LOCUS       NM_002083                922 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1,
            mRNA.
ACCESSION   NM_002083
VERSION     NM_002083.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Nie,Q., Cao,H., Yang,J., Liu,T. and Wang,B.
  TITLE     Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in
            head and neck tumors by interacting with the ENO1 protein and
            promoting GPX2 transcription
  JOURNAL   PeerJ 11, e16140 (2023)
   PUBMED   37810778
  REMARK    GeneRIF: Long non-coding RNA NMRAL2P promotes glycolysis and
            reduces ROS in head and neck tumors by interacting with the ENO1
            protein and promoting GPX2 transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 922)
  AUTHORS   Lu,X., Liu,R., Liao,Y., Cui,L., Sun,H., Zhang,D., Wang,B., Fang,L.,
            Guan,X., Yao,Y., Liu,C. and Zhang,Y.
  TITLE     ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors
            in colorectal cancer by promoting USP15-mediated GPX2 stabilization
  JOURNAL   BMC Med 21 (1), 366 (2023)
   PUBMED   37743483
  REMARK    GeneRIF: ACVRL1 drives resistance to multitarget tyrosine kinase
            inhibitors in colorectal cancer by promoting USP15-mediated GPX2
            stabilization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 922)
  AUTHORS   Xu,H., Hu,C., Wang,Y., Shi,Y., Yuan,L., Xu,J., Zhang,Y., Chen,J.,
            Wei,Q., Qin,J., Xu,Z. and Cheng,X.
  TITLE     Glutathione peroxidase 2 knockdown suppresses gastric cancer
            progression and metastasis via regulation of kynurenine metabolism
  JOURNAL   Oncogene 42 (24), 1994-2006 (2023)
   PUBMED   37138031
  REMARK    GeneRIF: Glutathione peroxidase 2 knockdown suppresses gastric
            cancer progression and metastasis via regulation of kynurenine
            metabolism.
REFERENCE   4  (bases 1 to 922)
  AUTHORS   Cui,Z., Xu,L., Wu,H., Wang,M., Lu,L. and Wu,S.
  TITLE     Glutathione peroxidase 2: A key factor in the development of
            microsatellite instability in colon cancer
  JOURNAL   Pathol Res Pract 243, 154372 (2023)
   PUBMED   36796200
  REMARK    GeneRIF: Glutathione peroxidase 2: A key factor in the development
            of microsatellite instability in colon cancer.
REFERENCE   5  (bases 1 to 922)
  AUTHORS   Choi,J., Liu,R.M., Kundu,R.K., Sangiorgi,F., Wu,W., Maxson,R. and
            Forman,H.J.
  TITLE     Molecular mechanism of decreased glutathione content in human
            immunodeficiency virus type 1 Tat-transgenic mice
  JOURNAL   J Biol Chem 275 (5), 3693-3698 (2000)
   PUBMED   10652368
REFERENCE   6  (bases 1 to 922)
  AUTHORS   Opalenik,S.R., Ding,Q., Mallery,S.R. and Thompson,J.A.
  TITLE     Glutathione depletion associated with the HIV-1 TAT protein
            mediates the extracellular appearance of acidic fibroblast growth
            factor
  JOURNAL   Arch Biochem Biophys 351 (1), 17-26 (1998)
   PUBMED   9501919
REFERENCE   7  (bases 1 to 922)
  AUTHORS   Chu,F.F., Rohan de Silva,H.A., Esworthy,R.S., Boteva,K.K.,
            Walters,C.E., Roses,A., Rao,P.N. and Pettenati,M.J.
  TITLE     Polymorphism and chromosomal localization of the GI-form of human
            glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization
  JOURNAL   Genomics 32 (2), 272-276 (1996)
   PUBMED   8833155
REFERENCE   8  (bases 1 to 922)
  AUTHORS   Chu,F.F.
  TITLE     The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to
            chromosomes 14, 5, and 19, respectively
  JOURNAL   Cytogenet Cell Genet 66 (2), 96-98 (1994)
   PUBMED   8287691
REFERENCE   9  (bases 1 to 922)
  AUTHORS   Chu,F.F., Doroshow,J.H. and Esworthy,R.S.
  TITLE     Expression, characterization, and tissue distribution of a new
            cellular selenium-dependent glutathione peroxidase, GSHPx-GI
  JOURNAL   J Biol Chem 268 (4), 2571-2576 (1993)
   PUBMED   8428933
REFERENCE   10 (bases 1 to 922)
  AUTHORS   Akasaka,M., Mizoguchi,J. and Takahashi,K.
  TITLE     A human cDNA sequence of a novel glutathione peroxidase-related
            protein
  JOURNAL   Nucleic Acids Res 18 (15), 4619 (1990)
   PUBMED   2388849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG429974.1 and BC022820.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002083.3.
            
            Summary: The protein encoded by this gene belongs to the
            glutathione peroxidase family, members of which catalyze the
            reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by
            glutathione, and thereby protect cells against oxidative damage.
            Several isozymes of this gene family exist in vertebrates, which
            vary in cellular location and substrate specificity. This isozyme
            is predominantly expressed in the gastrointestinal tract (also in
            liver in human), is localized in the cytoplasm, and whose preferred
            substrate is hydrogen peroxide. Overexpression of this gene is
            associated with increased differentiation and proliferation in
            colorectal cancer. This isozyme is also a selenoprotein, containing
            the rare amino acid selenocysteine (Sec) at its active site. Sec is
            encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon, rather than as a stop signal. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005277.1, X53463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000389614.6/
                                               ENSP00000374265.5
            protein contains selenocysteine :: PMID: 2388849
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BG429974.1         162-178
            18-922              BC022820.1         1-905
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..922
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /note="glutathione peroxidase 2"
                     /db_xref="GeneID:2877"
                     /db_xref="HGNC:HGNC:4554"
                     /db_xref="MIM:138319"
     exon            1..241
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..592
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /EC_number="1.11.1.9"
                     /EC_number="1.11.1.12"
                     /note="UGA stop codon recoded as selenocysteine;
                     glutathione peroxidase-related protein 2; glutathione
                     peroxidase 2 (gastrointestinal); selenoprotein GPX2;
                     gastrointestinal glutathione peroxidase; phospholipid
                     hydroperoxide glutathione peroxidase GPX2"
                     /codon_start=1
                     /transl_except=(pos:137..139,aa:Sec)
                     /product="glutathione peroxidase 2"
                     /protein_id="NP_002074.2"
                     /db_xref="CCDS:CCDS41964.1"
                     /db_xref="GeneID:2877"
                     /db_xref="HGNC:HGNC:4554"
                     /db_xref="MIM:138319"
                     /translation="MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTT
                     RDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLV
                     QKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIG
                     PEGEPFRRYSRTFPTINIEPDIKRLLKVAI"
     exon            242..922
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      811..875
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="GPX2"
                     /gene_synonym="GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI;
                     GSHPx-2; GSHPX-GI"
                     /note="major polyA site"
ORIGIN      
        1 gctcactctg cgcttcacca tggctttcat tgccaagtcc ttctatgacc tcagtgccat
       61 cagcctggat ggggagaagg tagatttcaa tacgttccgg ggcagggccg tgctgattga
      121 gaatgtggct tcgctctgag gcacaaccac ccgggacttc acccagctca acgagctgca
      181 atgccgcttt cccaggcgcc tggtggtcct tggcttccct tgcaaccaat ttggacatca
      241 ggagaactgt cagaatgagg agatcctgaa cagtctcaag tatgtccgtc ctgggggtgg
      301 ataccagccc accttcaccc ttgtccaaaa atgtgaggtg aatgggcaga acgagcatcc
      361 tgtcttcgcc tacctgaagg acaagctccc ctacccttat gatgacccat tttccctcat
      421 gaccgatccc aagctcatca tttggagccc tgtgcgccgc tcagatgtgg cctggaactt
      481 tgagaagttc ctcatagggc cggagggaga gcccttccga cgctacagcc gcaccttccc
      541 aaccatcaac attgagcctg acatcaagcg cctccttaaa gttgccatat agatgtgaac
      601 tgctcaacac acagatctcc tactccatcc agtcctgagg agccttagga tgcagcatgc
      661 cttcaggaga cactgctgga cctcagcatt cccttgatat cagtcccctt cactgcagag
      721 ccttgccttt cccctctgcc tgtttccttt tcctctccca accctctggt tggtgattca
      781 acttgggctc caagacttgg gtaagctctg ggccttcaca gaatgatggc accttcctaa
      841 accctcatgg gtggtgtctg agaggcgtga agggcctgga gccactctgc tagaagagac
      901 caataaaggg caggtgtgga aa
//
