LOCUS       NM_001276501            1213 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G protein signaling modulator 3 (GPSM3), transcript
            variant 1, mRNA.
ACCESSION   NM_001276501
VERSION     NM_001276501.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1213)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1213)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1213)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1213)
  AUTHORS   Gall,B.J., Schroer,A.B., Gross,J.D., Setola,V. and Siderovski,D.P.
  TITLE     Reduction of GPSM3 expression akin to the arthritis-protective SNP
            rs204989 differentially affects migration in a neutrophil model
  JOURNAL   Genes Immun 17 (6), 321-327 (2016)
   PUBMED   27307211
  REMARK    GeneRIF: role for GPSM3 in neutrophil migration toward
            proinflammatory chemoattractants LTB4 and CXCL8-a discovery that
            helps strengthen the association between the promoter-weakening
            GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis
REFERENCE   5  (bases 1 to 1213)
  AUTHORS   Gall,B.J., Wilson,A., Schroer,A.B., Gross,J.D., Stoilov,P.,
            Setola,V., Watkins,C.M. and Siderovski,D.P.
  TITLE     Genetic variations in GPSM3 associated with protection from
            rheumatoid arthritis affect its transcript abundance
  JOURNAL   Genes Immun 17 (2), 139-147 (2016)
   PUBMED   26821282
  REMARK    GeneRIF: Genetic variations in GPSM3 which are associated with
            protection from rheumatoid arthritis affect its transcript
            abundance.
REFERENCE   6  (bases 1 to 1213)
  AUTHORS   Cao,X., Cismowski,M.J., Sato,M., Blumer,J.B. and Lanier,S.M.
  TITLE     Identification and characterization of AGS4: a protein containing
            three G-protein regulatory motifs that regulate the activation
            state of Gialpha
  JOURNAL   J Biol Chem 279 (26), 27567-27574 (2004)
   PUBMED   15096500
REFERENCE   7  (bases 1 to 1213)
  AUTHORS   Kimple,R.J., Willard,F.S., Hains,M.D., Jones,M.B., Nweke,G.K. and
            Siderovski,D.P.
  TITLE     Guanine nucleotide dissociation inhibitor activity of the triple
            GoLoco motif protein G18: alanine-to-aspartate mutation restores
            function to an inactive second GoLoco motif
  JOURNAL   Biochem J 378 (Pt 3), 801-808 (2004)
   PUBMED   14656218
  REMARK    GeneRIF: Mutational analysis of the role of GoLoco motifs in
            guanine nucleotide dissociation inhibitor activity of G18 protein.
REFERENCE   8  (bases 1 to 1213)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   9  (bases 1 to 1213)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 1213)
  AUTHORS   Kendall,E., Sargent,C.A. and Campbell,R.D.
  TITLE     Human major histocompatibility complex contains a new cluster of
            genes between the HLA-D and complement C4 loci
  JOURNAL   Nucleic Acids Res 18 (24), 7251-7257 (1990)
   PUBMED   2259622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA979033.1 and BC018724.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001276501.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.618232.1,
                                           SRR1163657.19409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375040.8/ ENSP00000364180.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                DA979033.1         273-337
            66-1213             BC018724.1         1-1148
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1213
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /note="G protein signaling modulator 3"
                     /db_xref="GeneID:63940"
                     /db_xref="HGNC:HGNC:13945"
                     /db_xref="MIM:618558"
     exon            1..172
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..613
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /note="activator of G-protein signaling 4; G-protein
                     signalling modulator 3 (AGS3-like, C. elegans); G-protein
                     signaling modulator 3 (AGS3-like, C. elegans)"
                     /codon_start=1
                     /product="G-protein-signaling modulator 3"
                     /protein_id="NP_001263430.1"
                     /db_xref="CCDS:CCDS34419.1"
                     /db_xref="GeneID:63940"
                     /db_xref="HGNC:HGNC:13945"
                     /db_xref="MIM:618558"
                     /translation="MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPG
                     TRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLE
                     DREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC
                     "
     exon            173..275
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..475
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1213
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /note="hexamer: AATAAA"
     polyA_site      1213
                     /gene="GPSM3"
                     /gene_synonym="AGS4; C6orf9; G18; G18.1a; G18.1b; G18.2;
                     NG1"
                     /note="major polyA site"
ORIGIN      
        1 agtacccagg catccagccc ccagctcacc cccacccctt ccagccccca ctcccctcag
       61 gaacccaagg ttccagccct cctcccaaat cccagccacc cctcccccac cagtttctcc
      121 cctctagggg atggaggctg agagacccca ggaagaagag gatggtgagc agggcccccc
      181 tcaggatgag gaaggctggc cccctccaaa ctccaccact cggccttggc gatctgctcc
      241 tccatcccct cctcctccag ggacccgcca cacagccctg ggaccccgct cggcctccct
      301 gctctccctg cagactgaac tccttctgga cctggtggct gaagcccagt cccgccgcct
      361 ggaggagcag agggccacct tctacacccc ccaaaacccc tcaagcctag cccctgcccc
      421 actccgtcct ctcgaggaca gagaacagct ttacagcact atcctcagtc accagtgcca
      481 gcggatggaa gcccagcggt cagagcctcc cctccctcca ggggggcaag agctcctgga
      541 gttgctgctg agagttcagg gtgggggtcg aatggaggag caaaggtccc ggccccccac
      601 acacacctgc tgagacttga gccccaacca gcccttcctt gccactggtc tcaaagctgg
      661 gcagcccatt gcatgccctc aactcttgct tggcaggggt accagagact gaaagacacg
      721 gcacaaatct caatattcat ctcccacatc accttccctg ggaactggac agggtgaaag
      781 tcctcaaact ctgggaacag gcgagatgga acagggattt aactccccgc ccacaggtcc
      841 atgggagctt gaggcagtaa gggggatccc aggcacccat ctcaaggagt ggctgggagt
      901 cttttcccta acttgtgggg acaccaccag ttgtcaagct actaggcagt agggtctgag
      961 ggctcaggcc tccacctgag aggttataac ctgagagaca gctctaccct tcctcccagt
     1021 aagaagggaa ggtgggtggg cacctgagag attaagacta ttctcccagt cccactacca
     1081 gcacccccga tccctgagac tgaggggttt acgggctgtg aatggacctt cagccctgcc
     1141 caccctccct ccccactgct gctgagtctg tctgatgttt tggttgtgtg aataaatata
     1201 attcccctct gga
//
