LOCUS       NM_148963               2908 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor class C group 6 member A
            (GPRC6A), transcript variant 1, mRNA.
ACCESSION   NM_148963
VERSION     NM_148963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2908)
  AUTHORS   Jawich,K., Rocca,M.S., Al Fahoum,S., Alhalabi,M., Di Nisio,A.,
            Foresta,C., Ferlin,A. and De Toni,L.
  TITLE     RS 2247911 polymorphism of GPRC6A gene and serum
            undercarboxylated-osteocalcin are associated with testis function
  JOURNAL   J Endocrinol Invest 45 (9), 1673-1682 (2022)
   PUBMED   35482214
  REMARK    GeneRIF: RS 2247911 polymorphism of GPRC6A gene and serum
            undercarboxylated-osteocalcin are associated with testis function.
REFERENCE   2  (bases 1 to 2908)
  AUTHORS   Pi,M., Nishimoto,S.K. and Darryl Quarles,L.
  TITLE     Explaining Divergent Observations Regarding Osteocalcin/GPRC6A
            Endocrine Signaling
  JOURNAL   Endocrinology 162 (4) (2021)
   PUBMED   33474566
  REMARK    GeneRIF: Explaining Divergent Observations Regarding
            Osteocalcin/GPRC6A Endocrine Signaling.
            Review article
REFERENCE   3  (bases 1 to 2908)
  AUTHORS   Qi,N., Chen,Y., Zeng,Y., Bao,M., Long,X., Guo,Y., Tan,A., Gao,Y.,
            Zhang,H., Yang,X., Hu,Y., Mo,Z. and Jiang,Y.
  TITLE     rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA
            in a Southern Chinese male population
  JOURNAL   Gene 763, 145067 (2020)
   PUBMED   32827681
  REMARK    GeneRIF: rs2274911 polymorphism in GPRC6A associated with serum E2
            and PSA in a Southern Chinese male population.
REFERENCE   4  (bases 1 to 2908)
  AUTHORS   Kaune,T., Ruffert,C., Hesselbarth,N., Damm,M., Krug,S., Cardinal
            von Widdern,J., Masson,E., Chen,J.M., Rebours,V., Buscail,L.,
            Ferec,C., Grutzmann,R., Te Morsche,R.H.M., Drenth,J.P.,
            Cavestro,G.M., Zuppardo,R.A., Saftoiu,A., Malecka-Panas,E.,
            Gluszek,S., Bugert,P., Lerch,M.M., Sendler,M., Weiss,F.U.,
            Zou,W.B., Deng,S.J., Liao,Z., Scholz,M., Kirsten,H., Hegyi,P.,
            Witt,H., Michl,P., Griesmann,H. and Rosendahl,J.
  TITLE     Analysis of GPRC6A variants in different pancreatitis etiologies
  JOURNAL   Pancreatology 20 (7), 1262-1267 (2020)
   PUBMED   32859544
  REMARK    GeneRIF: Analysis of GPRC6A variants in different pancreatitis
            etiologies.
REFERENCE   5  (bases 1 to 2908)
  AUTHORS   Pi,M., Xu,F., Ye,R., Nishimoto,S.K., Kesterson,R.A., Williams,R.W.,
            Lu,L. and Quarles,L.D.
  TITLE     Humanized GPRC6AKGKY is a gain-of-function polymorphism in mice
  JOURNAL   Sci Rep 10 (1), 11143 (2020)
   PUBMED   32636482
  REMARK    GeneRIF: Humanized GPRC6A(KGKY) is a gain-of-function polymorphism
            in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2908)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (bases 1 to 2908)
  AUTHORS   Pi,M., Faber,P., Ekema,G., Jackson,P.D., Ting,A., Wang,N.,
            Fontilla-Poole,M., Mays,R.W., Brunden,K.R., Harrington,J.J. and
            Quarles,L.D.
  TITLE     Identification of a novel extracellular cation-sensing
            G-protein-coupled receptor
  JOURNAL   J Biol Chem 280 (48), 40201-40209 (2005)
   PUBMED   16199532
  REMARK    GeneRIF: GPRC6A is a cation-, calcimimetic-, and
            osteocalcin-sensing receptor
REFERENCE   8  (bases 1 to 2908)
  AUTHORS   Wellendorph,P., Hansen,K.B., Balsgaard,A., Greenwood,J.R.,
            Egebjerg,J. and Brauner-Osborne,H.
  TITLE     Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid
            receptor with preference for basic amino acids
  JOURNAL   Mol Pharmacol 67 (3), 589-597 (2005)
   PUBMED   15576628
  REMARK    GeneRIF: elucidating agonist interaction with GPRC6A, a novel
            family C G-protein-coupled receptor.
REFERENCE   9  (bases 1 to 2908)
  AUTHORS   Wellendorph,P. and Brauner-Osborne,H.
  TITLE     Molecular cloning, expression, and sequence analysis of GPRC6A, a
            novel family C G-protein-coupled receptor
  JOURNAL   Gene 335, 37-46 (2004)
   PUBMED   15194188
  REMARK    GeneRIF: GPRC6A is widely expressed in brain and peripheral tissues
            with highest levels in kidney, skeletal muscle, testis, and
            leucocytes.
REFERENCE   10 (bases 1 to 2908)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354716.9.
            
            On Nov 22, 2019 this sequence version replaced NM_148963.3.
            
            Summary: Members of family C of the G protein-coupled receptor
            (GPCR) superfamily, such as GPRC6A, are characterized by an
            evolutionarily conserved amino acid-sensing motif linked to an
            intramembranous 7-transmembrane loop region. Several members of
            GPCR family C, including GPRC6A, also have a long N-terminal domain
            (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF502962.1, AY435125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267754, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310357.8/ ENSP00000309493.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL354716.9         87342-87605         c
            265-568             AL354716.9         67836-68139         c
            569-1405            AL354716.9         64892-65728         c
            1406-1618           AL354716.9         59106-59318         c
            1619-1742           AL354716.9         54234-54357         c
            1743-2908           AL354716.9         50607-51772         c
FEATURES             Location/Qualifiers
     source          1..2908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..2908
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /note="G protein-coupled receptor class C group 6 member
                     A"
                     /db_xref="GeneID:222545"
                     /db_xref="HGNC:HGNC:18510"
                     /db_xref="MIM:613572"
     exon            1..264
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2851
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; seven transmembrane helix receptor; predicted
                     with SOSUI analysis; G-protein coupled receptor GPCR33; G
                     protein-coupled receptor, family C, group 6, member A"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 6
                     member A isoform 1 precursor"
                     /protein_id="NP_683766.2"
                     /db_xref="CCDS:CCDS5112.1"
                     /db_xref="GeneID:222545"
                     /db_xref="HGNC:HGNC:18510"
                     /db_xref="MIM:613572"
                     /translation="MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAI
                     HEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDT
                     CTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLN
                     LQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDD
                     DYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVV
                     FLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNIS
                     SFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAI
                     ERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVL
                     KNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQET
                     KNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCN
                     NKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVV
                     KSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSL
                     KILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVI
                     ILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITF
                     IPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSY
                     SSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSV
                     SKTLPRKRMSSI"
     exon            265..568
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1405
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1618
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1742
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2908
                     /gene="GPRC6A"
                     /gene_synonym="bA86F4.3; GPCR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttgctgg cactccgtgc acttaatgat tcctaagaac tcacatgaac tgagcaaatg
       61 agatagaaac atggcattct taattatact aattacctgc tttgtgatta ttcttgctac
      121 ttcacagcct tgccagaccc ctgatgactt tgtggctgcc acttctccgg gacatatcat
      181 aattggaggt ttgtttgcta ttcatgaaaa aatgttgtcc tcagaagact ctcccagacg
      241 accacaaatc caggagtgtg ttggctttga aatatcagtt tttcttcaaa ctcttgccat
      301 gatacacagc attgagatga tcaacaattc aacactctta cctggagtca aactggggta
      361 tgaaatctat gacacttgta cagaagtcac agtggcaatg gcagccactc tgaggtttct
      421 ttctaaattc aactgctcca gagaaactgt ggagtttaag tgtgactatt ccagctacat
      481 gccaagagtt aaggctgtca taggttctgg gtactcagaa ataactatgg ctgtctccag
      541 gatgttgaat ttacagctca tgccacaggt gggttatgaa tcaactgcag aaatcctgag
      601 tgacaaaatt cgctttcctt catttttacg gactgtgccc agtgacttcc atcaaattaa
      661 agcaatggct cacctgattc agaaatctgg ttggaactgg attggcatca taaccacaga
      721 tgatgactat ggacgattgg ctcttaacac ttttataatt caggctgaag caaataacgt
      781 gtgcatagcc ttcaaagagg ttcttccagc ctttctttca gataatacca ttgaagtcag
      841 aatcaatcgg acactgaaga aaatcatttt agaagcccag gttaatgtca ttgtggtatt
      901 tctgaggcaa ttccatgttt ttgatctctt caataaagcc attgaaatga atataaataa
      961 gatgtggatt gctagtgata attggtcaac tgccaccaag attaccacca ttcctaatgt
     1021 taaaaagatt ggcaaagttg tagggtttgc ctttagaaga gggaatatat cctctttcca
     1081 ttcctttctt caaaatctgc acttgcttcc cagtgacagt cacaaactct tacatgaata
     1141 tgccatgcat ttatctgcct gcgcatatgt caaggacact gatttgagtc aatgcatatt
     1201 caatcattct caaaggactt tggcctacaa ggctaacaag gctatagaaa ggaacttcgt
     1261 catgagaaat gacttcctct gggactatgc tgagccagga ctcattcata gtattcagct
     1321 tgcagtgttt gcccttggtt atgccattcg ggatctgtgt caagctcgtg actgtcagaa
     1381 ccccaacgcc tttcaaccat gggagttact tggtgtgcta aaaaatgtga cattcactga
     1441 tggatggaat tcatttcatt ttgatgctca cggggattta aatactggat atgatgttgt
     1501 gctctggaag gagatcaatg gacacatgac tgtcactaag atggcagaat atgacctaca
     1561 gaatgatgtc ttcatcatcc cagatcagga aacaaaaaat gagttcagga atcttaagca
     1621 aattcaatct aaatgctcca aggaatgcag tcctgggcaa atgaagaaaa ctacaagaag
     1681 tcaacacatc tgttgctatg aatgtcagaa ctgtcctgaa aatcattaca ctaatcagac
     1741 agatatgcct cactgccttt tatgcaacaa caaaactcac tgggcccctg ttaggagcac
     1801 tatgtgcttt gaaaaggaag tggaatatct caactggaat gactccttgg ccatcctact
     1861 cctgattctc tccctactgg gaatcatatt tgttctggtt gttggcataa tatttacaag
     1921 aaacctgaac acacctgttg tgaaatcatc cgggggatta agagtctgct atgtgatcct
     1981 tctctgtcat ttcctcaatt ttgccagcac gagctttttc attggagaac cacaagactt
     2041 cacatgtaaa accaggcaga caatgtttgg agtgagcttt actctttgca tctcctgcat
     2101 tttgacgaag tctctgaaaa ttttgctagc cttcagcttt gatcccaaat tacagaaatt
     2161 tctgaagtgc ctctatagac cgatccttat tatcttcact tgcacgggca tccaggttgt
     2221 catttgcaca ctctggctaa tctttgcagc acctactgta gaggtgaatg tctccttgcc
     2281 cagagtcatc atcctggagt gtgaggaggg atccatactt gcatttggca ccatgctggg
     2341 ctacattgcc atcctggcct tcatttgctt catatttgct ttcaaaggca aatatgagaa
     2401 ttacaatgaa gccaaattca ttacatttgg catgctcatt tacttcatag cttggatcac
     2461 attcatccct atctatgcta ccacatttgg caaatatgta ccagctgtgg agattattgt
     2521 catattaata tctaactatg gaatcctgta ttgcacattc atccccaaat gctatgttat
     2581 tatttgtaag caagagatta acacaaagtc tgcctttctc aagatgatct acagttattc
     2641 ttcccatagt gtgagcagca ttgccctgag tcctgcttca ctggactcca tgagcggcaa
     2701 tgtcacaatg accaatccca gctctagtgg caagtctgca acctggcaga aaagcaaaga
     2761 tcttcaggca caagcatttg cacacatatg cagggaaaat gccacaagtg tatctaaaac
     2821 tttgcctcga aaaagaatgt caagtatatg aataagcctt aggagatgcc acattccaga
     2881 ataaaatgtt tccagggtct ttgcatct
//
