LOCUS       NM_001385282            9279 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein regulated inducer of neurite outgrowth 2
            (GPRIN2), transcript variant 8, mRNA.
ACCESSION   NM_001385282 XM_011540400
VERSION     NM_001385282.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9279)
  AUTHORS   Khalilipour,N., Baranova,A., Jebelli,A., Heravi-Moussavi,A.,
            Bruskin,S. and Abbaszadegan,M.R.
  TITLE     Familial Esophageal Squamous Cell Carcinoma with damaging
            rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes
  JOURNAL   Cancer Genet 221, 46-52 (2018)
   PUBMED   29405996
  REMARK    GeneRIF: Four of these 16 variants were rare damaging mutations
            including novel mutations in KCNJ12/KCNJ18, and GPRIN2 genes. This
            WES study in Iranian patients with ESCC, provides insight into the
            identification of novel germline mutations in familial ESCC. Our
            data suggest an association between specific mutations and
            increased risk of ESCC
REFERENCE   2  (bases 1 to 9279)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9279)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   4  (bases 1 to 9279)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   5  (bases 1 to 9279)
  AUTHORS   Iida,N. and Kozasa,T.
  TITLE     Identification and biochemical analysis of GRIN1 and GRIN2
  JOURNAL   Methods Enzymol 390, 475-483 (2004)
   PUBMED   15488195
REFERENCE   6  (bases 1 to 9279)
  AUTHORS   Chen,L.T., Gilman,A.G. and Kozasa,T.
  TITLE     A candidate target for G protein action in brain
  JOURNAL   J Biol Chem 274 (38), 26931-26938 (1999)
   PUBMED   10480904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356056.22, AL645529.4 and AL732434.21.
            
            On Jul 15, 2020 this sequence version replaced XM_011540400.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.3375.1,
                                           SRR18074967.466485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374314.6/ ENSP00000363433.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AL356056.22        180433-180593
            162-272             AL356056.22        182396-182506
            273-8351            AL645529.4         4373-12451
            8352-9279           AL732434.21        61600-62527         c
FEATURES             Location/Qualifiers
     source          1..9279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..9279
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="G protein regulated inducer of neurite outgrowth 2"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
     exon            1..161
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            162..272
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     exon            273..9279
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1655
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="isoform 1 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="G protein-regulated inducer of neurite outgrowth
                     2 isoform 1"
                     /protein_id="NP_001372211.1"
                     /db_xref="CCDS:CCDS73101.1"
                     /db_xref="GeneID:9721"
                     /db_xref="HGNC:HGNC:23730"
                     /db_xref="MIM:611240"
                     /translation="MSSSRPEPGPWAPLSPRLQPLSQSSSSLLGEGREQRPELRKTAS
                     STVWQAQLGEASTRPQAPEEEGNPPESMKPARASGPKARPSAGGHWWSSTVGNVSTMG
                     GSDLCRLRAPSAAAMQRSHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGG
                     TSGQGGQAPAGLERDLAPEDETSNSAWMLGASQLSVPPLDLGDTTAHSSSAQAEPKAA
                     EQLATTTCHALPPAALLCGMREVRAGGCCHALPATGILAFPKLVASVSESGLQAQHGV
                     KIHCRLSGGLPGHSHCCAHLWGPAGLVPEPGSRTKDVWTMTSANDLAPAEASPLSAQD
                     AGVQAAPVAACKAVATSPSLEAPAALHVFPEVTLGSSLEEVPSPVRDVRWDAEGMTWE
                     VYGAAVDLEVLGVAIQKHLEMQFEQLQRAPASEDSLSVEGRRGPLRAVMQSLRRPSCC
                     GCSGAAPE"
     polyA_site      1971
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
     regulatory      9250..9255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="hexamer: ATTAAA"
     polyA_site      9279
                     /gene="GPRIN2"
                     /gene_synonym="GRIN2; KIAA0514"
                     /note="major polyA site"
ORIGIN      
        1 gtacccggcg cttgctccgc gggccgggcc gacggcggcg ggcggcgtct cgcgcccagg
       61 ccaggtcggc tctggctcca tcttgggccg cggcacctgg cacctgtggc ggccgcagga
      121 gcagcgcttc ccccgcctgc gcggccccgg cgggcgagag gttgctgaca ggtggaacct
      181 gaggcagcag gacagcctgg cattggccac gggacatcgg ccacaaccat agcaacttcg
      241 gcatcaaatg gggcaggaga gagaacatta aggcagccat gagctccagc cgccccgagc
      301 cgggtccctg ggcacccctg agcccccgcc ttcagcccct gtcccagagc tcttccagcc
      361 tgctgggtga aggccgggaa cagaggccag agctccgcaa gactgccagc agcaccgtgt
      421 ggcaggccca gctgggcgag gccagcacca gaccccaggc cccggaggaa gaggggaacc
      481 cgcctgagag catgaagcca gcacgggcct ctggccccaa ggcgcgaccc agtgctggag
      541 gccactggtg gagcagcact gtgggcaatg tgtccaccat gggcggcagt gacctgtgtc
      601 gcctgcgggc ccctagtgct gctgctatgc agaggagcca ttcagacctg gtccgtagca
      661 cccagatgcg gggacacagt ggtgctcgga aggccagtct cagctgctca gcccttggca
      721 gcagccctgt ccacagggct cagctgcagc caggtggtac ttctggccag ggtggccagg
      781 cccctgcagg cctggaaagg gacctggctc ctgaggatga gacttctaac tcagcctgga
      841 tgctgggggc gagtcagttg tcagtgccac cactagacct gggggacaca actgcccaca
      901 gcagcagtgc ccaggctgag cccaaagctg ctgaacagct ggctaccacc acctgccatg
      961 ctctgccccc agctgctcta ctctgtggca tgagggaggt gagggctggt ggctgctgcc
     1021 atgccctacc tgccacaggg atcctggcct ttcccaaact agtggcgtca gtgagcgagt
     1081 ctgggctgca ggctcagcat ggggtgaaga tccactgtag gttgtctggg gggctccctg
     1141 ggcattccca ttgctgtgcc cacctttggg gtcccgctgg gttagtccca gagcctggct
     1201 ctaggaccaa agatgtgtgg accatgacct cagccaatga cttggcccct gcagaggcat
     1261 ccccgctgtc agcccaggat gctggtgtgc aggcggcccc agtggcggcc tgcaaggctg
     1321 tggccaccag tccgtccctg gaagcgcctg cagccctgca tgtgttccca gaggtaactc
     1381 tggggtccag cctggaggag gtgccgtccc ctgtgcggga tgtgcgatgg gatgctgagg
     1441 gcatgacatg ggaggtgtac ggagctgcgg tggacctgga ggtgctcggt gtggccatcc
     1501 agaagcacct ggagatgcag tttgagcagc tgcagcgggc gcccgccagc gaggacagcc
     1561 tgtctgtgga gggccggagg gggccactgc gggctgtcat gcagtccctg cggcgcccca
     1621 gctgctgcgg ctgctccggc gcggcccccg agtgaggagc tgtggccctt ggagctggcc
     1681 tgggcccact gacttagtcc tagacctggg ccagggacgg tgggggctcc gtgccccctg
     1741 gacccaccgg cagctgggca catctctcac ctgaatattg gctgcctcca gaccacagga
     1801 ctgcagcctg gggcttccgg ccctacacag ctgggctgtt ttcttaaggg cttgatttcc
     1861 aagggccaca tctctgcacc ttccgggctc tgaactttga gacagggctt tagcactgtg
     1921 cagaggggag atcctgagtt ttctgtaaaa aatgaccttt tgttcactcc accctcagaa
     1981 ctctgccatg ttgcctcgtc agactcttgg tggctttatt tgaaatcagt gctgagaaat
     2041 agtgaattct cgacatgaaa tgtgaggccc cagtgacagg gactgcccag gtctttaggg
     2101 aaggggactg atgttatcag aggcctcctg tgtgccacat actgtgcttg tcctgtcttc
     2161 acctcttcat cctggcaagc cttcatttgg caaggctgta gccgatgtgc cccacgctgg
     2221 acagcttgaa gaggtgggac tgagatccaa agccagggcc agctgagccg tgggtgttgc
     2281 cctgtagcat gtgcccggtc cagtcagtgc agtcatgtat gaggagaatt tactgagctc
     2341 atactctgtg ctgggttctg tggattctgt ggtgaatgag acagaggctg cccctgccct
     2401 ggctgagctc atggtgtggg ttggggatgg caggggagga tgctgaccat tacggagggc
     2461 tgccaggctt ccagggtcat tgtgtcagag gctggcctga ggaaggggag aatgggtggc
     2521 cacctgccct aatctcagtt acaaagccta aaattgcact attttcacct cattctgtcg
     2581 gctgaaggat ttctccccag ctggtgcagt ttgtggaagg agggagggca ggaatggagg
     2641 gggacagggc aggagtttgc cctggccctg gggtaggggc tgtgaggctg tgggggctcg
     2701 cttgcccaca tgacctgacc taggctaggc agtgggggcc aggggccttg gagagacaga
     2761 aacatgggct ttggcacagt ctgacttcat tgcccaaaga tttctcgagg cctgtgaaga
     2821 atgggagtgg gcttgtgttc ttgtcctggg tctttgtctt gaagatccta agatcccgtg
     2881 acacagcccc ccaatccacc cgtgtgaggg accagagggc tagtgtgggg tcatggccca
     2941 cgacctggcc tgtttctgga gcctcttctg cacctaggag cccaggaccc ccacagtggt
     3001 ggcttacttt tccccatcct caaggacctg gtactcattg aggtggaaat gactcatgca
     3061 acagttggtg aatttgtaaa gcaggagtgg catttcaaca ggccacaagg acaaagtgac
     3121 aaaggcgtgc gtcaggtcag atgcctcctg aagcccaacg atggaccatt ctcacccgta
     3181 aacatgcctt tcccatatgc ataggtgcac cccttgggat tctggggctg tcagtccctt
     3241 tgtgtatggt gccagggcag gcagctcacg ttctggggag tgacacatgg gtatatgcca
     3301 tcttcatgcc tggctcccca tggagtctcc aggaacccca gcctgttagg gccacatgag
     3361 agagaacaaa tggctgtggg tgcatgggga gggacctttc acacagggcc atagctaagt
     3421 agggtcttga ggatgcaggg gttagacagg tgggtggaga gagggcagga cctgcctggc
     3481 agatggaaca gcctggtcag atacttggat gtgcctgtcc tgcctgggcc ataatgagtt
     3541 tctgcagtgg cggctcattt ggagcgtttg ttgggttggg aggtgaccag gggtccccat
     3601 tgtgaagatc ctgatgtaaa tgaggaaagg aactttaagg gaactgtgga aggggttctg
     3661 aggtgggacc agatttcagt ttagaaatat ccatttggct tccagtggag atgtgccagg
     3721 tgacaccaag gaggggcctg tttaggggca atggagtggg cagctggggg ctgggttcat
     3781 acacgtgcac acacacgcat acacaggcac acatgtgtgc aatggatttg gggaggaggc
     3841 atttcaggat gctgaggttt ccagtttgag caagaggagg gtgaggccac tacctgggtc
     3901 aaggtgaatg gcatgttcag caggtgcaga aagggccacc tgccacaggg tttggctggg
     3961 accagtgaaa cctacttcat gaagagactt tcttctgtgt cacgtgcaga ttcttatgca
     4021 ttcacgctgg ctgggtgcca ctctgtgcta cctccatgct gccctggctt gccaggatgg
     4081 caggccgggc tgggctcagc caagctccca ctcacctcat cgtcactgag atgagtattt
     4141 gcagagcggt gctgaaatcc aacacctgtg tcttggctgg ggccccagat gattctcctg
     4201 gctaaaccac gatccttgtc tccctagccc agttgcacag ctgctgctga caggtctacc
     4261 tgaagtgact gcagcctcat ttctgattgg aactggagac ccctcccaac cccctttgct
     4321 gtgccctctc ctggaacagc cctgatgcct gcagtggttt agggccccag agcatggcca
     4381 gcggtttagt ttacagatct cctccccttg gactctagat ttctggccag actttctggg
     4441 tccctttcag gccctgctct gggaggtgtt ggagttcact gttgatgtgt ttgtttggct
     4501 ttgaattcaa aacagataca aatttggagg tgagagcttt gccagacccc agcagggatg
     4561 gggcatcggt cctgactggt cttgtttatt ttgtcctggt aaattctgtt ctttggagca
     4621 taaaccctgg agtcctagag ccccttgcct cagcaggaat cccccctctg tctgctccag
     4681 gggctccctg cttctgccca cctgctctcc ttccatggca ttcaggaccc ccgacagctg
     4741 aagcctctct tcatatagct tgtcccctct gggcctgcct gtcttgtgtc caggacacaa
     4801 gacacgcatc ccttgtctgg ccccaggctg ccatcactgt cacaagaaac tcatagagta
     4861 gagctggtct gaggtcacag tgctggtggt ggtggaaaag cagggatggc ctgttccact
     4921 gtgatcttac ctcctgtgtc acctggattg ggtctctgtc cccttagaca tgctagatcc
     4981 taactttaca agggctgaag gggtcttcta cacgcaggtc ccaacacttt gggctggggt
     5041 tggccaccgt agcttagtgg gctaaagctg gagtttgaat ctggatatat aggatccaca
     5101 cctatagcca tgtgatcttg ggcaagttac aagccttgat catcttcctc atctgtaaga
     5161 tggggatgac aatggtgcct ccttcacatg cttggtgtgg agattaaata gaataaccca
     5221 agtagtgcct ggcactgagt tagtgctcag cacacaggct ggtagtgttg ggcacccctc
     5281 tcatagccac attcaggggc cacctcttac cctgccagct tggctgtgat cacagcccac
     5341 atcccacttc cttaaaagtc ccttgttcag agcctctttc caggttcctc gccccacagc
     5401 tttgcaccct gcctgggact tggccctctg gctggggctt ctgaaaatgt agttcccaga
     5461 gtgcattgag gagggctacc ctagccctca ccactcatct tgggctgggt tccccagaag
     5521 cttctgctga gatgaggatg ctggagttat tagggagggg agagcaagtt aagggagggg
     5581 cagaaggcaa ggcagggtgt gatttcagtc caagtcagac cctaaagggg agccctggat
     5641 gcagtcccac ctcagagtaa ggactaccca ggggtgaaga tgtagcctcc aggcacttct
     5701 gctctctggc aggcaggcta ggaagctcta ggagccccag ggtaggtttc tgctggagtc
     5761 gtagggccta ttttggggga agttgtgcac agaaaccacc agagggagtc acaggcatct
     5821 gggggtgcac ccattgacat ttgcatccat gtcatgccaa gcttgtagcc cacaaatgcc
     5881 caaccctttt ctccatgcat tgctctgtct cagttttgtt cacgccaagc agccttggtt
     5941 agttaaatgc agagcttggc atttgcccat gttaaattcc ttctcctttt tcattctggc
     6001 ctggcctggt tttgccatct gaagctatga caagtccttt atcagttttc atccaacttg
     6061 tcaggcaggg cagggctggt atgaagccca ggacatatca ctgggacatc ccataggtct
     6121 gtgagattcc caggtccctc caaatccaca cggtcatcat gggcaaatta gtttaagtct
     6181 gatctgttaa gatccagatc tctcacacca acagcacaca cccctttttc ccatggccat
     6241 ggaaggaggg tagcatagcc tgactcgagt cctcgttctc agcagaactg gttctgtggt
     6301 ggccacttcc ctttctcaac ttttacctac ttctgtttaa taggttgttc tgcaagtctg
     6361 agagcaacag caagcttaga agtgtggact cagcctggta cagtggctca tgcctgtaat
     6421 cccagcactt tgggaggctg aggtgggctg actgcttgag ctcaggagtt cgaaaccagc
     6481 ttgggcagca tggagaaatc ccatctctac aaaaaataca aaaattagct gggcatggtg
     6541 gtgtgcatct gtagcctcag ctactcaggg ggttgaggtg ggaagatggc ttgagcccag
     6601 gaggtggagg ttgcagtgag ccgagatagt gccactgtgc tccagcctgg atgacggagc
     6661 cagaccctgt ttcaaaaaaa gaaaaagaca agaaagaagt atggactcta ccttcttgcc
     6721 cttgtggaga ttgggaactg cctgcccttg gcctctttcc tgtccatctt gtattatgaa
     6781 aggctgtttc tggcacaccc gggctcctct gtgtggtttc tgggaagtga ctgagggtca
     6841 ggggaatgga gcccctctgc agccggccgc tggtaccttc cctattgaac ccttctttag
     6901 gtttgctcac tctttttgat gggtgtcttt ccaaagctgg ctggggacct ccctgattga
     6961 gagacatggg gccagttctg ttgctgtggc tacacgggaa taataaagca gaagaacacc
     7021 tgaggaaagc tgatgtttac taaaaaaaaa aacaagcgaa accaaagtga cgtgggccca
     7081 taggattggg gatgggtggt ggggtctgac tgccttgtcc caagagttgg gtgaatgccg
     7141 cctttgctca cttgtgcggt cactctccag gactcctgcc tggcttctcc cactccaagc
     7201 ccgagatagc ccagcaagga ggaaggtctg gccccaaaat acgagctccc caagtggata
     7261 tcctaaaatt catctttcat ggccctactt tattgggagg gaatgtgaaa attgtgggaa
     7321 tatgtccatt gacatctggg gctcagggca ggggagtgtg tctagtttta aggtgtgcgc
     7381 ttttagccat gcagtcatcg cccagtctgt cctgcctgga gcttttcatt tccctgcagc
     7441 tttcctgaga aaagacagag tgtgctttct ctgcatccta tgaacatggc cccaggactg
     7501 cagcacctct gtgtgcacac agccaaggac agtcggggga cctctgctgg tcctgcaccc
     7561 gctgccctgg gtgctctgtc atccccatcc cccatttctc tttaatctgt tcttcttttg
     7621 tggtttcatg ttctctttgt tctgggttat tcagaacctg tctgcctccc cactgtccat
     7681 tgtacttgtt cctgcctcct cctgctttgt gccaaggatt tacttgcctt cgccttctgg
     7741 ctccatacag tagtctctct tcttgcggtc ttggccattc cccccaccag gcccccagct
     7801 gtggctgtgt ctgggtcttg gcatttgtga tttacatggg tctaggccct ttctctccac
     7861 ctgtccttcc cctctttgga cacaaaccaa aacatctgag catctcctta cagagggagg
     7921 tctccctggg gttgctgtgc caagtttcca ttgcttttgc ccagaatgag aaatcagttg
     7981 tcagtggccc tgctgggtga atggaaggac tttggtcggg ctggaagggc accccatcag
     8041 tcctaacttt tggtggccct tgttggtggc tggctggcta ggctgctaga gaggtacatc
     8101 aggtgggtgg cacccatctg ctggctttag gcaggccatc tcctcatcca tgttttcaga
     8161 atcttcttgc atggcttgta attgggttgg ggtgtggcct gagcccctgt ggggacacac
     8221 tgcactgtcc cacctgtatg cttctctgct gtcaggaact ggattcgtgt ccaagagcca
     8281 aggctaggga ctggaggagg agatttctgt ctttgacccc tccatattag tccattttca
     8341 tgctgctata aagaactgcc tgagactggg taatttataa aggaaagagg tttaattgac
     8401 tcacagttcc acgtggcccg gggagcctca ggaaacttac aggaagcctc aggaaactta
     8461 caatcatggc agacagcgaa ggagaagcaa ggcaccttct tcacaaggca gcaggaagga
     8521 aaatgaatgc agaaggaact accaaacact tataaaacca tcagatctcg tgagaactta
     8581 ctatcacaag aacagcatgg gggaaccgcc cccacgattc catcacctcc acctgatctc
     8641 tcccttgtca catggggatt atagggatta caattcaaga tgagattttg ggtggggaca
     8701 cagccaaagc atatcaccct cccaggcctg agcaaggccc aagcagggag cctctgttgg
     8761 ggctggaacc ctgggagggg tagaattctc ccctccactc agatttgttc cctgttgctg
     8821 cccacctggc ccctgccctg cagccttctg cctggccttc tctctgttca cttctcattt
     8881 ttagcagtca acagactggg agatggtggc caagggtgtc attttgtaca caagctttgt
     8941 ggcttttgta agcccagcct gcaactcttg aggaaaactc tttggtttga ttttttttct
     9001 cttcagagtt gggggtattc agggagatgg gcaagggctt cttgtgaaga tttcaattct
     9061 tgaaggggtg gaagcctcct gggctggggg aaggggtggg gcaggaacca gcaggggtgt
     9121 ggacacaggg ggctggcacc tgggataccg taggacagct gggcaggaag tcggatgctg
     9181 ctttattgaa atttttgata ttttatcatt ttttcattag tttttatttt aaaacactgc
     9241 tttaaaataa ttaaaatatg atttatcttg gttaccgaa
//
