LOCUS       NM_004489               1176 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.
ACCESSION   NM_004489 NM_032938
VERSION     NM_004489.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1176)
  AUTHORS   Zhao,L., Gu,C., Zhang,Y., Yan,J., Qiu,L., Qin,X. and Wang,Y.
  TITLE     Regulation mechanism of GPS2 on PGC-1alpha/Drp1-mediated
            mitochondrial dynamics in inflammation of acute lung injury
  JOURNAL   Int Immunopharmacol 140, 112838 (2024)
   PUBMED   39116501
  REMARK    GeneRIF: Regulation mechanism of GPS2 on PGC-1alpha/Drp1-mediated
            mitochondrial dynamics in inflammation of acute lung injury.
REFERENCE   2  (bases 1 to 1176)
  AUTHORS   Lu,Y., Ma,W.B., Ren,G.M., Li,Y.T., Wang,T., Zhan,Y.Q., Xiang,S.S.,
            Chen,H., Gao,H.Y., Zhao,K., Yu,M., Li,C.Y., Yang,X.M. and Yin,R.H.
  TITLE     GPS2 promotes erythroid differentiation in K562 erythroleukemia
            cells primarily via NCOR1
  JOURNAL   Int J Hematol 120 (2), 157-166 (2024)
   PUBMED   38814500
  REMARK    GeneRIF: GPS2 promotes erythroid differentiation in K562
            erythroleukemia cells primarily via NCOR1.
REFERENCE   3  (bases 1 to 1176)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1176)
  AUTHORS   Si,Y., Zhang,H., Peng,P., Zhu,C., Shen,J., Xiong,Y., Liu,X.,
            Xiang,Y., Li,W., Ren,Y., Wan,F., Zhang,L. and Liu,Y.
  TITLE     G protein pathway suppressor 2 suppresses gastric cancer by
            destabilizing epidermal growth factor receptor
  JOURNAL   Cancer Sci 112 (12), 4867-4882 (2021)
   PUBMED   34609770
  REMARK    GeneRIF: G protein pathway suppressor 2 suppresses gastric cancer
            by destabilizing epidermal growth factor receptor.
            Erratum:[Cancer Sci. 2025 Jan;116(1):279. doi: 10.1111/cas.16391..
            PMID: 39500631]
REFERENCE   5  (bases 1 to 1176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1176)
  AUTHORS   Degenhardt,Y.Y. and Silverstein,S.J.
  TITLE     Gps2, a protein partner for human papillomavirus E6 proteins
  JOURNAL   J Virol 75 (1), 151-160 (2001)
   PUBMED   11119584
REFERENCE   7  (bases 1 to 1176)
  AUTHORS   Peng,Y.C., Breiding,D.E., Sverdrup,F., Richard,J. and Androphy,E.J.
  TITLE     AMF-1/Gps2 binds p300 and enhances its interaction with
            papillomavirus E2 proteins
  JOURNAL   J Virol 74 (13), 5872-5879 (2000)
   PUBMED   10846067
REFERENCE   8  (bases 1 to 1176)
  AUTHORS   Breiding,D.E., Sverdrup,F., Grossel,M.J., Moscufo,N., Boonchai,W.
            and Androphy,E.J.
  TITLE     Functional interaction of a novel cellular protein with the
            papillomavirus E2 transactivation domain
  JOURNAL   Mol Cell Biol 17 (12), 7208-7219 (1997)
   PUBMED   9372953
REFERENCE   9  (bases 1 to 1176)
  AUTHORS   Jin,D.Y., Teramoto,H., Giam,C.Z., Chun,R.F., Gutkind,J.S. and
            Jeang,K.T.
  TITLE     A human suppressor of c-Jun N-terminal kinase 1 activation by tumor
            necrosis factor alpha
  JOURNAL   J Biol Chem 272 (41), 25816-25823 (1997)
   PUBMED   9325311
REFERENCE   10 (bases 1 to 1176)
  AUTHORS   Spain,B.H., Bowdish,K.S., Pacal,A.R., Staub,S.F., Koo,D.,
            Chang,C.Y., Xie,W. and Colicelli,J.
  TITLE     Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11),
            suppress G-protein- and mitogen-activated protein kinase-mediated
            signal transduction in yeast and mammalian cells
  JOURNAL   Mol Cell Biol 16 (12), 6698-6706 (1996)
   PUBMED   8943324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026954.14 and BC013652.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004489.4.
            
            Summary: This gene encodes a protein involved in G
            protein-mitogen-activated protein kinase (MAPK) signaling cascades.
            When overexpressed in mammalian cells, this gene could potently
            suppress a RAS- and MAPK-mediated signal and interfere with JNK
            activity, suggesting that the function of this gene may be signal
            repression. The encoded protein is an integral subunit of the
            NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3)
            complex, and it was shown that the complex inhibits JNK activation
            through this subunit and thus could potentially provide an
            alternative mechanism for hormone-mediated antagonism of AP1
            (activator protein 1) function. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.68963.1,
                                           SRR1803612.98914.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380728.7/ ENSP00000370104.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC026954.14        36826-36846         c
            22-1176             BC013652.1         1-1155
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1176
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /note="G protein pathway suppressor 2"
                     /db_xref="GeneID:2874"
                     /db_xref="HGNC:HGNC:4550"
                     /db_xref="MIM:601935"
     exon            1..30
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            31..191
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1081
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /note="GPS-2"
                     /codon_start=1
                     /product="G protein pathway suppressor 2"
                     /protein_id="NP_004480.1"
                     /db_xref="CCDS:CCDS11100.1"
                     /db_xref="GeneID:2874"
                     /db_xref="HGNC:HGNC:4550"
                     /db_xref="MIM:601935"
                     /translation="MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKM
                     KEEQERRKKKEMEERMSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRR
                     KEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLT
                     TRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPA
                     VQYLSQPQPQPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHP
                     QALHPAPGLLASPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK"
     exon            192..301
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..414
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..494
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..577
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..731
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..821
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..901
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..997
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1176
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1176
                     /gene="GPS2"
                     /gene_synonym="AMF-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgctg agaaagcgca gagaaggcgg gccccgtctg aggtctggca gtcagagaca
       61 gccgggcgcc cacggcccga gcgcccacgg cagcaccatg cccgcactcc tggagcgccc
      121 caagctttcc aacgccatgg ccagggcgct gcaccggcac attatgatgg agcgggagcg
      181 caagcggcag gaggaagaag aggtggataa gatgatggaa cagaagatga aggaagaaca
      241 ggagagaagg aagaaaaagg agatggaaga gagaatgtca ttagaggaga ccaaggaaca
      301 aattctgaag ttggaggaga agcttttggc tctacaggaa gagaagcacc agcttttcct
      361 gcagctcaag aaagttttac atgaggaaga aaaacggagg cgaaaggaac agagtgacct
      421 gaccacccta acatcagctg cataccagca gagcctgact gttcacacag gaactcatct
      481 cctcagcatg caggggagcc ctggaggaca caatcgccca ggcaccctca tggcagctga
      541 cagagccaaa caaatgtttg gaccccaagt gcttacgacc cggcactacg tgggctcagc
      601 agctgctttt gcagggacac cagagcatgg acaattccaa ggcagtcctg gtggtgccta
      661 tgggactgct cagcccccac ctcactatgg gcccacacag ccagcttata gtcctagtca
      721 gcagctcaga gctccttcgg cattccctgc agtgcagtac ctatctcagc cacagccaca
      781 gccctatgct gtgcatggcc actttcagcc cactcagaca ggtttcctcc agcctggtgg
      841 tgccctgtcc ttgcaaaagc agatggaaca tgctaaccag cagactggct tctccgactc
      901 atcctctctg cgccccatgc acccccaggc tctgcatcca gcccctggac tccttgcttc
      961 cccccagctc cctgtgcaga tgcagccagc aggaaagtcg ggctttgcag ctaccagcca
     1021 acctggccct cggctcccct tcatccaaca cagccagaac ccgcgattct accacaagtg
     1081 accatcagat tatatcttca acaccacacc ccccacccca tcgtgggtga gggtatcccc
     1141 tgtgtgtccc aggccaataa aatctacctg ccactg
//
