LOCUS       NM_001385298            9673 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein regulated inducer of neurite outgrowth 2
            (GPRIN2), transcript variant 19, mRNA.
ACCESSION   NM_001385298
VERSION     NM_001385298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9673)
  AUTHORS   Khalilipour,N., Baranova,A., Jebelli,A., Heravi-Moussavi,A.,
            Bruskin,S. and Abbaszadegan,M.R.
  TITLE     Familial Esophageal Squamous Cell Carcinoma with damaging
            rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes
  JOURNAL   Cancer Genet 221, 46-52 (2018)
   PUBMED   29405996
  REMARK    GeneRIF: Four of these 16 variants were rare damaging mutations
            including novel mutations in KCNJ12/KCNJ18, and GPRIN2 genes. This
            WES study in Iranian patients with ESCC, provides insight into the
            identification of novel germline mutations in familial ESCC. Our
            data suggest an association between specific mutations and
            increased risk of ESCC
REFERENCE   2  (bases 1 to 9673)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9673)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   4  (bases 1 to 9673)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   5  (bases 1 to 9673)
  AUTHORS   Iida,N. and Kozasa,T.
  TITLE     Identification and biochemical analysis of GRIN1 and GRIN2
  JOURNAL   Methods Enzymol 390, 475-483 (2004)
   PUBMED   15488195
REFERENCE   6  (bases 1 to 9673)
  AUTHORS   Chen,L.T., Gilman,A.G. and Kozasa,T.
  TITLE     A candidate target for G protein action in brain
  JOURNAL   J Biol Chem 274 (38), 26931-26938 (1999)
   PUBMED   10480904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356056.22, AL645529.4 and AL732434.21.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.441148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AL356056.22        179958-179998
            42-196              AL356056.22        181562-181716
            197-307             AL356056.22        182396-182506
            308-506             AL645529.4         2955-3153
            507-666             AL645529.4         3540-3699
            667-8745            AL645529.4         4373-12451
            8746-9673           AL732434.21        61600-62527         c
FEATURES             Location/Qualifiers
     source          1..9673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..9673
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="G protein regulated inducer of neurite outgrowth 2"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
     exon            1..41
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            42..196
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            197..307
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            308..506
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            507..666
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..2049
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="isoform 2 is encoded by transcript variant 19"
                     /codon_start=1
                     /product="G protein-regulated inducer of neurite outgrowth
                     2 isoform 2"
                     /protein_id="NP_001372227.1"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
                     /translation="MLNESLMEKADAWGLSLPLELEAAMSSSRPEPGPWAPLSPRLQP
                     LSQSSSSLLGEGREQRPELRKTASSTVWQAQLGEASTRPQAPEEEGNPPESMKPARAS
                     GPKARPSAGGHWWSSTVGNVSTMGGSDLCRLRAPSAAAMQRSHSDLVRSTQMRGHSGA
                     RKASLSCSALGSSPVHRAQLQPGGTSGQGGQAPAGLERDLAPEDETSNSAWMLGASQL
                     SVPPLDLGDTTAHSSSAQAEPKAAEQLATTTCHALPPAALLCGMREVRAGGCCHALPA
                     TGILAFPKLVASVSESGLQAQHGVKIHCRLSGGLPGHSHCCAHLWGPAGLVPEPGSRT
                     KDVWTMTSANDLAPAEASPLSAQDAGVQAAPVAACKAVATSPSLEAPAALHVFPEVTL
                     GSSLEEVPSPVRDVRWDAEGMTWEVYGAAVDLEVLGVAIQKHLEMQFEQLQRAPASED
                     SLSVEGRRGPLRAVMQSLRRPSCCGCSGAAPE"
     exon            667..9673
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2365
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
     regulatory      9644..9649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="hexamer: ATTAAA"
     polyA_site      9673
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
ORIGIN      
        1 gtgagaggcg gagctaggat ggagaaggcg agaggaaagg ggaatgctgc ctgctgcttt
       61 gcccagagtt ggccctgagt gttcctatca ggccccgttc actctggggt ggattaaacc
      121 acctcctgga gggtgctgta tccccactgt gcaatggggg tttgtgctgt gtgcattcct
      181 gcctggtcct tgagagttgc tgacaggtgg aacctgaggc agcaggacag cctggcattg
      241 gccacgggac atcggccaca accatagcaa cttcggcatc aaatggggca ggagagagaa
      301 cattaaggcc tgacttacgt ggctggtcct ccaggaagcc ttttctcatc tctcaccctc
      361 cgtgagctct cctgccttgg tggtgccctc cctcagaccc catttttggc actcagtgcc
      421 ctcctctgtg ggtgtgttct tgtatttgct tgttctcttg gtcaggcaca cagcagataa
      481 tcctctgagt gccgacgaca catcaggggt acagaaaggt ctgaatgaat cccatgttcc
      541 ctagccctac agctgggcac gcagtagggg ctcaggagat gctgtggaat caatgaccag
      601 atgctgaatg agtccctcat ggaaaaagct gatgcatggg gcctctcctt gcccctggag
      661 ctagaggcag ccatgagctc cagccgcccc gagccgggtc cctgggcacc cctgagcccc
      721 cgccttcagc ccctgtccca gagctcttcc agcctgctgg gtgaaggccg ggaacagagg
      781 ccagagctcc gcaagactgc cagcagcacc gtgtggcagg cccagctggg cgaggccagc
      841 accagacccc aggccccgga ggaagagggg aacccgcctg agagcatgaa gccagcacgg
      901 gcctctggcc ccaaggcgcg acccagtgct ggaggccact ggtggagcag cactgtgggc
      961 aatgtgtcca ccatgggcgg cagtgacctg tgtcgcctgc gggcccctag tgctgctgct
     1021 atgcagagga gccattcaga cctggtccgt agcacccaga tgcggggaca cagtggtgct
     1081 cggaaggcca gtctcagctg ctcagccctt ggcagcagcc ctgtccacag ggctcagctg
     1141 cagccaggtg gtacttctgg ccagggtggc caggcccctg caggcctgga aagggacctg
     1201 gctcctgagg atgagacttc taactcagcc tggatgctgg gggcgagtca gttgtcagtg
     1261 ccaccactag acctggggga cacaactgcc cacagcagca gtgcccaggc tgagcccaaa
     1321 gctgctgaac agctggctac caccacctgc catgctctgc ccccagctgc tctactctgt
     1381 ggcatgaggg aggtgagggc tggtggctgc tgccatgccc tacctgccac agggatcctg
     1441 gcctttccca aactagtggc gtcagtgagc gagtctgggc tgcaggctca gcatggggtg
     1501 aagatccact gtaggttgtc tggggggctc cctgggcatt cccattgctg tgcccacctt
     1561 tggggtcccg ctgggttagt cccagagcct ggctctagga ccaaagatgt gtggaccatg
     1621 acctcagcca atgacttggc ccctgcagag gcatccccgc tgtcagccca ggatgctggt
     1681 gtgcaggcgg ccccagtggc ggcctgcaag gctgtggcca ccagtccgtc cctggaagcg
     1741 cctgcagccc tgcatgtgtt cccagaggta actctggggt ccagcctgga ggaggtgccg
     1801 tcccctgtgc gggatgtgcg atgggatgct gagggcatga catgggaggt gtacggagct
     1861 gcggtggacc tggaggtgct cggtgtggcc atccagaagc acctggagat gcagtttgag
     1921 cagctgcagc gggcgcccgc cagcgaggac agcctgtctg tggagggccg gagggggcca
     1981 ctgcgggctg tcatgcagtc cctgcggcgc cccagctgct gcggctgctc cggcgcggcc
     2041 cccgagtgag gagctgtggc ccttggagct ggcctgggcc cactgactta gtcctagacc
     2101 tgggccaggg acggtggggg ctccgtgccc cctggaccca ccggcagctg ggcacatctc
     2161 tcacctgaat attggctgcc tccagaccac aggactgcag cctggggctt ccggccctac
     2221 acagctgggc tgttttctta agggcttgat ttccaagggc cacatctctg caccttccgg
     2281 gctctgaact ttgagacagg gctttagcac tgtgcagagg ggagatcctg agttttctgt
     2341 aaaaaatgac cttttgttca ctccaccctc agaactctgc catgttgcct cgtcagactc
     2401 ttggtggctt tatttgaaat cagtgctgag aaatagtgaa ttctcgacat gaaatgtgag
     2461 gccccagtga cagggactgc ccaggtcttt agggaagggg actgatgtta tcagaggcct
     2521 cctgtgtgcc acatactgtg cttgtcctgt cttcacctct tcatcctggc aagccttcat
     2581 ttggcaaggc tgtagccgat gtgccccacg ctggacagct tgaagaggtg ggactgagat
     2641 ccaaagccag ggccagctga gccgtgggtg ttgccctgta gcatgtgccc ggtccagtca
     2701 gtgcagtcat gtatgaggag aatttactga gctcatactc tgtgctgggt tctgtggatt
     2761 ctgtggtgaa tgagacagag gctgcccctg ccctggctga gctcatggtg tgggttgggg
     2821 atggcagggg aggatgctga ccattacgga gggctgccag gcttccaggg tcattgtgtc
     2881 agaggctggc ctgaggaagg ggagaatggg tggccacctg ccctaatctc agttacaaag
     2941 cctaaaattg cactattttc acctcattct gtcggctgaa ggatttctcc ccagctggtg
     3001 cagtttgtgg aaggagggag ggcaggaatg gagggggaca gggcaggagt ttgccctggc
     3061 cctggggtag gggctgtgag gctgtggggg ctcgcttgcc cacatgacct gacctaggct
     3121 aggcagtggg ggccaggggc cttggagaga cagaaacatg ggctttggca cagtctgact
     3181 tcattgccca aagatttctc gaggcctgtg aagaatggga gtgggcttgt gttcttgtcc
     3241 tgggtctttg tcttgaagat cctaagatcc cgtgacacag ccccccaatc cacccgtgtg
     3301 agggaccaga gggctagtgt ggggtcatgg cccacgacct ggcctgtttc tggagcctct
     3361 tctgcaccta ggagcccagg acccccacag tggtggctta cttttcccca tcctcaagga
     3421 cctggtactc attgaggtgg aaatgactca tgcaacagtt ggtgaatttg taaagcagga
     3481 gtggcatttc aacaggccac aaggacaaag tgacaaaggc gtgcgtcagg tcagatgcct
     3541 cctgaagccc aacgatggac cattctcacc cgtaaacatg cctttcccat atgcataggt
     3601 gcaccccttg ggattctggg gctgtcagtc cctttgtgta tggtgccagg gcaggcagct
     3661 cacgttctgg ggagtgacac atgggtatat gccatcttca tgcctggctc cccatggagt
     3721 ctccaggaac cccagcctgt tagggccaca tgagagagaa caaatggctg tgggtgcatg
     3781 gggagggacc tttcacacag ggccatagct aagtagggtc ttgaggatgc aggggttaga
     3841 caggtgggtg gagagagggc aggacctgcc tggcagatgg aacagcctgg tcagatactt
     3901 ggatgtgcct gtcctgcctg ggccataatg agtttctgca gtggcggctc atttggagcg
     3961 tttgttgggt tgggaggtga ccaggggtcc ccattgtgaa gatcctgatg taaatgagga
     4021 aaggaacttt aagggaactg tggaaggggt tctgaggtgg gaccagattt cagtttagaa
     4081 atatccattt ggcttccagt ggagatgtgc caggtgacac caaggagggg cctgtttagg
     4141 ggcaatggag tgggcagctg ggggctgggt tcatacacgt gcacacacac gcatacacag
     4201 gcacacatgt gtgcaatgga tttggggagg aggcatttca ggatgctgag gtttccagtt
     4261 tgagcaagag gagggtgagg ccactacctg ggtcaaggtg aatggcatgt tcagcaggtg
     4321 cagaaagggc cacctgccac agggtttggc tgggaccagt gaaacctact tcatgaagag
     4381 actttcttct gtgtcacgtg cagattctta tgcattcacg ctggctgggt gccactctgt
     4441 gctacctcca tgctgccctg gcttgccagg atggcaggcc gggctgggct cagccaagct
     4501 cccactcacc tcatcgtcac tgagatgagt atttgcagag cggtgctgaa atccaacacc
     4561 tgtgtcttgg ctggggcccc agatgattct cctggctaaa ccacgatcct tgtctcccta
     4621 gcccagttgc acagctgctg ctgacaggtc tacctgaagt gactgcagcc tcatttctga
     4681 ttggaactgg agacccctcc caaccccctt tgctgtgccc tctcctggaa cagccctgat
     4741 gcctgcagtg gtttagggcc ccagagcatg gccagcggtt tagtttacag atctcctccc
     4801 cttggactct agatttctgg ccagactttc tgggtccctt tcaggccctg ctctgggagg
     4861 tgttggagtt cactgttgat gtgtttgttt ggctttgaat tcaaaacaga tacaaatttg
     4921 gaggtgagag ctttgccaga ccccagcagg gatggggcat cggtcctgac tggtcttgtt
     4981 tattttgtcc tggtaaattc tgttctttgg agcataaacc ctggagtcct agagcccctt
     5041 gcctcagcag gaatcccccc tctgtctgct ccaggggctc cctgcttctg cccacctgct
     5101 ctccttccat ggcattcagg acccccgaca gctgaagcct ctcttcatat agcttgtccc
     5161 ctctgggcct gcctgtcttg tgtccaggac acaagacacg catcccttgt ctggccccag
     5221 gctgccatca ctgtcacaag aaactcatag agtagagctg gtctgaggtc acagtgctgg
     5281 tggtggtgga aaagcaggga tggcctgttc cactgtgatc ttacctcctg tgtcacctgg
     5341 attgggtctc tgtcccctta gacatgctag atcctaactt tacaagggct gaaggggtct
     5401 tctacacgca ggtcccaaca ctttgggctg gggttggcca ccgtagctta gtgggctaaa
     5461 gctggagttt gaatctggat atataggatc cacacctata gccatgtgat cttgggcaag
     5521 ttacaagcct tgatcatctt cctcatctgt aagatgggga tgacaatggt gcctccttca
     5581 catgcttggt gtggagatta aatagaataa cccaagtagt gcctggcact gagttagtgc
     5641 tcagcacaca ggctggtagt gttgggcacc cctctcatag ccacattcag gggccacctc
     5701 ttaccctgcc agcttggctg tgatcacagc ccacatccca cttccttaaa agtcccttgt
     5761 tcagagcctc tttccaggtt cctcgcccca cagctttgca ccctgcctgg gacttggccc
     5821 tctggctggg gcttctgaaa atgtagttcc cagagtgcat tgaggagggc taccctagcc
     5881 ctcaccactc atcttgggct gggttcccca gaagcttctg ctgagatgag gatgctggag
     5941 ttattaggga ggggagagca agttaaggga ggggcagaag gcaaggcagg gtgtgatttc
     6001 agtccaagtc agaccctaaa ggggagccct ggatgcagtc ccacctcaga gtaaggacta
     6061 cccaggggtg aagatgtagc ctccaggcac ttctgctctc tggcaggcag gctaggaagc
     6121 tctaggagcc ccagggtagg tttctgctgg agtcgtaggg cctattttgg gggaagttgt
     6181 gcacagaaac caccagaggg agtcacaggc atctgggggt gcacccattg acatttgcat
     6241 ccatgtcatg ccaagcttgt agcccacaaa tgcccaaccc ttttctccat gcattgctct
     6301 gtctcagttt tgttcacgcc aagcagcctt ggttagttaa atgcagagct tggcatttgc
     6361 ccatgttaaa ttccttctcc tttttcattc tggcctggcc tggttttgcc atctgaagct
     6421 atgacaagtc ctttatcagt tttcatccaa cttgtcaggc agggcagggc tggtatgaag
     6481 cccaggacat atcactggga catcccatag gtctgtgaga ttcccaggtc cctccaaatc
     6541 cacacggtca tcatgggcaa attagtttaa gtctgatctg ttaagatcca gatctctcac
     6601 accaacagca cacacccctt tttcccatgg ccatggaagg agggtagcat agcctgactc
     6661 gagtcctcgt tctcagcaga actggttctg tggtggccac ttccctttct caacttttac
     6721 ctacttctgt ttaataggtt gttctgcaag tctgagagca acagcaagct tagaagtgtg
     6781 gactcagcct ggtacagtgg ctcatgcctg taatcccagc actttgggag gctgaggtgg
     6841 gctgactgct tgagctcagg agttcgaaac cagcttgggc agcatggaga aatcccatct
     6901 ctacaaaaaa tacaaaaatt agctgggcat ggtggtgtgc atctgtagcc tcagctactc
     6961 agggggttga ggtgggaaga tggcttgagc ccaggaggtg gaggttgcag tgagccgaga
     7021 tagtgccact gtgctccagc ctggatgacg gagccagacc ctgtttcaaa aaaagaaaaa
     7081 gacaagaaag aagtatggac tctaccttct tgcccttgtg gagattggga actgcctgcc
     7141 cttggcctct ttcctgtcca tcttgtatta tgaaaggctg tttctggcac acccgggctc
     7201 ctctgtgtgg tttctgggaa gtgactgagg gtcaggggaa tggagcccct ctgcagccgg
     7261 ccgctggtac cttccctatt gaacccttct ttaggtttgc tcactctttt tgatgggtgt
     7321 ctttccaaag ctggctgggg acctccctga ttgagagaca tggggccagt tctgttgctg
     7381 tggctacacg ggaataataa agcagaagaa cacctgagga aagctgatgt ttactaaaaa
     7441 aaaaaacaag cgaaaccaaa gtgacgtggg cccataggat tggggatggg tggtggggtc
     7501 tgactgcctt gtcccaagag ttgggtgaat gccgcctttg ctcacttgtg cggtcactct
     7561 ccaggactcc tgcctggctt ctcccactcc aagcccgaga tagcccagca aggaggaagg
     7621 tctggcccca aaatacgagc tccccaagtg gatatcctaa aattcatctt tcatggccct
     7681 actttattgg gagggaatgt gaaaattgtg ggaatatgtc cattgacatc tggggctcag
     7741 ggcaggggag tgtgtctagt tttaaggtgt gcgcttttag ccatgcagtc atcgcccagt
     7801 ctgtcctgcc tggagctttt catttccctg cagctttcct gagaaaagac agagtgtgct
     7861 ttctctgcat cctatgaaca tggccccagg actgcagcac ctctgtgtgc acacagccaa
     7921 ggacagtcgg gggacctctg ctggtcctgc acccgctgcc ctgggtgctc tgtcatcccc
     7981 atcccccatt tctctttaat ctgttcttct tttgtggttt catgttctct ttgttctggg
     8041 ttattcagaa cctgtctgcc tccccactgt ccattgtact tgttcctgcc tcctcctgct
     8101 ttgtgccaag gatttacttg ccttcgcctt ctggctccat acagtagtct ctcttcttgc
     8161 ggtcttggcc attcccccca ccaggccccc agctgtggct gtgtctgggt cttggcattt
     8221 gtgatttaca tgggtctagg ccctttctct ccacctgtcc ttcccctctt tggacacaaa
     8281 ccaaaacatc tgagcatctc cttacagagg gaggtctccc tggggttgct gtgccaagtt
     8341 tccattgctt ttgcccagaa tgagaaatca gttgtcagtg gccctgctgg gtgaatggaa
     8401 ggactttggt cgggctggaa gggcacccca tcagtcctaa cttttggtgg cccttgttgg
     8461 tggctggctg gctaggctgc tagagaggta catcaggtgg gtggcaccca tctgctggct
     8521 ttaggcaggc catctcctca tccatgtttt cagaatcttc ttgcatggct tgtaattggg
     8581 ttggggtgtg gcctgagccc ctgtggggac acactgcact gtcccacctg tatgcttctc
     8641 tgctgtcagg aactggattc gtgtccaaga gccaaggcta gggactggag gaggagattt
     8701 ctgtctttga cccctccata ttagtccatt ttcatgctgc tataaagaac tgcctgagac
     8761 tgggtaattt ataaaggaaa gaggtttaat tgactcacag ttccacgtgg cccggggagc
     8821 ctcaggaaac ttacaggaag cctcaggaaa cttacaatca tggcagacag cgaaggagaa
     8881 gcaaggcacc ttcttcacaa ggcagcagga aggaaaatga atgcagaagg aactaccaaa
     8941 cacttataaa accatcagat ctcgtgagaa cttactatca caagaacagc atgggggaac
     9001 cgcccccacg attccatcac ctccacctga tctctccctt gtcacatggg gattataggg
     9061 attacaattc aagatgagat tttgggtggg gacacagcca aagcatatca ccctcccagg
     9121 cctgagcaag gcccaagcag ggagcctctg ttggggctgg aaccctggga ggggtagaat
     9181 tctcccctcc actcagattt gttccctgtt gctgcccacc tggcccctgc cctgcagcct
     9241 tctgcctggc cttctctctg ttcacttctc atttttagca gtcaacagac tgggagatgg
     9301 tggccaaggg tgtcattttg tacacaagct ttgtggcttt tgtaagccca gcctgcaact
     9361 cttgaggaaa actctttggt ttgatttttt ttctcttcag agttgggggt attcagggag
     9421 atgggcaagg gcttcttgtg aagatttcaa ttcttgaagg ggtggaagcc tcctgggctg
     9481 ggggaagggg tggggcagga accagcaggg gtgtggacac agggggctgg cacctgggat
     9541 accgtaggac agctgggcag gaagtcggat gctgctttat tgaaattttt gatattttat
     9601 cattttttca ttagttttta ttttaaaaca ctgctttaaa ataattaaaa tatgatttat
     9661 cttggttacc gaa
//
