LOCUS       NM_017577               3807 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens GRAM domain containing 1C (GRAMD1C), transcript
            variant 1, mRNA.
ACCESSION   NM_017577
VERSION     NM_017577.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079944.17, BC035040.1, AK292846.1 and CV575069.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017577.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035040.1, SRR1660803.210240.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358160.9/ ENSP00000350881.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC079944.17        77390-77435         c
            47-110              BC035040.1         7-70
            111-2473            AK292846.1         1-2363
            2474-3009           BC035040.1         2434-2969
            3010-3343           CV575069.1         285-618
            3344-3807           BC035040.1         3304-3767
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..3807
                     /gene="GRAMD1C"
                     /note="GRAM domain containing 1C"
                     /db_xref="GeneID:54762"
                     /db_xref="HGNC:HGNC:25252"
                     /db_xref="MIM:620180"
     exon            1..149
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2111
                     /gene="GRAMD1C"
                     /note="isoform 1 is encoded by transcript variant 1; GRAM
                     domain-containing protein 1C; protein Aster-C"
                     /codon_start=1
                     /product="protein Aster-C isoform 1"
                     /protein_id="NP_060047.3"
                     /db_xref="CCDS:CCDS33826.1"
                     /db_xref="GeneID:54762"
                     /db_xref="HGNC:HGNC:25252"
                     /db_xref="MIM:620180"
                     /translation="MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQ
                     GPNLHNWSGDWSFWISSSTYKDRNEEYRRQFTHLPDTERLIADYACALQRDILLQGRL
                     YLSENWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIVTESEKFFFTSFG
                     ARDRSYLSIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMENLSLSIEDVQP
                     RSPGRSSLDDSGERDEKLSKSISFTSESISRVSETESFDGNSSKGGLGKEESQNEKQT
                     KKSLLPTLEKKLTRVPSKSLDLNKNEYLSLDKSSTSDSVDEENVPEKDLHGRLFINRI
                     FHISADRMFELLFTSSRFMQKFASSRNIIDVVSTPWTAELGGDQLRTMTYTIVLNSPL
                     TGKCTAATEKQTLYKESREARFYLVDSEVLTHDVPYHDYFYTVNRYCIIRSSKQKCRL
                     RVSTDLKYRKQPWGLVKSLIEKNSWSSLEDYFKQLESDLLIEESVLNQAIEDPGKLTG
                     LRRRRRTFNRTAETVPKLSSQHSSGDVGLGAKGDITGKKKEMENYNVTLIVVMSIFVL
                     LLVLLNVTLFLKLSKIEHAAQSFYRLRLQEEKSLNLASDMVSRAETIQKNKDQAHRLK
                     GVLRDSIVMLEQLKSSLIMLQKTFDLLNKNKTGMAVES"
     exon            150..296
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            297..381
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            382..485
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            486..581
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            582..662
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            663..778
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            779..911
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1074
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1212
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1331
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1474
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1578
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1755
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1813
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1924
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2030
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..3807
                     /gene="GRAMD1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRAMD1C"
                     /note="hexamer: AATAAA"
     polyA_site      3807
                     /gene="GRAMD1C"
                     /note="major polyA site"
ORIGIN      
        1 actcggaggg ccggcggagg aggcgcgcgg agcctgtaac tcgcagcgcg cgctggaggt
       61 gggcgcgggg cggtgcggtg cggtgcgcgc ggggcggtgc cgcggcggcg gagggagccg
      121 cgatggaggg cgctccgact gtccgtcagg tgatgaatga aggggattca agccttgcca
      181 ccgacttaca ggaagatgta gaggaaaatc ctagtccaac tgtggaagag aataatgtgg
      241 tagttaaaaa acaggggcca aatttacata attggagtgg tgactggagc ttttggattt
      301 caagttccac ctataaagac aggaatgagg aatacagaag acagttcaca catctacctg
      361 atacagagag gctgatagca gattatgctt gtgctcttca gagggacatt ttgcttcagg
      421 gacgactata cctttcagaa aactggctat gtttctatag caacatcttc agatgggaaa
      481 ctacaatttc tattgcttta aagaatataa ccttcatgac caaggaaaaa actgctcgac
      541 tcatcccaaa cgctatccag atagttacag aaagtgaaaa gtttttcttc acatcttttg
      601 gtgccaggga tagaagttac ctcagtatct ttaggttgtg gcagaatgta ttattagata
      661 agagcctgac tagacaggaa ttctggcaac tgctccagca gaactatggc actgagctag
      721 gtttaaatgc tgaggagatg gaaaacttgt cactgtcgat tgaggatgtg cagccaagaa
      781 gtccaggaag aagcagcttg gatgactctg gggagagaga tgaaaaatta tccaagtcaa
      841 tcagttttac cagtgaatca attagtcggg tttcagaaac agagtcattc gatggaaatt
      901 catcaaaagg aggattaggc aaagaggagt cccaaaatga gaaacagacc aaaaagagtc
      961 tcttaccaac tttggaaaag aagttaacta gagtgccatc aaagtcactg gacttgaata
     1021 aaaatgaata tctttctctg gacaaaagca gcacttcaga ttctgttgat gaagaaaatg
     1081 ttcctgagaa agatcttcat ggaagacttt ttatcaaccg tatttttcat atcagtgctg
     1141 acagaatgtt tgaattgctc tttaccagtt cacgctttat gcagaaattt gccagttcta
     1201 gaaatataat agatgtagta tctacccctt ggactgcaga acttggaggt gatcagctga
     1261 gaacgatgac ctacactata gtccttaata gtccacttac tggaaaatgc actgctgcca
     1321 ctgaaaagca gacactgtat aaagaaagtc gggaagcacg attttatttg gtagattcag
     1381 aagtactgac acatgatgtc ccctaccatg attacttcta taccgtgaac agatactgta
     1441 tcatccgatc ttcaaaacag aaatgcaggc taagagtttc cacagatttg aaatacagaa
     1501 aacagccatg gggccttgtc aaatctttaa ttgaaaagaa ttcctggagt tctttggagg
     1561 actatttcaa acagcttgaa tcagatttgt taattgaaga atctgtatta aatcaggcca
     1621 ttgaagaccc tggaaaactt actggcctac gaaggagaag gcgaaccttc aaccgaacag
     1681 cagaaacagt tcctaaactt tcctctcagc attcctctgg agatgtgggc ttaggtgcca
     1741 aaggggatat tacaggaaag aaaaaggaaa tggaaaacta taacgtcact cttattgtgg
     1801 taatgagtat ttttgtgttg ttattagttt tgttgaatgt gacactgttt ctgaagctgt
     1861 caaagataga acatgctgct cagtcctttt accgtctccg cctccaagaa gagaaatctt
     1921 taaatttagc ctctgatatg gtgtcaagag cagaaactat tcagaagaat aaagatcagg
     1981 cccatcgttt aaagggagtg ctccgagact ccatagtgat gcttgaacag ctgaagagct
     2041 cactcattat gcttcagaaa acgtttgatc tactaaataa gaataagact ggcatggctg
     2101 ttgaaagcta gtgatctgaa ggactaaaac cgcagagata cttggaactt aaagaaaata
     2161 cctggaagaa aaccagacga atgaaggatt ttggcataga acatttctat gttttttcat
     2221 tattgagatt tctaatatga acatttcttt cagtaacatt tatttgataa ttagtttctg
     2281 ctggccttaa taatccatcc tttcacttct tatagatatt tttaagctgt gaatttcttc
     2341 agtgaaccat gaaatatatt atagaactga atttctctga tacaaaaaga aaatgacaca
     2401 ccctgaattg agtggtatgg tctcatttct acagtgaagt ctgatgcttt gttagcacag
     2461 aatccgtaca tgtccaatag gtcgcttttg taactgagat aagaccaaga ggataaacag
     2521 gacaatataa gaagaaacct ctatgtcatt actgatttta aaggttctgt tttcaggcat
     2581 ataacatttc caggtttgtg tactgtaaag attataatgt cttcatttat ttagcatgca
     2641 aatttaatag tcaaactttt tgaatctgca tgttgatgat gattatcaga aagggtcttc
     2701 tgccatgctg tatctttatg aaagaaatag ttgttttttc ttaaggtaac tatcagaggt
     2761 gggattatct tgcctcctca cttagaatac caacagtcaa aaggaagaac catcctctga
     2821 gttttaaaaa ccagaaggtt atgttaaaat ctgggcattt agtgacagat caaatgcata
     2881 cttgaactaa gattggcttc agcttagcag tctttcatgg tggaagtgac acatctggtt
     2941 gaaaataatt tgtgtatttt cagtaaccat gtatggcttc cttctttatg tatgtgtgtg
     3001 acttgttttg attggtaagt tataagccag acatagattt tagctcttta ataaaaactt
     3061 caggggcacg tatgtcccag tacaagtgta ctgactatca agttttaact cagatgcaag
     3121 ctttggctct ttcataaaaa gtttttatgc atatgtgtct ccatacaagt ggctcattaa
     3181 aataagaact ttgtaaactg acttaaaatc agatattttt tcaagagtta gggaaagttg
     3241 aagtgtttta ctgttttgtc tcttgagccc tttctctggg gaaaaaatac atatccatct
     3301 atctatctat atataaactg tgtatacatt cttactgttt gaacaactat tgcctttaat
     3361 taaatgtttc atttttctcc agagtcccca aagccacatg gcattattat agtcattttt
     3421 gagatgcctg tagagaatga aagtattgac tccgttagag ggaaaatggg tttctctggg
     3481 tgaattccaa cgaagcatac ctaggggtaa cagtgaacct acctgggttt gttttgtttt
     3541 ggtaaggatt tatgtagtgt ctggctgtaa gcaagaatga gtggattata aacttgaaga
     3601 tttctctgtt aaagtcacaa aaatgatcga caaacaatat ttttgtgatg tttatttaaa
     3661 cgttgtattt tataacatac ttcaaggaag agtatcgaag taagttgctt tataaattaa
     3721 gactaaattc gtatggatgc agaattcaat taataaaatt tgagcctgtt acgtaaattg
     3781 aatattaata aaattgaaaa tttctga
//
