LOCUS       NM_001145638            3566 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein signaling modulator 1 (GPSM1), transcript
            variant 1, mRNA.
ACCESSION   NM_001145638
VERSION     NM_001145638.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3566)
  AUTHORS   Vural,A. and Lanier,S.M.
  TITLE     Properties of biomolecular condensates defined by Activator of
            G-protein Signaling 3
  JOURNAL   J Cell Sci 137 (4) (2024)
   PUBMED   38264908
  REMARK    GeneRIF: Properties of biomolecular condensates defined by
            Activator of G-protein Signaling 3.
REFERENCE   2  (bases 1 to 3566)
  AUTHORS   Yang,C., Yaolin,S., Lu,W., Wenwen,R., Hailei,S., Han,Z. and
            Xiaoming,X.
  TITLE     G-protein signaling modulator 1 promotes colorectal cancer
            metastasis by PI3K/AKT/mTOR signaling and autophagy
  JOURNAL   Int J Biochem Cell Biol 157, 106388 (2023)
   PUBMED   36758790
  REMARK    GeneRIF: G-protein signaling modulator 1 promotes colorectal cancer
            metastasis by PI3K/AKT/mTOR signaling and autophagy.
REFERENCE   3  (bases 1 to 3566)
  AUTHORS   Zhang,Y., Zhou,B., Sun,J., He,Q. and Zhao,Y.
  TITLE     Knockdown of GPSM1 Inhibits the Proliferation and Promotes the
            Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by
            Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway
  JOURNAL   Pathol Oncol Res 27, 643376 (2021)
   PUBMED   34257610
  REMARK    GeneRIF: Knockdown of GPSM1 Inhibits the Proliferation and Promotes
            the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by
            Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3566)
  AUTHORS   Cai,X., Fu,H., Wang,Y., Liu,Q. and Wang,X.
  TITLE     Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via
            cAMP-PKA-CREB pathway in vitro
  JOURNAL   J Ovarian Res 13 (1), 136 (2020)
   PUBMED   33220708
  REMARK    GeneRIF: Depletion of GPSM1 enhances ovarian granulosa cell
            apoptosis via cAMP-PKA-CREB pathway in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3566)
  AUTHORS   Kaushik,R., Yu,F., Chia,W., Yang,X. and Bahri,S.
  TITLE     Subcellular localization of LGN during mitosis: evidence for its
            cortical localization in mitotic cell culture systems and its
            requirement for normal cell cycle progression
  JOURNAL   Mol Biol Cell 14 (8), 3144-3155 (2003)
   PUBMED   12925752
  REMARK    GeneRIF: cortical localization in mitotic cell culture systems and
            requirement for normal cell cycle progression
REFERENCE   6  (bases 1 to 3566)
  AUTHORS   Pattingre,S., De Vries,L., Bauvy,C., Chantret,I., Cluzeaud,F.,
            Ogier-Denis,E., Vandewalle,A. and Codogno,P.
  TITLE     The G-protein regulator AGS3 controls an early event during
            macroautophagy in human intestinal HT-29 cells
  JOURNAL   J Biol Chem 278 (23), 20995-21002 (2003)
   PUBMED   12642577
  REMARK    GeneRIF: AGS3 is involved in an early event during the autophagic
            pathway probably prior to the formation of the autophagosome.
REFERENCE   7  (bases 1 to 3566)
  AUTHORS   Blumer,J.B., Chandler,L.J. and Lanier,S.M.
  TITLE     Expression analysis and subcellular distribution of the two
            G-protein regulators AGS3 and LGN indicate distinct functionality.
            Localization of LGN to the midbody during cytokinesis
  JOURNAL   J Biol Chem 277 (18), 15897-15903 (2002)
   PUBMED   11832491
REFERENCE   8  (bases 1 to 3566)
  AUTHORS   Pizzinat,N., Takesono,A. and Lanier,S.M.
  TITLE     Identification of a truncated form of the G-protein regulator AGS3
            in heart that lacks the tetratricopeptide repeat domains
  JOURNAL   J Biol Chem 276 (20), 16601-16610 (2001)
   PUBMED   11278352
REFERENCE   9  (bases 1 to 3566)
  AUTHORS   Natochin,M., Lester,B., Peterson,Y.K., Bernard,M.L., Lanier,S.M.
            and Artemyev,N.O.
  TITLE     AGS3 inhibits GDP dissociation from galpha subunits of the Gi
            family and rhodopsin-dependent activation of transducin
  JOURNAL   J Biol Chem 275 (52), 40981-40985 (2000)
   PUBMED   11024022
REFERENCE   10 (bases 1 to 3566)
  AUTHORS   Peterson,Y.K., Bernard,M.L., Ma,H., Hazard,S. 3rd, Graber,S.G. and
            Lanier,S.M.
  TITLE     Stabilization of the GDP-bound conformation of Gialpha by a peptide
            derived from the G-protein regulatory motif of AGS3
  JOURNAL   J Biol Chem 275 (43), 33193-33196 (2000)
   PUBMED   10969064
  REMARK    GeneRIF: The GPR motif in this protein and other proteins is
            actually associated with activity as a GDI - guanine nucleotide
            dissociation inhibitor and not GTPase activator as initially
            suggested.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009979.1, AY173053.1,
            BQ214873.1 and BC017257.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001145638.2.
            
            Summary: G-protein signaling modulators (GPSMs) play diverse
            functional roles through their interaction with G-protein subunits.
            This gene encodes a receptor-independent activator of G protein
            signaling, which is one of several factors that influence the basal
            activity of G-protein signaling systems. The protein contains seven
            tetratricopeptide repeats in its N-terminal half and four G-protein
            regulatory (GPR) motifs in its C-terminal half. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as
            AGS3-FL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440944.6/ ENSP00000392828.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               BC009979.1         73-298
            227-2185            AY173053.1         1-1959
            2186-2707           BQ214873.1         193-714
            2708-3566           BC017257.2         1458-2316
FEATURES             Location/Qualifiers
     source          1..3566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3566
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /note="G protein signaling modulator 1"
                     /db_xref="GeneID:26086"
                     /db_xref="HGNC:HGNC:17858"
                     /db_xref="MIM:609491"
     exon            1..225
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2185
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /note="isoform a is encoded by transcript variant 1;
                     G-protein signalling modulator 1 (AGS3-like, C. elegans);
                     activator of G-protein signaling 3"
                     /codon_start=1
                     /product="G-protein-signaling modulator 1 isoform a"
                     /protein_id="NP_001139110.2"
                     /db_xref="CCDS:CCDS48055.1"
                     /db_xref="GeneID:26086"
                     /db_xref="HGNC:HGNC:17858"
                     /db_xref="MIM:609491"
                     /translation="MAGPAPPAADELPGPAARRLYSRMEASCLELALEGERLCKAGDF
                     KTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDR
                     MGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG
                     KQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNT
                     HYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL
                     QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWS
                     LGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASE
                     KPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPV
                     RSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSS
                     RMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQ
                     RASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPR
                     GPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS"
     exon            226..447
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..583
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..735
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..859
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..975
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1131
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1240
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1364
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1435
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1612
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1769
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1978
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..3566
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /note="hexamer: AATAAA"
     polyA_site      3566
                     /gene="GPSM1"
                     /gene_synonym="AGS3"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcgg cgcctccccg ggggaggacg ggcgaacgag gcgcggacgg acaggcggac
       61 agcagggcgg acagcaggga ggacagcagg gcgggcaggg ggcggacggc cacggcgcgg
      121 ggggcgctcc cggctcccgc tcccgcgtcc ccgacccatg gcgggcccgg ccccgcccgc
      181 ggccgacgag ctcccgggcc cggccgccag gcgcctctac tccaggatgg aggcgtcctg
      241 cctagagctg gcgctggagg gcgagcgtct gtgcaaggcg ggcgacttca agacaggcgt
      301 ggccttcttt gaggctgctg tgcaggtggg caccgaggac ctgaagacac tgagtgccat
      361 ctacagccag ctgggcaacg cctacttcta cctgaaggag cacggccggg cgctggaata
      421 ccacaagcat gacctcctgc tggcgcggac catcggtgac cgcatggggg aggccaaggc
      481 cagtggaaac ctgggaaaca cactcaaggt cctggggcgc ttcgacgagg ctgccgtctg
      541 ctgccagcgg catctgagca tcgcccaaga gcagggagac aaggttgggg aggcgagggc
      601 cctctacaac atcgggaacg tgtaccacgc caaaggcaag caactgtcct ggaacgccgc
      661 aaacgccacg caggaccccg ggcacctgcc gcccgatgtc cgagagaccc tgtgcaaggc
      721 ctccgagttc tacgagagga acctgtccct ggtgaaggag ctgggcgacc gtgcggcgca
      781 gggcagggcc tacggcaacc tgggcaacac ccactatttg ttggggaact tcacagaggc
      841 cacgaccttc cacaaggagc gcctggccat tgctaaggag tttggagaca aggcagccga
      901 gaggagggcc tacagcaacc tggggaacgc ccacgtcttc ctggggcgct ttgacgtggc
      961 cgccgagtac tacaagaaga cgctgcaact gtctcggcag ctcagggacc aggcagtgga
     1021 ggcgcaggcc tgctacagtc tgggcaacac ctacacgctg ctgcaggact acgagcgcgc
     1081 ggccgagtac cacctgcggc acctgctcat tgcccaggag ctggccgaca gagtgggcga
     1141 gggccgggcg tgctggagcc tgggaaatgc ctacgtgtcc atggggcgcc cagcgcaggc
     1201 cctgaccttc gccaagaagc acctgcagat ctcccaggag atcggggacc gccatgggga
     1261 gctcacggcc cgcatgaacg tggcgcagct gcagctggtg ctcggccgcc tgaccagccc
     1321 ggcagcctca gagaagcctg acctggccgg ctatgaggcc cagggggcca gacccaagag
     1381 gacgcagagg ctgagcgcgg agacctggga cctgctgaga ctccccctgg agcgggagca
     1441 gaatggagac agccaccatt caggggactg gcgggggccc agcagggact cgctacccct
     1501 ccccgtgagg agcaggaagt accaggaagg cccggacgct gagaggaggc cccgggaggg
     1561 cagccactcc ccgctggaca gcgccgacgt ccgggtgcac gtgccacgca cgagcatccc
     1621 gagggccccg tcttcggacg aggagtgctt ctttgacctg ttgaccaagt tccagagcag
     1681 ccgcatggac gaccagcgtt gtcccctgga cgatggccag gccggggctg ccgaggccac
     1741 ggccgccccc accctggagg acaggatcgc ccagccctcg atgacggcct cgccccagac
     1801 cgaggaattc ttcgacctca tcgccagctc ccagagccgc cggctggacg accagcgggc
     1861 cagcgtgggc agcctgccgg ggctgcgaat cacccacagc aatgcagggc acctccgagg
     1921 ccacggcgag ccccaggagc cgggggacga cttcttcaac atgctcatca agtaccagtc
     1981 ctccaggatc gatgaccagc gctgcccgcc acctgacgta ctgccccggg gccctaccat
     2041 gccggacgag gacttcttca gcctcattca gagggtgcag gctaagcgca tggacgagca
     2101 gcgggtggac ctcgccgggg gcccggagca gggggcaggc ggcccgcccg agccccagca
     2161 gcagtgccag cctggtgcga gctaaggccc tgtgcccacc gccaggccca ccctgccccc
     2221 actcctggac gccggtctca cagtcacagc cacgtcctcc cgaggccatt gccgaggaca
     2281 ggcactgggc atgcagcccc acggcctccc cgacccaggg cgacaggctc aggccaagct
     2341 gcccgtggtg ggagggcgtg cttccatccc gggctggccc ccatggccct cagcttcctc
     2401 ccttctgccc ctgccgcagg ccggacgggg ccttcggcat gtcggccccg acctggtgct
     2461 gtcagactcc cgcatcctct cccccaagcc cttcccgttc tgccctgccc tgccaaatgt
     2521 gaaaccctgc tgtctccccc accctcccca aaggtgtctc tgagccgcct cttggggcca
     2581 ccaaggacag ggccatgttc tgtcccccca gagctggtct tgggatggcc gtgtgacagg
     2641 catgctccac ccctccagct tcgtcctggg gcagggctcc ctccaagcct gtctccccac
     2701 tccccggcca gaggtcagca accacagaag gccccccaga ccacgcatgg cagaccaggc
     2761 tgcagtggca gccctgaggt gccccccgcc gagtcccagg gccctgcagg ggcctcgaca
     2821 ggagccgggc ctatctctaa agcagaggga atggctgggc atgaacttcg acattccaaa
     2881 accccaagcc aggaaaaagg gcagggcctg gtcctaggga tgcttactgg cagcaagagc
     2941 agtgcccagt cagggtggga ggtagcacca ggctctgtga ccctcaccca agtggggggg
     3001 tggtcagtgg aagctgggga ggcttcactc agctcaaccc tgcagacccc ccatatgaga
     3061 acccccctcc tcccaccagc tgggggagat gacatcactg ctctctccat ggggaggggg
     3121 ctcacagggc accaagttcg ggatcctagg actggcagga cctgctggag cctgagatgg
     3181 gccccagggg cctgaggttg cctcctcctg tccagaccca gccttggcac ctcccaagac
     3241 tgccaagggc cctaccatgg ccccacagcc cccagggctg gcagttccat ctaggagggt
     3301 gcctctaggc cccactctca ggctaggatg gagaggcaga tctgggcctg gtgaggtgac
     3361 ctgcttctgg aggggcaggg ccgcacccga gagcagggac aggtgcccga acacagggtc
     3421 tccaggacgt agcgcccccc cgcatacttg aatgtatgtg cgtatttatt gctcacgtct
     3481 gtgccatgtt gtcaatgggt cctttccaac ccaagaggta catttgtttt tctgtttttc
     3541 ctgaaaaata aagtcggcca agtgag
//
