121 ccaggaatct gggggttcct agacggagcc agacttcgga acgggtgtcc tgctactcct
      181 gctggggctc ctccaggaca agggcacaca actggttccg ttaagcccct ctcttgctca
      241 gacgccatgg agctggatct gtctccacct catcttagca gctctccgga agacctttgc
      301 ccagcccctg ggacccctcc tgggactccc cggccccctg atacccctct gcctgaggag
      361 gtaaagaggt cccagcctct cctcatccca accaccggca ggaaacttcg agaggaggag
      421 aggcgtgcca cctccctccc ctctatcccc aaccccttcc ctgagctctg cagtcctccc
      481 tcacagagcc caattctcgg gggcccctcc agtgcaaggg ggctgctccc ccgcgatgcc
      541 agccgccccc atgtagtaaa ggtgtacagt gaggatgggg cctgcaggtc tgtggaggtg
      601 gcagcaggtg ccacagctcg ccacgtgtgt gaaatgctgg tgcagcgagc tcacgccttg
      661 agcgacgaga cctgggggct ggtggagtgc cacccccacc tagcactgga gcggggtttg
      721 gaggaccacg agtccgtggt ggaagtgcag gctgcctggc ccgtgggcgg agatagccgc
      781 ttcgtcttcc ggaaaaactt cgccaagtac gaactgttca agagctcccc acactccctg
      841 ttcccagaaa aaatggtctc cagctgtctc gatgcacaca ctggtatatc ccatgaagac
      901 ctcatccaga acttcctgaa tgctggcagc tttcctgaga tccagggctt tctgcagctg
      961 cggggttcag gacggaagct ttggaaacgc tttttctgct tcttgcgccg atctggcctc
     1021 tattactcca ccaagggcac ctctaaggat ccgaggcacc tgcagtacgt ggcagatgtg
     1081 aacgagtcca acgtgtacgt ggtgacgcag ggccgcaagc tctacgggat gcccactgac
     1141 ttcggtttct gtgtcaagcc caacaagctt cgaaatggcc acaaggggct tcggatcttc
     1201 tgcagtgaag atgagcagag ccgcacctgc tggctggctg ccttccgcct cttcaagtac
     1261 ggggtgcagc tgtacaagaa ttaccagcag gcacagtctc gccatctgca tccatcttgt
     1321 ttgggctccc cacccttgag aagtgcctca gataataccc tggtggccat ggacttctct
     1381 ggccatgctg ggcgtgtcat tgagaacccc cgggaggctc tgagtgtggc cctggaggag
     1441 gcccaggcct ggaggaagaa gacaaaccac cgcctcagcc tgcccatgcc agcctccggc
     1501 acgagcctca gtgcagccat ccaccgcacc caactctggt tccacgggcg catttcccgt
     1561 gaggagagcc agcggcttat tggacagcag ggcttggtag acggcctgtt cctggtccgg
     1621 gagagtcagc ggaaccccca gggctttgtc ctctctttgt gccacctgca gaaagtgaag
     1681 cattatctca tcctgccgag cgaggaggag ggccgcctgt acttcagcat ggatgatggc
     1741 cagacccgct tcactgacct gctgcagctc gtggagttcc accagctgaa ccgcggcatc
     1801 ctgccgtgct tgctgcgcca ttgctgcacg cgggtggccc tctgaccagg ccgtggactg
     1861 gctcatgcct cagcccgcct tcaggctgcc cgccgcccct ccacccatcc agtggactct
     1921 ggggcgcggc cacaggggac gggatgagga gcgggagggt tccgccactc cagttttctc
     1981 ctctgcttct ttgcctccct cagatagaaa acagccccca ctccagtcca ctcctgaccc
     2041 ctctcctcaa gggaaggcct tgggtggccc cctctccttc tcctagctct ggaggtgctg
     2101 ctctagggca gggaattatg ggagaagtgg gggcagccca ggcggtttca cgccccacac
     2161 tttgtacaga ccgagaggcc agttgatctg ctctgtttta tactagtgac aataaagatt
     2221 attttttgat aca
//
