LOCUS       NM_001385283            9434 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein regulated inducer of neurite outgrowth 2
            (GPRIN2), transcript variant 9, mRNA.
ACCESSION   NM_001385283 XM_005277666
VERSION     NM_001385283.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9434)
  AUTHORS   Khalilipour,N., Baranova,A., Jebelli,A., Heravi-Moussavi,A.,
            Bruskin,S. and Abbaszadegan,M.R.
  TITLE     Familial Esophageal Squamous Cell Carcinoma with damaging
            rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes
  JOURNAL   Cancer Genet 221, 46-52 (2018)
   PUBMED   29405996
  REMARK    GeneRIF: Four of these 16 variants were rare damaging mutations
            including novel mutations in KCNJ12/KCNJ18, and GPRIN2 genes. This
            WES study in Iranian patients with ESCC, provides insight into the
            identification of novel germline mutations in familial ESCC. Our
            data suggest an association between specific mutations and
            increased risk of ESCC
REFERENCE   2  (bases 1 to 9434)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9434)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   4  (bases 1 to 9434)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   5  (bases 1 to 9434)
  AUTHORS   Iida,N. and Kozasa,T.
  TITLE     Identification and biochemical analysis of GRIN1 and GRIN2
  JOURNAL   Methods Enzymol 390, 475-483 (2004)
   PUBMED   15488195
REFERENCE   6  (bases 1 to 9434)
  AUTHORS   Chen,L.T., Gilman,A.G. and Kozasa,T.
  TITLE     A candidate target for G protein action in brain
  JOURNAL   J Biol Chem 274 (38), 26931-26938 (1999)
   PUBMED   10480904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356056.22, AL645529.4 and AL732434.21.
            
            On Jul 15, 2020 this sequence version replaced XM_005277666.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.441198.1,
                                           SRR7346977.1262687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AL356056.22        180433-180593
            162-316             AL356056.22        181562-181716
            317-427             AL356056.22        182396-182506
            428-8506            AL645529.4         4373-12451
            8507-9434           AL732434.21        61600-62527         c
FEATURES             Location/Qualifiers
     source          1..9434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..9434
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="G protein regulated inducer of neurite outgrowth 2"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
     exon            1..161
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            162..316
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            317..427
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            428..9434
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1810
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="isoform 1 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="G protein-regulated inducer of neurite outgrowth
                     2 isoform 1"
                     /protein_id="NP_001372212.1"
                     /db_xref="CCDS:CCDS73101.1"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
                     /translation="MSSSRPEPGPWAPLSPRLQPLSQSSSSLLGEGREQRPELRKTAS
                     STVWQAQLGEASTRPQAPEEEGNPPESMKPARASGPKARPSAGGHWWSSTVGNVSTMG
                     GSDLCRLRAPSAAAMQRSHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGG
                     TSGQGGQAPAGLERDLAPEDETSNSAWMLGASQLSVPPLDLGDTTAHSSSAQAEPKAA
                     EQLATTTCHALPPAALLCGMREVRAGGCCHALPATGILAFPKLVASVSESGLQAQHGV
                     KIHCRLSGGLPGHSHCCAHLWGPAGLVPEPGSRTKDVWTMTSANDLAPAEASPLSAQD
                     AGVQAAPVAACKAVATSPSLEAPAALHVFPEVTLGSSLEEVPSPVRDVRWDAEGMTWE
                     VYGAAVDLEVLGVAIQKHLEMQFEQLQRAPASEDSLSVEGRRGPLRAVMQSLRRPSCC
                     GCSGAAPE"
     polyA_site      2126
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
     regulatory      9405..9410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="hexamer: ATTAAA"
     polyA_site      9434
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
ORIGIN      
        1 gtacccggcg cttgctccgc gggccgggcc gacggcggcg ggcggcgtct cgcgcccagg
       61 ccaggtcggc tctggctcca tcttgggccg cggcacctgg cacctgtggc ggccgcagga
      121 gcagcgcttc ccccgcctgc gcggccccgg cgggcgagag ggaatgctgc ctgctgcttt
      181 gcccagagtt ggccctgagt gttcctatca ggccccgttc actctggggt ggattaaacc
      241 acctcctgga gggtgctgta tccccactgt gcaatggggg tttgtgctgt gtgcattcct
      301 gcctggtcct tgagagttgc tgacaggtgg aacctgaggc agcaggacag cctggcattg
      361 gccacgggac atcggccaca accatagcaa cttcggcatc aaatggggca ggagagagaa
      421 cattaaggca gccatgagct ccagccgccc cgagccgggt ccctgggcac ccctgagccc
      481 ccgccttcag cccctgtccc agagctcttc cagcctgctg ggtgaaggcc gggaacagag
      541 gccagagctc cgcaagactg ccagcagcac cgtgtggcag gcccagctgg gcgaggccag
      601 caccagaccc caggccccgg aggaagaggg gaacccgcct gagagcatga agccagcacg
      661 ggcctctggc cccaaggcgc gacccagtgc tggaggccac tggtggagca gcactgtggg
      721 caatgtgtcc accatgggcg gcagtgacct gtgtcgcctg cgggccccta gtgctgctgc
      781 tatgcagagg agccattcag acctggtccg tagcacccag atgcggggac acagtggtgc
      841 tcggaaggcc agtctcagct gctcagccct tggcagcagc cctgtccaca gggctcagct
      901 gcagccaggt ggtacttctg gccagggtgg ccaggcccct gcaggcctgg aaagggacct
      961 ggctcctgag gatgagactt ctaactcagc ctggatgctg ggggcgagtc agttgtcagt
     1021 gccaccacta gacctggggg acacaactgc ccacagcagc agtgcccagg ctgagcccaa
     1081 agctgctgaa cagctggcta ccaccacctg ccatgctctg cccccagctg ctctactctg
     1141 tggcatgagg gaggtgaggg ctggtggctg ctgccatgcc ctacctgcca cagggatcct
     1201 ggcctttccc aaactagtgg cgtcagtgag cgagtctggg ctgcaggctc agcatggggt
     1261 gaagatccac tgtaggttgt ctggggggct ccctgggcat tcccattgct gtgcccacct
     1321 ttggggtccc gctgggttag tcccagagcc tggctctagg accaaagatg tgtggaccat
     1381 gacctcagcc aatgacttgg cccctgcaga ggcatccccg ctgtcagccc aggatgctgg
     1441 tgtgcaggcg gccccagtgg cggcctgcaa ggctgtggcc accagtccgt ccctggaagc
     1501 gcctgcagcc ctgcatgtgt tcccagaggt aactctgggg tccagcctgg aggaggtgcc
     1561 gtcccctgtg cgggatgtgc gatgggatgc tgagggcatg acatgggagg tgtacggagc
     1621 tgcggtggac ctggaggtgc tcggtgtggc catccagaag cacctggaga tgcagtttga
     1681 gcagctgcag cgggcgcccg ccagcgagga cagcctgtct gtggagggcc ggagggggcc
     1741 actgcgggct gtcatgcagt ccctgcggcg ccccagctgc tgcggctgct ccggcgcggc
     1801 ccccgagtga ggagctgtgg cccttggagc tggcctgggc ccactgactt agtcctagac
     1861 ctgggccagg gacggtgggg gctccgtgcc ccctggaccc accggcagct gggcacatct
     1921 ctcacctgaa tattggctgc ctccagacca caggactgca gcctggggct tccggcccta
     1981 cacagctggg ctgttttctt aagggcttga tttccaaggg ccacatctct gcaccttccg
     2041 ggctctgaac tttgagacag ggctttagca ctgtgcagag gggagatcct gagttttctg
     2101 taaaaaatga ccttttgttc actccaccct cagaactctg ccatgttgcc tcgtcagact
     2161 cttggtggct ttatttgaaa tcagtgctga gaaatagtga attctcgaca tgaaatgtga
     2221 ggccccagtg acagggactg cccaggtctt tagggaaggg gactgatgtt atcagaggcc
     2281 tcctgtgtgc cacatactgt gcttgtcctg tcttcacctc ttcatcctgg caagccttca
     2341 tttggcaagg ctgtagccga tgtgccccac gctggacagc ttgaagaggt gggactgaga
     2401 tccaaagcca gggccagctg agccgtgggt gttgccctgt agcatgtgcc cggtccagtc
     2461 agtgcagtca tgtatgagga gaatttactg agctcatact ctgtgctggg ttctgtggat
     2521 tctgtggtga atgagacaga ggctgcccct gccctggctg agctcatggt gtgggttggg
     2581 gatggcaggg gaggatgctg accattacgg agggctgcca ggcttccagg gtcattgtgt
     2641 cagaggctgg cctgaggaag gggagaatgg gtggccacct gccctaatct cagttacaaa
     2701 gcctaaaatt gcactatttt cacctcattc tgtcggctga aggatttctc cccagctggt
     2761 gcagtttgtg gaaggaggga gggcaggaat ggagggggac agggcaggag tttgccctgg
     2821 ccctggggta ggggctgtga ggctgtgggg gctcgcttgc ccacatgacc tgacctaggc
     2881 taggcagtgg gggccagggg ccttggagag acagaaacat gggctttggc acagtctgac
     2941 ttcattgccc aaagatttct cgaggcctgt gaagaatggg agtgggcttg tgttcttgtc
     3001 ctgggtcttt gtcttgaaga tcctaagatc ccgtgacaca gccccccaat ccacccgtgt
     3061 gagggaccag agggctagtg tggggtcatg gcccacgacc tggcctgttt ctggagcctc
     3121 ttctgcacct aggagcccag gacccccaca gtggtggctt acttttcccc atcctcaagg
     3181 acctggtact cattgaggtg gaaatgactc atgcaacagt tggtgaattt gtaaagcagg
     3241 agtggcattt caacaggcca caaggacaaa gtgacaaagg cgtgcgtcag gtcagatgcc
     3301 tcctgaagcc caacgatgga ccattctcac ccgtaaacat gcctttccca tatgcatagg
     3361 tgcacccctt gggattctgg ggctgtcagt ccctttgtgt atggtgccag ggcaggcagc
     3421 tcacgttctg gggagtgaca catgggtata tgccatcttc atgcctggct ccccatggag
     3481 tctccaggaa ccccagcctg ttagggccac atgagagaga acaaatggct gtgggtgcat
     3541 ggggagggac ctttcacaca gggccatagc taagtagggt cttgaggatg caggggttag
     3601 acaggtgggt ggagagaggg caggacctgc ctggcagatg gaacagcctg gtcagatact
     3661 tggatgtgcc tgtcctgcct gggccataat gagtttctgc agtggcggct catttggagc
     3721 gtttgttggg ttgggaggtg accaggggtc cccattgtga agatcctgat gtaaatgagg
     3781 aaaggaactt taagggaact gtggaagggg ttctgaggtg ggaccagatt tcagtttaga
     3841 aatatccatt tggcttccag tggagatgtg ccaggtgaca ccaaggaggg gcctgtttag
     3901 gggcaatgga gtgggcagct gggggctggg ttcatacacg tgcacacaca cgcatacaca
     3961 ggcacacatg tgtgcaatgg atttggggag gaggcatttc aggatgctga ggtttccagt
     4021 ttgagcaaga ggagggtgag gccactacct gggtcaaggt gaatggcatg ttcagcaggt
     4081 gcagaaaggg ccacctgcca cagggtttgg ctgggaccag tgaaacctac ttcatgaaga
     4141 gactttcttc tgtgtcacgt gcagattctt atgcattcac gctggctggg tgccactctg
     4201 tgctacctcc atgctgccct ggcttgccag gatggcaggc cgggctgggc tcagccaagc
     4261 tcccactcac ctcatcgtca ctgagatgag tatttgcaga gcggtgctga aatccaacac
     4321 ctgtgtcttg gctggggccc cagatgattc tcctggctaa accacgatcc ttgtctccct
     4381 agcccagttg cacagctgct gctgacaggt ctacctgaag tgactgcagc ctcatttctg
     4441 attggaactg gagacccctc ccaaccccct ttgctgtgcc ctctcctgga acagccctga
     4501 tgcctgcagt ggtttagggc cccagagcat ggccagcggt ttagtttaca gatctcctcc
     4561 ccttggactc tagatttctg gccagacttt ctgggtccct ttcaggccct gctctgggag
     4621 gtgttggagt tcactgttga tgtgtttgtt tggctttgaa ttcaaaacag atacaaattt
     4681 ggaggtgaga gctttgccag accccagcag ggatggggca tcggtcctga ctggtcttgt
     4741 ttattttgtc ctggtaaatt ctgttctttg gagcataaac cctggagtcc tagagcccct
     4801 tgcctcagca ggaatccccc ctctgtctgc tccaggggct ccctgcttct gcccacctgc
     4861 tctccttcca tggcattcag gacccccgac agctgaagcc tctcttcata tagcttgtcc
     4921 cctctgggcc tgcctgtctt gtgtccagga cacaagacac gcatcccttg tctggcccca
     4981 ggctgccatc actgtcacaa gaaactcata gagtagagct ggtctgaggt cacagtgctg
     5041 gtggtggtgg aaaagcaggg atggcctgtt ccactgtgat cttacctcct gtgtcacctg
     5101 gattgggtct ctgtcccctt agacatgcta gatcctaact ttacaagggc tgaaggggtc
     5161 ttctacacgc aggtcccaac actttgggct ggggttggcc accgtagctt agtgggctaa
     5221 agctggagtt tgaatctgga tatataggat ccacacctat agccatgtga tcttgggcaa
     5281 gttacaagcc ttgatcatct tcctcatctg taagatgggg atgacaatgg tgcctccttc
     5341 acatgcttgg tgtggagatt aaatagaata acccaagtag tgcctggcac tgagttagtg
     5401 ctcagcacac aggctggtag tgttgggcac ccctctcata gccacattca ggggccacct
     5461 cttaccctgc cagcttggct gtgatcacag cccacatccc acttccttaa aagtcccttg
     5521 ttcagagcct ctttccaggt tcctcgcccc acagctttgc accctgcctg ggacttggcc
     5581 ctctggctgg ggcttctgaa aatgtagttc ccagagtgca ttgaggaggg ctaccctagc
     5641 cctcaccact catcttgggc tgggttcccc agaagcttct gctgagatga ggatgctgga
     5701 gttattaggg aggggagagc aagttaaggg aggggcagaa ggcaaggcag ggtgtgattt
     5761 cagtccaagt cagaccctaa aggggagccc tggatgcagt cccacctcag agtaaggact
     5821 acccaggggt gaagatgtag cctccaggca cttctgctct ctggcaggca ggctaggaag
     5881 ctctaggagc cccagggtag gtttctgctg gagtcgtagg gcctattttg ggggaagttg
     5941 tgcacagaaa ccaccagagg gagtcacagg catctggggg tgcacccatt gacatttgca
     6001 tccatgtcat gccaagcttg tagcccacaa atgcccaacc cttttctcca tgcattgctc
     6061 tgtctcagtt ttgttcacgc caagcagcct tggttagtta aatgcagagc ttggcatttg
     6121 cccatgttaa attccttctc ctttttcatt ctggcctggc ctggttttgc catctgaagc
     6181 tatgacaagt cctttatcag ttttcatcca acttgtcagg cagggcaggg ctggtatgaa
     6241 gcccaggaca tatcactggg acatcccata ggtctgtgag attcccaggt ccctccaaat
     6301 ccacacggtc atcatgggca aattagttta agtctgatct gttaagatcc agatctctca
     6361 caccaacagc acacacccct ttttcccatg gccatggaag gagggtagca tagcctgact
     6421 cgagtcctcg ttctcagcag aactggttct gtggtggcca cttccctttc tcaactttta
     6481 cctacttctg tttaataggt tgttctgcaa gtctgagagc aacagcaagc ttagaagtgt
     6541 ggactcagcc tggtacagtg gctcatgcct gtaatcccag cactttggga ggctgaggtg
     6601 ggctgactgc ttgagctcag gagttcgaaa ccagcttggg cagcatggag aaatcccatc
     6661 tctacaaaaa atacaaaaat tagctgggca tggtggtgtg catctgtagc ctcagctact
     6721 cagggggttg aggtgggaag atggcttgag cccaggaggt ggaggttgca gtgagccgag
     6781 atagtgccac tgtgctccag cctggatgac ggagccagac cctgtttcaa aaaaagaaaa
     6841 agacaagaaa gaagtatgga ctctaccttc ttgcccttgt ggagattggg aactgcctgc
     6901 ccttggcctc tttcctgtcc atcttgtatt atgaaaggct gtttctggca cacccgggct
     6961 cctctgtgtg gtttctggga agtgactgag ggtcagggga atggagcccc tctgcagccg
     7021 gccgctggta ccttccctat tgaacccttc tttaggtttg ctcactcttt ttgatgggtg
     7081 tctttccaaa gctggctggg gacctccctg attgagagac atggggccag ttctgttgct
     7141 gtggctacac gggaataata aagcagaaga acacctgagg aaagctgatg tttactaaaa
     7201 aaaaaaacaa gcgaaaccaa agtgacgtgg gcccatagga ttggggatgg gtggtggggt
     7261 ctgactgcct tgtcccaaga gttgggtgaa tgccgccttt gctcacttgt gcggtcactc
     7321 tccaggactc ctgcctggct tctcccactc caagcccgag atagcccagc aaggaggaag
     7381 gtctggcccc aaaatacgag ctccccaagt ggatatccta aaattcatct ttcatggccc
     7441 tactttattg ggagggaatg tgaaaattgt gggaatatgt ccattgacat ctggggctca
     7501 gggcagggga gtgtgtctag ttttaaggtg tgcgctttta gccatgcagt catcgcccag
     7561 tctgtcctgc ctggagcttt tcatttccct gcagctttcc tgagaaaaga cagagtgtgc
     7621 tttctctgca tcctatgaac atggccccag gactgcagca cctctgtgtg cacacagcca
     7681 aggacagtcg ggggacctct gctggtcctg cacccgctgc cctgggtgct ctgtcatccc
     7741 catcccccat ttctctttaa tctgttcttc ttttgtggtt tcatgttctc tttgttctgg
     7801 gttattcaga acctgtctgc ctccccactg tccattgtac ttgttcctgc ctcctcctgc
     7861 tttgtgccaa ggatttactt gccttcgcct tctggctcca tacagtagtc tctcttcttg
     7921 cggtcttggc cattcccccc accaggcccc cagctgtggc tgtgtctggg tcttggcatt
     7981 tgtgatttac atgggtctag gccctttctc tccacctgtc cttcccctct ttggacacaa
     8041 accaaaacat ctgagcatct ccttacagag ggaggtctcc ctggggttgc tgtgccaagt
     8101 ttccattgct tttgcccaga atgagaaatc agttgtcagt ggccctgctg ggtgaatgga
     8161 aggactttgg tcgggctgga agggcacccc atcagtccta acttttggtg gcccttgttg
     8221 gtggctggct ggctaggctg ctagagaggt acatcaggtg ggtggcaccc atctgctggc
     8281 tttaggcagg ccatctcctc atccatgttt tcagaatctt cttgcatggc ttgtaattgg
     8341 gttggggtgt ggcctgagcc cctgtgggga cacactgcac tgtcccacct gtatgcttct
     8401 ctgctgtcag gaactggatt cgtgtccaag agccaaggct agggactgga ggaggagatt
     8461 tctgtctttg acccctccat attagtccat tttcatgctg ctataaagaa ctgcctgaga
     8521 ctgggtaatt tataaaggaa agaggtttaa ttgactcaca gttccacgtg gcccggggag
     8581 cctcaggaaa cttacaggaa gcctcaggaa acttacaatc atggcagaca gcgaaggaga
     8641 agcaaggcac cttcttcaca aggcagcagg aaggaaaatg aatgcagaag gaactaccaa
     8701 acacttataa aaccatcaga tctcgtgaga acttactatc acaagaacag catgggggaa
     8761 ccgcccccac gattccatca cctccacctg atctctccct tgtcacatgg ggattatagg
     8821 gattacaatt caagatgaga ttttgggtgg ggacacagcc aaagcatatc accctcccag
     8881 gcctgagcaa ggcccaagca gggagcctct gttggggctg gaaccctggg aggggtagaa
     8941 ttctcccctc cactcagatt tgttccctgt tgctgcccac ctggcccctg ccctgcagcc
     9001 ttctgcctgg ccttctctct gttcacttct catttttagc agtcaacaga ctgggagatg
     9061 gtggccaagg gtgtcatttt gtacacaagc tttgtggctt ttgtaagccc agcctgcaac
     9121 tcttgaggaa aactctttgg tttgattttt tttctcttca gagttggggg tattcaggga
     9181 gatgggcaag ggcttcttgt gaagatttca attcttgaag gggtggaagc ctcctgggct
     9241 gggggaaggg gtggggcagg aaccagcagg ggtgtggaca cagggggctg gcacctggga
     9301 taccgtagga cagctgggca ggaagtcgga tgctgcttta ttgaaatttt tgatatttta
     9361 tcattttttc attagttttt attttaaaac actgctttaa aataattaaa atatgattta
     9421 tcttggttac cgaa
//
