LOCUS       NM_001350814            5468 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens growth factor receptor bound protein 10 (GRB10),
            transcript variant 1, mRNA.
ACCESSION   NM_001350814 XM_011515304
VERSION     NM_001350814.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5468)
  AUTHORS   Ren,L.L., Wang,Z.W., Sen,R., Dai,Z.T., Liao,X.H. and Shen,L.J.
  TITLE     GRB10 is a novel factor associated with gastric cancer
            proliferation and prognosis
  JOURNAL   Aging (Albany NY) 15 (9), 3394-3409 (2023)
   PUBMED   37179120
  REMARK    GeneRIF: GRB10 is a novel factor associated with gastric cancer
            proliferation and prognosis.
REFERENCE   2  (bases 1 to 5468)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5468)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5468)
  AUTHORS   Wang,D., Ming,X., Xu,J. and Xiao,Y.
  TITLE     Circ_0009910 shuttled by exosomes regulates proliferation, cell
            cycle and apoptosis of acute myeloid leukemia cells by regulating
            miR-5195-3p/GRB10 axis
  JOURNAL   Hematol Oncol 39 (3), 390-400 (2021)
   PUBMED   33969901
  REMARK    GeneRIF: Circ_0009910 shuttled by exosomes regulates proliferation,
            cell cycle and apoptosis of acute myeloid leukemia cells by
            regulating miR-5195-3p/GRB10 axis.
REFERENCE   5  (bases 1 to 5468)
  AUTHORS   Monk,D., Arnaud,P., Frost,J., Hills,F.A., Stanier,P., Feil,R. and
            Moore,G.E.
  TITLE     Reciprocal imprinting of human GRB10 in placental trophoblast and
            brain: evolutionary conservation of reversed allelic expression
  JOURNAL   Hum Mol Genet 18 (16), 3066-3074 (2009)
   PUBMED   19487367
  REMARK    GeneRIF: GRB10 gene is expressed from the paternal allele in the
            brain, but from the maternal allele in the placental trophoblasts.
REFERENCE   6  (bases 1 to 5468)
  AUTHORS   Morrione,A., Valentinis,B., Li,S., Ooi,J.Y., Margolis,B. and
            Baserga,R.
  TITLE     Grb10: A new substrate of the insulin-like growth factor I receptor
  JOURNAL   Cancer Res 56 (14), 3165-3167 (1996)
   PUBMED   8764099
REFERENCE   7  (bases 1 to 5468)
  AUTHORS   Hansen,H., Svensson,U., Zhu,J., Laviola,L., Giorgino,F., Wolf,G.,
            Smith,R.J. and Riedel,H.
  TITLE     Interaction between the Grb10 SH2 domain and the insulin receptor
            carboxyl terminus
  JOURNAL   J Biol Chem 271 (15), 8882-8886 (1996)
   PUBMED   8621530
REFERENCE   8  (bases 1 to 5468)
  AUTHORS   Liu,F. and Roth,R.A.
  TITLE     Grb-IR: a SH2-domain-containing protein that binds to the insulin
            receptor and inhibits its function
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10287-10291 (1995)
   PUBMED   7479769
REFERENCE   9  (bases 1 to 5468)
  AUTHORS   Pandey,A., Duan,H., Di Fiore,P.P. and Dixit,V.M.
  TITLE     The Ret receptor protein tyrosine kinase associates with the
            SH2-containing adapter protein Grb10
  JOURNAL   J Biol Chem 270 (37), 21461-21463 (1995)
   PUBMED   7665556
REFERENCE   10 (bases 1 to 5468)
  AUTHORS   Saal,H.M., Harbison,M.D. and Netchine,I.
  TITLE     Silver-Russell Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004920.2, AC005153.2 and
            AC080092.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001350814.1.
            
            Summary: The product of this gene belongs to a small family of
            adapter proteins that are known to interact with a number of
            receptor tyrosine kinases and signaling molecules. This gene
            encodes a growth factor receptor-binding protein that interacts
            with insulin receptors and insulin-like growth-factor receptors.
            Overexpression of some isoforms of the encoded protein inhibits
            tyrosine kinase activity and results in growth suppression. This
            gene is imprinted in a highly isoform- and tissue-specific manner,
            with expression observed from the paternal allele in the brain, and
            from the maternal allele in the placental trophoblasts.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271366.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 10861285, 19487367
            MANE Ensembl match     :: ENST00000401949.6/ ENSP00000385770.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC004920.2         42061-42533         c
            474-583             AC004920.2         40264-40373         c
            584-753             AC004920.2         15524-15693         c
            754-850             AC005153.2         120852-120948       c
            851-938             AC005153.2         92401-92488         c
            939-1161            AC005153.2         63016-63238         c
            1162-1303           AC005153.2         58302-58443         c
            1304-1460           AC005153.2         15402-15558         c
            1461-1576           AC005153.2         7750-7865           c
            1577-1645           AC005153.2         6651-6719           c
            1646-1783           AC005153.2         4790-4927           c
            1784-1894           AC005153.2         3350-3460           c
            1895-1993           AC005153.2         1321-1419           c
            1994-2071           AC080092.9         25881-25958         c
            2072-2188           AC080092.9         24834-24950         c
            2189-2255           AC080092.9         23855-23921         c
            2256-2343           AC080092.9         23542-23629         c
            2344-2437           AC080092.9         14981-15074         c
            2438-5468           AC080092.9         9612-12642          c
FEATURES             Location/Qualifiers
     source          1..5468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.1"
     gene            1..5468
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="growth factor receptor bound protein 10"
                     /db_xref="GeneID:2887"
                     /db_xref="HGNC:HGNC:4564"
                     /db_xref="MIM:601523"
     exon            1..473
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            474..583
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            584..753
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            754..850
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     CDS             800..2584
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="isoform a is encoded by transcript variant 1;
                     maternally expressed gene 1; GRB10 adaptor protein;
                     insulin receptor-binding protein Grb-IR; GRB10 adapter
                     protein"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 10 isoform
                     a"
                     /protein_id="NP_001337743.1"
                     /db_xref="CCDS:CCDS43582.1"
                     /db_xref="GeneID:2887"
                     /db_xref="HGNC:HGNC:4564"
                     /db_xref="MIM:601523"
                     /translation="MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLAN
                     HQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQ
                     VSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLP
                     PSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHL
                     GLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGS
                     QTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQ
                     LLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMT
                     AFRLLKYGMLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAE
                     AQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIK
                     QQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSD
                     LIQLVDFYQLNKGVLPCKLKHHCIRVAL"
     exon            851..938
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1161
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1303
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1460
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1576
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1645
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1783
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1894
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1993
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2071
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2188
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2255
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2343
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2437
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..5468
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="hexamer: ATTAAA"
     polyA_site      2956
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="major polyA site"
     regulatory      5443..5448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="hexamer: AATAAA"
     polyA_site      5468
                     /gene="GRB10"
                     /gene_synonym="Grb-10; GRB-IR; IRBP; MEG1; RSS"
                     /note="major polyA site"
ORIGIN      
        1 gggattcctg ttgtgctcca ggaccgggcg ctgctccgtc gtcctcccgc tcctcaggag
       61 cgcccagtcc ctcggaggct gagtattgca gccgggcggc agccggctcc gcggaggggc
      121 ccccgggcac ctgcgtggtg atggcgctgg gagcccccgg gcacgctcgg gcggtggcgc
      181 ggcatcccac cctcgcccgg atggcgtccc cagaggcggc gttggcccgc ttttcgtgct
      241 agcgcgttcg cctggcgcgc ggtggccccg aggccccggg tcggttttct gcgccgcagg
      301 cccctggccg gggcggagcc gtggaggacc agcccggccc ggctccgagc gctgtccatg
      361 cggagcgctg tccacgcgcc gggcactgcg ggggccgggc cccgaagccc tacccgggcc
      421 ggcggcgcac acgcagcgac cccgtgcggc cagtgctgcc gcccgctctc cagacttggg
      481 aggctgcatt ctgataattc tcaggaggaa gaatgtatag gagagaccag ggtttttaag
      541 gtgtgacctc tgaaccacct acatcagagc tgactgcctc tcgctttggc gctgaccaca
      601 atgctgagca ggaagcagca gctgcaggcc cagtgactgg tagctcagtg accagcagcc
      661 cagtgaccgg cagccaggtc ctcacctggg tcctctcagt gaagccaggg tggccgcccc
      721 agcagacagt gctacagagc caactcctga caggtgctgc agcgcagtaa atgtaatttg
      781 aagaaggcag aaggaaccca tggctttagc cggctgccca gattcctttt tgcaccatcc
      841 gtactaccag gacaaggtgg agcagacacc tcgcagtcaa caagacccgg caggaccagg
      901 actccccgca cagtctgacc gacttgcgaa tcaccaggag gatgatgtgg acctggaagc
      961 cctggtgaac gatatgaatg catccctgga gagcctgtac tcggcctgca gcatgcagtc
     1021 agacacggtg cccctcctgc agaatggcca gcatgcccgc agccagcctc gggcttcagg
     1081 ccctcctcgg tccatccagc cacaggtgtc cccgaggcag agggtgcagc gctcccagcc
     1141 tgtgcacatc ctcgctgtca ggcgccttca ggaggaagac cagcagttta gaacctcatc
     1201 tctgccggcc atccccaatc cttttcctga actctgtggc cctgggagcc cccctgtgct
     1261 cacgccgggt tctttacctc cgagccaggc cgccgcaaag caggatgtta aagtctttag
     1321 tgaagatggg acaagcaaag tggtggagat tctagcagac atgacagcca gagacctgtg
     1381 ccaattgctg gtttacaaaa gtcactgtgt ggatgacaac agctggacac tagtggagca
     1441 ccacccgcac ctaggattag agaggtgctt ggaagaccat gagctggtgg tccaggtgga
     1501 gagtaccatg gccagtgaga gtaaatttct attcaggaag aattacgcaa aatacgagtt
     1561 ctttaaaaat cccatgaatt tcttcccaga acagatggtt acttggtgcc agcagtcaaa
     1621 tggcagtcaa acccagcttt tgcagaattt tctgaactcc agtagttgtc ctgaaattca
     1681 agggtttttg catgtgaaag agctgggaaa gaaatcatgg aaaaagctgt atgtgtgttt
     1741 gcggagatct ggcctttatt gctccaccaa gggaacttca aaggaaccca gacacctgca
     1801 gctgctggcc gacctggagg acagcaacat cttctccctg atcgctggca ggaagcagta
     1861 caacgcccct acagaccacg ggctctgcat aaagccaaac aaagtcagga atgaaactaa
     1921 agagctgagg ttgctctgtg cagaggacga gcaaaccagg acgtgctgga tgacagcgtt
     1981 cagactcctc aagtatggaa tgctccttta ccagaattac cgaatccctc agcagaggaa
     2041 ggccttgctg tccccgttct cgacgccagt gcgcagtgtc tccgagaact ccctcgtggc
     2101 aatggatttt tctgggcaaa caggacgcgt gatagagaat ccggcagagg cccagagcgc
     2161 agccctggag gagggccacg cctggaggaa gcgaagcaca cggatgaaca tcctaggtag
     2221 ccaaagtccc ctccaccctt ctaccctaag tacagtgatt cacaggacac agcactggtt
     2281 tcacgggagg atctccaggg aggaatccca caggatcatt aaacagcaag ggctcgtgga
     2341 tgggcttttt ctcctccgtg acagccagag taatccaaag gcatttgtac tcacactgtg
     2401 tcatcaccag aaaattaaaa atttccagat cttaccttgc gaggacgacg ggcagacgtt
     2461 cttcagccta gatgacggga acaccaaatt ctctgacctg atccagctgg ttgactttta
     2521 ccagctgaac aaaggagtcc tgccttgcaa actcaagcac cactgcatcc gagtggcctt
     2581 atgaccgcag atgtcctctc ggctgaagac tggaggaagt gaacactgga gtgaagaagc
     2641 ggtctgtgcg ttggtgaaga acacacatcg attctgcacc tggggaccca gagcgagatg
     2701 ggtttgttcg gtgccagccg accaagattg actagtttgt tggacttaaa cgacgatttg
     2761 ctgctgtgaa cccagcaggg tcgcctccct ctgcatcggc caaattgggg agggcatgga
     2821 agatccagcg gaaagttgaa aataaactgg aatgatcatc ttggcttggg ccgcttagga
     2881 acaagaaccg gagagaagtg attggaaatg aactcttgcc ctggaataat cttgacaatt
     2941 aaaactgata tgtttacttt ttttgtattg atcacttttt tgcactcctt ctttgttttc
     3001 aatattgtat tcagcctatt gtaggagggg gatgtggcgt ttcaactcat ataatacaga
     3061 aagagttttg aatgggcaga tttcaaactg aatatgggtc cccaaatgtt cccagagggt
     3121 cctccacacc ctctgccgac taccacggtg tggattcagc tcccaaatga caaacccagc
     3181 ccttcccagt atacttgaaa agctttcttg ttaaaataaa aggtgtcact gtggtaggca
     3241 tttggcatat tttgtggact cagtcaagca accacagtct gttaatcatt tctctatgct
     3301 cagatgtcag atcctcttgt tattagtgtg tcttgttctg cacagtgcag gagactttat
     3361 tcctttggaa aattcactgt tccacaaaca gcaggctgaa tggcctcgcc tctagattga
     3421 cgtgggccag cctccttgag acacacctgg cacccgtcat cggccagcgg tggatgctgc
     3481 ataatccacc tgggtacttc agccttgcgt ttccacagcc ttcagcctgt tctagaacga
     3541 tcactgcctt acccctgctg ctgcagtggt gtgagtcgtt tcacggctga tgtccctcgg
     3601 gggattaaag gatctaaaga gaaaatggca cctggttgtc ttcgtgctgt gtctcatggg
     3661 tttccatagt gataaagaca aggaaacgct gcaggggcca caggcacagg ctgatattta
     3721 aagatctttg cttgcagccc tccgtcctgc tgaaaacccc cataagccag tgaacacaga
     3781 gcagctagag gctcctcctc tgctggctta gggtcagaag tacctcacag tggttgtgga
     3841 catggaagag ttttgtcaac acaacacttt gtccccgctc cgggagatga gtcagatggt
     3901 ggcttgagtt gtcacttggt cccctccgcc cctcgggtgg ccccctttgc cacgtcccct
     3961 tagcttagtg atcaggtgtg agagtggcca tttccttacc tttgatccct gtaaagcaga
     4021 aaggactcct ttgacaggcg acaaactact gtggtgagca gaatgatttc ctttttcaag
     4081 acaacacctg cctggcttct attaatgtgt gctggccatg atattgcccc aaatccgccc
     4141 cactgaagtg ttccctaagg aacagcattt ctctgctcct cagtcaaccc ccgtagccta
     4201 gagcagtgtc acaagcttca gtaaggccag tcagctggaa gtcagtctac cgtatagtaa
     4261 cactgtatgt cagtctacag accacactct agttgttttc catgaaaggt atacaaatga
     4321 agaattttct agcaaaacat gtttttaacc atcagtgctc aattgcattt tcttcctttc
     4381 gcagccagtc agtctttcaa actattgaca gtaagataat tctcacgttc acacctggtg
     4441 gcaggcttca ctgtagggac ggacattgca gttacaccac gattccttcc tcttcactgg
     4501 ctcgaggtaa acccttttca aggaaaaaca actctaggat ttcttttttc tgtgtacgta
     4561 gaccagtccc atcagtgtat aatctctctc tcacacgcct ctctccaata gacagcttgt
     4621 atttgcagta tttcatattt ataaatatgc gtttatttaa aaggagaaca aaagcttgac
     4681 tctgattcac agttttgtat gtagctggtt tgacgtagtc ttttgtattt tccctgccga
     4741 agtgaattgt tggagaatgt aaaccgcctc cacgtggcgg cagacttcct aaggccccag
     4801 ctcgctggcc tcgcgctggg cggctgggaa ttccacctga gaacaagtcc cgcaaaccgg
     4861 ggacggaagg acatttgact tttatttttg tatttaattg acatgaatgt aaaggggaca
     4921 gctcagggtt gttttggagc ctgttgactt tgtatctctg cctgtgattt tcttttctaa
     4981 atgaaactcc atgtagcaac caggacgaag ttgagaagga aaacgccaaa tgctttggtt
     5041 attagagttt aataggtaag ctctgttaca ctaggtgtta gagttccaga atgttctttt
     5101 gtttgctaaa ccttgaagaa acatgtgcct cagcctagat gttttgtctt ctcttttctg
     5161 cacttaatac ctgacagtat gaccgatctc tgcgcctttc tgggggcggg caagctggcg
     5221 gtagatttgt gatgtcacag tgcaaactgc agtgactgta aattggcctg gcgtgtataa
     5281 acgttttcag ggaatgcaga aggtattaat gaagagacaa aacctttatt ccatgtgctt
     5341 tgcttcattc tgtacatagc tctttggctc gtgaacctaa ttgtaaactt tcaggtattt
     5401 ttgtacaaat aagggactga tgttctgttt cttgtaatta gaaataaaca ttaatacagt
     5461 gttcttca
//
