LOCUS       NM_001129778            1199 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens GRB2 related adaptor protein like (GRAPL), transcript
            variant 1, mRNA.
ACCESSION   NM_001129778 XM_001720657 XM_001723190
VERSION     NM_001129778.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007952.16.
            
            On May 17, 2019 this sequence version replaced NM_001129778.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.529079.1,
                                           SRR1163655.55374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344415.9/ ENSP00000437409.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC007952.16        107828-107936
            110-207             AC007952.16        112881-112978
            208-330             AC007952.16        118705-118827
            331-1199            AC007952.16        138558-139426
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1199
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /note="GRB2 related adaptor protein like"
                     /db_xref="GeneID:400581"
                     /db_xref="HGNC:HGNC:37240"
     exon            1..109
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..388
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GRB2-related adapter protein LOC400581; GRB2-related
                     adapter protein-like; GRAPL long non-coding downstream
                     RNA"
                     /codon_start=1
                     /product="GRB2-related adapter protein-like isoform 1"
                     /protein_id="NP_001123250.1"
                     /db_xref="CCDS:CCDS45627.1"
                     /db_xref="GeneID:400581"
                     /db_xref="HGNC:HGNC:37240"
                     /translation="MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGV
                     EGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNNR
                     AQRGPCLGPKSHSRLG"
     exon            110..207
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /inference="alignment:Splign:2.1.0"
     exon            208..330
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1199
                     /gene="GRAPL"
                     /gene_synonym="GRAPLDR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccagct gctggagccc cgagcagcgg catggagtcc gtggccctgt acagctttca
       61 ggctacagag agcgacgagc tggccttcaa caagggagac acactcaaga tcctgaacat
      121 ggaggatgac cagaactggt acaaggccga gctccggggt gtcgagggat ttattcccaa
      181 gaactacatc cgcgtcaagc cccatccgtg gtactcgggc aggatttccc ggcagctggc
      241 cgaagagatt ctgatgaagc ggaaccatct gggagccttc ctgatccggg agagtgagag
      301 ctccccaggg gagttctctg tgtctgtgaa taacagagcc cagaggggtc cctgcctggg
      361 cccaaaatca cacagcagat tggggtagag ccggagagga cccgagactc ctgtgccagc
      421 ctgggcatcc cctccactgc cagggaagga ctgcatccaa gtcgcatccg tacccaggcc
      481 gaggtgtccg aggcccaggc tgaaatccgg ttgctgctgc agagaccaag tttccaaggc
      541 cttgtcaagt gggctgtgcc agacgatccc caggcctgtc attggctgct cttcggctcg
      601 gacacaccaa acctcaccaa gcacttccat ttctgaggga atagaggttg tggcttccgt
      661 caagcaccca tttaccccac cctcctcctc ctcttcctgc aaacttgagt cacagctgcc
      721 ctgctgggct caggccccag ggatgtctga gtcagcctgg ctggggttcc agtcctgaca
      781 ccgcccttac cagctgggag actccgggaa cctccaaccc tgctgagcct ccacttcgac
      841 atccgtgaaa cagccatgaa taagcaggtc tcaaaggtcg actcctgtat gcagggacac
      901 agcatgcagt aggtgcccaa tcataacagc agcacccacc tggagcccct tatagcagcc
      961 cttctcctct gcacttccac atggcatctc atttaacctt caccacaacc caactaggaa
     1021 ggcaccatca ttatcccatt ttactgatga agaaactgag gcccaggaag gtgaatttac
     1081 cagccagctc acaaatggac tagtagatgg cagtttgtgg attggagccc agaggctgtg
     1141 ctcctgccca caccctctca aatgagggct ataaaataac actctaagag ctcttccta
//
