LOCUS       NM_002084               1603 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens glutathione peroxidase 3 (GPX3), transcript variant 1,
            mRNA.
ACCESSION   NM_002084
VERSION     NM_002084.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Bramble,M.S., Fourcassie,V., Vashist,N., Roux-Dalvai,F., Zhou,Y.,
            Bumoko,G., Kasendue,M.L., Spencer,D., Musasa Hanshi-Hatuhu,H.,
            Kambale-Mastaki,V., Manalo,R.V.M., Mohammed,A., McIlwain,D.R.,
            Cunningham,G., Summar,M., Boivin,M.J., Caldovic,L., Vilain,E.,
            Mumba-Ngoyi,D., Tshala-Katumbay,D. and Droit,A.
  TITLE     Glutathione peroxidase 3 is a potential biomarker for konzo
  JOURNAL   Nat Commun 15 (1), 7811 (2024)
   PUBMED   39242582
  REMARK    GeneRIF: Glutathione peroxidase 3 is a potential biomarker for
            konzo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Zhang,N., Liao,H., Lin,Z. and Tang,Q.
  TITLE     Insights into the Role of Glutathione Peroxidase 3 in
            Non-Neoplastic Diseases
  JOURNAL   Biomolecules 14 (6), 689 (2024)
   PUBMED   38927092
  REMARK    GeneRIF: Insights into the Role of Glutathione Peroxidase 3 in
            Non-Neoplastic Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Liao,L., Tao,P., Xu,Q., Chen,W., Chen,J., Liu,W., Liu,W., Hu,J. and
            Lu,J.
  TITLE     TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis
            in Renal Tubular Epithelial Cells via Ubiquitination and
            Degradation of GPX3 Protein
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 58 (2024)
   PUBMED   38420829
  REMARK    GeneRIF: TRIM6 Promotes ROS-Mediated Inflammasome Activation and
            Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and
            Degradation of GPX3 Protein.
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Zhang,Y., Yang,Y., Kuang,S., Zhang,Y., Qin,H. and Xie,J.
  TITLE     GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels
            in Stomach Adenocarcinoma via the AMPK/mTOR Pathway
  JOURNAL   Int J Clin Pract 2024, 6875417 (2024)
   PUBMED   38322113
  REMARK    GeneRIF: GPX3-Mediated Oxidative Stress Affects Pyrimidine
            Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR
            Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Bierl,C., Voetsch,B., Jin,R.C., Handy,D.E. and Loscalzo,J.
  TITLE     Determinants of human plasma glutathione peroxidase (GPx-3)
            expression
  JOURNAL   J Biol Chem 279 (26), 26839-26845 (2004)
   PUBMED   15096516
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Yoshimura,S., Suemizu,H., Taniguchi,Y., Arimori,K., Kawabe,N. and
            Moriuchi,T.
  TITLE     The human plasma glutathione peroxidase-encoding gene:
            organization, sequence and localization to chromosome 5q32
  JOURNAL   Gene 145 (2), 293-297 (1994)
   PUBMED   8056346
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Chu,F.F., Esworthy,R.S., Doroshow,J.H., Doan,K. and Liu,X.F.
  TITLE     Expression of plasma glutathione peroxidase in human liver in
            addition to kidney, heart, lung, and breast in humans and rodents
  JOURNAL   Blood 79 (12), 3233-3238 (1992)
   PUBMED   1339300
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Esworthy,R.S., Chu,F.F., Paxton,R.J., Akman,S. and Doroshow,J.H.
  TITLE     Characterization and partial amino acid sequence of human plasma
            glutathione peroxidase
  JOURNAL   Arch Biochem Biophys 286 (2), 330-336 (1991)
   PUBMED   1897960
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Takahashi,K., Akasaka,M., Yamamoto,Y., Kobayashi,C., Mizoguchi,J.
            and Koyama,J.
  TITLE     Primary structure of human plasma glutathione peroxidase deduced
            from cDNA sequences
  JOURNAL   J Biochem 108 (2), 145-148 (1990)
   PUBMED   2229017
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Avissar,N., Whitin,J.C., Allen,P.Z., Palmer,I.S. and Cohen,H.J.
  TITLE     Antihuman plasma glutathione peroxidase antibodies: immunologic
            investigations to determine plasma glutathione peroxidase protein
            and selenium content in plasma
  JOURNAL   Blood 73 (1), 318-323 (1989)
   PUBMED   2491950
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI522602.1 and BC050378.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002084.4.
            
            Summary: The protein encoded by this gene belongs to the
            glutathione peroxidase family, members of which catalyze the
            reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by
            glutathione, and thereby protect cells against oxidative damage.
            Several isozymes of this gene family exist in vertebrates, which
            vary in cellular location and substrate specificity. This isozyme
            is secreted, and is abundantly found in plasma. Downregulation of
            expression of this gene by promoter hypermethylation has been
            observed in a wide spectrum of human malignancies, including
            thyroid cancer, hepatocellular carcinoma and chronic myeloid
            leukemia. This isozyme is also a selenoprotein, containing the rare
            amino acid selenocysteine (Sec) at its active site. Sec is encoded
            by the UGA codon, which normally signals translation termination.
            The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop
            structure, designated the Sec insertion sequence (SECIS) element,
            that is necessary for the recognition of UGA as a Sec codon, rather
            than as a stop signal. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.184378.1,
                                           SRR1660803.82772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000388825.9/
                                               ENSP00000373477.4
            protein contains selenocysteine :: PMID: 2229017
            RefSeq Select criteria          :: based on conservation,
                                               expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BI522602.1         180-191
            13-1603             BC050378.1         1-1591
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..1603
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /note="glutathione peroxidase 3"
                     /db_xref="GeneID:2878"
                     /db_xref="HGNC:HGNC:4555"
                     /db_xref="MIM:138321"
     exon            1..151
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..745
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /EC_number="1.11.1.9"
                     /note="UGA stop codon recoded as selenocysteine; isoform 1
                     precursor is encoded by transcript variant 1;
                     extracellular glutathione peroxidase; glutathione
                     peroxidase 3 (plasma); GPx-3; plasma glutathione
                     peroxidase; selenoprotein GPX3"
                     /codon_start=1
                     /transl_except=(pos:281..283,aa:Sec)
                     /product="glutathione peroxidase 3 isoform 1 precursor"
                     /protein_id="NP_002075.2"
                     /db_xref="CCDS:CCDS43389.1"
                     /db_xref="GeneID:2878"
                     /db_xref="HGNC:HGNC:4555"
                     /db_xref="MIM:138321"
                     /translation="MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYG
                     ALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCN
                     QFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTS
                     ELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQ
                     AALGVKRK"
     exon            152..305
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            306..423
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            424..523
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1603
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1126
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
     regulatory      1395..1471
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /note="hexamer: AGTAAA"
     polyA_site      1603
                     /gene="GPX3"
                     /gene_synonym="GPx-P; GSHPx-3; GSHPx-P"
                     /note="major polyA site"
ORIGIN      
        1 agacggacgg tggccaggga tcaggcagcg gctcaggcga ccctgagtgt gcccccaccc
       61 cgccatggcc cggctgctgc aggcgtcctg cctgctttcc ctgctcctgg ccggcttcgt
      121 ctcgcagagc cggggacaag agaagtcgaa gatggactgc catggtggca taagtggcac
      181 catttacgag tacggagccc tcaccattga tggggaggag tacatcccct tcaagcagta
      241 tgctggcaaa tacgtcctct ttgtcaacgt ggccagctac tgaggcctga cgggccagta
      301 cattgaactg aatgcactac aggaagagct tgcaccattc ggtctggtca ttctgggctt
      361 tccctgcaac caatttggaa aacaggaacc aggagagaac tcagagatcc ttcctaccct
      421 caagtatgtc cgaccaggtg gaggctttgt ccctaatttc cagctctttg agaaagggga
      481 tgtcaatgga gagaaagagc agaaattcta cactttccta aagaactcct gtcctcccac
      541 ctcggagctc ctgggtacat ctgaccgcct cttctgggaa cccatgaagg ttcacgacat
      601 ccgctggaac tttgagaagt tcctggtggg gccagatggt atacccatca tgcgctggca
      661 ccaccggacc acggtcagca acgtcaagat ggacatcctg tcctacatga ggcggcaggc
      721 agccctgggg gtcaagagga agtaactgaa ggccgtctca tcccatgtcc accatgtagg
      781 ggagggactt tgttcaggaa gaaatccgtg tctccaacca cactatctac ccatcacaga
      841 cccctttcct atcactcaag gccccagcct ggcacaaatg gatgcataca gttctgtgta
      901 ctgccaggca tgtgggtgtg ggtgcatgtg ggtgtttaca cacatgccta caggtatgcg
      961 tgattgtgtg tgtgtgcatg ggtgtacagc cacgtgtcta cctatgtgtc tttctgggaa
     1021 tgtgtaccat ctgtgtgcct gcagctgtgt agtgctggac agtgacaacc ctttctctcc
     1081 agttctccac tccaatgata atagttcact tacacctaaa cccaaaggaa aaaccagctc
     1141 taggtccaat tgttctgctc taactgatac ctcaaccttg gggccagcat ctcccactgc
     1201 ctccaaatat tagtaactat gactgacgtc cccagaagtt tctgggtcta ccacactccc
     1261 caacccccca ctcctacttc ctgaagggcc ctcccaaggc tacatcccca ccccacagtt
     1321 ctccctgaga gagatcaacc tccctgagat caaccaaggc agatgtgaca gcaagggcca
     1381 cggaccccat ggcaggggtg gcgtcttcat gagggagggg cccaaagccc ttgtgggcgg
     1441 acctcccctg agcctgtctg aggggccagc ccttagtgca ttcaggctaa ggcccctggg
     1501 cagggatgcc acccctgctc cttcggagga cgtgccctca cccctcactg gtccactggc
     1561 ttgagactca ccccgtctgc ccagtaaaag cctttctgca gca
//
