LOCUS       NM_001008397            3731 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens glutathione peroxidase 8 (putative) (GPX8), transcript
            variant 1, mRNA.
ACCESSION   NM_001008397
VERSION     NM_001008397.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3731)
  AUTHORS   Tao,C.Y., Wu,X.L., Song,S.S., Tang,Z., Zhou,Y.F., Tian,M.X.,
            Jiang,X.F., Fang,Y., Zhu,G.Q., Huang,R., Qu,W.F., Gao,J., Chu,T.H.,
            Yang,R., Chen,J.F., Zhao,Q.F., Ding,Z.B., Dai,Z., Zhou,J.,
            Liu,W.R., Shi,Y.H. and Fan,J.
  TITLE     Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor
            stemness and migration
  JOURNAL   Cell Oncol (Dordr) 47 (4), 1391-1403 (2024)
   PUBMED   38607517
  REMARK    GeneRIF: Downregulation of GPX8 in hepatocellular carcinoma: impact
            on tumor stemness and migration.
REFERENCE   2  (bases 1 to 3731)
  AUTHORS   Bai,Y., Han,T., Dong,Y., Liang,C., Gao,L., Liu,Y., Zhou,J., Guo,J.,
            Ge,D., Wu,J. and Hu,D.
  TITLE     GPX8+ cancer-associated fibroblast, as a cancer-promoting factor in
            lung adenocarcinoma, is related to the immunosuppressive
            microenvironment
  JOURNAL   BMC Med Genomics 17 (1), 77 (2024)
   PUBMED   38515109
  REMARK    GeneRIF: GPX8[+] cancer-associated fibroblast, as a
            cancer-promoting factor in lung adenocarcinoma, is related to the
            immunosuppressive microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3731)
  AUTHORS   Chen,X., Yuan,L., Zhang,L., Chen,L., He,Y., Wang,C., Wu,J.,
            Chen,S., Zhao,W. and Yu,D.
  TITLE     GPX8 deficiency-induced oxidative stress reprogrammed m6A
            epitranscriptome of oral cancer cells
  JOURNAL   Epigenetics 18 (1), 2208707 (2023)
   PUBMED   37170591
  REMARK    GeneRIF: GPX8 deficiency-induced oxidative stress reprogrammed m6A
            epitranscriptome of oral cancer cells.
REFERENCE   4  (bases 1 to 3731)
  AUTHORS   Chen,Z., Zheng,D., Lin,Z., Zhang,C., Wei,C., Deng,X., Yan,P.,
            Zheng,C., Lan,C., Qin,C., Wei,X., Qin,D., Wu,Y., Peng,J., Miao,C.,
            Lu,L., Xia,Y. and Luo,Q.
  TITLE     GPX8 regulates pan-apoptosis in gliomas to promote microglial
            migration and mediate immunotherapy responses
  JOURNAL   Front Immunol 14, 1260169 (2023)
   PUBMED   37795080
  REMARK    GeneRIF: GPX8 regulates pan-apoptosis in gliomas to promote
            microglial migration and mediate immunotherapy responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3731)
  AUTHORS   Yang,Z.S., Yang,Q., Sun,X.X., Xiong,K., Zhu,X.T., Wang,Y.C.,
            Ren,Q.Y., Wu,G.H., Wang,S.M., Cao,X.Q., Yang,X.R. and Jiang,W.G.
  TITLE     GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target
            in Primary Glioma
  JOURNAL   J Immunol Res 2022, 8025055 (2022)
   PUBMED   36052280
  REMARK    GeneRIF: GPX8 as a Novel Prognostic Factor and Potential
            Therapeutic Target in Primary Glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3731)
  AUTHORS   Morikawa,K., Gouttenoire,J., Hernandez,C., Dao Thi,V.L., Tran,H.T.,
            Lange,C.M., Dill,M.T., Heim,M.H., Donze,O., Penin,F., Quadroni,M.
            and Moradpour,D.
  TITLE     Quantitative proteomics identifies the membrane-associated
            peroxidase GPx8 as a cellular substrate of the hepatitis C virus
            NS3-4A protease
  JOURNAL   Hepatology 59 (2), 423-433 (2014)
   PUBMED   23929719
  REMARK    GeneRIF: Quantitative proteomics identifies the membrane-associated
            peroxidase GPx8 as a cellular substrate of the hepatitis C virus
            NS3-4A protease.
REFERENCE   7  (bases 1 to 3731)
  AUTHORS   Nguyen,V.D., Saaranen,M.J., Karala,A.R., Lappi,A.K., Wang,L.,
            Raykhel,I.B., Alanen,H.I., Salo,K.E., Wang,C.C. and Ruddock,L.W.
  TITLE     Two endoplasmic reticulum PDI peroxidases increase the efficiency
            of the use of peroxide during disulfide bond formation
  JOURNAL   J Mol Biol 406 (3), 503-515 (2011)
   PUBMED   21215271
  REMARK    GeneRIF: GPx8 labeled as secreted glutathione peroxidase, is
            actually endoplasmic reticulum-resident protein disulfide isomerase
            peroxidase
REFERENCE   8  (bases 1 to 3731)
  AUTHORS   Toppo,S., Vanin,S., Bosello,V. and Tosatto,S.C.
  TITLE     Evolutionary and structural insights into the multifaceted
            glutathione peroxidase (Gpx) superfamily
  JOURNAL   Antioxid Redox Signal 10 (9), 1501-1514 (2008)
   PUBMED   18498225
REFERENCE   9  (bases 1 to 3731)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 3731)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074216.1, CN390753.1, BX537894.1, BX647770.1 and BM988796.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001008397.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029424.1, SRR5189667.32575.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503787.6/ ENSP00000423822.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               AK074216.1         57-622
            567-844             CN390753.1         407-684
            845-2353            BX537894.1         762-2270
            2354-3487           BX647770.1         2095-3228
            3488-3731           BM988796.1         23-266              c
FEATURES             Location/Qualifiers
     source          1..3731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..3731
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /note="glutathione peroxidase 8 (putative)"
                     /db_xref="GeneID:493869"
                     /db_xref="HGNC:HGNC:33100"
                     /db_xref="MIM:617172"
     exon            1..226
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..652
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /EC_number="1.11.1.9"
                     /note="isoform a is encoded by transcript variant 1;
                     probable glutathione peroxidase 8"
                     /codon_start=1
                     /product="probable glutathione peroxidase 8 isoform a"
                     /protein_id="NP_001008398.2"
                     /db_xref="CCDS:CCDS34156.1"
                     /db_xref="GeneID:493869"
                     /db_xref="HGNC:HGNC:33100"
                     /db_xref="MIM:617172"
                     /translation="MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKI
                     NSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFS
                     VLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKK
                     EPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL"
     exon            227..488
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3731
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3709..3714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /note="hexamer: AATAAA"
     polyA_site      3731
                     /gene="GPX8"
                     /gene_synonym="EPLA847; GPx-8; GSHPx-8; UNQ847"
                     /note="major polyA site"
ORIGIN      
        1 cttccctcta gaatcctcca acatggagcc tcttgcagct tacccgctaa aatgttccgg
       61 gcccagagca aaggtatttg cagttttgct gtctatagtt ctatgcacag taacgctatt
      121 tcttctacaa ctaaaattcc tcaaacctaa aatcaacagc ttttatgcct ttgaagtgaa
      181 ggatgcaaaa ggaagaactg tttctctgga aaagtataaa ggcaaagttt cactagttgt
      241 aaacgtggcc agtgactgcc aactcacaga cagaaattac ttagggctga aggaactgca
      301 caaagagttt ggaccatccc acttcagcgt gttggctttt ccctgcaatc agtttggaga
      361 atcggagccc cgcccaagca aggaagtaga atcttttgca agaaaaaact acggagtaac
      421 tttccccatc ttccacaaga ttaagattct aggatctgaa ggagaacctg catttagatt
      481 tcttgttgat tcttcaaaga aggaaccaag gtggaatttt tggaagtatc ttgtcaaccc
      541 tgagggtcaa gttgtgaagt tctggaagcc agaggagccc attgaagtca tcaggcctga
      601 catagcagct ctggttagac aagtgatcat aaaaaagaaa gaggatctat gagaatgcca
      661 ttgcgtttct aatagaacag agaaatgtct ccatgagggt ttggtctcat tttaaacatt
      721 ttttttttgg agacagtgtc tcactctgtc acccaggctg gagtgcagta gtgcgttctc
      781 agctcattgc aacctctgcc tttttaaaca tgctattaaa tgtggcaatg aaggattttt
      841 ttttaatgtt atcttgctat taagtggtaa tgaatgttcc caggatgagg atgttaccca
      901 aagcaaaaat caagagtagc caaagaatca acatgaaata tattaactac ttcctctgac
      961 catactaaag aattcagaat acacagtgac caatgtgcct caatatctta ttgttcaact
     1021 tgacattttc taggactgta cttgatgaaa atgccaacac actagaccac tctttggatt
     1081 caagagcact gtgtatgact gaaatttctg gaataactgt aaatggttat gttaatggaa
     1141 taaaacacaa atgttgaaaa atgtaaaata tatatacata gattcaaatc cttatatatg
     1201 tatgcttgtt ttgtgtacag gattttgttt tttcttttta agtacaggtt cctagtgttt
     1261 tactataact gtcactatgt atgtaactga catatataaa tagtcattta taaatgaccg
     1321 tattataaca tttgaaaaag tcttcatcat tttcagtatt tctctctgca ttatttttta
     1381 gaagcaactc aaattctgta atcataatat taccaagtaa gtcagtcttt atttttgcgt
     1441 gaaaatccca agtgtagaaa aaaggacatg agtataagat catttaactt gattccttat
     1501 aggctgattt gggttgctaa tgtattcgta ctagattagc cacttgggag gaattcaatg
     1561 ctgcatcatt ctgatagctg aaatagtaaa agtcaactcc aaacagccta aattctagta
     1621 taaaaagggg gtgatcatac aagtcctaaa gtgtagatca gcagtcactg aacctcttag
     1681 agtcacaagg catttcttct cccaaagtca tgacctttat attttgttag ccttataatt
     1741 gactaacaaa gcaacctgcc aagttggtga aggttaatta ttgcctcatg aaatatacat
     1801 tcatcgcata aaagaattaa ataggaagat ggccaaaaat gtaaaaaagt cgtataaatt
     1861 tgtctaagaa gaaaaagacc caatttaagt agtctgtgac ttgactccca aattctgacc
     1921 tgatggatga aagtgaagat gtttcgtatg gcaaattcag taatgctacc tcagtatata
     1981 gttctgtata cgtatttgga ccaaagttat tagataaacc aaaaatattt catgaagcat
     2041 cttctgcttc agagtccata tccagccacc cagctatgaa tgtatttaga aagatatttg
     2101 gtggaggtgg aatttctacc agaggtcaag aggatttgta gggatagcct caagaatgcc
     2161 agatgagtgt gtcagaaagc ctgctcctac ctctcgccag ctgcgtgact ttaggcaagt
     2221 cacttaagta ccttatttca gtttcctcac ctgtaaattg aacaggggtt gaatggaata
     2281 aaaagccctt tgcaactcta aaagtcaatt aacacactta ctaaggtgtt ttaagtgacc
     2341 aggaaggaaa tcagaactaa cctggattgt tagcgaagaa aacagaagcc accaacaagc
     2401 ctatctgtcc tttgcaattt tgctccaaga gcctattagc aatttgaatt ctgagcctct
     2461 aagaaaactt atgctcaggt ggcccctcca agtgttggtg ccagagcact cttgccttgt
     2521 atcctcacct acgccttcca tgaactcata gcagtgctgt ggcactgcag gggtgtttta
     2581 tgcattcacg ttaggagcat gagcagaact gcatatgcca gcaccacatg ggcagcagag
     2641 actccccact gccagatgga tgataatgga gctgcactgg gaacaaccag gactgtccca
     2701 gtcaacatga tacagatgaa catcctgcct taagtcacta gctctctcca aagccagata
     2761 aagtgggttt cttcacttac atctctctaa tcttggctgc cttattcaac ctacagactc
     2821 tatgtcagtg ctggattttc tccccttgcc ctttaggtaa gcagagtagg caggaggaga
     2881 tttgaaagcg tgtcatacat attgccttga aagaaaggac attcaggtgt cccttcgggg
     2941 ttctgtaaca attaggctat gtgtgctgag agagggagcg gagtcatttg ctgatgtgct
     3001 gctacctgta actcaaatgc ctcataggaa taccagcgga caaacacata gaggaaaagt
     3061 tgaatctttc ctatattgga caatcttcct tcagtcttgt ttctgcatca aaaagtctgg
     3121 gacacagagt gctacaggat gcctgggcta aggactgtaa cagaaaaata tcaacatcag
     3181 agcctggcac agtggctcac accggtaatc ccagcacttt gggaggccga ggcgggtgga
     3241 tcacttcagg tcaggagttc gagaccatcc tggccaacat ggtgaaaccc ccatctctac
     3301 taaaaataca aaaattagcc gggcacggtg gcacatgcct gtaatcccag ctacctggga
     3361 ggctgagtca gaagaatcac ttgaaaacag gaggctgagg ttgcaatgag ccaagattgc
     3421 accactgcac tccaacctgg gcaacagagc gagaccccat cttaaagacc ctgtctcaaa
     3481 aaagagagaa aaagaaaaag aaaaatatca ggcatcacat gaaagagtat tcagctgtcg
     3541 ttcttgtgaa aaaggaaaag gacaaaatca aatgcatttt aactgtggta actaattcac
     3601 tgacttgaag tttgctttgt ttgttttctt tggtgcgtag agaagaatac ttcatactaa
     3661 ctcctgatca tcttacagca gacataacaa cagagtgtta gagactggaa taaatatgaa
     3721 tttggctgaa a
//
