LOCUS       NM_001321092            1841 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens G protein pathway suppressor 1 (GPS1), transcript
            variant 6, mRNA.
ACCESSION   NM_001321092 XM_005256363
VERSION     NM_001321092.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Wei,H., Niu,Z., Ji,R., Jiang,W., Tang,J., Meng,Z., Cao,X., Zhang,X.
            and Liu,X.
  TITLE     Bioinformatics analysis of GPS1 expression and biological function
            in breast cancer
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 52 (2024)
   PUBMED   38289496
  REMARK    GeneRIF: Bioinformatics analysis of GPS1 expression and biological
            function in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Fu,H., Zhang,Y., Chen,Y., Chen,J. and Chen,P.
  TITLE     CSN1 facilitates proliferation and migration of hepatocellular
            carcinoma cells by upregulating cyclin A2 expression
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33200803
  REMARK    GeneRIF: CSN1 facilitates proliferation and migration of
            hepatocellular carcinoma cells by upregulating cyclin A2
            expression.
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Feber,A., Worth,D.C., Chakravarthy,A., de Winter,P., Shah,K.,
            Arya,M., Saqib,M., Nigam,R., Malone,P.R., Tan,W.S., Rodney,S.,
            Freeman,A., Jameson,C., Wilson,G.A., Powles,T., Beck,S., Fenton,T.,
            Sharp,T.V., Muneer,A. and Kelly,J.D.
  TITLE     CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
  JOURNAL   Cancer Res 76 (16), 4720-4727 (2016)
   PUBMED   27325650
  REMARK    GeneRIF: We identified recurrent mutations in the novel penile
            cancer tumor suppressor genes CSN1(GPS1) and FAT1
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Lyapina,S., Cope,G., Shevchenko,A., Serino,G., Tsuge,T., Zhou,C.,
            Wolf,D.A., Wei,N., Shevchenko,A. and Deshaies,R.J.
  TITLE     Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
  JOURNAL   Science 292 (5520), 1382-1385 (2001)
   PUBMED   11337588
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Tsuge,T., Matsui,M. and Wei,N.
  TITLE     The subunit 1 of the COP9 signalosome suppresses gene expression
            through its N-terminal domain and incorporates into the complex
            through the PCI domain
  JOURNAL   J Mol Biol 305 (1), 1-9 (2001)
   PUBMED   11114242
  REMARK    GeneRIF: The N-terminal half of CSN1/GPS1 is required to repress
            c-fos expression and to inhibit AP-1 and SRE transactivation, while
            the C-terminal half allows integration of the protein into the COP9
            signalosome.
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Spain,B.H., Bowdish,K.S., Pacal,A.R., Staub,S.F., Koo,D.,
            Chang,C.Y., Xie,W. and Colicelli,J.
  TITLE     Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11),
            suppress G-protein- and mitogen-activated protein kinase-mediated
            signal transduction in yeast and mammalian cells
  JOURNAL   Mol Cell Biol 16 (12), 6698-6706 (1996)
   PUBMED   8943324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135056.4.
            
            On May 4, 2021 this sequence version replaced NM_001321092.2.
            
            Summary: This gene is known to suppress G-protein and
            mitogen-activated signal transduction in mammalian cells. The
            encoded protein shares significant similarity with Arabidopsis
            FUS6, which is a regulator of light-mediated signal transduction in
            plant cells. [provided by RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225248.1, AK222508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000578552.6/ ENSP00000462265.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC135056.4         18261-18327
            68-160              AC135056.4         19637-19729
            161-342             AC135056.4         20231-20412
            343-643             AC135056.4         20873-21173
            644-721             AC135056.4         21261-21338
            722-782             AC135056.4         21525-21585
            783-868             AC135056.4         22103-22188
            869-963             AC135056.4         22364-22458
            964-1069            AC135056.4         22649-22754
            1070-1150           AC135056.4         22833-22913
            1151-1288           AC135056.4         22992-23129
            1289-1423           AC135056.4         23203-23337
            1424-1841           AC135056.4         23416-23833
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1841
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /note="G protein pathway suppressor 1"
                     /db_xref="GeneID:2873"
                     /db_xref="HGNC:HGNC:4549"
                     /db_xref="MIM:601934"
     exon            1..67
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1498
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /note="isoform 6 is encoded by transcript variant 6; COP9
                     signalosome complex subunit 1; JAB1-containing signalosome
                     subunit 1"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 1 isoform 6"
                     /protein_id="NP_001308021.1"
                     /db_xref="CCDS:CCDS82226.1"
                     /db_xref="GeneID:2873"
                     /db_xref="HGNC:HGNC:4549"
                     /db_xref="MIM:601934"
                     /translation="MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDL
                     EQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEAT
                     RELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
                     HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYV
                     SKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDF
                     PELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKY
                     ASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTT
                     VAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMM
                     LRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM"
     exon            68..160
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..342
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..643
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..721
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..782
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..868
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..963
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1069
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1150
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1288
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1423
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1841
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /note="hexamer: ATTAAA"
     polyA_site      1841
                     /gene="GPS1"
                     /gene_synonym="COPS1; CSN1; SGN1"
                     /note="major polyA site"
ORIGIN      
        1 agtggacggc acgccgcggc ggggtgggtg caagatgccg ctgccggttc aggtgtttaa
       61 cttgcagggg gccgtggagc ccatgcagat cgacgtggac ccccaggaag acccgcagaa
      121 tgcacctgac gtcaactacg tggtggagaa ccccagcctg gatctggaac agtacgcggc
      181 cagctacagc ggcctgatgc gcatcgaacg gctgcagttc attgctgatc actgccccac
      241 gctgcgggtg gaggccctga agatggccct ctccttcgtg cagagaacct ttaacgtgga
      301 catgtacgag gagatccacc gcaagctctc agaggccacc agggagctgc agaacgcacc
      361 cgacgccatc cctgagagcg gcgtggagcc cccagccctg gacacggcct gggtggaggc
      421 cacgcggaag aaggcgctgc tgaagctgga gaagctggac acagacctga agaactacaa
      481 gggcaactcc atcaaagaga gcatccggcg cggccacgac gacctgggcg accactacct
      541 ggactgtggg gacctcagca acgccctcaa gtgctattcc cgggcccggg actactgcac
      601 cagcgccaaa cacgtcatca acatgtgcct caatgtcatc aaggtcagcg tctacttgca
      661 gaattggtct catgtgctca gctacgtcag caaggctgag tccaccccag agattgccga
      721 gcagcgagga gagcgtgaca gccagaccca ggccatcctc accaagctca agtgtgccgc
      781 aggcttggca gagctggccg ccaggaagta caagcaggct gccaagtgcc tcctgctggc
      841 ttcctttgat cactgtgact tccctgagct gctgtccccc agcaacgtgg ccatctacgg
      901 tggcctgtgc gccttggcta cctttgaccg gcaggagctg cagcgcaatg tcatctccag
      961 cagctccttc aagttgttct tggagctgga gccacaggtc cgagacatca tcttcaaatt
     1021 ctacgagtcc aagtacgcct catgtctcaa gatgctggac gagatgaagg acaacctgct
     1081 cctggacatg tatctggccc cccatgtcag gaccctgtac acccagattc gcaaccgtgc
     1141 cctcatccag tatttcagcc cctacgtgtc agccgacatg cataggatgg cggcagcctt
     1201 caataccacg gtggccgccc tggaggacga gctgacgcag ctaatcctgg aggggctgat
     1261 cagtgcccgt gtggactcac acagcaagat cctatacgcc cgggacgtgg atcagcgcag
     1321 caccaccttt gagaagtctc tgttgatggg caaggagttc cagcgccgcg ccaaggccat
     1381 gatgctgcgg gcagctgtgc tccgcaacca gatccatgtc aagtccccgc ccagagaagg
     1441 gagccagggg gagctgactc cagccaacag ccagtcccgg atgagcacca acatgtgagg
     1501 ggtgaacctt ggcctccagg acatctgcac cccctcccca cctccacgga cctcggacct
     1561 ccaggcggct cagtgctgcc tgcggcccag ctaaggggcc tggccactgg gtgccaccca
     1621 gcctgtgtgc cctccctggg gctgaggagg caggcggctg ctagttgtgg cccttcctgg
     1681 aaggagaggc ctgcagggct cgaccctgtg ggtttctgtc cccagggagc agactgtgcg
     1741 gcacccaggc ccagtggcac catttcccag acccctcctg ttcccgcctc agtcaggtgc
     1801 agacaagtgg gcggtgtcca ttaaagagca gactcagcgt t
//
