LOCUS       NM_001509               1587 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens glutathione peroxidase 5 (GPX5), transcript variant 1,
            mRNA.
ACCESSION   NM_001509
VERSION     NM_001509.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Moyer,A.M., Sun,Z., Batzler,A.J., Li,L., Schaid,D.J., Yang,P. and
            Weinshilboum,R.M.
  TITLE     Glutathione pathway genetic polymorphisms and lung cancer survival
            after platinum-based chemotherapy
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (3), 811-821 (2010)
   PUBMED   20200426
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1587)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1587)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 1587)
  AUTHORS   Rejraji,H., Vernet,P. and Drevet,J.R.
  TITLE     GPX5 is present in the mouse caput and cauda epididymidis lumen at
            three different locations
  JOURNAL   Mol Reprod Dev 63 (1), 96-103 (2002)
   PUBMED   12211066
REFERENCE   6  (bases 1 to 1587)
  AUTHORS   Williams,K., Frayne,J. and Hall,L.
  TITLE     Expression of extracellular glutathione peroxidase type 5 (GPX5) in
            the rat male reproductive tract
  JOURNAL   Mol Hum Reprod 4 (9), 841-848 (1998)
   PUBMED   9783843
REFERENCE   7  (bases 1 to 1587)
  AUTHORS   Hall,L., Williams,K., Perry,A.C., Frayne,J. and Jury,J.A.
  TITLE     The majority of human glutathione peroxidase type 5 (GPX5)
            transcripts are incorrectly spliced: implications for the role of
            GPX5 in the male reproductive tract
  JOURNAL   Biochem J 333 (Pt 1) (Pt 1), 5-9 (1998)
   PUBMED   9639555
REFERENCE   8  (bases 1 to 1587)
  AUTHORS   Opalenik,S.R., Ding,Q., Mallery,S.R. and Thompson,J.A.
  TITLE     Glutathione depletion associated with the HIV-1 TAT protein
            mediates the extracellular appearance of acidic fibroblast growth
            factor
  JOURNAL   Arch Biochem Biophys 351 (1), 17-26 (1998)
   PUBMED   9501919
REFERENCE   9  (bases 1 to 1587)
  AUTHORS   Vernet,P., Faure,J., Dufaure,J.P. and Drevet,J.R.
  TITLE     Tissue and developmental distribution, dependence upon testicular
            factors and attachment to spermatozoa of GPX5, a murine
            epididymis-specific glutathione peroxidase
  JOURNAL   Mol Reprod Dev 47 (1), 87-98 (1997)
   PUBMED   9110319
REFERENCE   10 (bases 1 to 1587)
  AUTHORS   Perry,A.C., Jones,R., Niang,L.S., Jackson,R.M. and Hall,L.
  TITLE     Genetic evidence for an androgen-regulated epididymal secretory
            glutathione peroxidase whose transcript does not contain a
            selenocysteine codon
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 863-870 (1992)
   PUBMED   1386734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049543.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 1, 2019 this sequence version replaced NM_001509.2.
            
            Summary: This gene belongs to the glutathione peroxidase family. It
            is specifically expressed in the epididymis in the mammalian male
            reproductive tract, and is androgen-regulated. Unlike several other
            characterized glutathione peroxidases, this enzyme is not a
            selenoprotein, lacking the selenocysteine residue. Thus, it is
            selenium-independent, and has been proposed to play a role in
            protecting the membranes of spermatozoa from the damaging effects
            of lipid peroxidation and/or preventing premature acrosome
            reaction. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ460514.1, AJ005277.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412168.7/ ENSP00000392398.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AL049543.17        79514-79733         c
            221-374             AL049543.17        76010-76163         c
            375-492             AL049543.17        73719-73836         c
            493-592             AL049543.17        73194-73293         c
            593-1587            AL049543.17        70659-71653         c
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1587
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /note="glutathione peroxidase 5"
                     /db_xref="GeneID:2880"
                     /db_xref="HGNC:HGNC:4557"
                     /db_xref="MIM:603435"
     exon            1..220
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..799
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /EC_number="1.11.1.9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epididymal androgen-related protein; epididymal
                     secretory glutathione peroxidase; epididymis-specific
                     glutathione peroxidase-like protein; epididymis secretory
                     sperm binding protein Li 75p"
                     /codon_start=1
                     /product="epididymal secretory glutathione peroxidase
                     isoform 1 precursor"
                     /protein_id="NP_001500.1"
                     /db_xref="CCDS:CCDS4652.1"
                     /db_xref="GeneID:2880"
                     /db_xref="HGNC:HGNC:4557"
                     /db_xref="MIM:603435"
                     /translation="MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYE
                     AIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCN
                     QFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPS
                     EILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQF
                     KTK"
     exon            221..374
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /inference="alignment:Splign:2.1.0"
     exon            375..492
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /inference="alignment:Splign:2.1.0"
     exon            493..592
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1587
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /note="hexamer: AATAAA"
     polyA_site      1587
                     /gene="GPX5"
                     /gene_synonym="EGLP; GPx-5; GSHPx-5; HEL-S-75p"
                     /note="major polyA site"
ORIGIN      
        1 atgcgtcggg aatccttgca gccctgtgac tggcctgtgg gggcttgggc taagtccctg
       61 ccaagatacc aaaagactgc agaggtgggc aaagacctca ggcccccaga ctagcaatct
      121 acaaacacta gtcatgacta cacagttaag ggtcgtccat ctgcttcccc ttctcctagc
      181 ctgctttgtg caaacaagtc ccaagcagga gaagatgaag atggattgcc acaaagacga
      241 gaaaggcacc atctatgact atgaggccat cgcacttaat aagaatgaat atgtttcctt
      301 caagcagtat gtgggcaagc acatcctctt cgtcaacgtg gccacctact gtggtctgac
      361 agcgcaatat cctgaactaa atgcactcca ggaggagctg aagccctatg gtctagttgt
      421 gttgggcttt ccctgcaacc aatttggaaa gcaagaacca ggagataaca aagagattct
      481 tcctgggctc aagtatgtcc gtccaggggg aggatttgta cctagtttcc agctttttga
      541 gaaaggggat gtgaatggtg aaaaagaaca gaaagtcttc agtttcttga agcactcctg
      601 tcctcatccc tctgagattt tgggcacatt caaatctata tcctgggacc ctgtaaaggt
      661 ccatgacatc cgttggaact ttgaaaagtt cctggtgggg cctgatggaa tccctgtcat
      721 gcgctggtcc caccgggcta cggtcagctc agtcaagaca gacatcctgg cgtacttgaa
      781 gcaattcaaa accaaatagg aaggtggagt taagggcagg agcaacccta cttctcacct
      841 aatgacttgc tctccccacc cctccaaaaa aaaggaatac ccatcttctc accacactct
      901 cttcctgcat gggctccacc tgagtaaatc accgccacat actgccagaa ttcccactct
      961 ccacaaacta gatttatatt tggaaggcta ctgctctttt gcctctcaag agtatgtggg
     1021 tgaagactga aacaaatgga aacctaaaat ccccagacct ctgttacagg ttgaatcatt
     1081 catatccacc agagggaaat catccttcca cgacaatggt tcagtcggcc atcacatcct
     1141 gaagaacatt cctagacatt ctgactcttc catctctctc taccctggag gtgtagaaat
     1201 agcaatgggg tcacagtcac acaatttagg ttccacttca taacattttt tgtctcctag
     1261 gacaaacgtg tatcatcagt ttccaactgt tttggctcag ttttcatcca tgacacctcc
     1321 ccctaccagc cattctcctg tgggagcaag aacattgctt caaaagaaga gagggcatct
     1381 ccatgcttgt gggacccaaa acctatctct ggccctacaa aagttttcct aattgtctga
     1441 tctttagtgc attcaggtta tggcacctgg agaggaatgc cctttatctt ttgaaggatg
     1501 ggatttccca tctcaaccct ggattcctca ccttcagaac gagccctgcc actgtctcca
     1561 ataaaatgtt ttctgcagca tcgacaa
//
