LOCUS       NM_018654               1347 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor class C group 5 member D
            (GPRC5D), mRNA.
ACCESSION   NM_018654 XM_017019582
VERSION     NM_018654.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Rodriguez-Otero,P., van de Donk,N.W.C.J., Pillarisetti,K.,
            Cornax,I., Vishwamitra,D., Gray,K., Hilder,B., Tolbert,J.,
            Renaud,T., Masterson,T., Heuck,C., Kane,C., Verona,R., Moreau,P.,
            Bahlis,N. and Chari,A.
  TITLE     GPRC5D as a novel target for the treatment of multiple myeloma: a
            narrative review
  JOURNAL   Blood Cancer J 14 (1), 24 (2024)
   PUBMED   38307865
  REMARK    GeneRIF: GPRC5D as a novel target for the treatment of multiple
            myeloma: a narrative review.
            Review article
            Erratum:[Blood Cancer J. 2024 Mar 6;14(1):40. doi:
            10.1038/s41408-024-01018-6.. PMID: 38448422]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Derrien,J., Gastineau,S., Frigout,A., Giordano,N., Cherkaoui,M.,
            Gaborit,V., Boinon,R., Douillard,E., Devic,M., Magrangeas,F.,
            Moreau,P., Minvielle,S., Touzeau,C. and Letouze,E.
  TITLE     Acquired resistance to a GPRC5D-directed T-cell engager in multiple
            myeloma is mediated by genetic or epigenetic target inactivation
  JOURNAL   Nat Cancer 4 (11), 1536-1543 (2023)
   PUBMED   37653140
  REMARK    GeneRIF: Acquired resistance to a GPRC5D-directed T-cell engager in
            multiple myeloma is mediated by genetic or epigenetic target
            inactivation.
            Erratum:[Nat Cancer. 2023 Nov;4(11):1610. doi:
            10.1038/s43018-023-00646-4.. PMID: 37684528]
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Mi,X., Penson,A., Abdel-Wahab,O. and Mailankody,S.
  TITLE     Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells
  JOURNAL   N Engl J Med 389 (15), 1435-1437 (2023)
   PUBMED   37819961
  REMARK    GeneRIF: Genetic Basis of Relapse after GPRC5D-Targeted CAR T
            Cells.
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Mei,J., Cai,Y., Jiang,G., He,Z., Wang,R., Song,C., Wan,Y. and
            Mao,W.
  TITLE     GPRC5D as a promising therapeutic target in EGFR-wild and
            immuno-cold non-small cell lung cancer
  JOURNAL   J Transl Med 21 (1), 542 (2023)
   PUBMED   37574551
  REMARK    GeneRIF: GPRC5D as a promising therapeutic target in EGFR-wild and
            immuno-cold non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Cohen,Y., Gutwein,O., Garach-Jehoshua,O., Bar-Haim,A. and
            Kornberg,A.
  TITLE     GPRC5D is a promising marker for monitoring the tumor load and to
            target multiple myeloma cells
  JOURNAL   Hematology 18 (6), 348-351 (2013)
   PUBMED   23510526
  REMARK    GeneRIF: GPRC5D in MM cells makes this gene and its encoded surface
            protein as promising markers for monitoring the tumor load and
            hopefully also as targets for antimyeloma antibodies.
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Atamaniuk,J., Gleiss,A., Porpaczy,E., Kainz,B., Grunt,T.W.,
            Raderer,M., Hilgarth,B., Drach,J., Ludwig,H., Gisslinger,H.,
            Jaeger,U. and Gaiger,A.
  TITLE     Overexpression of G protein-coupled receptor 5D in the bone marrow
            is associated with poor prognosis in patients with multiple myeloma
  JOURNAL   Eur J Clin Invest 42 (9), 953-960 (2012)
   PUBMED   22591013
  REMARK    GeneRIF: Overexpression of G protein-coupled receptor 5D in the
            bone marrow is associated with poor prognosis in patients with
            multiple myeloma.
REFERENCE   8  (bases 1 to 1347)
  AUTHORS   Yokoyama,K., Urashima,M., Ohkido,I., Kono,T., Yoshida,T.,
            Muramatsu,M., Niu,T. and Hosoya,T.
  TITLE     L-type voltage-dependent calcium channel alpha subunit 1C is a
            novel candidate gene associated with secondary hyperparathyroidism:
            an application of haplotype-based analysis for multiple linked
            single nucleotide polymorphisms
  JOURNAL   Nephron Clin Pract 115 (4), c237-c243 (2010)
   PUBMED   20424473
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1347)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 1347)
  AUTHORS   Brauner-Osborne,H., Jensen,A.A., Sheppard,P.O., Brodin,B.,
            Krogsgaard-Larsen,P. and O'Hara,P.
  TITLE     Cloning and characterization of a human orphan family C G-protein
            coupled receptor GPRC5D
  JOURNAL   Biochim Biophys Acta 1518 (3), 237-248 (2001)
   PUBMED   11311935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007688.15.
            
            On or before May 3, 2021 this sequence version replaced
            XM_017019582.2, NM_018654.1.
            
            Summary: The protein encoded by this gene is a member of the G
            protein-coupled receptor family; however, the specific function of
            this gene has not yet been determined. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1944118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228887.6/ ENSP00000228887.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC007688.15        55224-55287
            65-1004             AC007688.15        56965-57904
            1005-1072           AC007688.15        65066-65133
            1073-1347           AC007688.15        66545-66819
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..1347
                     /gene="GPRC5D"
                     /note="G protein-coupled receptor class C group 5 member
                     D"
                     /db_xref="GeneID:55507"
                     /db_xref="HGNC:HGNC:13310"
                     /db_xref="MIM:607437"
     exon            1..64
                     /gene="GPRC5D"
                     /inference="alignment:Splign:2.1.0"
     exon            65..1004
                     /gene="GPRC5D"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1147
                     /gene="GPRC5D"
                     /note="orphan G-protein coupled receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 5
                     member D"
                     /protein_id="NP_061124.1"
                     /db_xref="CCDS:CCDS8658.1"
                     /db_xref="GeneID:55507"
                     /db_xref="HGNC:HGNC:13310"
                     /db_xref="MIM:607437"
                     /translation="MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAF
                     LFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFAL
                     CFSCLLAHASNLVKLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGMMFVN
                     MTPCQLNVDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWV
                     VWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRSCRQECPLQ
                     GNACPVTAYQHSFQVENQELSRARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQA
                     KLSPQQDAGGV"
     exon            1005..1072
                     /gene="GPRC5D"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1347
                     /gene="GPRC5D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcattggc agttacaact ttgccagcac tacagcctaa gcttccagag tggacacgga
       61 gaagggcatc agaaaaccat tctggtgagg tccacaccca taagtcacca tgtacaagga
      121 ctgcatcgag tccactggag actattttct tctctgtgac gccgaggggc catggggcat
      181 cattctggag tccctggcca tacttggcat cgtggtcaca attctgctac tcttagcatt
      241 tctcttcctc atgcgaaaga tccaagactg cagccagtgg aatgtcctcc ccacccagct
      301 cctcttcctc ctgagtgtcc tggggctctt cggactcgct tttgccttca tcatcgagct
      361 caatcaacaa actgcccccg tacgctactt tctctttggg gttctctttg ctctctgttt
      421 ctcatgcctc ttagctcatg cctccaatct agtgaagctg gttcggggtt gtgtctcctt
      481 ctcctggacg acaattctgt gcattgctat tggttgcagt ctgttgcaaa tcattattgc
      541 cactgagtat gtgactctca tcatgaccag aggtatgatg tttgtgaata tgacaccctg
      601 ccagctcaat gtggactttg ttgtactcct ggtctatgtc ctcttcctga tggccctcac
      661 attcttcgtc tccaaagcca ccttctgtgg cccgtgtgag aactggaagc agcatggaag
      721 gctcatcttt atcactgtgc tcttctccat catcatctgg gtggtgtgga tctccatgct
      781 cctgagaggc aacccgcagt tccagcgaca gccccagtgg gacgacccgg tcgtctgcat
      841 tgctctggtc accaacgcat gggttttcct gctgctgtac atcgtccctg agctctgcat
      901 tctctacaga tcgtgtagac aggagtgccc tttacaaggc aatgcctgcc ccgtcacagc
      961 ctaccaacac agcttccaag tggagaacca ggagctctcc agagcccgag acagtgatgg
     1021 agctgaggag gatgtagcat taacttcata tggtactccc attcagccgc agactgttga
     1081 tcccacacaa gagtgtttca tcccacaggc taaactaagc ccccagcaag atgcaggagg
     1141 agtataaatc tacaggaaac acaagtggag aaaacccagc agaccgtcct gggtagcata
     1201 gccctgatag cccacggggg cccacagagt cacgctgcca atgaagagtc agcatcccac
     1261 cttctgtttc ctaacccctc catccaccag gaccctccac cagaagacca ccattttgag
     1321 cataattaca atcttgctgg ccaccct
//
