LOCUS       NM_015696               1229 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.
ACCESSION   NM_015696
VERSION     NM_015696.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Chen,B., Fu,W., Jie,C., Zhang,G., Li,Z., Liu,Y. and Zhou,S.
  TITLE     GPX7 reduces chondrocyte inflammation and extracellular matrix
            degradation triggered by IL-1beta, via a mechanism mediated by
            ferroptosis
  JOURNAL   Mol Med Rep 30 (1) (2024)
   PUBMED   38757339
  REMARK    GeneRIF: GPX7 reduces chondrocyte inflammation and extracellular
            matrix degradation triggered by IL-1beta, via a mechanism mediated
            by ferroptosis.
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Ferreira,W.A.S., Vitiello,G.A.F., da Silva Medina,T. and de
            Oliveira,E.H.C.
  TITLE     Comprehensive analysis of epigenetics regulation, prognostic and
            the correlation with immune infiltrates of GPX7 in adult gliomas
  JOURNAL   Sci Rep 12 (1), 6442 (2022)
   PUBMED   35440701
  REMARK    GeneRIF: Comprehensive analysis of epigenetics regulation,
            prognostic and the correlation with immune infiltrates of GPX7 in
            adult gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Hu,X., Li,B., Wu,F., Liu,X., Liu,M., Wang,C., Shi,Y. and Ye,L.
  TITLE     GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR
            Pathway
  JOURNAL   J Cell Mol Med 25 (22), 10454-10465 (2021)
   PUBMED   34626080
  REMARK    GeneRIF: GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress
            and mTOR Pathway.
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Hanouskova,B., Vavrova,G., Ambroz,M., Bousova,I., Karlsen,T.A.,
            Skalova,L. and Matouskova,P.
  TITLE     MicroRNAs mediated regulation of glutathione peroxidase 7
            expression and its changes during adipogenesis
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (10), 194734 (2021)
   PUBMED   34339889
  REMARK    GeneRIF: MicroRNAs mediated regulation of glutathione peroxidase 7
            expression and its changes during adipogenesis.
REFERENCE   5  (bases 1 to 1229)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1229)
  AUTHORS   Moyer,A.M., Sun,Z., Batzler,A.J., Li,L., Schaid,D.J., Yang,P. and
            Weinshilboum,R.M.
  TITLE     Glutathione pathway genetic polymorphisms and lung cancer survival
            after platinum-based chemotherapy
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (3), 811-821 (2010)
   PUBMED   20200426
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1229)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1229)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 1229)
  AUTHORS   Utomo,A., Jiang,X., Furuta,S., Yun,J., Levin,D.S., Wang,Y.C.,
            Desai,K.V., Green,J.E., Chen,P.L. and Lee,W.H.
  TITLE     Identification of a novel putative non-selenocysteine containing
            phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential
            for alleviating oxidative stress generated from polyunsaturated
            fatty acids in breast cancer cells
  JOURNAL   J Biol Chem 279 (42), 43522-43529 (2004)
   PUBMED   15294905
  REMARK    GeneRIF: NPGPx plays an essential role in breast cancer cells in
            alleviating oxidative stress generated from polyunsaturated fatty
            acid metabolism
REFERENCE   10 (bases 1 to 1229)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI550170.1, AK027683.1 and BU627166.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015696.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358402.1, AK027683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361314.5/ ENSP00000354677.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               BI550170.1         6-280
            276-1228            AK027683.1         276-1228
            1229-1229           BU627166.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1229
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /note="glutathione peroxidase 7"
                     /db_xref="GeneID:2882"
                     /db_xref="HGNC:HGNC:4559"
                     /db_xref="MIM:615784"
     exon            1..177
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..603
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /EC_number="1.11.1.9"
                     /note="glutathione peroxidase 6; non-selenocysteine
                     containing phospholipid hydroperoxide glutathione
                     peroxidase"
                     /codon_start=1
                     /product="glutathione peroxidase 7 precursor"
                     /protein_id="NP_056511.2"
                     /db_xref="CCDS:CCDS569.1"
                     /db_xref="GeneID:2882"
                     /db_xref="HGNC:HGNC:4559"
                     /db_xref="MIM:615784"
                     /translation="MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYR
                     GSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIES
                     FARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWD
                     PTVSVEEVRPQITALVRKLILLKREDL"
     exon            178..439
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /inference="alignment:Splign:2.1.0"
     exon            440..1229
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /note="hexamer: AATAAA"
     polyA_site      1082
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /note="major polyA site"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /note="hexamer: AATAAA"
     polyA_site      1229
                     /gene="GPX7"
                     /gene_synonym="CL683; GPx-7; GPX6; GSHPx-7; NPGPx"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgccc tcgcgacgcc gccacctccg gaacaagcca tggtggcggc gacggtggca
       61 gcggcgtggc tgctcctgtg ggctgcggcc tgcgcgcagc aggagcagga cttctacgac
      121 ttcaaggcgg tcaacatccg gggcaaactg gtgtcgctgg agaagtaccg cggatcggtg
      181 tccctggtgg tgaatgtggc cagcgagtgc ggcttcacag accagcacta ccgagccctg
      241 cagcagctgc agcgagacct gggcccccac cactttaacg tgctcgcctt cccctgcaac
      301 cagtttggcc aacaggagcc tgacagcaac aaggagattg agagctttgc ccgccgcacc
      361 tacagtgtct cattccccat gtttagcaag attgcagtca ccggtactgg tgcccatcct
      421 gccttcaagt acctggccca gacttctggg aaggagccca cctggaactt ctggaagtac
      481 ctagtagccc cagatggaaa ggtggtaggg gcttgggacc caactgtgtc agtggaggag
      541 gtcagacccc agatcacagc gctcgtgagg aagctcatcc tactgaagcg agaagactta
      601 taaccaccgc gtctcctcct ccaccacctc atcccgccca cctgtgtggg gctgaccaat
      661 gcaaactcaa atggtgcttc aaagggagag acccactgac tctccttcct ttactcttat
      721 gccattggtc ccatcattct tgtgggggaa aaattctagt attttgatta tttgaatctt
      781 acagcaacaa ataggaactc ctggccaatg agagctcttg accagtgaat caccagccga
      841 tacgaacgtc ttgccaacaa aaatgtgtgg caaatagaag tatatcaagc aataatctcc
      901 cacccaaggc ttctgtaaac tgggaccaat gattacctca tagggctgtt gtgaggatta
      961 ggatgaaata cctgtgaaag tgcctaggca gtgccagcca aataggaggc attcaatgaa
     1021 cattttttgc atataaacca aaaaataact tgttatcaat aaaaacttgc atccaacatg
     1081 aatttccagc cgatgataat ccaggccaaa ggtttagttg ttgttatttc ctctgtatta
     1141 ttttcttcat tacaaaagaa atgcaagttc attgtaacaa tccaaacaat acctcacgat
     1201 ataaaataaa aatgaaagta tcctcctca
//
